JP2017105793A5 - - Google Patents

Download PDF

Info

Publication number
JP2017105793A5
JP2017105793A5 JP2017006285A JP2017006285A JP2017105793A5 JP 2017105793 A5 JP2017105793 A5 JP 2017105793A5 JP 2017006285 A JP2017006285 A JP 2017006285A JP 2017006285 A JP2017006285 A JP 2017006285A JP 2017105793 A5 JP2017105793 A5 JP 2017105793A5
Authority
JP
Japan
Prior art keywords
compound
following formula
pharmaceutical composition
salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017006285A
Other languages
English (en)
Japanese (ja)
Other versions
JP6550083B2 (ja
JP2017105793A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2017105793A publication Critical patent/JP2017105793A/ja
Publication of JP2017105793A5 publication Critical patent/JP2017105793A5/ja
Application granted granted Critical
Publication of JP6550083B2 publication Critical patent/JP6550083B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017006285A 2013-09-27 2017-01-18 Hivインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体 Expired - Fee Related JP6550083B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361883463P 2013-09-27 2013-09-27
US61/883,463 2013-09-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016516931A Division JP6081662B2 (ja) 2013-09-27 2014-09-26 Hivインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体

Publications (3)

Publication Number Publication Date
JP2017105793A JP2017105793A (ja) 2017-06-15
JP2017105793A5 true JP2017105793A5 (enExample) 2017-09-07
JP6550083B2 JP6550083B2 (ja) 2019-07-24

Family

ID=52744477

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016516931A Expired - Fee Related JP6081662B2 (ja) 2013-09-27 2014-09-26 Hivインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体
JP2017006285A Expired - Fee Related JP6550083B2 (ja) 2013-09-27 2017-01-18 Hivインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016516931A Expired - Fee Related JP6081662B2 (ja) 2013-09-27 2014-09-26 Hivインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体

Country Status (31)

