PL2276485T3 - Stosowanie epotilonu D w leczeniu chorób związanych z Tau, w tym choroby Alzheimera - Google Patents
Stosowanie epotilonu D w leczeniu chorób związanych z Tau, w tym choroby AlzheimeraInfo
- Publication number
- PL2276485T3 PL2276485T3 PL09735906T PL09735906T PL2276485T3 PL 2276485 T3 PL2276485 T3 PL 2276485T3 PL 09735906 T PL09735906 T PL 09735906T PL 09735906 T PL09735906 T PL 09735906T PL 2276485 T3 PL2276485 T3 PL 2276485T3
- Authority
- PL
- Poland
- Prior art keywords
- epothilone
- disease
- diseases including
- associated diseases
- including alzheimer
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- XOZIUKBZLSUILX-UKMAFROXSA-N epothilone d Chemical compound O1C(=O)C[C@@H](O)C(C)(C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CCC\C(C)=C/C[C@@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-UKMAFROXSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4772908P | 2008-04-24 | 2008-04-24 | |
| PCT/US2009/041634 WO2009132253A1 (en) | 2008-04-24 | 2009-04-24 | Use of epothelone d in treating tau-associated diseases including alzheimer's disease |
| EP09735906.1A EP2276485B1 (en) | 2008-04-24 | 2009-04-24 | Use of epothilone d in treating tau-associated diseases including alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2276485T3 true PL2276485T3 (pl) | 2014-12-31 |
Family
ID=40887113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09735906T PL2276485T3 (pl) | 2008-04-24 | 2009-04-24 | Stosowanie epotilonu D w leczeniu chorób związanych z Tau, w tym choroby Alzheimera |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US20090270465A1 (pl) |
| EP (1) | EP2276485B1 (pl) |
| JP (1) | JP5548675B2 (pl) |
| KR (1) | KR20100137576A (pl) |
| CN (3) | CN104666297A (pl) |
| AR (1) | AR071598A1 (pl) |
| AU (1) | AU2009240538B2 (pl) |
| BR (1) | BRPI0911482A2 (pl) |
| CA (1) | CA2722371C (pl) |
| CL (1) | CL2009000990A1 (pl) |
| CY (1) | CY1115617T1 (pl) |
| DK (1) | DK2276485T3 (pl) |
| EA (1) | EA021758B1 (pl) |
| ES (1) | ES2501565T3 (pl) |
| HR (1) | HRP20140783T1 (pl) |
| HU (1) | HUE024506T2 (pl) |
| IL (1) | IL208926A0 (pl) |
| MX (1) | MX2010011209A (pl) |
| NZ (1) | NZ588555A (pl) |
| PL (1) | PL2276485T3 (pl) |
| PT (1) | PT2276485E (pl) |
| SI (1) | SI2276485T1 (pl) |
| TW (1) | TWI472329B (pl) |
| WO (1) | WO2009132253A1 (pl) |
| ZA (1) | ZA201007460B (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| HUE036165T2 (hu) | 2006-04-07 | 2018-06-28 | Vertex Pharma | ATP-kötõ kazetta transzportereinek modulátorai |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US20100184803A1 (en) * | 2007-03-09 | 2010-07-22 | Link Medicine Corporation | Treatment of Lysosomal Storage Diseases |
| WO2009151683A2 (en) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
| PL2276485T3 (pl) | 2008-04-24 | 2014-12-31 | Bristol Myers Squibb Co | Stosowanie epotilonu D w leczeniu chorób związanych z Tau, w tym choroby Alzheimera |
| WO2010057006A1 (en) | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
| BRPI0921113A2 (pt) * | 2008-11-13 | 2016-02-16 | Link Medicine Corp | tratamento de proteinopatias usando um inibidor de farnesil transferase. |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| JP2013525371A (ja) | 2010-04-22 | 2013-06-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | シクロアルキルカルボキサミド−インドール化合物の製造方法 |
| US8563593B2 (en) * | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| US20130202659A1 (en) * | 2012-01-31 | 2013-08-08 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
| AU2013286680B2 (en) | 2012-07-03 | 2018-07-05 | Washington University | Antibodies to tau |
| CA2878057A1 (en) | 2012-07-16 | 2014-01-23 | Rossitza Gueorguieva Alargova | Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| ES2675858T3 (es) | 2014-04-15 | 2018-07-13 | Vertex Pharmaceuticals Incorporated | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| JP6321521B2 (ja) * | 2014-11-04 | 2018-05-09 | Well Stone 有限会社 | タウ蛋白産生促進剤、タウ蛋白の欠乏に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物 |
| EP3484918A1 (en) | 2016-07-14 | 2019-05-22 | BioArctic Neuroscience AB | Brain delivery protein |
| PL4062913T3 (pl) * | 2020-09-02 | 2024-07-22 | Beijing Biostar Pharmaceuticals Co., Ltd. | Stały preparat doustny utidelonu |
| CN113005086B (zh) * | 2021-02-01 | 2022-10-28 | 中国科学院遗传与发育生物学研究所 | 埃博霉素D和Apol8在调控神经干细胞定向神经元分化中的应用 |
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| DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
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| AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
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| US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| UA69413C2 (uk) | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
