JP2000516257A - タキキニンアンタゴニスト - Google Patents
タキキニンアンタゴニストInfo
- Publication number
- JP2000516257A JP2000516257A JP10533609A JP53360998A JP2000516257A JP 2000516257 A JP2000516257 A JP 2000516257A JP 10533609 A JP10533609 A JP 10533609A JP 53360998 A JP53360998 A JP 53360998A JP 2000516257 A JP2000516257 A JP 2000516257A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acid addition
- addition salt
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式I [式中、 Xは-CH2-、-CO-または結合手であり、 Yは-O-、-S-または-NH-であり、 R1はフェニルであり、 R2は水素またはフェニルであり、ならびに R3は水素またはメチルである] の化合物またはその酸付加塩。 2.Xが-CO-であり、Yが-NH-であり、R2が水素であり、そしてR3がメチルである 、請求項1に記載の化合物またはその酸付加塩。 3.R2およびR3がそれぞれ水素であり、 a)Xが-CO-であり、Yが-O-であり、または b)Xが-CO-であり、Yが-NH-であり; c)Xが結合手であり、Yが-O-または-NH-である;または d)Xが-CH2-であり、Yが-O-である、 請求項1に記載の化合物またはその酸付加塩。 4.式Iにおいて、アスタリスク(*)で印を付けた炭素原子が両方ともS-配置とな る、請求項1〜3の何れかに記載の化合物またはその酸付加塩。 5.Xが-CO-であり、Yが-NH-であり、R2が水素であり、R3がメチルである、請求 項4に記載の化合物またはその酸付加塩。 6.a)式II[式中、R1〜R3は請求項1に記載の意味の通り] の化合物を式III [式中、Yは請求項1に記載の意味の通りであり、Z'は脱離基である] の化合物と反応させること; b)式I[式中、Xは-CO-であり、Yは-O-または-S-である]の化合物の製造のために 、上記式IIの化合物を式IV [式中、Z"は脱離基であり、Y’は-O-または-S-である] の化合物と反応させること;または c)式I[式中、Xは-CO-であり、Yは-NH-である]の化合物の製造のために、式V [式中、R1、R3は請求項1に記載の意味の通り] の化合物をハロゲン化アルキルで処理すること; ならびに遊離形または酸付加塩形で得られた式Iの化合物を回収すること、 を含む工程であり、請求項1に記載の式Iの化合物またはその酸付加塩の製造の ための工程。 7.請求項6に記載の式IIの相当する化合物を請求項6に記載の式IIIの化合物[ 式中、XおよびYは上記の通りであり、Z'はハロゲンである]と反応させることを 含む、式Iの化合物[式中、Xは-CO-であり、Yは-NH-であり、R2は水素であり、そ してR3はメチルである]またはその酸付加塩の製造のための請求項6に記載の工 程。 8.薬学的に許容される製剤用希釈剤または担体と共に、請求項1〜5の何れか に記載の化合物またはその薬学的に許容される酸付加塩を含む医薬組成物。 9.医薬として使用する、請求項1〜5の何れかに記載の化合物。 10.請求項1〜5の何れかに記載の化合物またはその薬学的に許容される酸付 加塩の鎮痛有効量を患者に投与することを含む、それらを必要とする患者おける 痛みの処置方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9700597.9A GB9700597D0 (en) | 1997-01-14 | 1997-01-14 | Organic compounds |
GB9700597.9 | 1997-01-14 | ||
PCT/EP1997/007307 WO1998031704A2 (en) | 1997-01-14 | 1997-12-29 | Tachykinin antagonists |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005344056A Division JP3817256B2 (ja) | 1997-01-14 | 2005-11-29 | タキキニンアンタゴニスト |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000516257A true JP2000516257A (ja) | 2000-12-05 |
JP2000516257A5 JP2000516257A5 (ja) | 2009-05-07 |
JP4306804B2 JP4306804B2 (ja) | 2009-08-05 |
Family
ID=10805904
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53360998A Expired - Fee Related JP4306804B2 (ja) | 1997-01-14 | 1997-12-29 | タキキニンアンタゴニスト |
JP2005344056A Expired - Fee Related JP3817256B2 (ja) | 1997-01-14 | 2005-11-29 | タキキニンアンタゴニスト |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005344056A Expired - Fee Related JP3817256B2 (ja) | 1997-01-14 | 2005-11-29 | タキキニンアンタゴニスト |
Country Status (14)
Country | Link |
---|---|
US (1) | US6107293A (ja) |
EP (1) | EP0964867B1 (ja) |
JP (2) | JP4306804B2 (ja) |
AR (1) | AR011521A1 (ja) |
AT (1) | ATE290546T1 (ja) |
