CN100469767C - 联哌啶衍生物及其作为趋化因子受体抑制剂的用途 - Google Patents

联哌啶衍生物及其作为趋化因子受体抑制剂的用途 Download PDF

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CN100469767C
CN100469767C CNB028079507A CN02807950A CN100469767C CN 100469767 C CN100469767 C CN 100469767C CN B028079507 A CNB028079507 A CN B028079507A CN 02807950 A CN02807950 A CN 02807950A CN 100469767 C CN100469767 C CN 100469767C
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compound
formula
phenyl
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CN1501915A (zh
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R·阿尔贝特
C·布伦斯
F·农宁格
M·施特赖夫
G·托马
H-G·策尔韦斯
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Novartis AG
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
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    • C07D211/96—Sulfur atom
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  • Orthopedic Medicine & Surgery (AREA)
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CNB028079507A 2001-04-09 2002-04-08 联哌啶衍生物及其作为趋化因子受体抑制剂的用途 Expired - Fee Related CN100469767C (zh)

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GB0108876.4 2001-04-09
GBGB0108876.4A GB0108876D0 (en) 2001-04-09 2001-04-09 Organic Compounds

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CN1501915A CN1501915A (zh) 2004-06-02
CN100469767C true CN100469767C (zh) 2009-03-18

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US (1) US20040142920A1 (enExample)
EP (1) EP1379504B1 (enExample)
JP (1) JP4366079B2 (enExample)
KR (1) KR100616039B1 (enExample)
CN (1) CN100469767C (enExample)
AR (1) AR035815A1 (enExample)
AT (1) ATE446950T1 (enExample)
AU (1) AU2002302511B2 (enExample)
BR (1) BR0208741A (enExample)
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GB0223223D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
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US20090124635A1 (en) * 2005-01-20 2009-05-14 Pfizer Inc. Chemical compounds
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WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
EP2088860A4 (en) * 2006-12-06 2010-12-22 Genzyme Corp COMPOUNDS FOR BINDING TO A CHEMOKINE RECEPTOR
AU2010232729A1 (en) 2009-03-31 2011-10-20 Arqule, Inc. Substituted indolo-pyridinone compounds
US10952415B2 (en) 2011-03-09 2021-03-23 Richard G. Pestell Prostate cancer cell lines, gene signatures and uses thereof
HK1209673A1 (en) * 2012-05-14 2016-04-08 Prostagene Llc Using modulators of ccr5 for treating cancer
JP2017501164A (ja) 2013-12-19 2017-01-12 バイエル ファーマ アクチエンゲゼルシャフト 置換されたピペリジニルテトラヒドロキノリン類
CA2934134A1 (en) 2013-12-19 2015-06-25 Bayer Pharma Aktiengesellschaft Substituted bipiperidinyl derivatives as adrenoreceptor alpha 2c antagonists
JP2017503783A (ja) 2013-12-19 2017-02-02 バイエル ファーマ アクチエンゲゼルシャフト アドレナリン受容体アルファ２ｃ拮抗薬としての置換されたビピペリジニル誘導体
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CA2439241C (en) 2010-06-08
KR20030087066A (ko) 2003-11-12
GB0108876D0 (en) 2001-05-30
PE20021004A1 (es) 2003-01-03
NZ528712A (en) 2005-07-29
IL157428A0 (en) 2004-03-28
AR035815A1 (es) 2004-07-14
JP2004525174A (ja) 2004-08-19
ES2335393T3 (es) 2010-03-26
ZA200306432B (en) 2004-06-04
HUP0303724A2 (hu) 2004-03-01
PL363011A1 (en) 2004-11-15
ATE446950T1 (de) 2009-11-15
PT1379504E (pt) 2010-01-04
SK12422003A3 (sk) 2004-05-04
ECSP034765A (es) 2003-10-28
MXPA03009220A (es) 2004-01-29
NO20034324D0 (no) 2003-09-26
KR100616039B1 (ko) 2006-08-28
DE60234167D1 (de) 2009-12-10
RU2003130642A (ru) 2005-04-10
BR0208741A (pt) 2004-06-22
RU2296751C2 (ru) 2007-04-10
WO2002081449A1 (en) 2002-10-17
CA2439241A1 (en) 2002-10-17
EP1379504B1 (en) 2009-10-28
NO20034324L (no) 2003-09-26
AU2002302511B2 (en) 2005-08-04
CZ20032723A3 (cs) 2003-12-17
CN1501915A (zh) 2004-06-02
HUP0303724A3 (en) 2007-09-28
US20040142920A1 (en) 2004-07-22
JP4366079B2 (ja) 2009-11-18
EP1379504A1 (en) 2004-01-14

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