MX2018006776A - Usos de pirimido-piridazinonas para tratar el cancer. - Google Patents
Usos de pirimido-piridazinonas para tratar el cancer.Info
- Publication number
- MX2018006776A MX2018006776A MX2018006776A MX2018006776A MX2018006776A MX 2018006776 A MX2018006776 A MX 2018006776A MX 2018006776 A MX2018006776 A MX 2018006776A MX 2018006776 A MX2018006776 A MX 2018006776A MX 2018006776 A MX2018006776 A MX 2018006776A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- growth
- compound
- methods
- tumor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se divulgan métodos para tratar el cáncer, que incluyen administrar una cantidad terapéuticamente eficaz de un compuesto de la Fórmula (I), o una sal o éster farmacéuticamente aceptable del mismo, a un sujeto que lo necesite. (ver Fórmula) También se describen métodos para inhibir el crecimiento y la proliferación de células cancerosas in vitro o in vivo, que incluyen poner en contacto las células con una cantidad del compuesto de la fórmula (I) eficaz para inhibir el crecimiento o la proliferación de las células cancerosas. Se describen además métodos para inhibir el crecimiento tumoral, que incluyen poner en contacto el tumor con una cantidad del compuesto de la fórmula (I) eficaz para inhibir el crecimiento del tumor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562263398P | 2015-12-04 | 2015-12-04 | |
PCT/US2016/064178 WO2017095898A1 (en) | 2015-12-04 | 2016-11-30 | Uses of pyrimido-pyrimidazinones to treat cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018006776A true MX2018006776A (es) | 2018-08-15 |
Family
ID=57570591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018006776A MX2018006776A (es) | 2015-12-04 | 2016-11-30 | Usos de pirimido-piridazinonas para tratar el cancer. |
Country Status (15)
Country | Link |
---|---|
US (2) | US10188654B2 (es) |
EP (1) | EP3383399A1 (es) |
JP (1) | JP2018535995A (es) |
KR (1) | KR20180084983A (es) |
CN (1) | CN108601785A (es) |
AR (1) | AR106830A1 (es) |
AU (1) | AU2016365215A1 (es) |
BR (1) | BR112018011196A2 (es) |
CA (1) | CA3006762A1 (es) |
IL (1) | IL259781A (es) |
MX (1) | MX2018006776A (es) |
RU (1) | RU2018124289A (es) |
TW (1) | TW201726141A (es) |
WO (1) | WO2017095898A1 (es) |
ZA (1) | ZA201803593B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE065564T2 (hu) * | 2011-08-23 | 2024-06-28 | Libertas Bio Inc | Pirimido-piridazinon vegyületek és alkalmazásuk |
CN110809471A (zh) | 2017-04-28 | 2020-02-18 | 阿沙纳生物科学公司 | 治疗特应性皮炎以及提高活性药物成分稳定性的制剂、方法、试剂盒和剂型 |
CN111961035B (zh) * | 2019-05-20 | 2022-11-01 | 南京科技职业学院 | 一类含有羟基异喹啉类结构的化合物、药物组合物以及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2723205C (en) | 2008-04-16 | 2017-03-14 | Portola Pharmaceuticals, Inc. | 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors |
EP2330909B1 (en) * | 2008-08-12 | 2013-09-18 | GlaxoSmithKline LLC | Chemical compounds |
TR201802464T4 (tr) * | 2009-10-29 | 2018-03-21 | Genosco | Ki̇naz i̇nhi̇bi̇törleri̇ |
WO2013013031A1 (en) * | 2011-07-19 | 2013-01-24 | Abbvie Inc. | Pyridazino [4, 5 -d] pyrimidin- (6h) -one inhibitors of wee - 1 kinase |
HUE065564T2 (hu) * | 2011-08-23 | 2024-06-28 | Libertas Bio Inc | Pirimido-piridazinon vegyületek és alkalmazásuk |
-
2016
- 2016-11-25 AR ARP160103628A patent/AR106830A1/es unknown
- 2016-11-28 TW TW105138865A patent/TW201726141A/zh unknown
- 2016-11-30 CA CA3006762A patent/CA3006762A1/en not_active Abandoned
- 2016-11-30 KR KR1020187017697A patent/KR20180084983A/ko unknown
- 2016-11-30 BR BR112018011196A patent/BR112018011196A2/pt not_active IP Right Cessation
- 2016-11-30 MX MX2018006776A patent/MX2018006776A/es unknown
- 2016-11-30 AU AU2016365215A patent/AU2016365215A1/en not_active Abandoned
- 2016-11-30 RU RU2018124289A patent/RU2018124289A/ru not_active Application Discontinuation
- 2016-11-30 US US15/365,222 patent/US10188654B2/en active Active
- 2016-11-30 EP EP16813264.5A patent/EP3383399A1/en not_active Withdrawn
- 2016-11-30 JP JP2018528583A patent/JP2018535995A/ja active Pending
- 2016-11-30 CN CN201680081107.0A patent/CN108601785A/zh active Pending
- 2016-11-30 WO PCT/US2016/064178 patent/WO2017095898A1/en active Application Filing
-
2018
- 2018-05-30 ZA ZA2018/03593A patent/ZA201803593B/en unknown
- 2018-06-03 IL IL259781A patent/IL259781A/en unknown
- 2018-11-02 US US16/179,274 patent/US20190070182A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3383399A1 (en) | 2018-10-10 |
CN108601785A (zh) | 2018-09-28 |
AU2016365215A1 (en) | 2018-07-05 |
US20170157126A1 (en) | 2017-06-08 |
TW201726141A (zh) | 2017-08-01 |
IL259781A (en) | 2018-07-31 |
BR112018011196A2 (pt) | 2018-11-21 |
CA3006762A1 (en) | 2017-06-08 |
ZA201803593B (en) | 2019-04-24 |
US10188654B2 (en) | 2019-01-29 |
RU2018124289A (ru) | 2020-01-14 |
AR106830A1 (es) | 2018-02-21 |
WO2017095898A1 (en) | 2017-06-08 |
JP2018535995A (ja) | 2018-12-06 |
KR20180084983A (ko) | 2018-07-25 |
US20190070182A1 (en) | 2019-03-07 |
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