AU (1) | AU5764298A (ja) |
CA (1) | CA2278057C (ja) |
CO (1) | CO4950614A1 (ja) |
DE (1) | DE69732715T2 (ja) |
ES (1) | ES2239368T3 (ja) |
GB (1) | GB9700597D0 (ja) |
PT (1) | PT964867E (ja) |
WO (1) | WO1998031704A2 (ja) |
ZA (1) | ZA98256B (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6426331B1 (en) | 1998-07-08 | 2002-07-30 | Tularik Inc. | Inhibitors of STAT function |
GB9815696D0 (en) * | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
WO2000048623A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
AU2000249828A1 (en) * | 2000-05-03 | 2001-11-12 | Taisho Pharmaceutical Co. Ltd. | Stat4 and stat6 binding dipeptide derivatives |
US6884782B2 (en) | 2000-11-08 | 2005-04-26 | Amgen Inc. | STAT modulators |
US20070219214A1 (en) * | 2006-02-01 | 2007-09-20 | Solvay Pharmaceuticals Gmbh | Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation |
US8426386B2 (en) | 2006-10-16 | 2013-04-23 | Lion Corporation | NK1 receptor antagonist composition |
US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
US20210015834A1 (en) | 2018-02-26 | 2021-01-21 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
WO2021180885A1 (en) | 2020-03-11 | 2021-09-16 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ210669A (en) * | 1983-12-27 | 1988-05-30 | Syntex Inc | Benzoxazin-4-one derivatives and pharmaceutical compositions |
GB8929070D0 (en) * | 1989-12-22 | 1990-02-28 | Fujisawa Pharmaceutical Co | Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same |
FR2719312B1 (fr) * | 1994-04-28 | 1996-06-14 | Adir | Nouveau pseudopeptides dérivés de neurokinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1997
- 1997-01-14 GB GBGB9700597.9A patent/GB9700597D0/en active Pending
- 1997-12-29 JP JP53360998A patent/JP4306804B2/ja not_active Expired - Fee Related
- 1997-12-29 AT AT97953927T patent/ATE290546T1/de not_active IP Right Cessation
- 1997-12-29 CA CA002278057A patent/CA2278057C/en not_active Expired - Fee Related
- 1997-12-29 EP EP97953927A patent/EP0964867B1/en not_active Expired - Lifetime
- 1997-12-29 AU AU57642/98A patent/AU5764298A/en not_active Abandoned
- 1997-12-29 US US09/341,626 patent/US6107293A/en not_active Expired - Lifetime
- 1997-12-29 ES ES97953927T patent/ES2239368T3/es not_active Expired - Lifetime
- 1997-12-29 DE DE69732715T patent/DE69732715T2/de not_active Expired - Lifetime
- 1997-12-29 WO PCT/EP1997/007307 patent/WO1998031704A2/en active IP Right Grant
- 1997-12-29 PT PT97953927T patent/PT964867E/pt unknown
-
1998
- 1998-01-09 AR ARP980100097A patent/AR011521A1/es active IP Right Grant
- 1998-01-13 CO CO98001002A patent/CO4950614A1/es unknown
- 1998-01-13 ZA ZA98256A patent/ZA98256B/xx unknown
-
2005
- 2005-11-29 JP JP2005344056A patent/JP3817256B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4306804B2 (ja) | 2009-08-05 |
