JP2017510660A5 - - Google Patents
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- Publication number
- JP2017510660A5 JP2017510660A5 JP2017504608A JP2017504608A JP2017510660A5 JP 2017510660 A5 JP2017510660 A5 JP 2017510660A5 JP 2017504608 A JP2017504608 A JP 2017504608A JP 2017504608 A JP2017504608 A JP 2017504608A JP 2017510660 A5 JP2017510660 A5 JP 2017510660A5
- Authority
- JP
- Japan
- Prior art keywords
- alkenyl
- alkyl
- compound according
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 36
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- -1 nitro, cyano, amino Chemical group 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- BZDKOUKSFMIFNT-NSCUHMNNSA-N C/C=C/C(NO)=O Chemical compound C/C=C/C(NO)=O BZDKOUKSFMIFNT-NSCUHMNNSA-N 0.000 description 1
- KHHQEHKVVFCSTN-ULUSZKPHSA-N C[C@H](CC=C1)C2[IH]1=C2 Chemical compound C[C@H](CC=C1)C2[IH]1=C2 KHHQEHKVVFCSTN-ULUSZKPHSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461978606P | 2014-04-11 | 2014-04-11 | |
| US61/978,606 | 2014-04-11 | ||
| PCT/US2015/025084 WO2015157504A1 (en) | 2014-04-11 | 2015-04-09 | Histone deacetylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510660A JP2017510660A (ja) | 2017-04-13 |
| JP2017510660A5 true JP2017510660A5 (enExample) | 2018-05-31 |
| JP6726658B2 JP6726658B2 (ja) | 2020-07-22 |
Family
ID=54288395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504608A Active JP6726658B2 (ja) | 2014-04-11 | 2015-04-09 | ヒストン脱アセチル化酵素阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10246455B2 (enExample) |
| EP (1) | EP3129373B1 (enExample) |
| JP (1) | JP6726658B2 (enExample) |
| CN (1) | CN107001354B (enExample) |
| TW (1) | TWI573787B (enExample) |
| WO (1) | WO2015157504A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201792028A1 (ru) | 2015-03-13 | 2018-04-30 | Форма Терапьютикс, Инк. | Альфа-цинамидные соединения и композиции как ингибиторы hdac8 |
| US10525040B2 (en) * | 2015-06-29 | 2020-01-07 | Nantbio, Inc. | Compositions and methods of Rit1 inhibition |
| CN108430515B (zh) | 2015-10-29 | 2021-11-12 | 诺华股份有限公司 | 包含toll-样受体激动剂的抗体缀合物 |
| CN105622605B (zh) * | 2016-03-01 | 2017-10-13 | 苏州艾缇克药物化学有限公司 | 一种5‑溴‑7‑氮杂吲哚的合成方法 |
| TWI659949B (zh) * | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
| CN107011238B (zh) * | 2017-03-14 | 2020-05-01 | 北京化工大学 | 一类组蛋白去乙酰化酶抑制剂及其制备方法和用途 |
| EP3615025A4 (en) * | 2017-04-26 | 2020-11-25 | The Board of Trustees of the University of Illionis | NRF AND HIF ACTIVATORS / HDAC INHIBITORS AND THERAPEUTIC METHODS USING THEM |
| CN109705015B (zh) * | 2017-10-25 | 2022-05-24 | 成都先导药物开发股份有限公司 | 组蛋白去乙酰化酶抑制剂及其制备方法与用途 |
| CN108794469A (zh) * | 2018-04-28 | 2018-11-13 | 通化师范学院 | 一种吡咯化合物的合成新工艺及抗肿瘤作用的用途 |
| CN115636774B (zh) * | 2022-12-01 | 2023-12-22 | 南开大学 | 一种贝利司他的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4288595A (en) | 1980-04-24 | 1981-09-08 | American Home Products Corporation | 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines |
| GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
| GB0318254D0 (en) * | 2003-08-04 | 2003-09-10 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide |
| US20070065485A1 (en) | 2003-08-04 | 2007-03-22 | Motterlini Roberto A | Therapeutic delivery of carbon monoxide |
| WO2006050076A1 (en) * | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| KR20080032188A (ko) * | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| US20110288070A1 (en) * | 2008-05-05 | 2011-11-24 | ROGERS Kathryn | Methods for treating cognitive disorders using inhibitors of histone deacetylase |
| CA2768466C (en) | 2009-07-22 | 2018-08-14 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
| US8119683B2 (en) * | 2009-08-10 | 2012-02-21 | Taipei Medical University | Aryl substituted sulfonamide compounds and their use as anticancer agents |
| ME02800B (me) * | 2009-12-01 | 2018-01-20 | Abbvie Inc | Nova triciklična jedinjenja |
| EP2528893B1 (en) | 2010-01-29 | 2018-10-10 | Dana-Farber Cancer Institute, Inc. | Small molecules for the modulation of mcl-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders |
| TWI429628B (zh) * | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
| US9273028B2 (en) | 2010-10-29 | 2016-03-01 | Biogen Ma Inc. | Heterocyclic tyrosine kinase inhibitors |
| AU2012212323A1 (en) * | 2011-02-01 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
| CN103906732A (zh) * | 2011-10-28 | 2014-07-02 | 株式会社钟根堂 | 用作hdac抑制剂的异羟肟酸酯衍生物以及包含所述衍生物的药物组合物 |
| WO2013097052A1 (en) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| US9650379B2 (en) | 2013-12-12 | 2017-05-16 | Chong Kun Dang Pharmaceutical Corp. | Azaindole derivatives as selective histone deacetylase (HDAC) inhibitors and pharmaceutical compositions comprising the same |
-
2015
- 2015-04-09 WO PCT/US2015/025084 patent/WO2015157504A1/en not_active Ceased
- 2015-04-09 CN CN201580019257.4A patent/CN107001354B/zh active Active
- 2015-04-09 US US15/302,739 patent/US10246455B2/en active Active
- 2015-04-09 EP EP15776965.4A patent/EP3129373B1/en active Active
- 2015-04-09 JP JP2017504608A patent/JP6726658B2/ja active Active
- 2015-04-13 TW TW104111835A patent/TWI573787B/zh active