JP2004525174A5 - - Google Patents

Info

Publication number

JP2004525174A5

JP2004525174A5 JP2002579437A JP2002579437A JP2004525174A5 JP 2004525174 A5 JP2004525174 A5 JP 2004525174A5 JP 2002579437 A JP2002579437 A JP 2002579437A JP 2002579437 A JP2002579437 A JP 2002579437A JP 2004525174 A5 JP2004525174 A5 JP 2004525174A5

Authority

JP

Japan

Prior art keywords

optionally substituted

compound

formula

nhc

nhr

Prior art date

2002-04-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 17
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
• 101100079984 Caenorhabditis elegans nhr-9 gene Proteins 0.000 claims 7
• 125000001072 heteroaryl group Chemical group 0.000 claims 7
• 150000003839 salts Chemical group 0.000 claims 5
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
• 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 3
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 2
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
• 230000009435 amidation Effects 0.000 claims 1
• 238000007112 amidation reaction Methods 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• -1 heteroaryl N-oxide Chemical class 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 125000004430 oxygen atom Chemical group O* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 238000006268 reductive amination reaction Methods 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1