|
US6329418B1
(en)
|
1998-04-14 |
2001-12-11 |
The Procter & Gamble Company |
Substituted pyrrolidine hydroxamate metalloprotease inhibitors
|
|
US20030017528A1
(en)
|
1998-11-20 |
2003-01-23 |
Ruoping Chen |
Human orphan G protein-coupled receptors
|
|
US6221660B1
(en)
|
1999-02-22 |
2001-04-24 |
Synaptic Pharmaceutical Corporation |
DNA encoding SNORF25 receptor
|
|
WO2002102783A1
(en)
|
2001-06-19 |
2002-12-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
DE10225574A1
(de)
|
2002-06-10 |
2003-12-18 |
Merck Patent Gmbh |
Aryloxime
|
|
US7342115B2
(en)
|
2002-11-08 |
2008-03-11 |
Neurogen Corporation |
3-substituted-6-aryl pyridines
|
|
KR101078098B1
(ko)
|
2003-01-14 |
2011-10-28 |
아레나 파마슈티칼스, 인크. |
대사 조절제로서의 １,２,３-삼치환된 아릴 및 헤테로아릴유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된장애의 예방 및 치료
|
|
US7083933B1
(en)
|
2003-05-09 |
2006-08-01 |
Prosidion Limited |
Methods for identification of modulators of OSGPR116 activity
|
|
AR045047A1
(es)
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
CN1898235A
(zh)
|
2003-12-24 |
2007-01-17 |
普罗西迪恩有限公司 |
作为gpcr受体激动剂的杂环衍生物
|
|
HRP20090093T3
(en)
|
2004-06-04 |
2009-03-31 |
Arena Pharmaceuticals Inc. |
Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
WO2006067532A1
(en)
|
2004-12-24 |
2006-06-29 |
Prosidion Ltd |
G-protein coupled receptor agonists
|
|
NZ556017A
(en)
|
2004-12-24 |
2009-10-30 |
Prosidion Ltd |
G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes
|
|
GB0428514D0
(en)
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
MY148521A
(en)
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
US20080249091A1
(en)
|
2005-01-19 |
2008-10-09 |
Benjamin Pelcman |
Indoles Useful in the Treatment of Inflammation
|
|
EP1838669A1
(en)
|
2005-01-19 |
2007-10-03 |
Biolipox AB |
Indoles useful in the treatment of inflammation
|
|
JP2008527030A
(ja)
|
2005-01-19 |
2008-07-24 |
バイオリポックス エービー |
炎症の治療に有用なインドール類
|
|
US20090221644A1
(en)
|
2005-06-30 |
2009-09-03 |
Stuart Edward Bradley |
Gpcr Agonists
|
|
US20090203676A1
(en)
|
2005-06-30 |
2009-08-13 |
Oscar Barba |
G-protein Coupled Receptor Agonists
|
|
JP5114395B2
(ja)
|
2005-06-30 |
2013-01-09 |
プロシディオン・リミテッド |
Ｇｐｃｒアゴニスト
|
|
EP2308840A1
(en)
|
2005-06-30 |
2011-04-13 |
Prosidion Limited |
GPCR agonists
|
|
EP1931654B1
(en)
|
2005-09-16 |
2009-04-22 |
Arena Pharmaceuticals, Inc. |
Modulators of metabolism and the treatment of disorders related thereto
|
|
CN101563336A
(zh)
|
2006-03-16 |
2009-10-21 |
诺瓦提斯公司 |
用于治疗特别是黑素瘤的杂环有机化合物
|
|
KR20080109075A
(ko)
|
2006-04-06 |
2008-12-16 |
프로시디온 리미티드 |
헤테로사이클릭 ｇｐｃｒ 작용제
|
|
GB0607196D0
(en)
|
2006-04-11 |
2006-05-17 |
Prosidion Ltd |
G-protein coupled receptor agonists
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
BRPI0710597A2
(pt)
|
2006-04-11 |
2012-06-19 |
Arena Pharm Inc |
método de uso do receptor gpr119 para identificar compostos úteis para aumento da massa óssea em um indivìduo
|
|
GB0610746D0
(en)
|
2006-06-01 |
2006-07-12 |
Prosidion Ltd |
Method of treatment
|
|
TW200811140A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
