ATE493980T1 - Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung - Google Patents

Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung

Info

Publication number
ATE493980T1
ATE493980T1 AT03783726T AT03783726T ATE493980T1 AT E493980 T1 ATE493980 T1 AT E493980T1 AT 03783726 T AT03783726 T AT 03783726T AT 03783726 T AT03783726 T AT 03783726T AT E493980 T1 ATE493980 T1 AT E493980T1
Authority
AT
Austria
Prior art keywords
transplant rejection
chronic transplant
prevent chronic
diamide derivative
subject
Prior art date
Application number
AT03783726T
Other languages
German (de)
English (en)
Inventor
John Williams
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE493980T1 publication Critical patent/ATE493980T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03783726T 2002-11-21 2003-11-21 Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung ATE493980T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42833202P 2002-11-21 2002-11-21
PCT/US2003/037318 WO2004047825A1 (en) 2002-11-21 2003-11-21 Use of diamide derivatives for inhibiting chronic tissue transplant rejection

Publications (1)

Publication Number Publication Date
ATE493980T1 true ATE493980T1 (de) 2011-01-15

Family

ID=32393386

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03783726T ATE493980T1 (de) 2002-11-21 2003-11-21 Verwendung eines diamidderivats zur verhinderung der chronischen transplantatabstossung

Country Status (9)

Country Link
US (2) US7687530B2 (enExample)
EP (1) EP1567138B1 (enExample)
JP (2) JP4928079B2 (enExample)
AT (1) ATE493980T1 (enExample)
AU (1) AU2003291134A1 (enExample)
DE (1) DE60335652D1 (enExample)
ES (1) ES2363914T3 (enExample)
PT (1) PT1567138E (enExample)
WO (1) WO2004047825A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001259691B2 (en) 2000-05-12 2006-02-16 Genzyme Corporation Modulators of TNF-alpha signaling
PT1562571E (pt) * 2002-11-21 2011-11-25 Genzyme Corp Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica
EP1567138B1 (en) * 2002-11-21 2011-01-05 Genzyme Corporation Use of a diamide derivative for inhibiting chronic transplant rejection
EP1718768B1 (en) 2004-01-21 2012-05-09 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
USRE46843E1 (en) 2005-03-14 2018-05-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for evaluating graft survival in a solid organ transplant recipient
JP2008537875A (ja) 2005-03-14 2008-10-02 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 固形臓器移植レシピエントにおいて移植片生着を評価するための方法および組成物
EP2631301B1 (en) * 2008-08-18 2017-10-11 The Board of Trustees of the Leland Stanford Junior University Methods for determining a graft tolerant phenotype in a subject
US9938579B2 (en) 2009-01-15 2018-04-10 The Board Of Trustees Of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection
US9290813B2 (en) 2009-12-02 2016-03-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
EP2550371A4 (en) 2010-03-25 2013-11-20 Univ Leland Stanford Junior PROTEIN AND GENE BIOMARKERS FOR EXTRACTING ORGAN TRANSPLANTS
WO2012139051A2 (en) 2011-04-06 2012-10-11 The Board Of Trustees Of The Leland Stanford Junior University Autoantibody biomarkers for iga nephropathy
EP2827861A4 (en) * 2012-03-19 2016-03-16 Aposignal Bioscience Llc COMPOSITION AND METHODS FOR CELLULAR MODULATION
WO2017142879A1 (en) * 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels

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US4997950A (en) * 1989-04-20 1991-03-05 Richard Finbar Murphy Novel C-terminal gastrin antagonists
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5958413A (en) 1990-11-01 1999-09-28 Celltech Limited Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor
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PT1562571E (pt) * 2002-11-21 2011-11-25 Genzyme Corp Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica
EP1567138B1 (en) * 2002-11-21 2011-01-05 Genzyme Corporation Use of a diamide derivative for inhibiting chronic transplant rejection

Also Published As

Publication number Publication date
US7687530B2 (en) 2010-03-30
US20100256211A1 (en) 2010-10-07
DE60335652D1 (de) 2011-02-17
US20040163654A1 (en) 2004-08-26
AU2003291134A1 (en) 2004-06-18
PT1567138E (pt) 2011-04-11
JP2010280725A (ja) 2010-12-16
JP2006514013A (ja) 2006-04-27
ES2363914T3 (es) 2011-08-19
EP1567138A1 (en) 2005-08-31
WO2004047825A1 (en) 2004-06-10
EP1567138B1 (en) 2011-01-05
JP4928079B2 (ja) 2012-05-09

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