| DE59911151D1 (de) | 1998-07-27 | 2004-12-30 | Joergen Brosow | Sicherheitspapier sowie verfahren und vorrichtung zur prüfung der echtheit darauf aufgezeichneter urkunden |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| KR100851418B1 (ko) | 1998-11-20 | 2008-08-08 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
| TR200102401T2 (tr) * | 1999-02-22 | 2001-12-21 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) | C-21 Değiştirilmiş epotilonlar. |
| US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
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| AU2002221693A1 (en) | 2000-10-16 | 2002-04-29 | Morphochem Ag | Epothilone synthesis components iii and iv: asymmetrically substituted acyloins and acyloin derivatives, method for the production thereof and method for the production of epithilone b, d and epothilone derivatives |
| TW476749B (en) * | 2000-11-17 | 2002-02-21 | Nat Science Council | Process for preparing 2,6-dimethylphenol |
| FR2817117B1 (fr) | 2000-11-24 | 2005-11-04 | Commissariat Energie Atomique | Mammiferes non-humains transgeniques ou recombinants et leurs applications dans le criblage de medicaments utiles dans les desordres psychoactifs |
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| JP2004527478A (ja) * | 2001-02-02 | 2004-09-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 微小管安定化剤としてのクマリン化合物およびその治療的使用 |
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| WO2003078411A1 (en) * | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
| AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
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| AU2003260723A1 (en) | 2002-08-17 | 2004-03-03 | The Queens Universlty Of Belfast | Use of vinca alkaloyds, taxane, cryptophycine, ephitoline or eleutherobine for treating alzheimer |
| RS20050235A (sr) | 2002-09-23 | 2007-06-04 | Bristol Myers Squibb Company, | Postupci za pripremanje,izolaciju i prečišćavanje epotilona b i kristalne strukture epotilona b dobijene primenom x-zraka |
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| US6954131B2 (en) * | 2003-04-02 | 2005-10-11 | Illinois Tool Works Inc. | Electrical reactor assembly having center taps |
| JP2007524655A (ja) * | 2003-10-09 | 2007-08-30 | コーザン バイオサイエンシス インコーポレイテッド | 治療製剤 |
| EP1559447A1 (en) | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism |
| WO2006009178A1 (ja) | 2004-07-20 | 2006-01-26 | Toshinori Kato | 生体機能診断装置、生体機能診断方法、生体用プローブ、生体用プローブ装着具、生体用プローブ支持具及び生体用プローブ装着支援具 |
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| PL2276485T3 (pl) | 2008-04-24 | 2014-12-31 | Bristol Myers Squibb Co | Stosowanie epotilonu D w leczeniu chorób związanych z Tau, w tym choroby Alzheimera |
-
2009
- 2009-04-24 PL PL09735906T patent/PL2276485T3/pl unknown
- 2009-04-24 US US12/429,492 patent/US20090270465A1/en not_active Abandoned
- 2009-04-24 MX MX2010011209A patent/MX2010011209A/es active IP Right Grant
- 2009-04-24 CL CL2009000990A patent/CL2009000990A1/es unknown
- 2009-04-24 AR ARP090101472A patent/AR071598A1/es unknown
- 2009-04-24 EP EP09735906.1A patent/EP2276485B1/en active Active
- 2009-04-24 BR BRPI0911482A patent/BRPI0911482A2/pt not_active IP Right Cessation
- 2009-04-24 PT PT97359061T patent/PT2276485E/pt unknown
- 2009-04-24 AU AU2009240538A patent/AU2009240538B2/en not_active Ceased
- 2009-04-24 WO PCT/US2009/041634 patent/WO2009132253A1/en not_active Ceased
- 2009-04-24 CN CN201510082526.3A patent/CN104666297A/zh active Pending
- 2009-04-24 SI SI200931008T patent/SI2276485T1/sl unknown
- 2009-04-24 ES ES09735906.1T patent/ES2501565T3/es active Active
- 2009-04-24 CA CA2722371A patent/CA2722371C/en not_active Expired - Fee Related
- 2009-04-24 EA EA201001695A patent/EA021758B1/ru not_active IP Right Cessation
- 2009-04-24 TW TW98113762A patent/TWI472329B/zh not_active IP Right Cessation
- 2009-04-24 DK DK09735906.1T patent/DK2276485T3/da active
- 2009-04-24 JP JP2011506476A patent/JP5548675B2/ja not_active Expired - Fee Related
- 2009-04-24 HU HUE09735906A patent/HUE024506T2/en unknown
- 2009-04-24 KR KR1020107026208A patent/KR20100137576A/ko not_active Ceased
- 2009-04-24 CN CN201410305166.4A patent/CN104116736A/zh active Pending
- 2009-04-24 NZ NZ588555A patent/NZ588555A/en unknown
- 2009-04-24 CN CN2009801242965A patent/CN102076339A/zh active Pending
- 2009-04-24 HR HRP20140783AT patent/HRP20140783T1/hr unknown
-
2010
- 2010-10-19 ZA ZA2010/07460A patent/ZA201007460B/en unknown
- 2010-10-25 IL IL208926A patent/IL208926A0/en unknown
-
2011
- 2011-06-01 US US13/150,671 patent/US8673949B2/en active Active
-
2014
- 2014-01-23 US US14/162,286 patent/US20140135367A1/en not_active Abandoned
- 2014-10-10 CY CY20141100830T patent/CY1115617T1/el unknown
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