|
US6329418B1
(en)
|
1998-04-14 |
2001-12-11 |
The Procter & Gamble Company |
Substituted pyrrolidine hydroxamate metalloprotease inhibitors
|
|
US20030017528A1
(en)
|
1998-11-20 |
2003-01-23 |
Ruoping Chen |
Human orphan G protein-coupled receptors
|
|
US6221660B1
(en)
|
1999-02-22 |
2001-04-24 |
Synaptic Pharmaceutical Corporation |
DNA encoding SNORF25 receptor
|
|
WO2002102783A1
(en)
|
2001-06-19 |
2002-12-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
DE10225574A1
(de)
|
2002-06-10 |
2003-12-18 |
Merck Patent Gmbh |
Aryloxime
|
|
EP1565452B1
(en)
|
2002-11-08 |
2012-04-04 |
Novartis International Pharmaceutical Ltd. |
3-substituted-6-aryl pyridines as ligands of c5a receptors
|
|
CN102558155A
(zh)
|
2003-01-14 |
2012-07-11 |
阿伦纳药品公司 |
作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
|
|
US7083933B1
(en)
|
2003-05-09 |
2006-08-01 |
Prosidion Limited |
Methods for identification of modulators of OSGPR116 activity
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
JP4958560B2
(ja)
|
2003-12-24 |
2012-06-20 |
プロシディオン・リミテッド |
Ｇｐｃｒ受容体作動薬としてのヘテロ環誘導体
|
|
DE602005011279D1
(de)
|
2004-06-04 |
2009-01-08 |
Arena Pharm Inc |
Substituierte aryl- und heteroarylderivate als modulatoren des stoffwechsels und für die prophylaxe und behandlung von damit in zusammenhang stehenden erkrankungen
|
|
JP4980928B2
(ja)
|
2004-12-24 |
2012-07-18 |
プロシディオン・リミテッド |
Ｇタンパク質共役受容体（ｇｐｒ１１６）作動薬および肥満および糖尿病治療のためのその使用
|
|
WO2006067532A1
(en)
|
2004-12-24 |
2006-06-29 |
Prosidion Ltd |
G-protein coupled receptor agonists
|
|
GB0428514D0
(en)
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
MY148521A
(en)
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
EP1838669A1
(en)
|
2005-01-19 |
2007-10-03 |
Biolipox AB |
Indoles useful in the treatment of inflammation
|
|
US20100197687A1
(en)
|
2005-01-19 |
2010-08-05 |
Benjamin Pelcman |
Indoles Useful in the Treatment of Inflammation
|
|
US20080249091A1
(en)
|
2005-01-19 |
2008-10-09 |
Benjamin Pelcman |
Indoles Useful in the Treatment of Inflammation
|
|
US20090221644A1
(en)
|
2005-06-30 |
2009-09-03 |
Stuart Edward Bradley |
Gpcr Agonists
|
|
US20100063081A1
(en)
|
2005-06-30 |
2010-03-11 |
Stuart Edward Bradly |
CPCR Agonists
|
|
KR20080025190A
(ko)
|
2005-06-30 |
2008-03-19 |
프로시디온 리미티드 |
Ｇ-단백질 결합된 수용체 효능제
|
|
EP1907383A1
(en)
|
2005-06-30 |
2008-04-09 |
Prosidion Limited |
Gpcr agonists
|
|
RS20080112A
(sr)
|
2005-09-16 |
2009-05-06 |
Arena Pharmaceuticals Inc., |
Modulatori metabolizma i lečenje poremećaja koji su vezi sa njima
|
|
BRPI0710181A2
(pt)
|
2006-03-16 |
2011-08-09 |
Novartis Ag |
compostos orgánicos
|
|
JP2009532453A
(ja)
|
2006-04-06 |
2009-09-10 |
プロシディオン・リミテッド |
ヘテロサイクリックｇｐｃｒアゴニスト
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
GB0607196D0
(en)
|
2006-04-11 |
2006-05-17 |
Prosidion Ltd |
G-protein coupled receptor agonists
|
|
ES2354390T3
(es)
|
2006-04-11 |
2011-03-14 |
Arena Pharmaceuticals, Inc. |
Procedimientos de uso del receptor gpr119 para identificar compuestos útiles para aumentar la masa ósea en un individuo.
