|
US6329418B1
(en)
|
1998-04-14 |
2001-12-11 |
The Procter & Gamble Company |
Substituted pyrrolidine hydroxamate metalloprotease inhibitors
|
|
US20030017528A1
(en)
|
1998-11-20 |
2003-01-23 |
Ruoping Chen |
Human orphan G protein-coupled receptors
|
|
US6221660B1
(en)
|
1999-02-22 |
2001-04-24 |
Synaptic Pharmaceutical Corporation |
DNA encoding SNORF25 receptor
|
|
US20040171630A1
(en)
|
2001-06-19 |
2004-09-02 |
Yuntae Kim |
Tyrosine kinase inhibitors
|
|
DE10225574A1
(de)
|
2002-06-10 |
2003-12-18 |
Merck Patent Gmbh |
Aryloxime
|
|
AU2003291403A1
(en)
|
2002-11-08 |
2004-06-03 |
Neurogen Corporation |
3-substituted-6-aryl pyridined as ligands of c5a receptors
|
|
RS20050532A
(sr)
|
2003-01-14 |
2007-12-31 |
Arena Pharmaceuticals Inc., |
Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija
|
|
US7083933B1
(en)
|
2003-05-09 |
2006-08-01 |
Prosidion Limited |
Methods for identification of modulators of OSGPR116 activity
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
US8207147B2
(en)
|
2003-12-24 |
2012-06-26 |
Prosidion Limited |
Heterocyclic derivatives as GPCR receptor agonists
|
|
EA011671B1
(ru)
|
2004-06-04 |
2009-04-28 |
Арена Фармасьютикалз, Инк. |
Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств
|
|
EP1838706A1
(en)
|
2004-12-24 |
2007-10-03 |
Prosidion Limited |
G-protein coupled receptor agonists
|
|
KR20070091038A
(ko)
|
2004-12-24 |
2007-09-06 |
프로시디온 리미티드 |
G-단백질 결합 수용체(gpr116) 효능제 및 비만 및당뇨병을 치료하기 위한 이의 용도
|
|
GB0428514D0
(en)
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
MY148521A
(en)
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
JP2008527028A
(ja)
|
2005-01-19 |
2008-07-24 |
バイオリポックス エービー |
炎症の治療に有用なインドール類
|
|
WO2006077364A1
(en)
|
2005-01-19 |
2006-07-27 |
Biolipox Ab |
Indoles useful in the treatment of inflammation
|
|
WO2006077367A1
(en)
|
2005-01-19 |
2006-07-27 |
Biolipox Ab |
Indoles useful in the treatment of inflamation
|
|
JP2008545008A
(ja)
|
2005-06-30 |
2008-12-11 |
プロシディオン・リミテッド |
Gpcrアゴニスト
|
|
JP2008545010A
(ja)
|
2005-06-30 |
2008-12-11 |
プロシディオン・リミテッド |
Gタンパク質共役受容体アゴニスト
|
|
US20090325924A1
(en)
|
2005-06-30 |
2009-12-31 |
Stuart Edward |
GPCR Agonists
|
|
AU2006264649A1
(en)
|
2005-06-30 |
2007-01-11 |
Prosidion Limited |
GPCR agonists
|
|
BRPI0616245A2
(pt)
|
2005-09-16 |
2011-06-14 |
Arena Pharm Inc |
modulador de metabolismo, seus usos, composiÇço farmaceutica compreendendo o mesmo, bem como mÉtodo para produÇço da referida composiÇço
|
|
CN101563336A
(zh)
|
2006-03-16 |
2009-10-21 |
诺瓦提斯公司 |
用于治疗特别是黑素瘤的杂环有机化合物
|
|
NZ571869A
(en)
|
2006-04-06 |
2011-11-25 |
Prosidion Ltd |
Heterocyclic GPCR agonists
|
|
NZ571110A
(en)
|
2006-04-11 |
2011-03-31 |
Arena Pharm Inc |
