ES2619309T3 - Ácido hialurónico sulfatado para el tratamiento de la osteoartritis degenerativa - Google Patents

Ácido hialurónico sulfatado para el tratamiento de la osteoartritis degenerativa Download PDF

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Publication number
ES2619309T3
ES2619309T3 ES14173163.8T ES14173163T ES2619309T3 ES 2619309 T3 ES2619309 T3 ES 2619309T3 ES 14173163 T ES14173163 T ES 14173163T ES 2619309 T3 ES2619309 T3 ES 2619309T3
Authority
ES
Spain
Prior art keywords
treatment
hyaluronic acid
degenerative osteoarthritis
sulfated hyaluronic
degenerative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14173163.8T
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English (en)
Inventor
Lanfranco Callegaro
Davide Renier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici SpA filed Critical Fidia Farmaceutici SpA
Application granted granted Critical
Publication of ES2619309T3 publication Critical patent/ES2619309T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones farmacéuticas que contienen como el ingrediente activo ácido hialurónico sulfatado de peso molecular entre 50.000 y 800.000 D que tiene un grado de sulfatación entre 0.5 y 1.5 para usar en la prevención y/o tratamiento de daño del cartílago causado por formas crónicas de osteoartritis degenerativa, Sin secuelas inflamatorias, en donde la composición se administra por inyección intraarticular.

Description

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Claims (1)

  1. imagen1
ES14173163.8T 2006-05-31 2007-05-03 Ácido hialurónico sulfatado para el tratamiento de la osteoartritis degenerativa Active ES2619309T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPD20060219 2006-05-31
IT000219A ITPD20060219A1 (it) 2006-05-31 2006-05-31 Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi

Publications (1)

Publication Number Publication Date
ES2619309T3 true ES2619309T3 (es) 2017-06-26

Family

ID=38353080

Family Applications (2)

Application Number Title Priority Date Filing Date
ES14173163.8T Active ES2619309T3 (es) 2006-05-31 2007-05-03 Ácido hialurónico sulfatado para el tratamiento de la osteoartritis degenerativa
ES07724845.8T Active ES2534763T3 (es) 2006-05-31 2007-05-03 Ácido hialurónico sulfatado para el tratamiento de la osteoartritis degenerativa

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES07724845.8T Active ES2534763T3 (es) 2006-05-31 2007-05-03 Ácido hialurónico sulfatado para el tratamiento de la osteoartritis degenerativa

Country Status (15)