TW200811147A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
CN101511429A
(zh)
|
2006-07-13 |
2009-08-19 |
史密丝克莱恩比彻姆公司 |
二氢吲哚衍生物和gpr119激动剂
|
|
WO2008009924A2
(en)
|
2006-07-18 |
2008-01-24 |
Biolipox Ab |
Indoles useful in the treatment of inflammation
|
|
CA2661371A1
(en)
|
2006-08-30 |
2008-03-06 |
Biovitrum Ab (Publ) |
Pyrimidine compounds for treating gpr119 related disorders
|
|
BRPI0719941A2
(pt)
|
2006-12-06 |
2014-04-22 |
Smithkline Beecham Corp |
Composto, uso de um composto, método para o tratamento de distúrbios ou condições metabólicos, composição farmacêutica, e, processo para a preparação de uma composição farmacêutica
|
|
US7638541B2
(en)
|
2006-12-28 |
2009-12-29 |
Metabolex Inc. |
5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
|
|
AR064735A1
(es)
|
2007-01-04 |
2009-04-22 |
Prosidion Ltd |
Agonistas de gpcr y composicion farmaceutica en base al compuesto
|
|
ES2373181T3
(es)
|
2007-01-04 |
2012-02-01 |
Prosidion Ltd |
Agonistas de gpcr de piperidina.
|
|
GB0700122D0
(en)
|
2007-01-04 |
2007-02-14 |
Prosidion Ltd |
GPCR agonists
|
|
EP2114936A1
(en)
|
2007-01-04 |
2009-11-11 |
Prosidion Limited |
Piperidine gpcr agonists
|
|
PE20081849A1
(es)
|
2007-01-04 |
2009-01-26 |
Prosidion Ltd |
Derivados de piperidin-4-il-propoxi-benzamida como agonistas de gpcr
|
|
US20080186971A1
(en)
|
2007-02-02 |
2008-08-07 |
Tarari, Inc. |
Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
|
|
CL2008000582A1
(es)
|
2007-02-28 |
2008-06-27 |
Eisai R&D Man Co Ltd |
Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis.
|
|
ATE482209T1
(de)
|
2007-03-08 |
2010-10-15 |
Irm Llc |
Verbindungen und zusammensetzungen als modulatoren der gpr119-aktivität
|
|
MX2009010302A
(es)
|
2007-03-29 |
2009-10-16 |
Asubio Pharma Co Ltd |
Derivados de indol que tienen actividad inhibidora de cpla2 y aplicaciones y metodos de produccion.
|
|
PE20090213A1
(es)
|
2007-05-04 |
2009-02-28 |
Bristol Myers Squibb Co |
Agonistas del receptor acoplado a la proteina g gpr119 [6,5]-biciclicos
|
|
WO2008137435A1
(en)
|
2007-05-04 |
2008-11-13 |
Bristol-Myers Squibb Company |
[6,6] and [6,7]-bicyclic gpr119 g protein-coupled receptor agonists
|
|
EA018709B1
(ru)
|
2007-07-17 |
2013-10-30 |
Бристол-Маерс Сквибб Компани |
Пиридоновые агонисты сопряженного с g-белком рецептора gpr119
|
|
CA2693169C
(en)
|
2007-07-19 |
2016-01-12 |
Metabolex, Inc. |
N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
|
|
EP2200609A1
(en)
|
2007-09-10 |
2010-06-30 |
Prosidion Limited |
Compounds for the treatment of metabolic disorders
|
|
AU2008302570B2
(en)
|
2007-09-20 |
2012-05-31 |
Irm Llc |
Compounds and compositions as modulators of GPR119 activity
|
|
BRPI0818338A2
(pt)
|
2007-10-16 |
2015-04-22 |
Daiichi Sankyo Co Ltd |
Composto de pirimidil indolina
|
|
GB0720389D0
(en)
|
2007-10-18 |
2008-11-12 |
Prosidion Ltd |
G-Protein Coupled Receptor Agonists
|
|
GB0720390D0
(en)
|
2007-10-18 |
2007-11-28 |
Prosidion Ltd |
G-Protein coupled receptor agonists
|
|
KR20100075643A
(ko)
|
2007-10-22 |
