|
US6329418B1
(en)
|
1998-04-14 |
2001-12-11 |
The Procter & Gamble Company |
Substituted pyrrolidine hydroxamate metalloprotease inhibitors
|
|
US20030017528A1
(en)
|
1998-11-20 |
2003-01-23 |
Ruoping Chen |
Human orphan G protein-coupled receptors
|
|
US6221660B1
(en)
|
1999-02-22 |
2001-04-24 |
Synaptic Pharmaceutical Corporation |
DNA encoding SNORF25 receptor
|
|
WO2002102783A1
(en)
|
2001-06-19 |
2002-12-27 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
DE10225574A1
(de)
|
2002-06-10 |
2003-12-18 |
Merck Patent Gmbh |
Aryloxime
|
|
ATE552253T1
(de)
|
2002-11-08 |
2012-04-15 |
Novartis Int Pharm Ltd |
3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren
|
|
CN102558155A
(zh)
|
2003-01-14 |
2012-07-11 |
阿伦纳药品公司 |
作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
|
|
US7083933B1
(en)
|
2003-05-09 |
2006-08-01 |
Prosidion Limited |
Methods for identification of modulators of OSGPR116 activity
|
|
AR045047A1
(es)
*
|
2003-07-11 |
2005-10-12 |
Arena Pharm Inc |
Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
|
|
BRPI0418149A
(pt)
|
2003-12-24 |
2007-04-17 |
Prosidion Ltd |
derivados heterocìclicos como agonistas do receptor de gprc
|
|
HRP20090093T3
(en)
|
2004-06-04 |
2009-03-31 |
Arena Pharmaceuticals Inc. |
Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
EP1838706A1
(en)
|
2004-12-24 |
2007-10-03 |
Prosidion Limited |
G-protein coupled receptor agonists
|
|
WO2006067531A1
(en)
|
2004-12-24 |
2006-06-29 |
Prosidion Ltd |
G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes
|
|
GB0428514D0
(en)
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
MY148521A
(en)
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
JP2008527030A
(ja)
|
2005-01-19 |
2008-07-24 |
バイオリポックス エービー |
炎症の治療に有用なインドール類
|
|
US20080249091A1
(en)
|
2005-01-19 |
2008-10-09 |
Benjamin Pelcman |
Indoles Useful in the Treatment of Inflammation
|
|
US20090042949A1
(en)
|
2005-01-19 |
2009-02-12 |
Benjamin Pelcman |
Indoles Useful in the Treatment of Inflammation
|
|
NZ564759A
(en)
|
2005-06-30 |
2011-08-26 |
Prosidion Ltd |
GPCR agonists
|
|
JP2008545008A
(ja)
|
2005-06-30 |
2008-12-11 |
プロシディオン・リミテッド |
Gpcrアゴニスト
|
|
WO2007003960A1
(en)
|
2005-06-30 |
2007-01-11 |
Prosidion Limited |
Gpcr agonists
|
|
US20090203676A1
(en)
|
2005-06-30 |
2009-08-13 |
Oscar Barba |
G-protein Coupled Receptor Agonists
|
|
GEP20104966B
(en)
|
2005-09-16 |
2010-04-26 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
BRPI0710181A2
(pt)
|
2006-03-16 |
2011-08-09 |
Novartis Ag |
compostos orgánicos
|
|
NZ571869A
(en)
|
2006-04-06 |
2011-11-25 |
Prosidion Ltd |
Heterocyclic GPCR agonists
|
|
ES2354390T3
(es)
|
2006-04-11 |
2011-03-14 |
Arena Pharmaceuticals, Inc. |
Procedimientos de uso del receptor gpr119 para identificar compuestos útiles para aumentar la masa ósea en un individuo.