|
|
GB0610746D0
(en)
|
2006-06-01 |
2006-07-12 |
Prosidion Ltd |
Method of treatment
|
|
TW200811140A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
TW200811147A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
JP2009543805A
(ja)
*
|
2006-07-13 |
2009-12-10 |
スミスクライン ビーチャム コーポレーション |
インドリン誘導体及びｇｐｒ１１９作動物質
|
|
WO2008009924A2
(en)
|
2006-07-18 |
2008-01-24 |
Biolipox Ab |
Indoles useful in the treatment of inflammation
|
|
WO2008025800A1
(en)
|
2006-08-30 |
2008-03-06 |
Biovitrum Ab (Publ) |
Pyrimidine compounds for treating gpr119 related disorders
|
|
JP5330260B2
(ja)
|
2006-12-06 |
2013-10-30 |
スミスクライン ビーチャム コーポレーション |
二環式化合物ならびに抗糖尿病薬としての使用
|
|
US7638541B2
(en)
|
2006-12-28 |
2009-12-29 |
Metabolex Inc. |
5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
|
|
CL2008000017A1
(es)
|
2007-01-04 |
2008-08-01 |
Prosidion Ltd |
Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
|
|
PE20081659A1
(es)
|
2007-01-04 |
2008-10-24 |
Prosidion Ltd |
Agonistas de gpcr
|
|
GB0700122D0
(en)
|
2007-01-04 |
2007-02-14 |
Prosidion Ltd |
GPCR agonists
|
|
WO2008081208A1
(en)
|
2007-01-04 |
2008-07-10 |
Prosidion Limited |
Piperidine gpcr agonists
|
|
EP2377863A1
(en)
|
2007-01-04 |
2011-10-19 |
Prosidion Limited |
Piperidine GPCR agonists
|
|
US20080186971A1
(en)
|
2007-02-02 |
2008-08-07 |
Tarari, Inc. |
Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
|
|
PE20081791A1
(es)
|
2007-02-28 |
2009-02-07 |
Eisai Randd Man Co Ltd |
Dos derivados ciclicos de oxomorfolina
|
|
AU2008222812B2
(en)
|
2007-03-08 |
2012-03-22 |
Irm Llc |
Compounds and compositions as modulators of GPR119 activity
|
|
AU2008233553A1
(en)
|
2007-03-29 |
2008-10-09 |
Daiichi Sankyo Company, Limited |
Indole derivative having cPLA2 inhibitory activity, use of the same and method for producing the same
|
|
US7910583B2
(en)
|
2007-05-04 |
2011-03-22 |
Bristol-Myers Squibb Company |
[6,6] and [6,7]-bicyclic GPR119 G protein-coupled receptor agonists
|
|
EP2152707B1
(en)
|
2007-05-04 |
2012-06-20 |
Bristol-Myers Squibb Company |
[6,5]-bicyclic gpr119 g protein-coupled receptor agonists
|
|
CN101801956B
(zh)
|
2007-07-17 |
2013-11-20 |
百时美施贵宝公司 |
用于调节gpr119 g蛋白偶联受体的方法及所选化合物
|
|
AU2008279447A1
(en)
|
2007-07-19 |
2009-01-29 |
Metabolex, Inc. |
N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
|
|
US20100286112A1
(en)
|
2007-09-10 |
2010-11-11 |
Oscar Barba |
Compounds for the treatment of metabolic disorders
|
|
JP5465177B2
(ja)
|
2007-09-20 |
2014-04-09 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
Ｇｐｒ１１９活性のモジュレーターとしての化合物および組成物
|
|
