IT1397246B1 - Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica - Google Patents

Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica

Info

Publication number
IT1397246B1
IT1397246B1 ITPD2009A000134A ITPD20090134A IT1397246B1 IT 1397246 B1 IT1397246 B1 IT 1397246B1 IT PD2009A000134 A ITPD2009A000134 A IT PD2009A000134A IT PD20090134 A ITPD20090134 A IT PD20090134A IT 1397246 B1 IT1397246 B1 IT 1397246B1
Authority
IT
Italy
Prior art keywords
cithocinic
inhabiting
activating
activity
hyaluronic acid
Prior art date
Application number
ITPD2009A000134A
Other languages
English (en)
Inventor
Giovanni Gennari
Este Matteo D
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITPD2009A000134A priority Critical patent/IT1397246B1/it
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Priority to PL10721126T priority patent/PL2429515T3/pl
Priority to EP18185228.6A priority patent/EP3417855B1/en
Priority to HUE10721126A priority patent/HUE030673T2/hu
Priority to ES16178620T priority patent/ES2704921T3/es
Priority to LTEP10721126.0T priority patent/LT2429515T/lt
Priority to ES18185228T priority patent/ES2808575T3/es
Priority to PCT/EP2010/003050 priority patent/WO2010130468A1/en
Priority to PT107211260T priority patent/PT2429515T/pt
Priority to RU2011145992/15A priority patent/RU2543354C2/ru
Priority to EP10721126.0A priority patent/EP2429515B1/en
Priority to ES10721126.0T priority patent/ES2601681T3/es
Priority to EP16178620.7A priority patent/EP3103449B1/en
Priority to US13/320,000 priority patent/US20120121572A1/en
Priority to SI201031318A priority patent/SI2429515T1/sl
Priority to CA2995610A priority patent/CA2995610C/en
Priority to US13/320,000 priority patent/US9504708B2/en
Priority to CA2761628A priority patent/CA2761628C/en
Priority to CN201080020708.3A priority patent/CN102427808B/zh
Publication of ITPD20090134A1 publication Critical patent/ITPD20090134A1/it
Publication of IT1397246B1 publication Critical patent/IT1397246B1/it
Application granted granted Critical
Priority to RU2014146977A priority patent/RU2673661C2/ru
Priority to RU2014146985A priority patent/RU2673066C2/ru
Priority to US15/336,498 priority patent/US10435483B2/en
Priority to HRP20161574TT priority patent/HRP20161574T1/hr
Priority to SM201600455T priority patent/SMT201600455B/it
Priority to US16/550,810 priority patent/US11198741B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
ITPD2009A000134A 2009-05-14 2009-05-14 Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica IT1397246B1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITPD2009A000134A IT1397246B1 (it) 2009-05-14 2009-05-14 Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
SI201031318A SI2429515T1 (sl) 2009-05-14 2010-05-14 Nova zdravila za topično uporabo na osnovi sulfatirane hialuronske kisline kot sredstvo za aktiviranje ali inhibiranje citokinske aktivnosti
US13/320,000 US20120121572A1 (en) 2009-05-14 2010-05-14 New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
ES16178620T ES2704921T3 (es) 2009-05-14 2010-05-14 Medicamentos para uso tópico basados en ácido hialurónico sulfatado para el tratamiento de coágulos de fibrina y trombos
LTEP10721126.0T LT2429515T (lt) 2009-05-14 2010-05-14 Nauji vaistai, skirti vietiniam naudojimui sulfatuotos hialurono rūgšties, kaip citokinų aktyvumą aktyvuojančio arba inhibuojančio agento, pagrindu
ES18185228T ES2808575T3 (es) 2009-05-14 2010-05-14 Composiciones farmacéuticas para uso tópico basadas en ácido hialurónico sulfatado como promotor de absorción de la piel
PCT/EP2010/003050 WO2010130468A1 (en) 2009-05-14 2010-05-14 New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
PT107211260T PT2429515T (pt) 2009-05-14 2010-05-14 Novos medicamentos para uso tópico à base de ácido hialurónico sulfatado como agente de ativação ou inibição da atividade citoquínica
RU2011145992/15A RU2543354C2 (ru) 2009-05-14 2010-05-14 Новые лекарственные средства для местного применения на основе сульфатированной гиалуроновой кислоты в качестве стимуляторов или ингибиторов цитокиновой активности
EP18185228.6A EP3417855B1 (en) 2009-05-14 2010-05-14 Pharmaceutical compositions for topical use based on sulfated hyaluronic acid as skin absorption promoter
ES10721126.0T ES2601681T3 (es) 2009-05-14 2010-05-14 Nuevos medicamentos de uso tópico basados en ácido hialurónico sulfatado como agente de activación o inhibición de la actividad de las citoquinas
EP16178620.7A EP3103449B1 (en) 2009-05-14 2010-05-14 Medicines for topical use based on sulfated hyaluronic acid for the treatment of clots of fibrin and thrombi
PL10721126T PL2429515T3 (pl) 2009-05-14 2010-05-14 Nowe leki do stosowania miejscowego oparte na siarczanowanym kwasie hialuronowym jako środku aktywującym lub inhibitującym aktywność cytokin
HUE10721126A HUE030673T2 (hu) 2009-05-14 2010-05-14 Szulfatált hialuronsav alapú helyi alkalmazású új gyógyszerek mint citokin aktivitást aktiváló vagy gátló szerek
EP10721126.0A EP2429515B1 (en) 2009-05-14 2010-05-14 New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
US13/320,000 US9504708B2 (en) 2009-05-14 2010-05-14 Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
CA2761628A CA2761628C (en) 2009-05-14 2010-05-14 New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
CN201080020708.3A CN102427808B (zh) 2009-05-14 2010-05-14 基于作为细胞因子活性的活化剂或抑制剂的硫酸化透明质酸的新的用于局部应用的药剂
CA2995610A CA2995610C (en) 2009-05-14 2010-05-14 New medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
RU2014146985A RU2673066C2 (ru) 2009-05-14 2014-11-21 Новые лекарственные средства для местного применения на основе сульфатированной гиалуроновой кислоты в качестве стимуляторов или ингибиторов цитокиновой активности
RU2014146977A RU2673661C2 (ru) 2009-05-14 2014-11-21 Новые лекарственные средства для местного применения на основе сульфатированной гиалуроновой кислоты в качестве стимуляторов или ингибиторов цитокиновой активности
US15/336,498 US10435483B2 (en) 2009-05-14 2016-10-27 Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity
HRP20161574TT HRP20161574T1 (hr) 2009-05-14 2016-11-25 Novi lijekovi za topikalnu primjenu temeljeni na sulfatiranoj hijaluronskoj kiselini kao sredstvu za aktiviranje ili inhibiciju aktivnosti citokina
SM201600455T SMT201600455B (it) 2009-05-14 2016-12-14 Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attività citochinica
US16/550,810 US11198741B2 (en) 2009-05-14 2019-08-26 Medicines for topic use based on sulfated hyaluronic acid as activating or inhibiting agent of the cytokine activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD2009A000134A IT1397246B1 (it) 2009-05-14 2009-05-14 Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica

