CY1120045T1 - Διαμορφωτες μεταφορεων κασετας δεσμευσης με ατρ - Google Patents
Διαμορφωτες μεταφορεων κασετας δεσμευσης με ατρInfo
- Publication number
- CY1120045T1 CY1120045T1 CY20181100319T CY181100319T CY1120045T1 CY 1120045 T1 CY1120045 T1 CY 1120045T1 CY 20181100319 T CY20181100319 T CY 20181100319T CY 181100319 T CY181100319 T CY 181100319T CY 1120045 T1 CY1120045 T1 CY 1120045T1
- Authority
- CY
- Cyprus
- Prior art keywords
- attract
- present
- carriage transfer
- compounds
- transformers
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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Abstract
Ενώσεις της παρούσας εφεύρεσης και φαρμακευτικώς αποδεκτές συνθέσεις αυτών είναι χρήσιμες ως διαμορφωτές μεταφορέων κασέτας δέσμευσης ATP («ABC») ή θραυσμάτων αυτών, συμπεριλαμβανομένου του Ρυθμιστή Διαμεμβρανικής Αγωγιμότητας Κυστικής Ινωσης («CFTR»). Η παρούσα εφεύρεση σχετίζεται επίσης με μεθόδους αγωγής νόσων διαμεσολαβούμενων από μεταφορείς ABC δια της χρήσης ενώσεων της παρούσας εφεύρεσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79045906P | 2006-04-07 | 2006-04-07 | |
EP13167785.8A EP2674428B1 (en) | 2006-04-07 | 2007-04-09 | Modulators of ATP-binding cassette transporters |
EP07755298.2A EP2007756B1 (en) | 2006-04-07 | 2007-04-09 | Modulators of atp-binding cassette transporters |
Publications (1)
Publication Number | Publication Date |
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CY1120045T1 true CY1120045T1 (el) | 2018-12-12 |
Family
ID=38477342
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151101060T CY1116979T1 (el) | 2006-04-07 | 2015-11-25 | Διαμορφωτες μεταφορεων κασετας δεσμευσης ατρ |
CY20161100628T CY1117731T1 (el) | 2006-04-07 | 2016-07-05 | Διαμορφωτες μεταφορεων κασετας δεσμευσης ατρ |
CY20181100319T CY1120045T1 (el) | 2006-04-07 | 2018-03-19 | Διαμορφωτες μεταφορεων κασετας δεσμευσης με ατρ |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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CY20151101060T CY1116979T1 (el) | 2006-04-07 | 2015-11-25 | Διαμορφωτες μεταφορεων κασετας δεσμευσης ατρ |
CY20161100628T CY1117731T1 (el) | 2006-04-07 | 2016-07-05 | Διαμορφωτες μεταφορεων κασετας δεσμευσης ατρ |
Country Status (22)
Country | Link |
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US (9) | US7776905B2 (el) |
EP (5) | EP2674428B1 (el) |
JP (3) | JP5420395B2 (el) |
CN (2) | CN103254177A (el) |
AU (1) | AU2007235260B2 (el) |
BR (1) | BRPI0710965B8 (el) |
CA (2) | CA2869945C (el) |
CY (3) | CY1116979T1 (el) |
DK (3) | DK2674428T3 (el) |
ES (4) | ES2580803T3 (el) |
HU (4) | HUE055205T2 (el) |
IL (1) | IL194576A (el) |
IN (1) | IN2014KN02423A (el) |
LT (1) | LT3091011T (el) |
MX (1) | MX2008012945A (el) |
NZ (3) | NZ571803A (el) |
PL (4) | PL3091011T3 (el) |
PT (3) | PT2674428T (el) |
RU (1) | RU2451018C2 (el) |
SI (4) | SI3327016T1 (el) |
WO (1) | WO2007117715A2 (el) |
ZA (1) | ZA200809290B (el) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
ZA200602755B (en) | 2003-09-06 | 2007-06-27 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
EP2140865A1 (en) * | 2003-11-14 | 2010-01-06 | Vertex Pharmaceuticals Incorporated | Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters |
CA2554796A1 (en) * | 2004-01-30 | 2005-08-18 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
EP2530075A3 (en) | 2004-06-24 | 2014-12-24 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
CA2618057A1 (en) | 2005-08-11 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
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CA2981495C (en) | 2015-03-31 | 2023-09-26 | Vertex Pharmaceuticals (Europe) Limited | Deuterated vx-661 |
US20180280349A1 (en) | 2017-03-28 | 2018-10-04 | Vertex Pharmaceuticals Incorporated | Methods of treating cystic fibrosis in patients with residual function mutations |
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