JP2006514013A5 - - Google Patents
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- Publication number
- JP2006514013A5 JP2006514013A5 JP2004555563A JP2004555563A JP2006514013A5 JP 2006514013 A5 JP2006514013 A5 JP 2006514013A5 JP 2004555563 A JP2004555563 A JP 2004555563A JP 2004555563 A JP2004555563 A JP 2004555563A JP 2006514013 A5 JP2006514013 A5 JP 2006514013A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- substituted
- alkyl
- group
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- -1 1,2-diphenylethyl Chemical group 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 206010052779 Transplant rejections Diseases 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 5
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 3
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000005202 dialkylaminocarbonyloxy group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 0 *C(C(N*)=O)N(*)C(*)=O Chemical compound *C(C(N*)=O)N(*)C(*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42833202P | 2002-11-21 | 2002-11-21 | |
| US60/428,332 | 2002-11-21 | ||
| PCT/US2003/037318 WO2004047825A1 (en) | 2002-11-21 | 2003-11-21 | Use of diamide derivatives for inhibiting chronic tissue transplant rejection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010210237A Division JP2010280725A (ja) | 2002-11-21 | 2010-09-17 | 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006514013A JP2006514013A (ja) | 2006-04-27 |
| JP2006514013A5 true JP2006514013A5 (enExample) | 2007-01-11 |
| JP4928079B2 JP4928079B2 (ja) | 2012-05-09 |
Family
ID=32393386
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004555563A Expired - Fee Related JP4928079B2 (ja) | 2002-11-21 | 2003-11-21 | 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 |
| JP2010210237A Withdrawn JP2010280725A (ja) | 2002-11-21 | 2010-09-17 | 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010210237A Withdrawn JP2010280725A (ja) | 2002-11-21 | 2010-09-17 | 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7687530B2 (enExample) |
| EP (1) | EP1567138B1 (enExample) |
| JP (2) | JP4928079B2 (enExample) |
| AT (1) | ATE493980T1 (enExample) |
| AU (1) | AU2003291134A1 (enExample) |
| DE (1) | DE60335652D1 (enExample) |
| ES (1) | ES2363914T3 (enExample) |
| PT (1) | PT1567138E (enExample) |
| WO (1) | WO2004047825A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001259691B2 (en) | 2000-05-12 | 2006-02-16 | Genzyme Corporation | Modulators of TNF-alpha signaling |
| PT1562571E (pt) * | 2002-11-21 | 2011-11-25 | Genzyme Corp | Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica |
| EP1567138B1 (en) * | 2002-11-21 | 2011-01-05 | Genzyme Corporation | Use of a diamide derivative for inhibiting chronic transplant rejection |
| EP1718768B1 (en) | 2004-01-21 | 2012-05-09 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for determining a graft tolerant phenotype in a subject |
| USRE46843E1 (en) | 2005-03-14 | 2018-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
| JP2008537875A (ja) | 2005-03-14 | 2008-10-02 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 固形臓器移植レシピエントにおいて移植片生着を評価するための方法および組成物 |
| EP2631301B1 (en) * | 2008-08-18 | 2017-10-11 | The Board of Trustees of the Leland Stanford Junior University | Methods for determining a graft tolerant phenotype in a subject |
| US9938579B2 (en) | 2009-01-15 | 2018-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarker panel for diagnosis and prediction of graft rejection |
| US9290813B2 (en) | 2009-12-02 | 2016-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers for determining an allograft tolerant phenotype |
| EP2550371A4 (en) | 2010-03-25 | 2013-11-20 | Univ Leland Stanford Junior | PROTEIN AND GENE BIOMARKERS FOR EXTRACTING ORGAN TRANSPLANTS |
| WO2012139051A2 (en) | 2011-04-06 | 2012-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Autoantibody biomarkers for iga nephropathy |
| EP2827861A4 (en) * | 2012-03-19 | 2016-03-16 | Aposignal Bioscience Llc | COMPOSITION AND METHODS FOR CELLULAR MODULATION |
| WO2017142879A1 (en) * | 2016-02-16 | 2017-08-24 | The Regents Of The University Of California | Methods for immune system modulation with microporous annealed particle gels |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US4944796A (en) * | 1988-11-14 | 1990-07-31 | Ici Americas Inc. | Certain 2-(disubstituted amino) acetanilide herbicides |
| US5540931A (en) | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
| US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| US5958413A (en) | 1990-11-01 | 1999-09-28 | Celltech Limited | Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor |
| US6420374B1 (en) | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
| US5861382A (en) | 1992-05-01 | 1999-01-19 | Yeda Research And Development Co. Ltd. | Methods for regulation of active TNF-α |