Country Link
US (2) US9861620B2 (enExample)
EP (1) EP3049081B1 (enExample)
JP (2) JP6081662B2 (enExample)
KR (2) KR101809392B1 (enExample)
CN (1) CN105744936B (enExample)
AP (1) AP2016009157A0 (enExample)
AU (1) AU2014324829B2 (enExample)
BR (1) BR112016006651B8 (enExample)
CA (1) CA2924829C (enExample)
CL (1) CL2016000698A1 (enExample)
CR (1) CR20160140A (enExample)
DO (1) DOP2016000069A (enExample)
EA (1) EA030695B1 (enExample)
EC (1) ECSP16016726A (enExample)
ES (1) ES2768658T3 (enExample)
GT (1) GT201600056A (enExample)
HK (1) HK1221648A1 (enExample)
IL (1) IL244438B (enExample)
MA (1) MA38922A3 (enExample)
MD (1) MD4794B1 (enExample)
MX (1) MX367057B (enExample)
NI (1) NI201600040A (enExample)
PE (1) PE20160501A1 (enExample)
PH (1) PH12016500553B1 (enExample)
SA (1) SA516370826B1 (enExample)
SG (1) SG11201602217XA (enExample)
SV (1) SV2016005171A (enExample)
TN (1) TN2016000090A1 (enExample)
UA (1) UA117499C2 (enExample)
WO (1) WO2015048363A1 (enExample)
ZA (1) ZA201601708B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030003B1 (ru) 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
NO2865735T3 (enExample) 2013-07-12 2018-07-21
DK3019503T3 (da) 2013-07-12 2017-11-20 Gilead Sciences Inc Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner
CA2924829C (en) * 2013-09-27 2019-10-29 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
WO2015089847A1 (en) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (enExample) 2014-06-20 2018-06-23
WO2016027879A1 (ja) 2014-08-22 2016-02-25 塩野義製薬株式会社 インテグラーゼ阻害活性を有する多環性ピリドン誘導体
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
US10081647B2 (en) 2015-03-26 2018-09-25 Merck Sharp & Dohme Corp. Phosphate substituted quinolizine derivatives useful as HIV integrase inhibitors
CA2980362C (en) 2015-04-02 2020-02-25 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
WO2016187788A1 (en) * 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
EP3389380B1 (en) * 2015-12-15 2021-07-21 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors
US20190216725A1 (en) * 2016-09-21 2019-07-18 Merck Shapr & Dohme Corp. Drug delivery system for the delivery of integrase inhibitors
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
WO2018140368A1 (en) 2017-01-26 2018-08-02 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors
JP2019016012A (ja) * 2017-07-03 2019-01-31 東芝テック株式会社 プリンタ装置及びプログラム
US11413292B2 (en) 2018-02-15 2022-08-16 Merck, Sharp & Dohme LLC Tricyclic heterocycle compounds useful as HIV integrase inhibitors
CR20230571A (es) 2018-05-31 2024-01-22 Shionogi & Co DERIVADO POLICÍCLICO DE CARBAMOILPIRIDONA (divisional 2020-0644)
EP3805221A4 (en) 2018-05-31 2022-01-05 Shionogi & Co., Ltd POLYCYCLIC PYRIDONE DERIVATIVE
KR20240151256A (ko) 2019-03-22 2024-10-17 길리애드 사이언시즈, 인코포레이티드 가교된 트리시클릭 카르바모일피리돈 화합물 및 그의 제약 용도
US20200398978A1 (en) 2019-06-20 2020-12-24 Bell Helicopter Textron Inc. Low-drag rotor blade extension
KR102941434B1 (ko) 2019-07-31 2026-03-19 어드방스드 비오디자인 아미노티올에스터 화합물 및 이의 용도
CN112521386B (zh) * 2019-09-19 2023-05-26 周雨恬 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途
WO2021107065A1 (ja) 2019-11-28 2021-06-03 塩野義製薬株式会社 多環性ピリドピラジン誘導体
US12564595B2 (en) 2019-11-28 2026-03-03 Shionogi & Co., Ltd. Prophylactic and therapeutic pharmaceutical agent for HIV infectious diseases characterized by comprising combination of integrase inhibitor and anti-HIV agent
EP4110783A1 (en) 2020-02-24 2023-01-04 Gilead Sciences, Inc. Tetracyclic compounds for treating hiv infection
CN116390924B (zh) 2020-09-30 2025-11-07 吉利德科学公司 桥连三环氨基甲酰基吡啶酮化合物及其用途
CR20260070A (es) 2021-01-19 2026-04-24 Gilead Sciences Inc COMPUESTOS DE PIRIDOTRIAZINA SUSTITUIDOS Y USOS DE ESTOS (Divisional 2023-0315)
FR3119314B1 (fr) 2021-01-29 2025-01-10 Advanced Biodesign Nanocapsule lipidique comprenant au moins un composé aminothiolester ou un de ses dérivés pharmaceutiquement acceptable
TWI856796B (zh) 2022-04-06 2024-09-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
WO2025229179A1 (en) 2024-05-03 2025-11-06 Advanced Biodesign Use of aminothiolester compounds in combination with hypomethylating agents (hma) for the prevention and treatment of cancer