Methods of using GPR119 receptor to identify Glucose-dependent Insulinotropic Peptide (GIP) secretagogue compounds useful for increasing bone mass in an individual
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
GB0607196D0
(en)
|
2006-04-11 |
2006-05-17 |
Prosidion Ltd |
G-protein coupled receptor agonists
|
|
GB0610746D0
(en)
|
2006-06-01 |
2006-07-12 |
Prosidion Ltd |
Method of treatment
|
|
TW200811147A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
TW200811140A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
US8222261B2
(en)
*
|
2006-07-13 |
2012-07-17 |
GlaxoSmithKline, LLC |
Chemical compounds
|
|
WO2008009924A2
(en)
|
2006-07-18 |
2008-01-24 |
Biolipox Ab |
Indoles useful in the treatment of inflammation
|
|
EP2059517A1
(en)
|
2006-08-30 |
2009-05-20 |
Biovitrum AB (publ) |
Pyrimidine compounds for treating gpr119 related disorders
|
|
JP5330260B2
(ja)
|
2006-12-06 |
2013-10-30 |
スミスクライン ビーチャム コーポレーション |
二環式化合物ならびに抗糖尿病薬としての使用
|
|
US7638541B2
(en)
|
2006-12-28 |
2009-12-29 |
Metabolex Inc. |
5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
|
|
CL2008000018A1
(es)
|
2007-01-04 |
2008-08-01 |
Prosidion Ltd |
Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
|
|
EP2114933B1
(en)
|
2007-01-04 |
2011-09-07 |
Prosidion Ltd |
Piperidine gpcr agonists
|
|
GB0700122D0
(en)
|
2007-01-04 |
2007-02-14 |
Prosidion Ltd |
GPCR agonists
|
|
PE20081849A1
(es)
|
2007-01-04 |
2009-01-26 |
Prosidion Ltd |
Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
|
|
EA016507B1
(ru)
|
2007-01-04 |
2012-05-30 |
Прозидион Лимитед |
Пиперидиновые агонисты gpcr
|
|
US20080186971A1
(en)
|
2007-02-02 |
2008-08-07 |
Tarari, Inc. |
Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
|
|
TW200848054A
(en)
|
2007-02-28 |
2008-12-16 |
Eisai R&D Man Co Ltd |
Two cyclic oxomorpholine derivatives
|
|
DE602008002733D1
(de)
|
2007-03-08 |
2010-11-04 |
Irm Llc |
Verbindungen und zusammensetzungen als modulatoren der gpr119-aktivität
|
|
US8293781B2
(en)
|
2007-03-29 |
2012-10-23 |
Daiichi Sankyo Company, Limited |
Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same
|
|
EP2152707B1
(en)
|
2007-05-04 |
2012-06-20 |
Bristol-Myers Squibb Company |
[6,5]-bicyclic gpr119 g protein-coupled receptor agonists
|
|
PE20090222A1
(es)
|
2007-05-04 |
2009-03-27 |
Bristol Myers Squibb Co |
Compuestos [6,6] y [6,7]-biciclicos como agonistas del receptor acoplado a la proteina g gpr119
|
|
PL2170864T3
(pl)
|
2007-07-17 |
2012-02-29 |
Bristol Myers Squibb Co |
Agoniści receptora gpr119 sprężonego z białkiem g - pirydon
|
|
AU2008279447A1
(en)
|
2007-07-19 |
2009-01-29 |
Metabolex, Inc. |
N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
|
|
JP2010539152A
(ja)
|
2007-09-10 |
2010-12-16 |
プロシディオン・リミテッド |
代謝障害の治療のための化合物
|
|
ES2499018T3
(es)
|
2007-09-20 |
2014-09-26 |