MY151295A
(en)
*
|
2007-10-16 |
2014-04-30 |
Daiichi Sankyo Co Ltd |
Pyrimidyl indoline compound
|
|
GB0720389D0
(en)
|
2007-10-18 |
2008-11-12 |
Prosidion Ltd |
G-Protein Coupled Receptor Agonists
|
|
GB0720390D0
(en)
|
2007-10-18 |
2007-11-28 |
Prosidion Ltd |
G-Protein coupled receptor agonists
|
|
CA2703203C
(en)
|
2007-10-22 |
2015-12-15 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
WO2009073772A1
(en)
|
2007-12-06 |
2009-06-11 |
Smithkline Beecham Corporation |
Novel seh inhibitors and their use
|
|
CA2714703A1
(en)
|
2008-02-22 |
2009-08-27 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
EP2252613A1
(en)
|
2008-02-22 |
2010-11-24 |
Irm, Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
WO2009106561A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Pyrazine compounds for treating gpr119 related disorders
|
|
WO2009106565A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Agonists of gpr119
|
|
AU2009231906A1
(en)
|
2008-03-31 |
2009-10-08 |
Metabolex, Inc. |
Oxymethylene aryl compounds and uses thereof
|
|
AU2009232721B2
(en)
|
2008-03-31 |
2013-02-14 |
Zenyaku Kogyo Kabushikikaisha |
Pyrimidine derivative having cell protecting effect and uses thereof
|
|
WO2009125434A2
(en)
|
2008-04-07 |
2009-10-15 |
Cadila Healthcare Limited |
Oxime derivatives
|
|
CA2720950A1
(en)
|
2008-04-07 |
2009-10-15 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
EP2297129B1
(en)
|
2008-04-14 |
2013-07-24 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
|
US8188098B2
(en)
|
2008-05-19 |
2012-05-29 |
Hoffmann-La Roche Inc. |
GPR119 receptor agonists
|
|
WO2009150144A1
(en)
|
2008-06-10 |
2009-12-17 |
Inovacia Ab |
New gpr119modulators
|
|
AU2009271414A1
(en)
|
2008-06-20 |
2010-01-21 |
Metabolex, Inc. |
Aryl GPR119 agonists and uses thereof
|
|
KR20110036609A
(ko)
|
2008-07-10 |
2011-04-07 |
프로시디온 리미티드 |
피페리디닐 ｇｐｃｒ 작용제
|
|
CN102089301A
(zh)
|
2008-07-10 |
2011-06-08 |
普洛希典有限公司 |
哌啶gpcr激动剂
|
|
GB0812642D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812649D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812648D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812641D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
WO2010006191A1
(en)
|
2008-07-11 |
2010-01-14 |
Irm Llc |
4-phenoxymethylpiperidines as modulators of gpr119 activity
|
|
TW201006821A
(en)
|
2008-07-16 |
2010-02-16 |
Bristol Myers Squibb Co |
Pyridone and pyridazone analogues as GPR119 modulators
|
|
MX2011000664A
(es)
|
2008-07-16 |
2011-02-24 |
Schering Corp |
Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119.
