AU2000249828A1 - Stat4 and stat6 binding dipeptide derivatives - Google Patents

Stat4 and stat6 binding dipeptide derivatives

Info

Publication number
AU2000249828A1
AU2000249828A1 AU2000249828A AU4982800A AU2000249828A1 AU 2000249828 A1 AU2000249828 A1 AU 2000249828A1 AU 2000249828 A AU2000249828 A AU 2000249828A AU 4982800 A AU4982800 A AU 4982800A AU 2000249828 A1 AU2000249828 A1 AU 2000249828A1
Authority
AU
Australia
Prior art keywords
stat4
dipeptide derivatives
stat6 binding
stat6
binding dipeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2000249828A
Inventor
Timothy D. Cushing
Hiroshi Fukushima
Akira Hiratate
Judi Mckinney
Yutaka Ohuchi
Csaba Peto
Brian C. Raimundo
Feng Xu
Hiromitsu Yoshimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Tularik Inc
Original Assignee
Taisho Pharmaceutical Co Ltd
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co Ltd, Tularik Inc filed Critical Taisho Pharmaceutical Co Ltd
Publication of AU2000249828A1 publication Critical patent/AU2000249828A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2000249828A 2000-05-03 2000-05-03 Stat4 and stat6 binding dipeptide derivatives Abandoned AU2000249828A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/012079 WO2001083517A1 (en) 2000-05-03 2000-05-03 Stat4 and stat6 binding dipeptide derivatives

Publications (1)

Publication Number Publication Date
AU2000249828A1 true AU2000249828A1 (en) 2001-11-12

Family

ID=21741350

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2000249828A Abandoned AU2000249828A1 (en) 2000-05-03 2000-05-03 Stat4 and stat6 binding dipeptide derivatives

Country Status (2)

Country Link
AU (1) AU2000249828A1 (en)
WO (1) WO2001083517A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884782B2 (en) * 2000-11-08 2005-04-26 Amgen Inc. STAT modulators
US20070196395A1 (en) * 2003-12-12 2007-08-23 Mackerell Alexander Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain
US7829528B2 (en) 2004-09-14 2010-11-09 The Rockefeller University Compositions and methods for treating STAT-6 associated diseases or conditions
EP2404919B1 (en) 2005-11-08 2013-08-21 Vertex Pharmaceuticals Incorporated Heterocyclic compound useful as a modulator of ATP-binding cassette transporters.
CN102690221B (en) 2005-12-23 2014-12-03 西兰岛药物有限公司 Modified lysine-mimetic compounds
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
AR064626A1 (en) 2006-12-21 2009-04-15 Wyeth Corp SYNTHESIS OF PIRROLIDINE COMPOUNDS
CN101687842B (en) 2007-05-09 2013-03-06 沃泰克斯药物股份有限公司 Modulators of CFTR
MX367154B (en) 2007-12-07 2019-08-07 Vertex Pharma Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid.
LT2639224T (en) 2007-12-07 2016-10-25 Vertex Pharmaceuticals Incorporated Process for producing cycloalkylcarboxiamido-pyridine benzoic acids
CA2931134C (en) 2008-02-28 2019-07-30 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
WO2010118309A2 (en) 2009-04-10 2010-10-14 Board Of Regents, The University Of Texas System Inhibitors of stat3 and uses thereof
JP2013523833A (en) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド 3- (6- (1- (2,2-difluorobenzo [D] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid pharmaceutical composition and Its administration
WO2014182928A2 (en) * 2013-05-08 2014-11-13 Board Of Regents, The University Of Texas System Stat6 inhibitors
PL3068392T3 (en) 2013-11-12 2021-07-19 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
MX2017006443A (en) 2014-11-18 2017-09-11 Vertex Pharma Process of conducting high throughput testing high performance liquid chromatography.
CN110709096B (en) 2017-05-05 2023-10-31 泽兰德制药公司 Cell gap junction communication regulator and application thereof in treatment of diabetic eye disease
CA3068286A1 (en) 2017-06-22 2018-12-27 Board Of Regents, The University Of Texas System Methods for producing regulatory immune cells and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19527575A1 (en) * 1995-07-28 1997-01-30 Basf Ag Process for the preparation of peptide active ingredients
GB9700597D0 (en) * 1997-01-14 1997-03-05 Sandoz Pharma Uk Organic compounds
US6207391B1 (en) * 1998-03-31 2001-03-27 Tularik Inc. High-throughput screening assays for modulators of STAT4 and STAT6 activity

Also Published As

Publication number Publication date
WO2001083517A1 (en) 2001-11-08

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