JP2004511518A5 - - Google Patents
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- JP2004511518A5 JP2004511518A5 JP2002535660A JP2002535660A JP2004511518A5 JP 2004511518 A5 JP2004511518 A5 JP 2004511518A5 JP 2002535660 A JP2002535660 A JP 2002535660A JP 2002535660 A JP2002535660 A JP 2002535660A JP 2004511518 A5 JP2004511518 A5 JP 2004511518A5
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- JP
- Japan
- Prior art keywords
- group
- alkyl
- alkoxy
- substituted
- halogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24182500P | 2000-10-19 | 2000-10-19 | |
| PCT/IB2001/001942 WO2002032422A2 (en) | 2000-10-19 | 2001-10-15 | Ep4 receptor inhibitors to treat rheumatoid arthritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004511518A JP2004511518A (ja) | 2004-04-15 |
| JP2004511518A5 true JP2004511518A5 (enExample) | 2005-04-07 |
Family
ID=22912331
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002535660A Withdrawn JP2004511518A (ja) | 2000-10-19 | 2001-10-15 | リウマチ様関節炎の治療のためのep4受容体インヒビター |
| JP2002536282A Expired - Lifetime JP4060182B2 (ja) | 2000-10-19 | 2001-10-15 | 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物 |
| JP2007154590A Expired - Lifetime JP4703607B2 (ja) | 2000-10-19 | 2007-06-11 | 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002536282A Expired - Lifetime JP4060182B2 (ja) | 2000-10-19 | 2001-10-15 | 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物 |
| JP2007154590A Expired - Lifetime JP4703607B2 (ja) | 2000-10-19 | 2007-06-11 | 抗炎症剤及び鎮痛剤としてのアリール又はヘテロアリール縮合イミダゾール化合物 |
Country Status (50)
Families Citing this family (78)
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| US7544511B2 (en) * | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
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| BR0309200A (pt) * | 2002-04-12 | 2005-02-22 | Pfizer | Uso de ligandos receptores ep4 no tratamento de doenças envolvidas com a il-6 |
| JP2005532291A (ja) * | 2002-04-12 | 2005-10-27 | ファイザー株式会社 | 抗炎症薬および鎮痛薬としてのピラゾール化合物 |
| US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
| US20040185429A1 (en) * | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
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| FR2860514A1 (fr) * | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
| WO2005064307A2 (en) * | 2003-12-23 | 2005-07-14 | Roche Diagnostics Gmbh | Method of assessing rheumatoid arthritis by measuring anti-ccp and interleukin 6 |
| JP2007533723A (ja) * | 2004-04-20 | 2007-11-22 | ファイザー・プロダクツ・インク | α2δリガンドを含む組合せ |
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| WO2006055685A2 (en) | 2004-11-17 | 2006-05-26 | Neuralstem, Inc. | Transplantation of human neural cells for treatment of neurodegenerative conditions |
| US7442716B2 (en) * | 2004-12-17 | 2008-10-28 | Merck Frosst Canada Ltd. | 2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors |
| EP1828143B1 (en) * | 2004-12-17 | 2013-03-20 | Merck Frosst Canada Ltd. | 2-(phenyl or heterocyclic)-1h-phenantrho[9,10-d]imidazoles as mpges-1 inhibitors |