|
|
JP2011529897A
(ja)
|
2008-07-30 |
2011-12-15 |
グラクソスミスクライン エルエルシー |
化合物と使用
|
|
WO2010013849A1
(ja)
|
2008-08-01 |
2010-02-04 |
日本ケミファ株式会社 |
Ｇｐｒ１１９作動薬
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
US20100113479A1
(en)
|
2008-10-30 |
2010-05-06 |
Anusuya Choudhury |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists
|
|
WO2010059385A1
(en)
|
2008-10-30 |
2010-05-27 |
Janssen Pharmaceutica Nv |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidne derivatives useful as gdir agonists
|
|
EP2382204B1
(en)
|
2008-12-23 |
2018-07-11 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives as gpcr modulators for use in the treatment of obesity and diabetes
|
|
WO2010075273A1
(en)
|
2008-12-23 |
2010-07-01 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
JP2012513470A
(ja)
|
2008-12-23 |
2012-06-14 |
シェーリング コーポレイション |
二環式複素環誘導体及びその使用方法
|
|
ES2403120T3
(es)
|
2008-12-24 |
2013-05-14 |
Cadila Healthcare Limited |
Nuevos derivados de oxima
|
|
WO2010074271A1
(ja)
|
2008-12-26 |
2010-07-01 |
武田薬品工業株式会社 |
糖尿病治療剤
|
|
TW201031668A
(en)
|
2009-01-22 |
2010-09-01 |
Mitsubishi Tanabe Pharma Corp |
Novel pyrrolo[2,3-d] pyrimidine compound
|
|
WO2010088518A2
(en)
|
2009-01-31 |
2010-08-05 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
JP5657518B2
(ja)
|
2009-02-18 |
2015-01-21 |
武田薬品工業株式会社 |
縮合複素環化合物
|
|
GB0904285D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904287D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904284D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
CA2754523A1
(en)
|
2009-03-20 |
2010-09-23 |
Pfizer Inc. |
3-oxa-7-azabicyclo[3.3.1]nonanes
|
|
AR076024A1
(es)
|
2009-04-03 |
2011-05-11 |
Schering Corp |
Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos
|
|
WO2010114957A1
(en)
|
2009-04-03 |
2010-10-07 |
Schering Corporation |
Bicyclic piperidine and piperazine derivatives as gpcr modulators for the treatment of obesity, diabetes and other metabolic disorders
|
|
JP2010265258A
(ja)
*
|
2009-04-15 |
2010-11-25 |
Daiichi Sankyo Co Ltd |
ピリミジルインドリン化合物を含有する医薬組成物
|
|
TW201039827A
(en)
*
|
2009-04-15 |
2010-11-16 |
Daiichi Sankyo Co Ltd |
Indoline compound
|
|
JP2012136439A
(ja)
|
2009-04-24 |
2012-07-19 |
Nippon Chemiphar Co Ltd |
ジアザスピロアルカン誘導体
|
|
JP2012526096A
(ja)
*
|
2009-05-08 |
2012-10-25 |
ファイザー・インク |
Ｇｐｒ１１９調節因子
|
|
JP2012526097A
(ja)
*
|
2009-05-08 |
2012-10-25 |
ファイザー・インク |
Ｇｐｒ１１９調節因子
|
|
US20100285145A1
(en)
*
|
2009-05-08 |
2010-11-11 |
Pfizer Inc |
Gpr 119 modulators
|
|
US20100298362A1
(en)
|
2009-05-20 |
2010-11-25 |
Xun Li |
Process for the preparation of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
WO2010135505A2
(en)
|
2009-05-20 |
2010-11-25 |
Janssen Pharmaceutica Nv |
Crystalline forms of 4-[6-(6-methanesulfonyl-2-methylpyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
GEP20135907B
(en)
|
2009-06-05 |
2013-08-12 |
Pfizer |
L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
|
|
TW201111361A
(en)
|
2009-06-24 |
2011-04-01 |
Boehringer Ingelheim Int |
New compounds, pharmaceutical composition and methods relating thereto
|
|
TW201113269A
(en)
|
2009-06-24 |
2011-04-16 |
Boehringer Ingelheim Int |
New compounds, pharmaceutical composition and methods relating thereto
|
|
EP2566864B1
(en)
|
2010-05-07 |
2014-09-03 |
Boehringer Ingelheim International GmbH |
Pyridazinones as gpr119 agonists
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
UY33805A
(es)
|
2010-12-17 |
2012-07-31 |
Boehringer Ingelheim Int |
?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?.
|
|
MX2013008083A
(es)
|
2011-01-21 |
2013-09-13 |
Boehringer Ingelheim Int |
Dihidrofuranos fusionados como moduladores de gpr119 para el tratamiento de diabetes, obesidad y trastornos relacionados.
|
|
WO2012123449A1
(en)
|
2011-03-14 |
2012-09-20 |
Boehringer Ingelheim International Gmbh |
N- cyclopropyl - n- piperidinylbenzamides as gpr119 modulators
|