PT1567138E - Utilização de derivados de diamida para inibição de rejeição crónica de transplante - Google Patents
Utilização de derivados de diamida para inibição de rejeição crónica de transplante Download PDFInfo
- Publication number
- PT1567138E PT1567138E PT03783726T PT03783726T PT1567138E PT 1567138 E PT1567138 E PT 1567138E PT 03783726 T PT03783726 T PT 03783726T PT 03783726 T PT03783726 T PT 03783726T PT 1567138 E PT1567138 E PT 1567138E
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- rejection
- transplanted
- tissue
- compound
- chronic
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42833202P | 2002-11-21 | 2002-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1567138E true PT1567138E (pt) | 2011-04-11 |
Family
ID=32393386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03783726T PT1567138E (pt) | 2002-11-21 | 2003-11-21 | Utilização de derivados de diamida para inibição de rejeição crónica de transplante |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7687530B2 (enExample) |
| EP (1) | EP1567138B1 (enExample) |
| JP (2) | JP4928079B2 (enExample) |
| AT (1) | ATE493980T1 (enExample) |
| AU (1) | AU2003291134A1 (enExample) |
| DE (1) | DE60335652D1 (enExample) |
| ES (1) | ES2363914T3 (enExample) |
| PT (1) | PT1567138E (enExample) |
| WO (1) | WO2004047825A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001259691B2 (en) | 2000-05-12 | 2006-02-16 | Genzyme Corporation | Modulators of TNF-alpha signaling |
| PT1562571E (pt) * | 2002-11-21 | 2011-11-25 | Genzyme Corp | Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica |
| EP1567138B1 (en) * | 2002-11-21 | 2011-01-05 | Genzyme Corporation | Use of a diamide derivative for inhibiting chronic transplant rejection |
| EP1718768B1 (en) | 2004-01-21 | 2012-05-09 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for determining a graft tolerant phenotype in a subject |
| USRE46843E1 (en) | 2005-03-14 | 2018-05-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for evaluating graft survival in a solid organ transplant recipient |
| JP2008537875A (ja) | 2005-03-14 | 2008-10-02 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 固形臓器移植レシピエントにおいて移植片生着を評価するための方法および組成物 |
| EP2631301B1 (en) * | 2008-08-18 | 2017-10-11 | The Board of Trustees of the Leland Stanford Junior University | Methods for determining a graft tolerant phenotype in a subject |
| US9938579B2 (en) | 2009-01-15 | 2018-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarker panel for diagnosis and prediction of graft rejection |
| US9290813B2 (en) | 2009-12-02 | 2016-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers for determining an allograft tolerant phenotype |
| EP2550371A4 (en) | 2010-03-25 | 2013-11-20 | Univ Leland Stanford Junior | PROTEIN AND GENE BIOMARKERS FOR EXTRACTING ORGAN TRANSPLANTS |
| WO2012139051A2 (en) | 2011-04-06 | 2012-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Autoantibody biomarkers for iga nephropathy |
| EP2827861A4 (en) * | 2012-03-19 | 2016-03-16 | Aposignal Bioscience Llc | COMPOSITION AND METHODS FOR CELLULAR MODULATION |
| WO2017142879A1 (en) * | 2016-02-16 | 2017-08-24 | The Regents Of The University Of California | Methods for immune system modulation with microporous annealed particle gels |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US4944796A (en) * | 1988-11-14 | 1990-07-31 | Ici Americas Inc. | Certain 2-(disubstituted amino) acetanilide herbicides |
| US5540931A (en) | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
| US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| US5958413A (en) | 1990-11-01 | 1999-09-28 | Celltech Limited | Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor |
| US6420374B1 (en) | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
| US5861382A (en) | 1992-05-01 | 1999-01-19 | Yeda Research And Development Co. Ltd. | Methods for regulation of active TNF-α |
| WO1995009652A1 (en) | 1993-10-06 | 1995-04-13 | The Kennedy Institute For Rheumatology | Treatment of autoimmune and inflammatory disorders |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| EP0663836B1 (en) | 1992-10-08 | 1997-07-09 | The Kennedy Institute Of Rheumatology | Treatment of autoimmune and inflammatory disorders |
| US6030615A (en) | 1993-05-17 | 2000-02-29 | The Picower Institute For Medical Research | Combination method for treating diseases caused by cytokine-mediated toxicity |
| NZ278607A (en) | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
| DE4430127A1 (de) | 1994-08-25 | 1996-03-14 | Hoechst Ag | Kombinationspräparat, enthaltend Cyclosporin A oder FK506 und ein Xanthinderivat |