| US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| AU2006221699A1 (en) * | 2005-03-11 | 2006-09-14 | Pfizer Inc. | Crystal forms of an imidazole derivative |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| WO2007073405A1 (en) * | 2005-12-21 | 2007-06-28 | Decode Genetics Ehf | N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation |
| US20090192158A1 (en) * | 2006-05-02 | 2009-07-30 | Stacia Kargman | Methods for Treating or Preventing Neoplasias |
| CL2007002994A1 (es) * | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| CN101636385B (zh) * | 2007-03-26 | 2012-09-05 | 默克弗罗斯特加拿大有限公司 | 作为ep4受体拮抗剂的萘和喹啉磺酰脲衍生物 |
| DE102007037579B4 (de) | 2007-08-09 | 2012-05-16 | Emc Microcollections Gmbh | Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe |
| CA2698075C (en) | 2007-08-27 | 2016-04-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
| WO2009093026A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| MX2011003166A (es) | 2008-09-25 | 2011-04-27 | Merck Frosst Canada Ltd | Derivados de sulfonilurea beta-carbolina como antagonistas del receptor ep4. |
| WO2010087425A1 (ja) | 2009-01-30 | 2010-08-05 | 国立大学法人京都大学 | 前立腺癌の進行抑制剤および進行抑制方法 |
| CA2754702C (en) | 2009-04-22 | 2016-06-07 | Yukinori Take | Selective ep4 antagonistic substance for treatment of cancer |
| KR101041561B1 (ko) * | 2009-12-21 | 2011-06-15 | 짚라인코리아 (주) | 비행용 착용복 |
| CA2789665C (en) * | 2010-02-22 | 2020-06-16 | Askat Inc. | Use of ep4 receptor antagonists in the treatment of il-23 mediated diseases |
| SG187226A1 (en) | 2010-07-28 | 2013-03-28 | Neuralstem Inc | Methods for treating and/or reversing neurodegenerative diseases and/or disorders |
| WO2012039972A1 (en) | 2010-09-21 | 2012-03-29 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition |
| JPWO2012102254A1 (ja) * | 2011-01-25 | 2014-06-30 | キッセイ薬品工業株式会社 | インドール誘導体、またはその薬理学的に許容される塩 |
| TW201326154A (zh) * | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ep2受體拮抗劑之新穎2h-吲唑 |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| US10391086B2 (en) | 2013-03-19 | 2019-08-27 | Askat Inc. | Use of EP4 receptor antagonists in the treatment of cartilage disease |
| KR20150130404A (ko) * | 2013-03-19 | 2015-11-23 | 에스크엣 인크. | 연골질환 치료에서의 ep4 수용체 길항제의 용도 |
| WO2014153280A1 (en) * | 2013-03-22 | 2014-09-25 | Merck Sharp & Dohme Corp. | 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors |
| JP6484555B2 (ja) * | 2013-08-29 | 2019-03-13 | 京都薬品工業株式会社 | 新規芳香族化合物およびその用途 |
| TW201607943A (zh) | 2013-12-19 | 2016-03-01 | 拜耳製藥公司 | 作為ep4配體之新穎苯并咪唑衍生物 |
| US12109218B2 (en) | 2014-12-09 | 2024-10-08 | Aratana Therapeutics, Inc. | Compositions of grapiprant and methods for using the same |
| TWI664969B (zh) | 2014-03-06 | 2019-07-11 | 雅瑞塔那醫療公司 | 格拉匹綸(grapiprant)組合物及其使用方法 |
| CA2997692A1 (en) | 2014-03-06 | 2015-09-11 | Aratana Therapeutics, Inc. | Crystalline forms of grapiprant |
| CN107148275A (zh) | 2014-10-20 | 2017-09-08 | 神经干细胞公司 | 包含编码生长因子的外源多核苷酸的稳定的神经干细胞及其使用方法 |
| HUE057041T2 (hu) | 2015-07-06 | 2022-04-28 | Alkermes Inc | Hiszton deacetiláz hetero-halogén gátlói |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| CN105486851A (zh) * | 2015-11-20 | 2016-04-13 | 中国药科大学 | 一种基于荧光共振能量转移技术的前列腺素受体4筛选模型 |
| US10342785B2 (en) | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
| HRP20220223T1 (hr) | 2017-01-11 | 2022-04-29 | Alkermes, Inc. | Biciklički inhibitori histon deacetilaze |
