CL2009000990A1 - Uso de epotilona d para el tratamiento de enfermedades asociadas a tau, tal como enfermedad alzheimer, parkinson, entre otras. - Google Patents
Uso de epotilona d para el tratamiento de enfermedades asociadas a tau, tal como enfermedad alzheimer, parkinson, entre otras.Info
- Publication number
- CL2009000990A1 CL2009000990A1 CL2009000990A CL2009000990A CL2009000990A1 CL 2009000990 A1 CL2009000990 A1 CL 2009000990A1 CL 2009000990 A CL2009000990 A CL 2009000990A CL 2009000990 A CL2009000990 A CL 2009000990A CL 2009000990 A1 CL2009000990 A1 CL 2009000990A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- epothilone
- tau
- parkinson
- alzheimer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Uso de epotilona d para el tratamiento de enfermedades asociadas a tau, tales como Enfermedad de Parkinson, Alzheimer, entre otras.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4772908P | 2008-04-24 | 2008-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000990A1 true CL2009000990A1 (es) | 2010-10-15 |
Family
ID=40887113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000990A CL2009000990A1 (es) | 2008-04-24 | 2009-04-24 | Uso de epotilona d para el tratamiento de enfermedades asociadas a tau, tal como enfermedad alzheimer, parkinson, entre otras. |
Country Status (26)
Country | Link |
---|---|
US (3) | US20090270465A1 (es) |
EP (1) | EP2276485B1 (es) |
JP (1) | JP5548675B2 (es) |
KR (1) | KR20100137576A (es) |
CN (3) | CN102076339A (es) |
AR (1) | AR071598A1 (es) |
AU (1) | AU2009240538B2 (es) |
BR (1) | BRPI0911482A2 (es) |
CA (1) | CA2722371C (es) |
CL (1) | CL2009000990A1 (es) |
CY (1) | CY1115617T1 (es) |
DK (1) | DK2276485T3 (es) |
EA (1) | EA021758B1 (es) |
ES (1) | ES2501565T3 (es) |
HK (1) | HK1153152A1 (es) |
HR (1) | HRP20140783T1 (es) |
HU (1) | HUE024506T2 (es) |
IL (1) | IL208926A0 (es) |
MX (1) | MX2010011209A (es) |
NZ (1) | NZ588555A (es) |
PL (1) | PL2276485T3 (es) |
PT (1) | PT2276485E (es) |
SI (1) | SI2276485T1 (es) |
TW (1) | TWI472329B (es) |
WO (1) | WO2009132253A1 (es) |
ZA (1) | ZA201007460B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
HUE055205T2 (hu) | 2006-04-07 | 2021-11-29 | Vertex Pharma | ATP-kötõ kazetta transzporterek modulátorainak elõállítása |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
WO2008112525A2 (en) * | 2007-03-09 | 2008-09-18 | Link Medicine Corporation | Treatment of lysosomal storage diseases |
US8232402B2 (en) | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
CN102076339A (zh) | 2008-04-24 | 2011-05-25 | 百时美施贵宝公司 | 埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途 |
CA2743717A1 (en) | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
JP2012508765A (ja) * | 2008-11-13 | 2012-04-12 | リンク・メディスン・コーポレーション | ファルネシルトランスフェラーゼ阻害剤を使用するタンパク症の治療 |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
CA2797118C (en) | 2010-04-22 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
US8563593B2 (en) * | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
US20130202659A1 (en) * | 2012-01-31 | 2013-08-08 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
CN104781278B (zh) | 2012-07-03 | 2018-06-12 | 华盛顿大学 | 针对tau的抗体 |
EP2872122A1 (en) | 2012-07-16 | 2015-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
KR102447581B1 (ko) | 2014-04-15 | 2022-09-28 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막전도 조절자 매개 질환 치료용 약제학적 조성물 |
TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
JP6321521B2 (ja) * | 2014-11-04 | 2018-05-09 | Well Stone 有限会社 | タウ蛋白産生促進剤、タウ蛋白の欠乏に起因する疾患の治療薬・予防薬および治療用・予防用食品組成物 |
CA3028035A1 (en) | 2016-07-14 | 2018-01-18 | Bioarctic Ab | Brain delivery protein |
