CO4950614A1 - Antagonistas de taquiquinina - Google Patents
Antagonistas de taquiquininaInfo
- Publication number
- CO4950614A1 CO4950614A1 CO98001002A CO98001002A CO4950614A1 CO 4950614 A1 CO4950614 A1 CO 4950614A1 CO 98001002 A CO98001002 A CO 98001002A CO 98001002 A CO98001002 A CO 98001002A CO 4950614 A1 CO4950614 A1 CO 4950614A1
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- formula
- production
- acid addition
- addition salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula I: en donde: X es -CH2 -, -CO- ó un enlace directo, Y es -O-, -S- ó -NH-,R1 es fenilo,R2 es hidrógeno o fenilo, yR3 es hidrógeno o metilo, ó una sal de adición de ácido del mismo.Un proceso para la producción de un compuesto de la fórmula I como se define en la reivindicación 1, ó una sal de adición de ácido del mismo, cuyo proceso comprende: a) hacer reaccionar un compuesto de la fórmula II: en donde R1 a R3 tienen los significados dados en la reivindicación 1, con un compuesto de la fórmula III: - 2 -en donde X Y tienen los significados dados en la reivindicación 1, y Z´ es halógeno ó, cuando X es -CH2 -, es -NCN; b) para la producción de un compuesto de la fórmula I, en donde X es -CO-, e Y es -O- ó -S-, hacer reacccionar un compuesto de la fórmula II como se definió anteriormente, con un compuesto de la fórmula IV: en donde Z" es un grupo de salida, que incluye halógeno, como cloro, e Y´ es -O- ó -S- óc) para la producción de un compuesto de la fórmula Y, en donde X es -CO-, e Ym es -CO-, e Ym es -NH-, tratar un compuesto de la fórmula V: en donde R1 , R3 tienen los significados dados en la reivindicación 1, con un haluro de alquilo; y recuperar el compuesto de la fórmula I así obtenido, en forma libre o de sal de adición de ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9700597.9A GB9700597D0 (en) | 1997-01-14 | 1997-01-14 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4950614A1 true CO4950614A1 (es) | 2000-09-01 |
Family
ID=10805904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98001002A CO4950614A1 (es) | 1997-01-14 | 1998-01-13 | Antagonistas de taquiquinina |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6107293A (es) |
| EP (1) | EP0964867B1 (es) |
| JP (2) | JP4306804B2 (es) |
| AR (1) | AR011521A1 (es) |
| AT (1) | ATE290546T1 (es) |
| AU (1) | AU5764298A (es) |
| CA (1) | CA2278057C (es) |
| CO (1) | CO4950614A1 (es) |
| DE (1) | DE69732715T2 (es) |
| ES (1) | ES2239368T3 (es) |
| GB (1) | GB9700597D0 (es) |
| PT (1) | PT964867E (es) |
| WO (1) | WO1998031704A2 (es) |
| ZA (1) | ZA98256B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6426331B1 (en) | 1998-07-08 | 2002-07-30 | Tularik Inc. | Inhibitors of STAT function |
| GB9815696D0 (en) * | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
| CA2362290A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
| AU2000249828A1 (en) * | 2000-05-03 | 2001-11-12 | Taisho Pharmaceutical Co. Ltd. | Stat4 and stat6 binding dipeptide derivatives |
| US6884782B2 (en) | 2000-11-08 | 2005-04-26 | Amgen Inc. | STAT modulators |
| US20070219214A1 (en) * | 2006-02-01 | 2007-09-20 | Solvay Pharmaceuticals Gmbh | Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation |
| WO2008047709A1 (en) | 2006-10-16 | 2008-04-24 | Lion Corporation | Nk1 receptor antagonist composition |
| NO2729147T3 (es) | 2011-07-04 | 2018-02-03 | ||
| WO2019162519A1 (en) | 2018-02-26 | 2019-08-29 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
| EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210669A (en) * | 1983-12-27 | 1988-05-30 | Syntex Inc | Benzoxazin-4-one derivatives and pharmaceutical compositions |
| GB8929070D0 (en) * | 1989-12-22 | 1990-02-28 | Fujisawa Pharmaceutical Co | Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same |
| FR2719312B1 (fr) * | 1994-04-28 | 1996-06-14 | Adir | Nouveau pseudopeptides dérivés de neurokinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
-
1997
- 1997-01-14 GB GBGB9700597.9A patent/GB9700597D0/en active Pending
- 1997-12-29 WO PCT/EP1997/007307 patent/WO1998031704A2/en active IP Right Grant
- 1997-12-29 AU AU57642/98A patent/AU5764298A/en not_active Abandoned
- 1997-12-29 JP JP53360998A patent/JP4306804B2/ja not_active Expired - Fee Related
- 1997-12-29 CA CA002278057A patent/CA2278057C/en not_active Expired - Fee Related
- 1997-12-29 ES ES97953927T patent/ES2239368T3/es not_active Expired - Lifetime
- 1997-12-29 EP EP97953927A patent/EP0964867B1/en not_active Expired - Lifetime
- 1997-12-29 US US09/341,626 patent/US6107293A/en not_active Expired - Lifetime
- 1997-12-29 AT AT97953927T patent/ATE290546T1/de not_active IP Right Cessation
- 1997-12-29 DE DE69732715T patent/DE69732715T2/de not_active Expired - Lifetime
- 1997-12-29 PT PT97953927T patent/PT964867E/pt unknown
-
1998
- 1998-01-09 AR ARP980100097A patent/AR011521A1/es active IP Right Grant
- 1998-01-13 ZA ZA98256A patent/ZA98256B/xx unknown
- 1998-01-13 CO CO98001002A patent/CO4950614A1/es unknown
-
2005
- 2005-11-29 JP JP2005344056A patent/JP3817256B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000516257A (ja) | 2000-12-05 |
| PT964867E (pt) | 2005-07-29 |
| WO1998031704A3 (en) | 1998-09-11 |
| EP0964867B1 (en) | 2005-03-09 |
| JP3817256B2 (ja) | 2006-09-06 |
| JP2006089499A (ja) | 2006-04-06 |
| EP0964867A2 (en) | 1999-12-22 |
| CA2278057A1 (en) | 1998-07-23 |
| GB9700597D0 (en) | 1997-03-05 |
| AU5764298A (en) | 1998-08-07 |
| AR011521A1 (es) | 2000-08-30 |
| ES2239368T3 (es) | 2005-09-16 |
| US6107293A (en) | 2000-08-22 |
| JP4306804B2 (ja) | 2009-08-05 |
| ZA98256B (en) | 1998-07-14 |
| DE69732715D1 (de) | 2005-04-14 |
| CA2278057C (en) | 2004-05-04 |
| ATE290546T1 (de) | 2005-03-15 |
| WO1998031704A2 (en) | 1998-07-23 |
| DE69732715T2 (de) | 2006-04-13 |
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