| WO2018162562A1 (en) | 2017-03-10 | 2018-09-13 | Bayer Pharma Aktiengesellschaft | Use of an ep4 antagonist for the treatment of inflammatory pain |
| PE20191787A1 (es) | 2017-05-18 | 2019-12-24 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituidos |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| KR102612140B1 (ko) | 2017-05-18 | 2023-12-08 | 이도르시아 파마슈티컬스 리미티드 | 피리미딘 유도체 |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| WO2019038156A1 (en) | 2017-08-22 | 2019-02-28 | Bayer Pharma Aktiengesellschaft | USE OF AN EP4 ANTAGONIST FOR THE TREATMENT OF ARTHRITIS |
| RU2659169C1 (ru) * | 2017-10-31 | 2018-06-28 | Федеральное бюджетное учреждение науки "Уфимский научно-исследовательский институт медицины труда и экологии человека" | Способ прогнозирования риска развития иммуноопосредованных заболеваний у работающих в условиях обсеменённости воздуха рабочей зоны условно-патогенными микроорганизмами |
| CN112292128A (zh) | 2018-04-16 | 2021-01-29 | 阿瑞斯医疗有限公司 | Ep4抑制剂和其用途 |
| WO2019245590A1 (en) | 2018-06-18 | 2019-12-26 | Avista Pharma Solutions, Inc. | Chemical compounds |
| US20210315909A1 (en) * | 2018-07-11 | 2021-10-14 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| IL280051B2 (en) * | 2018-07-11 | 2024-03-01 | Arrys Therapeutics Inc | EP4 inhibitors and their synthesis |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
| US11512088B2 (en) | 2019-01-30 | 2022-11-29 | Avista Pharma Solutions, Inc. | Synthetic process and intermediates |
| CA3128024A1 (en) | 2019-01-30 | 2020-08-06 | Avista Pharma Solutions, Inc. | Chemical compounds |
| WO2021027722A1 (zh) * | 2019-08-09 | 2021-02-18 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| US11254675B2 (en) | 2019-08-12 | 2022-02-22 | Cadila Healthcare Limited | Process for preparation of grapiprant |
| WO2021226162A1 (en) | 2020-05-05 | 2021-11-11 | Arrys Therapeutics, Inc. | Ep4 antagonists and their use in the treatment of proliferative diseases |
| JP7816164B2 (ja) | 2020-11-13 | 2026-02-18 | 小野薬品工業株式会社 | Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療 |
| CN116478155B (zh) * | 2022-01-17 | 2025-06-13 | 洛阳惠中兽药有限公司 | 一种格拉匹伦及其中间体的制备方法 |
| CN117800905A (zh) * | 2022-09-26 | 2024-04-02 | 洛阳惠中兽药有限公司 | 4-(2,6-二甲基-3-硝基吡啶-4-基氨基)苯乙基氨基甲酸苄基酯的制备方法 |
Family Cites Families (14)
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|---|---|---|---|---|
| GB8804439D0 (en) * | 1988-02-25 | 1988-03-23 | Pfizer Ltd | Dihydropyridines |
| IL94805A (en) | 1989-06-28 | 1994-04-12 | Ciba Geigy Ag | (Arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids, processfor their preparation and pharmaceutical compositions containing them |
| GB9009469D0 (en) * | 1990-04-27 | 1990-06-20 | British Bio Technology | Compounds |
| GB9010404D0 (en) * | 1990-05-09 | 1990-06-27 | Pfizer Ltd | Therapeutic agents |
| GB2330307A (en) | 1998-02-07 | 1999-04-21 | Glaxo Group Ltd | EP4 Receptor antagonists as bone resorption inhibitors |
| WO1999047497A2 (en) * | 1998-03-13 | 1999-09-23 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
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| AU6427599A (en) * | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for stimulating bone formation |