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1040076A1 (zh) * 1998-09-21 2002-05-24 希雷生物化学有限公司 作为整联蛋白抑制剂的喹嗪酮
GB0110832D0 (en) * 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
ATE530520T1 (de) 2001-08-10 2011-11-15 Shionogi & Co Antivirales mittel
DE122009000048I1 (de) 2001-10-26 2010-04-08 Angeletti P Ist Richerche Bio N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase
CA2463975A1 (en) 2001-10-26 2003-05-01 Maria Emilia Di Francesco Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
EP1467970B1 (en) 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
WO2004024078A2 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
WO2004058756A1 (en) 2002-12-27 2004-07-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
WO2004062613A2 (en) 2003-01-13 2004-07-29 Bristol-Myers Squibb Company Hiv integrase inhibitors
US7037908B2 (en) 2003-04-24 2006-05-02 Bristol-Myers Squibb Company HIV integrase inhibitors
JP2006232849A (ja) * 2003-08-13 2006-09-07 Japan Tobacco Inc 含窒素縮合環化合物及びそのhivインテグラーゼ阻害剤としての利用
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
AR046938A1 (es) 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
AU2005221864A1 (en) * 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
WO2005087768A1 (en) * 2004-03-09 2005-09-22 Merck & Co., Inc. Hiv integrase inhibitors
US7273859B2 (en) 2004-05-12 2007-09-25 Bristol-Myers Squibb Company HIV integrase inhibitors: cyclic pyrimidinone compounds
US7115601B2 (en) 2004-05-18 2006-10-03 Bristol-Myers Squibb Company HIV integrase inhibitors
US7176196B2 (en) 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7192948B2 (en) 2004-05-28 2007-03-20 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7157447B2 (en) 2004-05-28 2007-01-02 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7173022B2 (en) 2004-05-28 2007-02-06 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
WO2006033422A1 (ja) * 2004-09-21 2006-03-30 Japan Tobacco Inc. キノリジノン化合物、およびそのhivインテグラーゼ阻害剤としての利用
US20060066414A1 (en) 2004-09-28 2006-03-30 Rockwell Scientific Licensing, Llc Method and apparatus for changing the polarization of a signal
CA2634499A1 (en) 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
WO2006088173A1 (ja) * 2005-02-21 2006-08-24 Shionogi & Co., Ltd. Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体
WO2006103399A1 (en) 2005-03-31 2006-10-05 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
CN101212903B (zh) * 2005-04-28 2013-07-24 史密丝克莱恩比彻姆公司 具有hiv整合酶抑制活性的多环氨基甲酰基吡啶酮衍生物
DK3187225T3 (da) 2005-04-28 2022-02-28 Viiv Healthcare Co Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet
JP2006342115A (ja) 2005-06-10 2006-12-21 Shionogi & Co Ltd Hivインテグラーゼ阻害活性を有する多環性化合物
US7494984B2 (en) 2005-08-31 2009-02-24 Bristol-Myers Squibb Company Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors
WO2007059125A2 (en) 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors
US7902182B2 (en) 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
US8039458B2 (en) 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
WO2007143446A1 (en) 2006-05-30 2007-12-13 Bristol-Myers Squibb Company Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors
US7893055B2 (en) 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
EP2470014A4 (en) * 2009-08-26 2013-01-16 Merck Sharp & Dohme HIV integrase inhibitors
WO2011045330A1 (en) 2009-10-13 2011-04-21 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
EP3351249A1 (en) 2010-01-27 2018-07-25 VIIV Healthcare Company Antiviral therapy
WO2011121105A1 (en) 2010-04-02 2011-10-06 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
CA2924829C (en) * 2013-09-27 2019-10-29 Merck Sharp & Dohme Corp. Substituted quinolizine derivatives useful as hiv integrase inhibitors

Similar Documents

Publication Publication Date Title
JP2015078230A5 (enExample)
WO2017083304A8 (en) Therapeutic compositions for treatment of human immunodeficiency virus
JP2020504733A5 (enExample)
FI3692040T3 (fi) Kemiallisia yhdisteitä
JP2017186358A5 (enExample)
JP2020097577A5 (enExample)
JP2016106149A5 (enExample)
EP4331677A3 (en) Methods of treating feline coronavirus infections
EP4616908A3 (en) Oxysterols and methods of use thereof
JP2014507446A5 (enExample)
EA201792592A1 (ru) Фармацевтические препараты, содержащие тенофовир и эмтрицитабин
JP2015038149A5 (enExample)
MX381187B (es) Nuevo derivado de quinoleina para usarse en el tratamiento y prevencion de infecciones virales.
JP2016530259A5 (enExample)
JP2013518107A5 (enExample)
JP2019500387A5 (enExample)
JP2014221779A5 (enExample)
JP2016515561A5 (enExample)
IL295418B1 (en) Beta-d-2'-deoxy-2' alpha-fluoro-2'-bata-c-modified-2-different-n6-purine modified nucleotides for the treatment of hepatitis c virus
HK1254343A1 (zh) 药物制剂
JP2018521020A5 (enExample)
JP2020500866A5 (enExample)
JP2016536286A5 (enExample)
MY175445A (en) Tri-cycle compound and applications thereof
JP2017518982A5 (enExample)