JP2000516257A5 - - Google Patents

Info

Publication number

JP2000516257A5

JP2000516257A5 JP1998533609A JP53360998A JP2000516257A5 JP 2000516257 A5 JP2000516257 A5 JP 2000516257A5 JP 1998533609 A JP1998533609 A JP 1998533609A JP 53360998 A JP53360998 A JP 53360998A JP 2000516257 A5 JP2000516257 A5 JP 2000516257A5

Authority

JP

Japan

Prior art keywords

page

line

formula

aspirin

pharmaceutically acceptable

Prior art date

1997-12-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 description 7
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
• 102000003141 Tachykinin Human genes 0.000 description 4
• 229960001138 acetylsalicylic acid Drugs 0.000 description 4
• 239000005557 antagonist Substances 0.000 description 4
• 108060008037 tachykinin Proteins 0.000 description 4
• 239000002253 acid Substances 0.000 description 3
• 239000000730 antalgic agent Substances 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 2
• 102100024304 Protachykinin-1 Human genes 0.000 description 2
• 101800003906 Substance P Proteins 0.000 description 2
• 229940035676 analgesics Drugs 0.000 description 2
• 239000012458 free base Substances 0.000 description 2
• 239000004530 micro-emulsion Substances 0.000 description 2
• 239000000203 mixture Substances 0.000 description 2
• 238000010998 test method Methods 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1