CN114727995A (zh) * | 2020-09-02 | 2022-07-08 | 北京华昊中天生物医药股份有限公司 | 优替德隆的固体口服制剂 |
CN113005086B (zh) * | 2021-02-01 | 2022-10-28 | 中国科学院遗传与发育生物学研究所 | 埃博霉素D和Apol8在调控神经干细胞定向神经元分化中的应用 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2809918A (en) | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
US4728512A (en) | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
US5225202A (en) | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
US5580898A (en) * | 1994-05-24 | 1996-12-03 | The Trustees Of The University Of Pennsylvania | Method of stabilizing microtubules |
ES2206607T3 (es) | 1995-11-17 | 2004-05-16 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Derivados de epotilones, preparacion y utilizacion. |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
AU756699B2 (en) * | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
KR100574454B1 (ko) * | 1997-12-04 | 2006-04-27 | 브리스톨-마이어즈 스퀴브 컴페니 | 옥시라닐 에포틸론을 환원시켜 올레핀계 에포틸론을 제조하는 방법 |
US6320045B1 (en) * | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
JP2002504540A (ja) | 1998-02-25 | 2002-02-12 | スローン−ケッタリング インスティトゥート フォア キャンサー リサーチ | エポチロンの合成、その中間体およびそのアナログ |
US6380395B1 (en) * | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
UA69413C2 (uk) | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
DE59914916D1 (de) | 1998-07-27 | 2009-01-08 | Joergen Brosow | Verfahren zur Prüfung der Echtheit von Urkunden |
KR100716272B1 (ko) | 1998-11-20 | 2007-05-09 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
GEP20033067B (en) * | 1999-02-22 | 2003-09-25 | Bristol Myers Squibb Co | C-21 Modified Epothilones |
US6998256B2 (en) | 2000-04-28 | 2006-02-14 | Kosan Biosciences, Inc. | Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate |
US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
AU7902501A (en) | 2000-07-25 | 2002-02-05 | Kosan Biosciences Inc | Fermentation process for epothilones |
JP3604337B2 (ja) * | 2000-10-03 | 2004-12-22 | 古河電気工業株式会社 | 絶縁電線の製造方法 |
DE50111753D1 (de) | 2000-10-16 | 2007-02-08 | R & D Biopharmaceuticals | Epothilon-synthesebausteine i: unsymmetrisch substituierte acyloine und acyloinderivate, verfahren zu deren herstellung sowie deren verwendung zur herstellung von epothilonen und epothilonderivaten |
TW476749B (en) * | 2000-11-17 | 2002-02-21 | Nat Science Council | Process for preparing 2,6-dimethylphenol |
FR2817117B1 (fr) | 2000-11-24 | 2005-11-04 | Commissariat Energie Atomique | Mammiferes non-humains transgeniques ou recombinants et leurs applications dans le criblage de medicaments utiles dans les desordres psychoactifs |
NZ526871A (en) | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
EP1363619A2 (en) * | 2001-02-02 | 2003-11-26 | The Regents of the University of California | Coumarin compounds as microtubule stabilizing agents and therapeutic uses thereof |
MXPA03010909A (es) * | 2001-06-01 | 2004-02-17 | Bristol Myers Squibb Co | Derivados de epotilona. |
ATE380861T1 (de) | 2002-02-25 | 2007-12-15 | Kosan Biosciences Inc | Modulation der verteilung artverwandter sekundärer metaboliten |
US7082674B2 (en) * | 2002-02-27 | 2006-08-01 | Sumitomo Heavy Industries, Ltd. | Method for winding a single coil of a coil unit for a linear motor |
EP1340498A1 (en) | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
US6719540B2 (en) * | 2002-03-12 | 2004-04-13 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
WO2003077903A1 (en) * | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
JP4597667B2 (ja) | 2002-07-15 | 2010-12-15 | リヒター,ヴォルフガング | がん治療用新規マクロサイクル |
AU2003260723A1 (en) | 2002-08-17 | 2004-03-03 | The Queens Universlty Of Belfast | Use of vinca alkaloyds, taxane, cryptophycine, ephitoline or eleutherobine for treating alzheimer |