| DE4430128A1 (de) | 1994-08-25 | 1996-02-29 | Hoechst Ag | Kombinationspräparat mit immunsuppressiven, kardiovaskulären und cerebralen Wirkungen |
| JPH11501289A (ja) * | 1994-12-02 | 1999-02-02 | 藤沢薬品工業株式会社 | Ｎｏ介在疾患の予防および／または治療のためのペプチド化合物 |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| FR2730411B1 (fr) * | 1995-02-14 | 1997-03-28 | Centre Nat Rech Scient | Association medicamenteuse utile pour la transfection et l'expression in vivo d'exogenes |
| US5654312A (en) | 1995-06-07 | 1997-08-05 | Andrulis Pharmaceuticals | Treatment of inflammatory and/or autoimmune dermatoses with thalidomide alone or in combination with other agents |
| ATE259235T1 (de) | 1995-07-20 | 2004-02-15 | Cell Eng Ag | Zubereitung enthaltend glykane übereinstimmend mit transferrin glykaner als aktives prinzip für die induktion der immuntoleranz gegen antigene |
| IL115245A (en) | 1995-09-11 | 2002-12-01 | Yissum Res Dev Co | Tumor necrosis factor inhibiting pharmaceuticals |
| NZ322565A (en) * | 1995-11-22 | 1999-11-29 | Darwin Discovery Ltd | Mercaptoalkykpeptidyl compounds having an imidazole substitutent and their use as inhibitors of matrix metalloproteinases and tumor necrosis factor |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US6211160B1 (en) | 1996-09-06 | 2001-04-03 | The Trustees Of The University Of Pennsylvania | Method for tolerizing a mammalian patient to administration of gene therapy virus vectors |
| PT942740E (pt) | 1996-12-06 | 2004-01-30 | Amgen Inc | Terapia de combinacao utilizando uma proteina de ligacao de tnf para tratamento de doencas mediadas por tnf |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| WO1998039026A2 (en) | 1997-03-07 | 1998-09-11 | Biogen, Inc. | Methods of therapeutic administration of anti-cd40l compounds |
| US5801193A (en) | 1997-04-15 | 1998-09-01 | Immune Modulation, Inc. | Compositions and methods for immunosuppressing |
| US6506569B1 (en) | 1997-05-30 | 2003-01-14 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR10 |
| US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| US6229878B1 (en) * | 1998-01-21 | 2001-05-08 | Lucent Technologies, Inc. | Telephone answering method and apparatus |
| US6359061B1 (en) * | 1999-03-19 | 2002-03-19 | Isis Pharmaceuticals, Inc. | Amide compound libraries |
| CA2366264A1 (en) | 1999-04-02 | 2000-10-12 | Bristol-Myers Squibb Company | Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase |
| US6204245B1 (en) | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
| AU1590201A (en) | 1999-11-09 | 2001-06-06 | Chiron Corporation | Compositions and methods for treating autoimmune diseases and transplant rejections |
| AU2001259691B2 (en) * | 2000-05-12 | 2006-02-16 | Genzyme Corporation | Modulators of TNF-alpha signaling |
| MXPA02011376A (es) | 2000-05-22 | 2004-02-26 | Leo Pharma As | Benzofenonas como inhibidores de il-1beta y tnf-alfa. |
| WO2004003154A2 (en) | 2002-06-26 | 2004-01-08 | The Trustees Of Columbia Uninersity In The City Of New York | Use of streptavidin to inhibit transplant rejection |
| PT1562571E (pt) * | 2002-11-21 | 2011-11-25 | Genzyme Corp | Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica |
| EP1567138B1 (en) * | 2002-11-21 | 2011-01-05 | Genzyme Corporation | Use of a diamide derivative for inhibiting chronic transplant rejection |
-
2003
- 2003-11-21 EP EP03783726A patent/EP1567138B1/en not_active Expired - Lifetime
- 2003-11-21 PT PT03783726T patent/PT1567138E/pt unknown
- 2003-11-21 AU AU2003291134A patent/AU2003291134A1/en not_active Abandoned
- 2003-11-21 WO PCT/US2003/037318 patent/WO2004047825A1/en not_active Ceased
- 2003-11-21 JP JP2004555563A patent/JP4928079B2/ja not_active Expired - Fee Related
- 2003-11-21 DE DE60335652T patent/DE60335652D1/de not_active Expired - Lifetime
- 2003-11-21 US US10/719,055 patent/US7687530B2/en not_active Expired - Lifetime
- 2003-11-21 ES ES03783726T patent/ES2363914T3/es not_active Expired - Lifetime
- 2003-11-21 AT AT03783726T patent/ATE493980T1/de not_active IP Right Cessation
-
2010
- 2010-01-06 US US12/683,157 patent/US20100256211A1/en not_active Abandoned
- 2010-09-17 JP JP2010210237A patent/JP2010280725A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US7687530B2 (en) | 2010-03-30 |
| US20100256211A1 (en) | 2010-10-07 |
| DE60335652D1 (de) | 2011-02-17 |
| US20040163654A1 (en) | 2004-08-26 |
| ATE493980T1 (de) | 2011-01-15 |
| AU2003291134A1 (en) | 2004-06-18 |
| JP2010280725A (ja) | 2010-12-16 |
| JP2006514013A (ja) | 2006-04-27 |
| ES2363914T3 (es) | 2011-08-19 |
| EP1567138A1 (en) | 2005-08-31 |
| WO2004047825A1 (en) | 2004-06-10 |
| EP1567138B1 (en) | 2011-01-05 |
| JP4928079B2 (ja) | 2012-05-09 |
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