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
GB0607196D0
(en)
|
2006-04-11 |
2006-05-17 |
Prosidion Ltd |
G-protein coupled receptor agonists
|
|
GB0610746D0
(en)
|
2006-06-01 |
2006-07-12 |
Prosidion Ltd |
Method of treatment
|
|
TW200811147A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
TW200811140A
(en)
|
2006-07-06 |
2008-03-01 |
Arena Pharm Inc |
Modulators of metabolism and the treatment of disorders related thereto
|
|
JP2009543805A
(ja)
*
|
2006-07-13 |
2009-12-10 |
スミスクライン ビーチャム コーポレーション |
インドリン誘導体及びgpr119作動物質
|
|
WO2008009924A2
(en)
|
2006-07-18 |
2008-01-24 |
Biolipox Ab |
Indoles useful in the treatment of inflammation
|
|
CA2661371A1
(en)
|
2006-08-30 |
2008-03-06 |
Biovitrum Ab (Publ) |
Pyrimidine compounds for treating gpr119 related disorders
|
|
CN101657471B
(zh)
|
2006-12-06 |
2013-07-03 |
史密丝克莱恩比彻姆公司 |
二环化合物及其作为抗糖尿病药的用途
|
|
US7638541B2
(en)
|
2006-12-28 |
2009-12-29 |
Metabolex Inc. |
5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
|
|
AR064736A1
(es)
|
2007-01-04 |
2009-04-22 |
Prosidion Ltd |
Agonistas de gpcr
|
|
CL2008000018A1
(es)
|
2007-01-04 |
2008-08-01 |
Prosidion Ltd |
Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
|
|
WO2008081208A1
(en)
|
2007-01-04 |
2008-07-10 |
Prosidion Limited |
Piperidine gpcr agonists
|
|
GB0700122D0
(en)
|
2007-01-04 |
2007-02-14 |
Prosidion Ltd |
GPCR agonists
|
|
BRPI0806498A2
(pt)
|
2007-01-04 |
2014-04-22 |
Prosidion Ltd |
Agonistas gpcr piperidina
|
|
US20080186971A1
(en)
|
2007-02-02 |
2008-08-07 |
Tarari, Inc. |
Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
|
|
US20080207900A1
(en)
|
2007-02-28 |
2008-08-28 |
Teiji Kimura |
Two cyclic oxomorphorin derivatives
|
|
WO2008109702A1
(en)
|
2007-03-08 |
2008-09-12 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
KR20090125799A
(ko)
|
2007-03-29 |
2009-12-07 |
아스비오파마 가부시키가이샤 |
Cpla2 저해 활성을 가지는 인돌 유도체 및 그 용도 및 제조 방법
|
|
CN101668759A
(zh)
|
2007-05-04 |
2010-03-10 |
百时美施贵宝公司 |
[6,5]-双环gpr119g蛋白-偶合受体激动剂
|
|
ES2388967T3
(es)
|
2007-05-04 |
2012-10-22 |
Bristol-Myers Squibb Company |
Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G
|
|
TW200904440A
(en)
|
2007-07-17 |
2009-02-01 |
Bristol Myers Squibb Co |
Method for modulating GPR119 G protein-coupled receptor and selected compounds
|
|
JP5489997B2
(ja)
|
2007-07-19 |
2014-05-14 |
シマベイ セラピューティクス, インコーポレーテッド |
糖尿病および代謝疾患の治療のためのRUP3またはGPRl19受容体のアゴニストとしてのN−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体
|
|
WO2009034388A1
(en)
|
2007-09-10 |
2009-03-19 |
Prosidion Limited |
Compounds for the treatment of metabolic disorders
|
|
CA2697551C
(en)
|
2007-09-20 |
2013-03-12 |
Irm Llc |
Piperidine derivatives as modulators of gpr119 activity
|
|
US8232287B2