WO2004026254A2 (en) | 2002-09-23 | 2004-04-01 | Bristol-Myers Squibb Company | Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b |
US7943800B2 (en) * | 2003-03-28 | 2011-05-17 | Sloan-Kettering Institute For Cancer Research | Migrastatin analogs and uses thereof |
US6954131B2 (en) * | 2003-04-02 | 2005-10-11 | Illinois Tool Works Inc. | Electrical reactor assembly having center taps |
MXPA06003835A (es) * | 2003-10-09 | 2006-06-14 | Kosan Biosciences Inc | Formulaciones terapeuticas. |
EP1559447A1 (en) * | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism |
EP1818016B1 (en) | 2004-07-20 | 2019-02-20 | Toshinori Kato | Biofunction diagnosis device, biofunction diagnosis method, bioprobe, bioprobe wearing tool, bioprobe support tool, and bioprobe wearing assisting tool |
WO2006033913A2 (en) * | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
JP2010501563A (ja) * | 2006-08-21 | 2010-01-21 | シンタ ファーマシューティカルズ コーポレーション | 増殖性障害を治療するための化合物 |
WO2008024305A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
SG174087A1 (en) * | 2006-08-21 | 2011-09-29 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
CN102076339A (zh) | 2008-04-24 | 2011-05-25 | 百时美施贵宝公司 | 埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途 |
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2009
- 2009-04-24 CN CN2009801242965A patent/CN102076339A/zh active Pending
- 2009-04-24 TW TW98113762A patent/TWI472329B/zh not_active IP Right Cessation
- 2009-04-24 AU AU2009240538A patent/AU2009240538B2/en not_active Ceased
- 2009-04-24 EP EP09735906.1A patent/EP2276485B1/en active Active
- 2009-04-24 HU HUE09735906A patent/HUE024506T2/en unknown
- 2009-04-24 SI SI200931008T patent/SI2276485T1/sl unknown
- 2009-04-24 CN CN201510082526.3A patent/CN104666297A/zh active Pending
- 2009-04-24 BR BRPI0911482A patent/BRPI0911482A2/pt not_active IP Right Cessation
- 2009-04-24 MX MX2010011209A patent/MX2010011209A/es active IP Right Grant
- 2009-04-24 US US12/429,492 patent/US20090270465A1/en not_active Abandoned
- 2009-04-24 WO PCT/US2009/041634 patent/WO2009132253A1/en active Application Filing
- 2009-04-24 CL CL2009000990A patent/CL2009000990A1/es unknown
- 2009-04-24 ES ES09735906.1T patent/ES2501565T3/es active Active
- 2009-04-24 NZ NZ588555A patent/NZ588555A/en unknown
- 2009-04-24 CA CA2722371A patent/CA2722371C/en not_active Expired - Fee Related
- 2009-04-24 JP JP2011506476A patent/JP5548675B2/ja not_active Expired - Fee Related
- 2009-04-24 EA EA201001695A patent/EA021758B1/ru not_active IP Right Cessation
- 2009-04-24 CN CN201410305166.4A patent/CN104116736A/zh active Pending
- 2009-04-24 PL PL09735906T patent/PL2276485T3/pl unknown
- 2009-04-24 DK DK09735906.1T patent/DK2276485T3/da active
- 2009-04-24 KR KR1020107026208A patent/KR20100137576A/ko not_active Application Discontinuation
- 2009-04-24 PT PT97359061T patent/PT2276485E/pt unknown
- 2009-04-24 AR ARP090101472A patent/AR071598A1/es unknown
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2010
- 2010-10-19 ZA ZA2010/07460A patent/ZA201007460B/en unknown
- 2010-10-25 IL IL208926A patent/IL208926A0/en unknown
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2011
- 2011-06-01 US US13/150,671 patent/US8673949B2/en active Active
- 2011-07-19 HK HK11107477.4A patent/HK1153152A1/xx not_active IP Right Cessation
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2014
- 2014-01-23 US US14/162,286 patent/US20140135367A1/en not_active Abandoned
- 2014-08-19 HR HRP20140783AT patent/HRP20140783T1/hr unknown
- 2014-10-10 CY CY20141100830T patent/CY1115617T1/el unknown
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