Publications (2)

Publication Number Publication Date
ITPD20090134A1 ITPD20090134A1 (it) 2010-11-15
IT1397246B1 true IT1397246B1 (it) 2013-01-04

Family

ID=41226841

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD2009A000134A IT1397246B1 (it) 2009-05-14 2009-05-14 Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica

Country Status (15)

Country Link
US (4) US20120121572A1 (it)
EP (3) EP3103449B1 (it)
CN (1) CN102427808B (it)
CA (2) CA2761628C (it)
ES (3) ES2601681T3 (it)
HR (1) HRP20161574T1 (it)
HU (1) HUE030673T2 (it)
IT (1) IT1397246B1 (it)
LT (1) LT2429515T (it)
PL (1) PL2429515T3 (it)
PT (1) PT2429515T (it)
RU (3) RU2543354C2 (it)
SI (1) SI2429515T1 (it)
SM (1) SMT201600455B (it)
WO (1) WO2010130468A1 (it)

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AU2009231634B2 (en) 2008-04-04 2014-05-15 University Of Utah Research Foundation Alkylated semi-synthetic glycosaminoglycosan ethers, and methods for making and using thereof
US8343942B2 (en) * 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
IT1397247B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
US20130209531A1 (en) 2010-06-08 2013-08-15 University Of Utah Research Foundation Applications of partially and fully sulfated hyaluronan
US9522162B2 (en) 2011-03-23 2016-12-20 University Of Utah Research Foundation Methods for treating or preventing urological inflammation
EP3206673A1 (en) 2014-10-17 2017-08-23 Fidia Farmaceutici S.p.A. Dermal therapeutic system with high adhesivity
ITUB20155623A1 (it) * 2015-11-16 2017-05-16 Fidia Farm Spa Processo migliorato per la produzione di HA solfatato di elevata purezza
WO2017186088A1 (zh) * 2016-04-25 2017-11-02 惠觅宙 小分子透明质酸片段的应用
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
IT201600117042A1 (it) * 2016-11-18 2018-05-18 Fidia Farm Spa Acidi ialuronici solfatati funzionalizzati con dopamina
IT201900003887A1 (it) 2019-03-18 2020-09-18 Fidia Farm Spa Sistemi di stabilizzazione e di rilascio controllato di farmaci instabili alla sterilizzazione
WO2021133000A1 (ko) * 2019-12-23 2021-07-01 주식회사 엘지화학 항염 또는 항혈관신생용 약제학적 조성물
WO2023080886A1 (en) * 2020-09-29 2023-05-11 Ziropa, Inc. Compositions and methods for pain relief and numbing
CN113754795B (zh) * 2021-10-19 2023-03-10 澳门大学 磺酸化透明质酸类化合物、其制备方法及其应用

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