Irm Llc |
Compuestos y composiciones como moduladores de la actividad de GPR119
|
|
KR101536021B1
(ko)
*
|
2007-10-16 |
2015-07-10 |
다이이찌 산쿄 가부시키가이샤 |
피리미딜 인돌린 화합물
|
|
GB0720389D0
(en)
|
2007-10-18 |
2008-11-12 |
Prosidion Ltd |
G-Protein Coupled Receptor Agonists
|
|
GB0720390D0
(en)
|
2007-10-18 |
2007-11-28 |
Prosidion Ltd |
G-Protein coupled receptor agonists
|
|
CA2703203C
(en)
|
2007-10-22 |
2015-12-15 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
WO2009073772A1
(en)
|
2007-12-06 |
2009-06-11 |
Smithkline Beecham Corporation |
Novel seh inhibitors and their use
|
|
KR20100120689A
(ko)
|
2008-02-22 |
2010-11-16 |
아이알엠 엘엘씨 |
Gpr119 활성의 조절제로서의 화합물 및 조성물
|
|
WO2009105717A1
(en)
|
2008-02-22 |
2009-08-27 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
WO2009106561A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Pyrazine compounds for treating gpr119 related disorders
|
|
WO2009106565A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Agonists of gpr119
|
|
CA2720049A1
(en)
|
2008-03-31 |
2009-10-08 |
Zenyaku Kogyo Kabushikikaisha |
Pyrimidine derivative having cell protecting effect and uses thereof
|
|
PL2280704T3
(pl)
|
2008-03-31 |
2015-10-30 |
Cymabay Therapeutics Inc |
Związki oksymetylenoarylowe i ich zastosowania
|
|
WO2009125434A2
(en)
|
2008-04-07 |
2009-10-15 |
Cadila Healthcare Limited |
Oxime derivatives
|
|
BRPI0911118A2
(pt)
|
2008-04-07 |
2015-10-06 |
Irm Llc |
composto e compisições como moduladores de atividade de gpr119
|
|
WO2009129036A1
(en)
|
2008-04-14 |
2009-10-22 |
Merck & Co., Inc. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
|
US8188098B2
(en)
|
2008-05-19 |
2012-05-29 |
Hoffmann-La Roche Inc. |
GPR119 receptor agonists
|
|
WO2009150144A1
(en)
|
2008-06-10 |
2009-12-17 |
Inovacia Ab |
New gpr119modulators
|
|
BRPI0914891A2
(pt)
|
2008-06-20 |
2015-11-24 |
Metabolex Inc |
agonistas de aril gpr119 e usos dos mesmos
|
|
ATE557024T1
(de)
|
2008-07-10 |
2012-05-15 |
Prosidion Ltd |
Piperidinverbindungen als gpcr-agonisten
|
|
GB0812648D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812642D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
EA201170151A1
(ru)
|
2008-07-10 |
2011-08-30 |
Просидион Лимитед |
Пиперидиниловые агонисты gpcr
|
|
GB0812641D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812649D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
ES2429129T3
(es)
|
2008-07-11 |
2013-11-13 |
Irm Llc |
4-Fenoximetilpiperidinas como moduladores de la actividad de GPR119
|
|
TW201006821A
(en)
|
2008-07-16 |
2010-02-16 |
Bristol Myers Squibb Co |
Pyridone and pyridazone analogues as GPR119 modulators
|
|
MX2011000664A
(es)
|
2008-07-16 |
2011-02-24 |
Schering Corp |
Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119.
