HUE040231T2 - Máj X receptor (LXR) modulátorok bõrbetegségek, rendellenességek és állapotok kezelésére - Google Patents

Máj X receptor (LXR) modulátorok bõrbetegségek, rendellenességek és állapotok kezelésére

Info

Publication number
HUE040231T2
HUE040231T2 HUE13754329A HUE13754329A HUE040231T2 HU E040231 T2 HUE040231 T2 HU E040231T2 HU E13754329 A HUE13754329 A HU E13754329A HU E13754329 A HUE13754329 A HU E13754329A HU E040231 T2 HUE040231 T2 HU E040231T2
Authority
HU
Hungary
Prior art keywords
lxr
modulators
disorders
liver
receptor
Prior art date
Application number
HUE13754329A
Other languages
English (en)
Hungarian (hu)
Inventor
Raju Mohan
Original Assignee
Ralexar Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ralexar Therapeutics Inc filed Critical Ralexar Therapeutics Inc
Publication of HUE040231T2 publication Critical patent/HUE040231T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HUE13754329A 2012-03-02 2013-02-28 Máj X receptor (LXR) modulátorok bõrbetegségek, rendellenességek és állapotok kezelésére HUE040231T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261606160P 2012-03-02 2012-03-02

Publications (1)

Publication Number Publication Date
HUE040231T2 true HUE040231T2 (hu) 2019-02-28

Family

ID=49083313

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13754329A HUE040231T2 (hu) 2012-03-02 2013-02-28 Máj X receptor (LXR) modulátorok bõrbetegségek, rendellenességek és állapotok kezelésére

Country Status (25)

Country Link
US (5) US8987318B2 (enExample)
EP (2) EP2820013B9 (enExample)
JP (2) JP6378630B2 (enExample)
KR (1) KR102112879B1 (enExample)
CN (1) CN104284893B (enExample)
AU (1) AU2013225840B2 (enExample)
BR (1) BR112014021515A2 (enExample)
CA (1) CA2866113C (enExample)
CY (1) CY1120742T1 (enExample)
DK (1) DK2820013T3 (enExample)
ES (1) ES2691079T3 (enExample)
HR (1) HRP20181623T1 (enExample)
HU (1) HUE040231T2 (enExample)
IL (1) IL234413B (enExample)
LT (1) LT2820013T (enExample)
MX (1) MX361349B (enExample)
NZ (1) NZ629636A (enExample)
PL (1) PL2820013T3 (enExample)
PT (1) PT2820013T (enExample)
RS (1) RS57863B9 (enExample)
SG (2) SG11201405378VA (enExample)
SI (1) SI2820013T1 (enExample)
SM (1) SMT201800630T1 (enExample)
TR (1) TR201815013T4 (enExample)
WO (1) WO2013130892A1 (enExample)

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EP2820013B9 (en) 2012-03-02 2019-01-09 Ralexar Therapeutics, Inc. Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
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CN104151300B (zh) * 2013-05-15 2018-07-13 中国医学科学院医药生物技术研究所 一组2,3-二取代的苯并喹唑啉类的肝x受体的激动剂及用途
CA2923178A1 (en) * 2013-09-04 2015-03-12 Alexar Therapeutics, Inc. Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
DK3041835T3 (da) * 2013-09-04 2020-07-13 Ellora Therapeutics Inc Modulatorer af lever-X-receptorer (LXR)
WO2015106164A1 (en) 2014-01-10 2015-07-16 Rgenix, Inc. Lxr agonists and uses thereof
EP3397258A2 (en) 2015-12-30 2018-11-07 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (CONICET) Use of brassinosteroid analogs for the treatment of dermal disorders by selectively modulating liver x receptors (lxr) and dermal disease treatment by brassinosteroid analogs acting as selective liver x receptor (lxr) modulators
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CN114126618A (zh) 2019-07-15 2022-03-01 诺华股份有限公司 用肝脏x受体激动剂治疗睑板腺功能障碍的方法
WO2021119397A1 (en) 2019-12-13 2021-06-17 Rgenix, Inc. Metal salts and uses thereof
WO2022249006A1 (en) * 2021-05-24 2022-12-01 Novartis Ag Use of 1,2,4-oxadiazole derivatives as liver x receptor agonists

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Also Published As

Publication number Publication date
TR201815013T4 (tr) 2018-11-21
CN104284893B (zh) 2017-04-19
LT2820013T (lt) 2018-10-25
CY1120742T1 (el) 2019-12-11
EP2820013A1 (en) 2015-01-07
MX361349B (es) 2018-12-04
ES2691079T3 (es) 2018-11-23
JP6800922B2 (ja) 2020-12-16
CN104284893A (zh) 2015-01-14
JP2015512883A (ja) 2015-04-30
AU2013225840B2 (en) 2017-11-23
JP6378630B2 (ja) 2018-08-22
SMT201800630T1 (it) 2019-01-11
EP3441390A1 (en) 2019-02-13
RS57863B1 (sr) 2018-12-31
US20210101895A1 (en) 2021-04-08
US20150152094A1 (en) 2015-06-04
SI2820013T1 (sl) 2018-11-30
DK2820013T3 (en) 2018-10-29
RS57863B9 (sr) 2019-10-31
EP2820013A4 (en) 2015-11-11
IL234413B (en) 2018-05-31
KR102112879B1 (ko) 2020-05-19
WO2013130892A1 (en) 2013-09-06
US8987318B2 (en) 2015-03-24
NZ629636A (en) 2017-02-24
ES2691079T9 (es) 2019-02-08
CA2866113A1 (en) 2013-09-06
US20180370959A1 (en) 2018-12-27
SG10201607345YA (en) 2016-11-29
PT2820013T (pt) 2018-10-25
SG11201405378VA (en) 2014-09-26
MX2014010537A (es) 2015-03-09
JP2018184467A (ja) 2018-11-22
BR112014021515A2 (pt) 2018-03-13
HK1206030A1 (en) 2015-12-31
EP2820013B1 (en) 2018-07-11
US20170334897A1 (en) 2017-11-23
US9637481B2 (en) 2017-05-02
EP2820013B9 (en) 2019-01-09
PL2820013T3 (pl) 2019-01-31
CA2866113C (en) 2020-05-12
US20150045399A1 (en) 2015-02-12
KR20140146089A (ko) 2014-12-24
HRP20181623T1 (hr) 2018-12-14
AU2013225840A1 (en) 2014-09-18

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