JP2017529347A5 - - Google Patents
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- Publication number
- JP2017529347A5 JP2017529347A5 JP2017514616A JP2017514616A JP2017529347A5 JP 2017529347 A5 JP2017529347 A5 JP 2017529347A5 JP 2017514616 A JP2017514616 A JP 2017514616A JP 2017514616 A JP2017514616 A JP 2017514616A JP 2017529347 A5 JP2017529347 A5 JP 2017529347A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- alkyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 37
- 150000003839 salts Chemical class 0.000 claims 34
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 102000008157 Histone Demethylases Human genes 0.000 claims 2
- 108010074870 Histone Demethylases Proteins 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020101063A JP6967632B2 (ja) | 2014-09-17 | 2020-06-10 | ヒストンデメチラーゼ阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051850P | 2014-09-17 | 2014-09-17 | |
| US62/051,850 | 2014-09-17 | ||
| PCT/US2015/049926 WO2016044138A1 (en) | 2014-09-17 | 2015-09-14 | Histone demethylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020101063A Division JP6967632B2 (ja) | 2014-09-17 | 2020-06-10 | ヒストンデメチラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529347A JP2017529347A (ja) | 2017-10-05 |
| JP2017529347A5 true JP2017529347A5 (enExample) | 2018-10-25 |
| JP6723663B2 JP6723663B2 (ja) | 2020-07-15 |
Family
ID=55533717
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514616A Expired - Fee Related JP6723663B2 (ja) | 2014-09-17 | 2015-09-14 | ヒストンデメチラーゼ阻害剤 |
| JP2020101063A Expired - Fee Related JP6967632B2 (ja) | 2014-09-17 | 2020-06-10 | ヒストンデメチラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020101063A Expired - Fee Related JP6967632B2 (ja) | 2014-09-17 | 2020-06-10 | ヒストンデメチラーゼ阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9758517B2 (enExample) |
| EP (1) | EP3194387B1 (enExample) |
| JP (2) | JP6723663B2 (enExample) |
| KR (1) | KR20170048601A (enExample) |
| CN (1) | CN107001330A (enExample) |
| AU (1) | AU2015318111A1 (enExample) |
| BR (1) | BR112017005510A2 (enExample) |
| CA (1) | CA2961580A1 (enExample) |
| CL (1) | CL2017000662A1 (enExample) |
| CO (1) | CO2017003445A2 (enExample) |
| EA (1) | EA201790604A1 (enExample) |
| EC (1) | ECSP17022542A (enExample) |
| ES (1) | ES2751464T3 (enExample) |
| IL (1) | IL251184A0 (enExample) |
| MX (1) | MX2017003463A (enExample) |
| SG (1) | SG11201702119PA (enExample) |
| WO (1) | WO2016044138A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2968282B1 (en) | 2013-03-12 | 2018-05-09 | Celgene Quanticel Research, Inc. | Histone dementhylase inhibitors |
| US9758517B2 (en) * | 2014-09-17 | 2017-09-12 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| JP7090639B2 (ja) * | 2017-04-11 | 2022-06-24 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | フッ素置換されたインダゾール化合物及びその使用 |
| CN109709333B (zh) * | 2018-08-01 | 2021-09-24 | 东南大学 | H4k20、h3k9及h3k36三甲基化量检测试剂在食管癌预后评估中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20030207910A1 (en) * | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7375228B2 (en) | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| PE20050206A1 (es) | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
| FR2876103B1 (fr) * | 2004-10-01 | 2008-02-22 | Aventis Pharma Sa | Nouveaux derives bis-azaindoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| WO2007056281A2 (en) | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
| US7371862B2 (en) | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| US8093220B2 (en) | 2006-12-04 | 2012-01-10 | Novartis Ag | Combination of an HDAC inhibitor and an antimetabolite |
| US20100137398A1 (en) | 2007-05-04 | 2010-06-03 | Novartis Ag | Use of hdac inhibitors for the treatment of gastrointestinal cancers |
| CA2778886C (en) * | 2009-11-10 | 2014-01-07 | Pfizer Inc. | N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| ES2534804T3 (es) * | 2010-05-07 | 2015-04-28 | Glaxosmithkline Llc | Indazoles |
| JP2012107001A (ja) | 2010-10-22 | 2012-06-07 | Shionogi & Co Ltd | インドールアミド化合物を含有する医薬 |
| WO2013028999A1 (en) | 2011-08-24 | 2013-02-28 | The Trustees Of Columbia University In The City Of New York | Small molecule inducers of gdnf as potential new therapeutics for neuropsychiatric disorders |
| US20150203453A1 (en) * | 2012-10-02 | 2015-07-23 | Epitherapeutics Aps | Inhibitors of histone demethylases |
| WO2014100463A1 (en) | 2012-12-19 | 2014-06-26 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| EP2968282B1 (en) * | 2013-03-12 | 2018-05-09 | Celgene Quanticel Research, Inc. | Histone dementhylase inhibitors |
| US9758517B2 (en) * | 2014-09-17 | 2017-09-12 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
-
2015
- 2015-09-14 US US14/852,860 patent/US9758517B2/en active Active
- 2015-09-14 JP JP2017514616A patent/JP6723663B2/ja not_active Expired - Fee Related
- 2015-09-14 MX MX2017003463A patent/MX2017003463A/es unknown
- 2015-09-14 EP EP15842582.7A patent/EP3194387B1/en active Active
- 2015-09-14 CA CA2961580A patent/CA2961580A1/en not_active Abandoned
- 2015-09-14 CN CN201580062304.3A patent/CN107001330A/zh active Pending
- 2015-09-14 AU AU2015318111A patent/AU2015318111A1/en not_active Abandoned
- 2015-09-14 WO PCT/US2015/049926 patent/WO2016044138A1/en not_active Ceased
- 2015-09-14 BR BR112017005510A patent/BR112017005510A2/pt not_active Application Discontinuation
- 2015-09-14 KR KR1020177010353A patent/KR20170048601A/ko not_active Withdrawn
- 2015-09-14 SG SG11201702119PA patent/SG11201702119PA/en unknown
- 2015-09-14 EA EA201790604A patent/EA201790604A1/ru unknown
- 2015-09-14 ES ES15842582T patent/ES2751464T3/es active Active
-
2017
- 2017-03-15 IL IL251184A patent/IL251184A0/en unknown
- 2017-03-17 CL CL2017000662A patent/CL2017000662A1/es unknown
- 2017-04-10 CO CONC2017/0003445A patent/CO2017003445A2/es unknown
- 2017-04-11 EC ECIEPI201722542A patent/ECSP17022542A/es unknown
- 2017-08-02 US US15/667,553 patent/US10016401B2/en active Active
-
2018
- 2018-06-01 US US15/996,316 patent/US10231957B2/en active Active
-
2020
- 2020-06-10 JP JP2020101063A patent/JP6967632B2/ja not_active Expired - Fee Related
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