|
|
EP2320910A4
(en)
|
2008-07-30 |
2012-12-19 |
Glaxosmithkline Llc |
CHEMICAL COMPOUNDS AND ITS USE
|
|
WO2010013849A1
(ja)
|
2008-08-01 |
2010-02-04 |
日本ケミファ株式会社 |
Gpr119作動薬
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
WO2010059384A1
(en)
|
2008-10-30 |
2010-05-27 |
Janssen Pharmaceutica Nv |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists
|
|
WO2010059385A1
(en)
|
2008-10-30 |
2010-05-27 |
Janssen Pharmaceutica Nv |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidne derivatives useful as gdir agonists
|
|
WO2010075273A1
(en)
|
2008-12-23 |
2010-07-01 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
AU2009330208A1
(en)
|
2008-12-23 |
2011-08-04 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
EP2382204B1
(en)
|
2008-12-23 |
2018-07-11 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives as gpcr modulators for use in the treatment of obesity and diabetes
|
|
ES2403120T3
(es)
|
2008-12-24 |
2013-05-14 |
Cadila Healthcare Limited |
Nuevos derivados de oxima
|
|
WO2010074271A1
(ja)
|
2008-12-26 |
2010-07-01 |
武田薬品工業株式会社 |
糖尿病治療剤
|
|
EP2390254A1
(en)
|
2009-01-22 |
2011-11-30 |
Mitsubishi Tanabe Pharma Corporation |
NOVEL PYRROLOÝ2,3-d¨PYRIMIDINE COMPOUND
|
|
WO2010088518A2
(en)
|
2009-01-31 |
2010-08-05 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
JP5657518B2
(ja)
*
|
2009-02-18 |
2015-01-21 |
武田薬品工業株式会社 |
縮合複素環化合物
|
|
GB0904287D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904284D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904285D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
CA2754523A1
(en)
|
2009-03-20 |
2010-09-23 |
Pfizer Inc. |
3-oxa-7-azabicyclo[3.3.1]nonanes
|
|
EP2414348B1
(en)
|
2009-04-03 |
2013-11-20 |
Merck Sharp & Dohme Corp. |
Bicyclic piperidine and piperazine derivatives as gpcr modulators for the treatment of obesity, diabetes and other metabolic disorders
|
|
AR076024A1
(es)
|
2009-04-03 |
2011-05-11 |
Schering Corp |
Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos
|
|
WO2010119881A1
(ja)
*
|
2009-04-15 |
2010-10-21 |
第一三共株式会社 |
インドリン化合物
|
|
JP2010265258A
(ja)
*
|
2009-04-15 |
2010-11-25 |
Daiichi Sankyo Co Ltd |
ピリミジルインドリン化合物を含有する医薬組成物
|
|
JP2012136439A
(ja)
|
2009-04-24 |
2012-07-19 |
Nippon Chemiphar Co Ltd |
ジアザスピロアルカン誘導体
|
|
EP2427448A1
(en)
|
2009-05-08 |
2012-03-14 |
Pfizer Inc. |
Gpr 119 modulators
|
|
US20100285145A1
(en)
*
|
2009-05-08 |
2010-11-11 |
Pfizer Inc |
Gpr 119 modulators
|
|
CA2759843A1
(en)
|
2009-05-08 |
2010-11-10 |
Pfizer Inc. |
Gpr 119 modulators
|
|
US20100298362A1
(en)
|
2009-05-20 |
2010-11-25 |
Xun Li |
Process for the preparation of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
US20110015215A1
(en)
|
2009-05-20 |
2011-01-20 |
Paul Deghetto |
Crystalline forms of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
GEP20135907B
(en)
|
2009-06-05 |
2013-08-12 |
Pfizer |
L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
|
|
US8481731B2
(en)
|
2009-06-24 |
2013-07-09 |
Boehringer Ingelheim International Gmbh |
Compounds, pharmaceutical composition and methods relating thereto
|
|
US8293729B2
(en)
|
2009-06-24 |
2012-10-23 |
Boehringer Ingelheim International Gmbh |
Compounds, pharmaceutical composition and methods relating thereto
|
|
JP5794297B2
(ja)
|
2010-05-07 |
2015-10-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Gpr119アゴニストとしてのピリダジノン
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
UY33805A
(es)
|
2010-12-17 |
2012-07-31 |
Boehringer Ingelheim Int |
?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?.
|
|
UY33871A
(es)
|
2011-01-21 |
2012-07-31 |
Boehringer Ingelheim Int |
Compuestos y formulaciones farmacéuticas basadas en derivados de benzo y heteroarilos condensados 2,3-dihidrofurán-2-il-piperidina y sus usos
|
|
WO2012123449A1
(en)
|
2011-03-14 |
2012-09-20 |
Boehringer Ingelheim International Gmbh |
N- cyclopropyl - n- piperidinylbenzamides as gpr119 modulators
|