Country Link
US (3) US20090197807A1 (es)
EP (2) EP2786782B1 (es)
JP (1) JP5537933B2 (es)
KR (1) KR20090014359A (es)
CN (1) CN101454048B (es)
AU (1) AU2007268195A1 (es)
CA (1) CA2653660C (es)
DK (1) DK2021078T3 (es)
ES (2) ES2619309T3 (es)
HK (2) HK1123235A1 (es)
IT (1) ITPD20060219A1 (es)
MX (1) MX2008015212A (es)
PL (2) PL2021078T3 (es)
SI (2) SI2021078T1 (es)
WO (1) WO2007137674A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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JP5088864B2 (ja) * 2007-03-16 2012-12-05 オリンパス株式会社 生体組織補填材とその製造方法
US20100285134A1 (en) * 2008-02-15 2010-11-11 Bone Therepeutics Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
JP5758797B2 (ja) 2008-04-04 2015-08-05 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
IT1393945B1 (it) * 2009-04-21 2012-05-17 Fidia Farmaceutici Composizioni comprendenti acido ialuronico, acido ialuronico solfatato, calcio e vitamina d3 nel trattamento delle malattie osteoarticolari e muscoloscheletriche
US20120219554A2 (en) * 2009-05-14 2012-08-30 Fidia Farmaceutici S.P.A. Extracellular yaluronidase from streptomyces koganeiensis
IT1397247B1 (it) 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
IT1397246B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
IT1397522B1 (it) * 2009-12-21 2013-01-16 Solartium Entpr Ltd Uso di una combinazione per il trattamento dell'osteoartrosi
US8546353B2 (en) 2010-05-06 2013-10-01 Glykos Finland Oy Compounds and combinations
EP2384759A1 (en) * 2010-05-06 2011-11-09 Suomen Punainen Risti Veripalvelu Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
AU2012230822A1 (en) 2011-03-23 2013-11-07 University Of Utah Research Foundation Methods for treating or preventing urological inflammation
KR101422689B1 (ko) * 2011-07-13 2014-07-23 (주)차바이오앤디오스텍 콜라겐, 히알루론산 유도체 및 포유류의 탯줄 유래 줄기세포를 포함하는 연골세포치료제
TWI466675B (zh) * 2011-09-16 2015-01-01 Univ China Medical 用於抑制發炎之醫藥組合物
ITPD20120098A1 (it) * 2012-03-30 2013-10-01 Fidia Farmaceutici "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico"
EA030022B1 (ru) * 2012-09-20 2018-06-29 Маккей Мемориал Хоспитал Применение pedf-производных полипептидов для лечения остеоартрита
US20140186306A1 (en) * 2012-09-28 2014-07-03 Paul Ronald Plante Novel ampk agonist compositions and methods of use
US10000582B2 (en) * 2013-04-02 2018-06-19 The Regents Of The University Of California Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof
KR101895950B1 (ko) * 2015-12-18 2018-09-06 (주)한국비엠아이 골관절염 치료를 위한 친수화된 설파살라진 및 히알루론산을 포함하는 조성물 및 이의제조방법
WO2017171672A1 (en) 2016-03-02 2017-10-05 Bortek Bor Teknolojileri Ve Mekatronik Sanayi Ticaret Anonim Sirketi Therapeutic mixtures for treating osteoarthritis comprising nano hexagonal boron nitride composition
TWI632915B (zh) * 2016-05-31 2018-08-21 大江生醫股份有限公司 用以治療關節炎之醫藥組成物
WO2018053111A1 (en) 2016-09-15 2018-03-22 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
WO2020055201A1 (ko) * 2018-09-13 2020-03-19 주식회사 엘지화학 황산화 히알루론산 기반의 하이드로겔 및 이를 포함하는 약제학적 조성물
KR102542329B1 (ko) * 2019-12-23 2023-06-13 주식회사 엘지화학 항염 또는 항혈관신생용 약제학적 조성물

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Also Published As

Publication number Publication date
DK2021078T3 (en) 2015-04-27
SI2021078T1 (sl) 2015-05-29
CA2653660C (en) 2014-07-29
CA2653660A1 (en) 2007-12-06
JP5537933B2 (ja) 2014-07-02
EP2786782B1 (en) 2017-03-08
US20120165254A1 (en) 2012-06-28
JP2009538840A (ja) 2009-11-12
AU2007268195A1 (en) 2007-12-06
PL2786782T3 (pl) 2017-08-31
PL2021078T3 (pl) 2015-08-31
CN101454048B (zh) 2013-06-19
EP2021078A1 (en) 2009-02-11
HK1197040A1 (en) 2015-01-02
US9295690B2 (en) 2016-03-29
US8765714B2 (en) 2014-07-01
KR20090014359A (ko) 2009-02-10
ES2534763T3 (es) 2015-04-28
CN101454048A (zh) 2009-06-10
US20090197807A1 (en) 2009-08-06
ITPD20060219A1 (it) 2007-12-01
US20140221294A1 (en) 2014-08-07
EP2786782A1 (en) 2014-10-08
SI2786782T1 (sl) 2017-06-30
WO2007137674A1 (en) 2007-12-06
EP2021078B1 (en) 2015-02-25
HK1123235A1 (en) 2009-06-12
MX2008015212A (es) 2008-12-09

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