KR100616039B1 - 비피페리디닐-유도체 및 이의 케모킨 수용체 억제제로서의 용도 - Google Patents

비피페리디닐-유도체 및 이의 케모킨 수용체 억제제로서의 용도 Download PDF

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KR100616039B1
KR100616039B1 KR1020037013161A KR20037013161A KR100616039B1 KR 100616039 B1 KR100616039 B1 KR 100616039B1 KR 1020037013161 A KR1020037013161 A KR 1020037013161A KR 20037013161 A KR20037013161 A KR 20037013161A KR 100616039 B1 KR100616039 B1 KR 100616039B1
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South Korea
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formula
compound
phenyl
substituted
bipiperidinyl
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Korean (ko)
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KR20030087066A (ko
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레이너 알버트
크리스티안 브룬스
프랑소와 누닌제르
마르쿠스 스트라이프
게브하르트 토마
한스-귄터 체르베스
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노파르티스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06—Antianaemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Orthopedic Medicine & Surgery (AREA)
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  • Ophthalmology & Optometry (AREA)
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KR1020037013161A 2001-04-09 2002-04-08 비피페리디닐-유도체 및 이의 케모킨 수용체 억제제로서의 용도 Expired - Fee Related KR100616039B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0108876.4 2001-04-09
GBGB0108876.4A GB0108876D0 (en) 2001-04-09 2001-04-09 Organic Compounds
PCT/EP2002/003871 WO2002081449A1 (en) 2001-04-09 2002-04-08 Bipiperidinyl-derivatives and their use as chemokine receptors inhibitors

Publications (2)

Publication Number Publication Date
KR20030087066A KR20030087066A (ko) 2003-11-12
KR100616039B1 true KR100616039B1 (ko) 2006-08-28

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KR1020037013161A Expired - Fee Related KR100616039B1 (ko) 2001-04-09 2002-04-08 비피페리디닐-유도체 및 이의 케모킨 수용체 억제제로서의 용도

Country Status (27)

Country Link
US (1) US20040142920A1 (enExample)
EP (1) EP1379504B1 (enExample)
JP (1) JP4366079B2 (enExample)
KR (1) KR100616039B1 (enExample)
CN (1) CN100469767C (enExample)
AR (1) AR035815A1 (enExample)
AT (1) ATE446950T1 (enExample)
AU (1) AU2002302511B2 (enExample)
BR (1) BR0208741A (enExample)
CA (1) CA2439241C (enExample)
CZ (1) CZ20032723A3 (enExample)
DE (1) DE60234167D1 (enExample)
EC (1) ECSP034765A (enExample)
ES (1) ES2335393T3 (enExample)
GB (1) GB0108876D0 (enExample)
HU (1) HUP0303724A3 (enExample)
IL (1) IL157428A0 (enExample)
MX (1) MXPA03009220A (enExample)
NO (1) NO20034324D0 (enExample)
NZ (1) NZ528712A (enExample)
PE (1) PE20021004A1 (enExample)
PL (1) PL363011A1 (enExample)
PT (1) PT1379504E (enExample)
RU (1) RU2296751C2 (enExample)
SK (1) SK12422003A3 (enExample)
WO (1) WO2002081449A1 (enExample)
ZA (1) ZA200306432B (enExample)

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GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
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US20080108586A1 (en) * 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
JP2010512340A (ja) * 2006-12-06 2010-04-22 ジェンザイム・コーポレーション ケモカイン受容体結合性化合物
US8410144B2 (en) 2009-03-31 2013-04-02 Arqule, Inc. Substituted indolo-pyridinone compounds
EP3597761B1 (en) 2011-03-09 2025-05-07 Richard G. Pestell Prostate cancer cell lines, gene signatures and uses thereof
EP2861302A4 (en) * 2012-05-14 2016-08-24 Prostagene Llc USE OF CCR5 MODULATORS IN THE TREATMENT OF CANCER
JP2017503783A (ja) 2013-12-19 2017-02-02 バイエル ファーマ アクチエンゲゼルシャフト アドレナリン受容体アルファ２ｃ拮抗薬としての置換されたビピペリジニル誘導体
JOP20200052A1 (ar) 2013-12-19 2017-06-16 Bayer Pharma AG بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
JP2017503778A (ja) 2013-12-19 2017-02-02 バイエル ファーマ アクチエンゲゼルシャフト アドレナリン受容体α２Ｃ拮抗薬としての置換されたビピペリジニル誘導体
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AR036366A1 (es) * 2001-08-29 2004-09-01 Schering Corp Derivados de piperidina utiles como antagonistas de ccr5, composiciones farmaceuticas, el uso de dichos derivados para la fabricación de un medicamento y un kit
GB0223223D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds

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EP1379504B1 (en) 2009-10-28
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CA2439241A1 (en) 2002-10-17
CN1501915A (zh) 2004-06-02
GB0108876D0 (en) 2001-05-30
ATE446950T1 (de) 2009-11-15
PE20021004A1 (es) 2003-01-03
CA2439241C (en) 2010-06-08
NZ528712A (en) 2005-07-29
AR035815A1 (es) 2004-07-14
HUP0303724A2 (hu) 2004-03-01
ECSP034765A (es) 2003-10-28
HUP0303724A3 (en) 2007-09-28
US20040142920A1 (en) 2004-07-22
ES2335393T3 (es) 2010-03-26
KR20030087066A (ko) 2003-11-12
NO20034324L (no) 2003-09-26
NO20034324D0 (no) 2003-09-26
WO2002081449A1 (en) 2002-10-17
JP2004525174A (ja) 2004-08-19
RU2003130642A (ru) 2005-04-10
JP4366079B2 (ja) 2009-11-18
CN100469767C (zh) 2009-03-18
BR0208741A (pt) 2004-06-22
DE60234167D1 (de) 2009-12-10
CZ20032723A3 (cs) 2003-12-17
SK12422003A3 (sk) 2004-05-04
PL363011A1 (en) 2004-11-15
RU2296751C2 (ru) 2007-04-10
EP1379504A1 (en) 2004-01-14
AU2002302511B2 (en) 2005-08-04
ZA200306432B (en) 2004-06-04
PT1379504E (pt) 2010-01-04

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