2010-07-02 |
쉐링 코포레이션 |
비사이클릭 헤테로사이클 유도체 및 ｇｐｒ119의 활성의 조절인자로서의 이의 용도
|
|
WO2009073772A1
(en)
|
2007-12-06 |
2009-06-11 |
Smithkline Beecham Corporation |
Novel seh inhibitors and their use
|
|
JP2011513233A
(ja)
|
2008-02-22 |
2011-04-28 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
Ｇｐｒ１１９活性モジュレーターとしての化合物および組成物
|
|
KR20100120689A
(ko)
|
2008-02-22 |
2010-11-16 |
아이알엠 엘엘씨 |
Ｇｐｒ119 활성의 조절제로서의 화합물 및 조성물
|
|
WO2009106565A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Agonists of gpr119
|
|
WO2009106561A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Pyrazine compounds for treating gpr119 related disorders
|
|
TW201002705A
(en)
|
2008-03-31 |
2010-01-16 |
Metabolex Inc |
Oxymethylene aryl compounds and uses thereof
|
|
CN102046609B
(zh)
|
2008-03-31 |
2014-05-14 |
全药工业株式会社 |
具有细胞保护效果的嘧啶衍生物及其应用
|
|
EA018703B1
(ru)
|
2008-04-07 |
2013-10-30 |
Айрм Ллк |
Соединения и композиции в качестве модуляторов активности gpr119
|
|
WO2009125434A2
(en)
|
2008-04-07 |
2009-10-15 |
Cadila Healthcare Limited |
Oxime derivatives
|
|
US8343990B2
(en)
|
2008-04-14 |
2013-01-01 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
|
US8188098B2
(en)
|
2008-05-19 |
2012-05-29 |
Hoffmann-La Roche Inc. |
GPR119 receptor agonists
|
|
WO2009150144A1
(en)
|
2008-06-10 |
2009-12-17 |
Inovacia Ab |
New gpr119modulators
|
|
CN102203074A
(zh)
|
2008-06-20 |
2011-09-28 |
麦它波莱克斯股份有限公司 |
芳基gpr119激动剂及其用途
|
|
GB0812642D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812641D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
KR20110036609A
(ko)
|
2008-07-10 |
2011-04-07 |
프로시디온 리미티드 |
피페리디닐 ｇｐｃｒ 작용제
|
|
ES2387865T3
(es)
|
2008-07-10 |
2012-10-03 |
Prosidion Ltd |
Agonistas de GPCR de piperidina
|
|
GB0812648D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812649D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
BRPI0915867A2
(pt)
|
2008-07-11 |
2017-06-20 |
Irm Llc |
4-fenoximetilpiperidinas como moduladores de atividade de gpr119
|
|
EP2318404B1
(en)
|
2008-07-16 |
2013-08-21 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocycle derivatives and use thereof as gpr119 modulators
|
|
TW201006821A
(en)
|
2008-07-16 |
2010-02-16 |
Bristol Myers Squibb Co |
Pyridone and pyridazone analogues as GPR119 modulators
|
|
US20110124652A1
(en)
|
2008-07-30 |
2011-05-26 |
Carpenter Andrew J |
Chemical Compounds and Uses
|
|
EP2311822A4
(en)
|
2008-08-01 |
2011-08-31 |
Nippon Chemiphar Co |
GPR119 AGONIST
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
WO2010059384A1
(en)
|
2008-10-30 |
2010-05-27 |
Janssen Pharmaceutica Nv |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists
|
|
US20100113480A1
(en)
|
2008-10-30 |
2010-05-06 |
Michael Reuman |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists
|
|
US8410122B2
(en)
|
2008-12-23 |
2013-04-02 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
WO2010075273A1
(en)
|
2008-12-23 |
2010-07-01 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
US8722882B2
(en)
|
2008-12-23 |