(en)
*
|
2007-10-16 |
2012-07-31 |
Daiichi Sankyo Company, Limited |
Pyrimidyl indoline compound
|
|
GB0720390D0
(en)
|
2007-10-18 |
2007-11-28 |
Prosidion Ltd |
G-Protein coupled receptor agonists
|
|
GB0720389D0
(en)
|
2007-10-18 |
2008-11-12 |
Prosidion Ltd |
G-Protein Coupled Receptor Agonists
|
|
JP2011500727A
(ja)
|
2007-10-22 |
2011-01-06 |
シェーリング コーポレイション |
Gpr119の活性のモジュレーターとしての二環式ヘテロ環誘導体およびその使用
|
|
JP2011506333A
(ja)
|
2007-12-06 |
2011-03-03 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
新規sEH阻害剤およびその使用
|
|
US20110166176A1
(en)
|
2008-02-22 |
2011-07-07 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
EA201001329A1
(ru)
|
2008-02-22 |
2011-04-29 |
Айрм Ллк |
Соединения и композиции в качестве модуляторов активности gpr119
|
|
WO2009106561A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Pyrazine compounds for treating gpr119 related disorders
|
|
WO2009106565A1
(en)
|
2008-02-27 |
2009-09-03 |
Biovitrum Ab (Publ) |
Agonists of gpr119
|
|
EP2284160B1
(en)
|
2008-03-31 |
2013-05-15 |
Zenyaku Kogyo Kabushikikaisha |
Pyrimidine derivative having cell-protecting activity and use thereof
|
|
TW201002705A
(en)
|
2008-03-31 |
2010-01-16 |
Metabolex Inc |
Oxymethylene aryl compounds and uses thereof
|
|
JP2011516557A
(ja)
|
2008-04-07 |
2011-05-26 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
Gpr119活性のモジュレーターとしての化合物および組成物
|
|
WO2009125434A2
(en)
|
2008-04-07 |
2009-10-15 |
Cadila Healthcare Limited |
Oxime derivatives
|
|
WO2009129036A1
(en)
|
2008-04-14 |
2009-10-22 |
Merck & Co., Inc. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
|
US8188098B2
(en)
|
2008-05-19 |
2012-05-29 |
Hoffmann-La Roche Inc. |
GPR119 receptor agonists
|
|
WO2009150144A1
(en)
|
2008-06-10 |
2009-12-17 |
Inovacia Ab |
New gpr119modulators
|
|
CN102203074A
(zh)
|
2008-06-20 |
2011-09-28 |
麦它波莱克斯股份有限公司 |
芳基gpr119激动剂及其用途
|
|
ES2387865T3
(es)
|
2008-07-10 |
2012-10-03 |
Prosidion Ltd |
Agonistas de GPCR de piperidina
|
|
GB0812648D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812641D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
GB0812649D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
EA201170151A1
(ru)
|
2008-07-10 |
2011-08-30 |
Просидион Лимитед |
Пиперидиниловые агонисты gpcr
|
|
GB0812642D0
(en)
|
2008-07-10 |
2008-08-20 |
Prosidion Ltd |
Compounds
|
|
AU2009268527B2
(en)
|
2008-07-11 |
2012-11-01 |
Irm Llc |
4-phenoxymethylpiperidines as modulators of GPR119 activity
|
|
TW201006821A
(en)
|
2008-07-16 |
2010-02-16 |
Bristol Myers Squibb Co |
Pyridone and pyridazone analogues as GPR119 modulators
|
|
MX2011000664A
(es)
|
2008-07-16 |
2011-02-24 |
Schering Corp |
Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119.