| WO1995009652A1 (en) | 1993-10-06 | 1995-04-13 | The Kennedy Institute For Rheumatology | Treatment of autoimmune and inflammatory disorders |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| EP0663836B1 (en) | 1992-10-08 | 1997-07-09 | The Kennedy Institute Of Rheumatology | Treatment of autoimmune and inflammatory disorders |
| US6030615A (en) | 1993-05-17 | 2000-02-29 | The Picower Institute For Medical Research | Combination method for treating diseases caused by cytokine-mediated toxicity |
| NZ278607A (en) | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
| DE4430127A1 (de) | 1994-08-25 | 1996-03-14 | Hoechst Ag | Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat |
| DE4430128A1 (de) | 1994-08-25 | 1996-02-29 | Hoechst Ag | Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen |
| JPH11501289A (ja) * | 1994-12-02 | 1999-02-02 | 藤沢薬品工業株式会社 | Ｎｏ介在疾患の予防および／または治療のためのペプチド化合物 |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| FR2730411B1 (fr) * | 1995-02-14 | 1997-03-28 | Centre Nat Rech Scient | Association medicamenteuse utile pour la transfection et l'expression in vivo d'exogenes |
| US5654312A (en) | 1995-06-07 | 1997-08-05 | Andrulis Pharmaceuticals | Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents |
| ATE259235T1 (de) | 1995-07-20 | 2004-02-15 | Cell Eng Ag | Zubereitung enthaltend glykane übereinstimmend mit transferrin glykaner als aktives prinzip für die induktion der immuntoleranz gegen antigene |
| IL115245A (en) | 1995-09-11 | 2002-12-01 | Yissum Res Dev Co | Tumor necrosis factor inhibiting pharmaceuticals |
| NZ322565A (en) * | 1995-11-22 | 1999-11-29 | Darwin Discovery Ltd | Mercaptoalkykpeptidyl compounds having an imidazole substitutent and their use as inhibitors of matrix metalloproteinases and tumor necrosis factor |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US6211160B1 (en) | 1996-09-06 | 2001-04-03 | The Trustees Of The University Of Pennsylvania | Method for tolerizing a mammalian patient to administration of gene therapy virus vectors |
| PT942740E (pt) | 1996-12-06 | 2004-01-30 | Amgen Inc | Terapia de combinacao utilizando uma proteina de ligacao de tnf para tratamento de doencas mediadas por tnf |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| WO1998039026A2 (en) | 1997-03-07 | 1998-09-11 | Biogen, Inc. | Methods of therapeutic administration of anti-cd40l compounds |
| US5801193A (en) | 1997-04-15 | 1998-09-01 | Immune Modulation, Inc. | Compositions and methods for immunosuppressing |
| US6506569B1 (en) | 1997-05-30 | 2003-01-14 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR10 |
| US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| US6229878B1 (en) * | 1998-01-21 | 2001-05-08 | Lucent Technologies, Inc. | Telephone answering method and apparatus |
| US6359061B1 (en) * | 1999-03-19 | 2002-03-19 | Isis Pharmaceuticals, Inc. | Amide compound libraries |
| CA2366264A1 (en) | 1999-04-02 | 2000-10-12 | Bristol-Myers Squibb Company | Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase |
| US6204245B1 (en) | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
| AU1590201A (en) | 1999-11-09 | 2001-06-06 | Chiron Corporation | Compositions and methods for treating autoimmune diseases and transplant rejections |
| AU2001259691B2 (en) * | 2000-05-12 | 2006-02-16 | Genzyme Corporation | Modulators of TNF-alpha signaling |
| MXPA02011376A (es) | 2000-05-22 | 2004-02-26 | Leo Pharma As | Benzofenonas como inhibidores de il-1beta y tnf-alfa. |
| WO2004003154A2 (en) | 2002-06-26 | 2004-01-08 | The Trustees Of Columbia Uninersity In The City Of New York | Use of streptavidin to inhibit transplant rejection |
| PT1562571E (pt) * | 2002-11-21 | 2011-11-25 | Genzyme Corp | Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica |
| EP1567138B1 (en) * | 2002-11-21 | 2011-01-05 | Genzyme Corporation | Use of a diamide derivative for inhibiting chronic transplant rejection |
-
2003
- 2003-11-21 EP EP03783726A patent/EP1567138B1/en not_active Expired - Lifetime
- 2003-11-21 PT PT03783726T patent/PT1567138E/pt unknown
- 2003-11-21 AU AU2003291134A patent/AU2003291134A1/en not_active Abandoned
- 2003-11-21 WO PCT/US2003/037318 patent/WO2004047825A1/en not_active Ceased
- 2003-11-21 JP JP2004555563A patent/JP4928079B2/ja not_active Expired - Fee Related
- 2003-11-21 DE DE60335652T patent/DE60335652D1/de not_active Expired - Lifetime
- 2003-11-21 US US10/719,055 patent/US7687530B2/en not_active Expired - Lifetime
- 2003-11-21 ES ES03783726T patent/ES2363914T3/es not_active Expired - Lifetime
- 2003-11-21 AT AT03783726T patent/ATE493980T1/de not_active IP Right Cessation
-
2010
- 2010-01-06 US US12/683,157 patent/US20100256211A1/en not_active Abandoned
- 2010-09-17 JP JP2010210237A patent/JP2010280725A/ja not_active Withdrawn