2014-05-13 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives as GPCR modulators for use in the treatment of obesity and diabetes
|
|
WO2010084512A1
(en)
|
2008-12-24 |
2010-07-29 |
Cadila Healthcare Limited |
Novel oxime derivatives
|
|
WO2010074271A1
(ja)
|
2008-12-26 |
2010-07-01 |
武田薬品工業株式会社 |
糖尿病治療剤
|
|
JPWO2010084944A1
(ja)
|
2009-01-22 |
2012-07-19 |
田辺三菱製薬株式会社 |
新規ピロロ［２，３−ｄ］ピリミジン化合物
|
|
WO2010088518A2
(en)
|
2009-01-31 |
2010-08-05 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
EP2399914A4
(en)
*
|
2009-02-18 |
2012-08-29 |
Takeda Pharmaceutical |
FUSED HETEROCYCLIC CORE COMPOUND
|
|
GB0904287D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904285D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904284D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
EP2408780A2
(en)
|
2009-03-20 |
2012-01-25 |
Pfizer Inc. |
3-oxa-7-azabicycloý3.3.1¨nonanes
|
|
US8580807B2
(en)
|
2009-04-03 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Bicyclic piperidine and piperazine derivatives as GPCR modulators for the treatment of obesity, diabetes and other metabolic disorders
|
|
AR076024A1
(es)
|
2009-04-03 |
2011-05-11 |
Schering Corp |
Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos
|
|
WO2010119881A1
(ja)
*
|
2009-04-15 |
2010-10-21 |
第一三共株式会社 |
インドリン化合物
|
|
JP2010265258A
(ja)
*
|
2009-04-15 |
2010-11-25 |
Daiichi Sankyo Co Ltd |
ピリミジルインドリン化合物を含有する医薬組成物
|
|
JP2012136439A
(ja)
|
2009-04-24 |
2012-07-19 |
Nippon Chemiphar Co Ltd |
ジアザスピロアルカン誘導体
|
|
US20100285145A1
(en)
*
|
2009-05-08 |
2010-11-11 |
Pfizer Inc |
Gpr 119 modulators
|
|
CA2759843A1
(en)
|
2009-05-08 |
2010-11-10 |
Pfizer Inc. |
Gpr 119 modulators
|
|
US20120052130A1
(en)
*
|
2009-05-08 |
2012-03-01 |
Pfizer Inc. |
Gpr 119 modulators
|
|
US20100298362A1
(en)
|
2009-05-20 |
2010-11-25 |
Xun Li |
Process for the preparation of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
US20110015215A1
(en)
|
2009-05-20 |
2011-01-20 |
Paul Deghetto |
Crystalline forms of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
AP2799A
(en)
|
2009-06-05 |
2013-11-30 |
Pfizer |
1-(Piperidin-4-YL)-pyrazole derivatives as GPR 119modulators
|
|
NZ596445A
(en)
|
2009-06-24 |
2013-04-26 |
Boehringer Ingelheim Int |
New compounds, pharmaceutical composition and methods relating thereto
|
|
TW201113269A
(en)
|
2009-06-24 |
2011-04-16 |
Boehringer Ingelheim Int |
New compounds, pharmaceutical composition and methods relating thereto
|
|
JP5794297B2
(ja)
|
2010-05-07 |
2015-10-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｇｐｒ１１９アゴニストとしてのピリダジノン
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
UY33805A
(es)
|
2010-12-17 |
2012-07-31 |
Boehringer Ingelheim Int |
?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?.
|
|
EP2665719B1
(en)
|
2011-01-21 |
2016-05-04 |
Boehringer Ingelheim International GmbH |
Fused dihydrofurans as gpr119 modulators for the treatment of diabetes, obesity and related disorders
|
|
US8822471B2
(en)
|
2011-03-14 |
2014-09-02 |
Boehringer Ingelheim International Gmbh |
Compounds, pharmaceutical compositions and uses thereof
|