BRPI0516407A - agonistas de receptor acoplado à proteìna g (gpr116) e uso destes para o tratamento de obesidade e diabetes - Google Patents
agonistas de receptor acoplado à proteìna g (gpr116) e uso destes para o tratamento de obesidade e diabetesInfo
- Publication number
- BRPI0516407A BRPI0516407A BRPI0516407-9A BRPI0516407A BRPI0516407A BR PI0516407 A BRPI0516407 A BR PI0516407A BR PI0516407 A BRPI0516407 A BR PI0516407A BR PI0516407 A BRPI0516407 A BR PI0516407A
- Authority
- BR
- Brazil
- Prior art keywords
- gpr116
- obesity
- diabetes
- treatment
- receptor agonists
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
AGONISTAS DE RECEPTOR ACOPLADO à PROTEìNA G (GPR116) E USO DESTES PARA O TRATAMENTO DE OBESIDADE E DIABETES. Compostos da fórmula (1), ou sais farmaceuticamente aceitáveis destes, são agonistas de GPR116 e são úteis para o tratamento de obesidade, e para o tratamento de diabetes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0428212A GB0428212D0 (en) | 2004-12-24 | 2004-12-24 | Compounds |
GB0513255A GB0513255D0 (en) | 2005-06-30 | 2005-06-30 | Compounds |
PCT/GB2005/050264 WO2006067531A1 (en) | 2004-12-24 | 2005-12-23 | G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0516407A true BRPI0516407A (pt) | 2008-09-02 |
Family
ID=36601424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0516407-9A BRPI0516407A (pt) | 2004-12-24 | 2005-12-23 | agonistas de receptor acoplado à proteìna g (gpr116) e uso destes para o tratamento de obesidade e diabetes |
Country Status (10)
Country | Link |
---|---|
US (1) | US20080312281A1 (pt) |
EP (1) | EP1838311A1 (pt) |
JP (1) | JP4980928B2 (pt) |
KR (1) | KR20070091038A (pt) |
AU (1) | AU2005317769A1 (pt) |
BR (1) | BRPI0516407A (pt) |
CA (1) | CA2591922A1 (pt) |
MX (1) | MX2007007553A (pt) |
NZ (1) | NZ556017A (pt) |
WO (1) | WO2006067531A1 (pt) |
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JP4521838B2 (ja) | 2006-04-11 | 2010-08-11 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 個体において骨質量を増加させるために有用である化合物を同定するためにgpr119受容体を用いる方法 |
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US20040167188A1 (en) * | 2003-02-14 | 2004-08-26 | Zhili Xin | Protein-tyrosine phosphatase inhibitors and uses thereof |
ES2316964T3 (es) * | 2003-02-24 | 2009-04-16 | Arena Pharmaceuticals, Inc. | Fenil-y piridilpipereidinia-derivados como moduladores del metabolismo de la glucosa. |
EP1622616B1 (en) * | 2003-04-24 | 2011-06-15 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
AR045496A1 (es) * | 2003-08-29 | 2005-11-02 | Schering Corp | Analolgos de benzimidazolpiperidinas 2- substiyuidas como antagonistas de los receptores de la hormona que concentra melanina selectivos para el tratamiento de la obesidad y trastornos relacionados |
CN1898235A (zh) * | 2003-12-24 | 2007-01-17 | 普罗西迪恩有限公司 | 作为gpcr受体激动剂的杂环衍生物 |
PL1756084T3 (pl) * | 2004-06-04 | 2009-06-30 | Arena Pharm Inc | Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie zaburzeń z metabolizmem związanych |
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KR20080027908A (ko) * | 2005-06-30 | 2008-03-28 | 프로시디온 리미티드 | Gpcr 효능제 |
CL2008000017A1 (es) * | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
CL2008000018A1 (es) * | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
-
2005
- 2005-12-23 MX MX2007007553A patent/MX2007007553A/es unknown
- 2005-12-23 BR BRPI0516407-9A patent/BRPI0516407A/pt not_active IP Right Cessation
- 2005-12-23 JP JP2007547681A patent/JP4980928B2/ja not_active Expired - Fee Related
- 2005-12-23 WO PCT/GB2005/050264 patent/WO2006067531A1/en active Application Filing
- 2005-12-23 EP EP05821803A patent/EP1838311A1/en not_active Withdrawn
- 2005-12-23 US US11/794,219 patent/US20080312281A1/en not_active Abandoned
- 2005-12-23 NZ NZ556017A patent/NZ556017A/en not_active IP Right Cessation
- 2005-12-23 AU AU2005317769A patent/AU2005317769A1/en not_active Abandoned
- 2005-12-23 KR KR1020077017095A patent/KR20070091038A/ko not_active Application Discontinuation
- 2005-12-23 CA CA002591922A patent/CA2591922A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1838311A1 (en) | 2007-10-03 |
JP4980928B2 (ja) | 2012-07-18 |
NZ556017A (en) | 2009-10-30 |
AU2005317769A1 (en) | 2006-06-29 |
WO2006067531A1 (en) | 2006-06-29 |
JP2008525416A (ja) | 2008-07-17 |
KR20070091038A (ko) | 2007-09-06 |
CA2591922A1 (en) | 2006-06-29 |
US20080312281A1 (en) | 2008-12-18 |
MX2007007553A (es) | 2007-08-15 |
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