BRPI0507668A - compostos e composições como inibidores de proteìna cinase - Google Patents
compostos e composições como inibidores de proteìna cinaseInfo
- Publication number
- BRPI0507668A BRPI0507668A BRPI0507668-4A BRPI0507668A BRPI0507668A BR PI0507668 A BRPI0507668 A BR PI0507668A BR PI0507668 A BRPI0507668 A BR PI0507668A BR PI0507668 A BRPI0507668 A BR PI0507668A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- compositions
- protein kinase
- kinase inhibitors
- abl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 abstract 1
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 abstract 1
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 abstract 1
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 abstract 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 108091008606 PDGF receptors Proteins 0.000 abstract 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 1
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPOSTOS E COMPOSIçõES COMO INIBIDORES DE PROTEìNA CINASE. A presente invenção refere-se a uma nova classe de compostos, composições farmacêuticas compreendendo tais compostos e métodos de empregar tais compostos para tratar ou prevenir doenças ou distúrbios associados a uma atividade de cinase desregulada ou anormal, particularmente doenças ou distúrbios que envolvem ativação anormal das FAK, Abl, BCR-Abl, PDGF-R, c-Kit, NPM-ALK, Flt-3, JAK2 E c-Met cinases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54494404P | 2004-02-14 | 2004-02-14 | |
PCT/US2005/004630 WO2005080393A1 (en) | 2004-02-14 | 2005-02-14 | Compounds and compositions as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0507668A true BRPI0507668A (pt) | 2007-07-17 |
Family
ID=34886099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0507668-4A BRPI0507668A (pt) | 2004-02-14 | 2005-02-14 | compostos e composições como inibidores de proteìna cinase |
Country Status (12)
Country | Link |
---|---|
US (1) | US7968557B2 (pt) |
EP (1) | EP1713806B1 (pt) |
JP (1) | JP4989233B2 (pt) |
CN (1) | CN1918158B (pt) |
AU (1) | AU2005214352B2 (pt) |
BR (1) | BRPI0507668A (pt) |
CA (1) | CA2553785C (pt) |
DK (1) | DK1713806T3 (pt) |
ES (1) | ES2424642T3 (pt) |
PL (1) | PL1713806T3 (pt) |
PT (1) | PT1713806E (pt) |
WO (1) | WO2005080393A1 (pt) |
Families Citing this family (111)
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WO2006042102A2 (en) * | 2004-10-05 | 2006-04-20 | Neurogen Corporation | Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds |
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WO2006133426A2 (en) | 2005-06-08 | 2006-12-14 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
ES2332423T3 (es) | 2005-10-28 | 2010-02-04 | Irm Llc | Compuestos y composiciones como inhibidores de proteina quinasas. |
CA2631182C (en) * | 2005-11-23 | 2019-08-06 | Gerard M. Housey | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators |
US8962643B2 (en) | 2006-02-24 | 2015-02-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
EP2450437B1 (en) | 2006-04-14 | 2017-05-17 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
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CN106232603B (zh) * | 2014-05-01 | 2019-07-05 | 诺华股份有限公司 | 作为toll-样受体7激动剂的化合物和组合物 |
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CN105111215B (zh) * | 2014-12-12 | 2019-06-18 | 苏州晶云药物科技股份有限公司 | 一种周期蛋白依赖性激酶抑制剂的晶型及其制备方法 |
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SU194829A1 (ru) * | 1966-07-08 | 1967-04-12 | Замещенных 5,6-дигидропирроло- | |
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AU2006205851A1 (en) * | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | 5-membered annelated heterocyclic pyrimidines as kinase inhibitors |
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2005
- 2005-02-14 PL PL05713510T patent/PL1713806T3/pl unknown
- 2005-02-14 AU AU2005214352A patent/AU2005214352B2/en not_active Ceased
- 2005-02-14 CA CA2553785A patent/CA2553785C/en not_active Expired - Fee Related
- 2005-02-14 JP JP2006553321A patent/JP4989233B2/ja not_active Expired - Fee Related
- 2005-02-14 ES ES05713510T patent/ES2424642T3/es active Active
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- 2005-02-14 BR BRPI0507668-4A patent/BRPI0507668A/pt not_active IP Right Cessation
- 2005-02-14 US US10/589,099 patent/US7968557B2/en not_active Expired - Fee Related
- 2005-02-14 WO PCT/US2005/004630 patent/WO2005080393A1/en active Application Filing
- 2005-02-14 CN CN2005800048955A patent/CN1918158B/zh not_active Expired - Fee Related
- 2005-02-14 EP EP05713510.5A patent/EP1713806B1/en not_active Not-in-force
- 2005-02-14 PT PT57135105T patent/PT1713806E/pt unknown
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EP1713806A1 (en) | 2006-10-25 |
ES2424642T3 (es) | 2013-10-07 |
EP1713806A4 (en) | 2009-11-11 |
US20070225306A1 (en) | 2007-09-27 |
CA2553785C (en) | 2011-02-08 |
PT1713806E (pt) | 2013-08-27 |
CA2553785A1 (en) | 2005-09-01 |
WO2005080393A1 (en) | 2005-09-01 |
EP1713806B1 (en) | 2013-05-08 |
CN1918158A (zh) | 2007-02-21 |
AU2005214352B2 (en) | 2009-11-12 |
US7968557B2 (en) | 2011-06-28 |
PL1713806T3 (pl) | 2013-09-30 |
AU2005214352A1 (en) | 2005-09-01 |
JP2007522241A (ja) | 2007-08-09 |
CN1918158B (zh) | 2011-03-02 |
DK1713806T3 (da) | 2013-08-05 |
JP4989233B2 (ja) | 2012-08-01 |
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