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| JP2002543067A (ja) | 1999-04-22 | 2002-12-17 | シナプティック・ファーマスーティカル・コーポレーション | 選択的なnpy(y5)のアンタゴニスト |
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| GB0031302D0 (en) | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
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2001
- 2001-10-08 HN HN2001000224A patent/HN2001000224A/es unknown
- 2001-10-15 EP EP01974609A patent/EP1326606A2/en not_active Withdrawn
- 2001-10-15 HR HR20030269A patent/HRP20030269A2/hr not_active Application Discontinuation
- 2001-10-15 CA CA002426487A patent/CA2426487A1/en not_active Abandoned
- 2001-10-15 CN CNA018199763A patent/CN1477960A/zh active Pending
- 2001-10-15 OA OA1200300110A patent/OA12523A/en unknown
- 2001-10-15 GE GE5160A patent/GEP20053673B/en unknown
- 2001-10-15 CN CN201010279474.6A patent/CN101967146B/zh not_active Expired - Lifetime
- 2001-10-15 SI SI200130519T patent/SI1326864T1/sl unknown
- 2001-10-15 EA EA200300391A patent/EA005991B1/ru not_active IP Right Cessation
- 2001-10-15 JP JP2002535660A patent/JP2004511518A/ja not_active Withdrawn
- 2001-10-15 DE DE60118020T patent/DE60118020T2/de not_active Expired - Lifetime
- 2001-10-15 ES ES01978702T patent/ES2258554T3/es not_active Expired - Lifetime
- 2001-10-15 HU HU0303766A patent/HUP0303766A3/hu unknown
- 2001-10-15 PT PT01978702T patent/PT1326864E/pt unknown
- 2001-10-15 WO PCT/IB2001/001942 patent/WO2002032422A2/en not_active Ceased
- 2001-10-15 JP JP2002536282A patent/JP4060182B2/ja not_active Expired - Lifetime
- 2001-10-15 OA OA1200300117A patent/OA12526A/en unknown
- 2001-10-15 DK DK01978702T patent/DK1326864T3/da active
- 2001-10-15 EP EP06110920.3A patent/EP1666480B1/en not_active Expired - Lifetime
- 2001-10-15 CZ CZ2003979A patent/CZ2003979A3/cs unknown
- 2001-10-15 EP EP01978702A patent/EP1326864B1/en not_active Expired - Lifetime
- 2001-10-15 DZ DZ013513A patent/DZ3513A1/fr active
- 2001-10-15 IL IL15543801A patent/IL155438A0/xx unknown
- 2001-10-15 PL PL01365781A patent/PL365781A1/xx not_active Application Discontinuation
- 2001-10-15 AP APAP/P/2001/002299A patent/AP2001002299A0/en unknown
- 2001-10-15 AT AT01978702T patent/ATE320428T1/de not_active IP Right Cessation
- 2001-10-15 AP APAP/P/2003/002806A patent/AP2003002806A0/en unknown
- 2001-10-15 CA CA002426457A patent/CA2426457C/en not_active Expired - Lifetime
- 2001-10-15 US US09/977,761 patent/US20020077329A1/en not_active Abandoned
- 2001-10-15 BR BRPI0114704A patent/BRPI0114704B8/pt not_active IP Right Cessation
- 2001-10-15 UA UA2003043568A patent/UA74391C2/uk unknown
- 2001-10-15 SK SK460-2003A patent/SK4602003A3/sk not_active Application Discontinuation
- 2001-10-15 AU AU2001294122A patent/AU2001294122A1/en not_active Abandoned
- 2001-10-15 EE EEP200300190A patent/EE200300190A/xx unknown
- 2001-10-15 ES ES06110920.3T patent/ES2524586T3/es not_active Expired - Lifetime
- 2001-10-15 YU YU31303A patent/YU31303A/sh unknown
- 2001-10-15 US US09/977,621 patent/US6710054B2/en not_active Expired - Lifetime
- 2001-10-15 EA EA200300387A patent/EA200300387A1/ru unknown
- 2001-10-15 AU AU2002210796A patent/AU2002210796B8/en not_active Ceased
