EA201270572A1 - Аналоги гетероциклил пиразолопиримидина в качестве ингибиторов jak - Google Patents

Аналоги гетероциклил пиразолопиримидина в качестве ингибиторов jak

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Publication number
EA201270572A1
EA201270572A1 EA201270572A EA201270572A EA201270572A1 EA 201270572 A1 EA201270572 A1 EA 201270572A1 EA 201270572 A EA201270572 A EA 201270572A EA 201270572 A EA201270572 A EA 201270572A EA 201270572 A1 EA201270572 A1 EA 201270572A1
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Eurasian Patent Office
Prior art keywords
compounds
jak inhibitors
pyrazolopyrimidine
heterocyclyl
analogues
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EA201270572A
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English (en)
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EA022120B1 (ru
Inventor
Найджель Рэмзден
Ричард Джон Хэррисон
Сэлли Оксенфорд
Кэсрин Бэль
Нелли Пайтн
Клаудио Дагостин
Сириль Буссар
Эндру Рэтклифф
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Целльзом Лимитид
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Publication of EA201270572A1 publication Critical patent/EA201270572A1/ru
Publication of EA022120B1 publication Critical patent/EA022120B1/ru

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Abstract

Настоящее изобретение касается соединений формулы (I)где X-X, Y, Z-Zи R имеют значение, как указано в описании и формуле изобретения. Указанные соединения пригодны в качестве ингибиторов JAK для лечения или профилактики иммунологических, воспалительных, аутоиммунных, аллергических расстройств и иммунологически обусловленных заболеваний. Изобретение также касается фармацевтических композиций, включающих указанные соединения, приготовления таких соединений, а также применения в качестве лекарственных средств.
EA201270572A 2009-10-20 2010-10-19 Аналоги гетероциклил пиразолопиримидина в качестве ингибиторов jak EA022120B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09173535 2009-10-20
US37535810P 2010-08-20 2010-08-20
PCT/EP2010/065700 WO2011048082A1 (en) 2009-10-20 2010-10-19 Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors

Publications (2)

Publication Number Publication Date
EA201270572A1 true EA201270572A1 (ru) 2012-12-28
EA022120B1 EA022120B1 (ru) 2015-11-30

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Country Status (15)

Country Link
US (1) US9242987B2 (ru)
EP (1) EP2491039A1 (ru)
JP (1) JP5744887B2 (ru)
KR (1) KR20120102601A (ru)
CN (1) CN102666545B (ru)
AR (1) AR078675A1 (ru)
AU (1) AU2010309882B2 (ru)
BR (1) BR112012009327A2 (ru)
CA (1) CA2775009A1 (ru)
EA (1) EA022120B1 (ru)
IL (1) IL218751A0 (ru)
MX (1) MX2012004020A (ru)
NZ (1) NZ598907A (ru)
TW (1) TW201125867A (ru)
WO (1) WO2011048082A1 (ru)

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