|
|
EP2320910A4
(en)
|
2008-07-30 |
2012-12-19 |
Glaxosmithkline Llc |
CHEMICAL COMPOUNDS AND ITS USE
|
|
WO2010013849A1
(ja)
|
2008-08-01 |
2010-02-04 |
日本ケミファ株式会社 |
Gpr119作動薬
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
WO2010059385A1
(en)
|
2008-10-30 |
2010-05-27 |
Janssen Pharmaceutica Nv |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidne derivatives useful as gdir agonists
|
|
US20100113479A1
(en)
|
2008-10-30 |
2010-05-06 |
Anusuya Choudhury |
Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists
|
|
WO2010075273A1
(en)
|
2008-12-23 |
2010-07-01 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
WO2010075271A1
(en)
|
2008-12-23 |
2010-07-01 |
Schering Corporation |
Bicyclic heterocycle derivatives and methods of use thereof
|
|
AU2009330206A1
(en)
|
2008-12-23 |
2011-07-07 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives as GPCR modttlators for use in the treatment of obesity and diabetes
|
|
WO2010084512A1
(en)
|
2008-12-24 |
2010-07-29 |
Cadila Healthcare Limited |
Novel oxime derivatives
|
|
WO2010074271A1
(ja)
|
2008-12-26 |
2010-07-01 |
武田薬品工業株式会社 |
糖尿病治療剤
|
|
WO2010084944A1
(ja)
|
2009-01-22 |
2010-07-29 |
田辺三菱製薬株式会社 |
新規ピロロ[2,3-d]ピリミジン化合物
|
|
WO2010088518A2
(en)
|
2009-01-31 |
2010-08-05 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
EP2399914A4
(en)
|
2009-02-18 |
2012-08-29 |
Takeda Pharmaceutical |
FUSED HETEROCYCLIC CORE COMPOUND
|
|
GB0904287D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904285D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
GB0904284D0
(en)
|
2009-03-12 |
2009-04-22 |
Prosidion Ltd |
Compounds for the treatment of metabolic disorders
|
|
WO2010106457A2
(en)
|
2009-03-20 |
2010-09-23 |
Pfizer Inc. |
3-oxa-7-azabicyclo[3.3.1]nonanes
|
|
AR076024A1
(es)
|
2009-04-03 |
2011-05-11 |
Schering Corp |
Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos
|
|
WO2010114957A1
(en)
|
2009-04-03 |
2010-10-07 |
Schering Corporation |
Bicyclic piperidine and piperazine derivatives as gpcr modulators for the treatment of obesity, diabetes and other metabolic disorders
|
|
TW201039827A
(en)
*
|
2009-04-15 |
2010-11-16 |
Daiichi Sankyo Co Ltd |
Indoline compound
|
|
JP2010265258A
(ja)
*
|
2009-04-15 |
2010-11-25 |
Daiichi Sankyo Co Ltd |
ピリミジルインドリン化合物を含有する医薬組成物
|
|
JP2012136439A
(ja)
|
2009-04-24 |
2012-07-19 |
Nippon Chemiphar Co Ltd |
ジアザスピロアルカン誘導体
|
|
US20100285145A1
(en)
*
|
2009-05-08 |
2010-11-11 |
Pfizer Inc |
Gpr 119 modulators
|
|
JP2012526097A
(ja)
*
|
2009-05-08 |
2012-10-25 |
ファイザー・インク |
Gpr119調節因子
|
|
JP2012526096A
(ja)
*
|
2009-05-08 |
2012-10-25 |
ファイザー・インク |
Gpr119調節因子
|
|
WO2010135506A1
(en)
|
2009-05-20 |
2010-11-25 |
Janssen Pharmaceutica Nv |
Process for the preparation of 4- [6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino) -5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
US20110015215A1
(en)
|
2009-05-20 |
2011-01-20 |
Paul Deghetto |
Crystalline forms of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester
|
|
KR20120061063A
(ko)
|
2009-06-05 |
2012-06-12 |
화이자 인코포레이티드 |
Gpr 119 조절제로서의 l-(피페리딘-4-일)-피라졸 유도체
|
|
NZ596445A
(en)
|
2009-06-24 |
2013-04-26 |
Boehringer Ingelheim Int |
New compounds, pharmaceutical composition and methods relating thereto
|
|
JP2012530758A
(ja)
|
2009-06-24 |
2012-12-06 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規化合物、医薬組成物及びそれに関する方法
|
|
JP5794297B2
(ja)
|
2010-05-07 |
2015-10-14 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Gpr119アゴニストとしてのピリダジノン
|
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
|
UY33805A
(es)
|
2010-12-17 |
2012-07-31 |
Boehringer Ingelheim Int |
?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?.
|
|
UY33871A
(es)
|
2011-01-21 |
2012-07-31 |
Boehringer Ingelheim Int |
Compuestos y formulaciones farmacéuticas basadas en derivados de benzo y heteroarilos condensados 2,3-dihidrofurán-2-il-piperidina y sus usos
|
|
US8822471B2
(en)
|
2011-03-14 |
2014-09-02 |
Boehringer Ingelheim International Gmbh |
Compounds, pharmaceutical compositions and uses thereof
|