GB9700597D0 (en) | 1997-03-05 |
PT964867E (pt) | 2005-07-29 |
AR011521A1 (es) | 2000-08-30 |
EP0964867B1 (en) | 2005-03-09 |
ATE290546T1 (de) | 2005-03-15 |
EP0964867A2 (en) | 1999-12-22 |
US6107293A (en) | 2000-08-22 |
ES2239368T3 (es) | 2005-09-16 |
JP3817256B2 (ja) | 2006-09-06 |
AU5764298A (en) | 1998-08-07 |
JP2006089499A (ja) | 2006-04-06 |
ZA98256B (en) | 1998-07-14 |
DE69732715D1 (de) | 2005-04-14 |
WO1998031704A3 (en) | 1998-09-11 |
WO1998031704A2 (en) | 1998-07-23 |
DE69732715T2 (de) | 2006-04-13 |
CA2278057C (en) | 2004-05-04 |
CA2278057A1 (en) | 1998-07-23 |
CO4950614A1 (es) | 2000-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6896113B2 (ja) | ジアザ二環式置換イミダゾピリミジンおよび呼吸障害を治療するためのその使用 | |
JP3817256B2 (ja) | タキキニンアンタゴニスト | |
JP3087763B2 (ja) | 新規な複素環式化合物およびそれを含有する医薬組成物 | |
CN109311851A (zh) | 二氢嘧啶基苯并氮杂*甲酰胺化合物 | |
JPH10511935A (ja) | タチキニンアンタゴニスト | |
WO2017167180A1 (zh) | 沃替西汀的帕莫酸盐及其晶型 | |
JP2002525371A (ja) | Cgrpリガンドとしてのベンゾイミダゾリニルピペリジン | |
KR20150028971A (ko) | 항바이러스성 화합물의 고체 형태 | |
CN109476665A (zh) | 取代的二氮杂杂双环化合物及其用途 | |
KR101539588B1 (ko) | (6,7-디히드로-2-니트로-5h-이미다졸[2,1-b][1,3]옥사진-6-일)아미드 화합물, 그의 제조방법 및 용도 | |
JP2000327575A (ja) | ジケトピペラジン誘導体含有炎症疾患治療剤および新規なジケトピペラジン誘導体 | |
JP2000505450A (ja) | キノロン類およびこれらの治療的使用 | |
JP2021512075A (ja) | 一過性受容体電位a1イオンチャネルの阻害 | |
CN114805478A (zh) | 氘代拟肽类化合物及其用途 | |
JPH07505868A (ja) | 置換フェニルカルバメート類および尿素類 | |
JP3353784B2 (ja) | 公知のブラジキニン拮抗剤のガラス体 | |
JP3190679B2 (ja) | 複素環式化学 | |
WO2019042443A1 (zh) | 一类具有降解酪氨酸蛋白激酶jak3活性的化合物 | |
MXPA02000033A (es) | Polimorfos de un diclorhidrato cristalino de azobiciclo (2, 2, 2)oct-3-ilamina y sus composiciones farmaceuticas. | |
WO1990001027A1 (en) | 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient | |
JP2000511909A (ja) | 修飾された形態を有するr(―)―n―(4,4―ジ(3―メチルチエン―2―イル)ブタ―3―エニル)―ニペコチン酸・塩酸塩 | |
WO2004080965A1 (ja) | ニューロペプチドff受容体拮抗剤 | |
JPH10316677A (ja) | 結 晶 | |
WO2008010794A1 (en) | Pharmaceutical preparations of crystalline lazabemide | |
JPH10298197A (ja) | 置換ベンズアミド誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20031208 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040115 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050802 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051129 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20060126 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20060202 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20071204 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20071207 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20080104 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20090316 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20090428 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120515 Year of fee payment: 3 |
|
LAPS | Cancellation because of no payment of annual fees |