- 2001-10-15 SK SK443-2003A patent/SK4432003A3/sk not_active Application Discontinuation
- 2001-10-15 CZ CZ20031010A patent/CZ20031010A3/cs unknown
- 2001-10-15 MX MXPA03003463A patent/MXPA03003463A/es active IP Right Grant
- 2001-10-15 KR KR10-2003-7005477A patent/KR20030048060A/ko not_active Ceased
- 2001-10-15 HU HU0600593A patent/HUP0600593A3/hu unknown
- 2001-10-15 WO PCT/IB2001/001940 patent/WO2002032900A2/en not_active Ceased
- 2001-10-15 AU AU1079602A patent/AU1079602A/xx active Pending
- 2001-10-15 MX MXPA03003448A patent/MXPA03003448A/es unknown
- 2001-10-15 NZ NZ525163A patent/NZ525163A/en unknown
- 2001-10-15 IL IL15543901A patent/IL155439A0/xx unknown
- 2001-10-15 CN CNA018192858A patent/CN1476448A/zh active Pending
- 2001-10-15 BR BR0114758-7A patent/BR0114758A/pt not_active IP Right Cessation
- 2001-10-15 EE EEP200300188A patent/EE200300188A/xx unknown
- 2001-10-15 KR KR1020037005443A patent/KR100582319B1/ko not_active Expired - Lifetime
- 2001-10-15 PL PL01362171A patent/PL362171A1/xx not_active Application Discontinuation
- 2001-10-17 PE PE2001001031A patent/PE20020548A1/es not_active Application Discontinuation
- 2001-10-17 PY PY200100125983A patent/PY0125983A/es unknown
- 2001-10-17 AR ARP010104879A patent/AR035498A1/es not_active Application Discontinuation
- 2001-10-18 TN TNTNSN01145A patent/TNSN01145A1/fr unknown
- 2001-10-18 SV SV2001000696A patent/SV2002000696A/es unknown
- 2001-10-18 TW TW095141488A patent/TW200716100A/zh unknown
- 2001-10-18 TW TW090125805A patent/TWI294424B/zh active
- 2001-10-19 GT GT200100211A patent/GT200100211A/es unknown
- 2001-10-19 PA PA20018531001A patent/PA8531001A1/es unknown
- 2001-10-19 UY UY26977A patent/UY26977A1/es not_active Application Discontinuation
- 2001-10-19 GT GT200100211AK patent/GT200100211AA/es unknown
- 2001-11-18 DO DO2001000271A patent/DOP2001000271A/es unknown
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2003
- 2003-03-31 IS IS6765A patent/IS6765A/is unknown
- 2003-04-03 BG BG107699A patent/BG107699A/bg unknown
- 2003-04-04 CR CR6951A patent/CR6951A/es not_active Application Discontinuation
- 2003-04-08 ZA ZA200302722A patent/ZA200302722B/en unknown
- 2003-04-08 NO NO20031582A patent/NO20031582L/no not_active Application Discontinuation
- 2003-04-08 MA MA27097A patent/MA26952A1/fr unknown
- 2003-04-10 NO NO20031658A patent/NO20031658L/no not_active Application Discontinuation
- 2003-04-10 CR CR6955A patent/CR6955A/es not_active Application Discontinuation
- 2003-04-14 IS IS6785A patent/IS6785A/is unknown
- 2003-04-15 MA MA27107A patent/MA26955A1/fr unknown
- 2003-04-16 ZA ZA200302991A patent/ZA200302991B/en unknown
- 2003-04-16 EC EC2003004563A patent/ECSP034563A/es unknown
- 2003-04-16 BG BG107732A patent/BG107732A/bg unknown
- 2003-04-24 EC EC2003004569A patent/ECSP034569A/es unknown
-
2004
- 2004-02-04 US US10/771,696 patent/US7141580B2/en not_active Expired - Lifetime
-
2006
- 2006-03-30 CY CY20061100447T patent/CY1105035T1/el unknown
- 2006-11-03 US US11/556,523 patent/US7479564B2/en not_active Expired - Lifetime
-
2007
- 2007-06-11 JP JP2007154590A patent/JP4703607B2/ja not_active Expired - Lifetime
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