ES2080726T3 - Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer. - Google Patents

Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer.

Info

Publication number
ES2080726T3
ES2080726T3 ES88311467T ES88311467T ES2080726T3 ES 2080726 T3 ES2080726 T3 ES 2080726T3 ES 88311467 T ES88311467 T ES 88311467T ES 88311467 T ES88311467 T ES 88311467T ES 2080726 T3 ES2080726 T3 ES 2080726T3
Authority
ES
Spain
Prior art keywords
aromatic
nitrosusstituted
cancer
treatment
heteroaromatic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88311467T
Other languages
English (en)
Inventor
Gerald Edward Adams
Edward Martin Fielden
Terence Charles Jenkins
Ian James Stratford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878728418A external-priority patent/GB8728418D0/en
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of ES2080726T3 publication Critical patent/ES2080726T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO PARA TRATAR UN PACIENTE QUE SE SABE O SE SOSPECHA QUE TIENE CELULAS HEPOXICAS, DE FORMULA (A), EN LA QUE X ES UN GRUPO NITRO - AROMATICOO HETERO AROMATICO CON UN POTENCIAL DE ELCTROREDUCCION A PH7 DE 250 A 500 MV; R''1 Y R''5 SON INDEPENDIENTEMENTE H O UN GRUPO ALQUILO, HIDROXIALQUILO, ARILO, ARALQUILO O ALQUILARILO; N ES 0 O 1; N ES 1 O 2; Y Z ES UN GRUPO SEPARABLE QUE TIENE UN POTENCIAL DE SEPARACION A TRAVES DE UNA REACCION DSE CICLACION INTRAMOLECULAR. TAMBIEN SE REFIERE LA INVENCION A UNA SAL DE ADICION DE ACIDO FISIOLOGICAMENTE ACEPTABLE, DE DICHO COMPUESTO.
ES88311467T 1987-12-04 1988-12-02 Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer. Expired - Lifetime ES2080726T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878728418A GB8728418D0 (en) 1987-12-04 1987-12-04 Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
GB888818348A GB8818348D0 (en) 1987-12-04 1988-08-02 Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer

Publications (1)

Publication Number Publication Date
ES2080726T3 true ES2080726T3 (es) 1996-02-16

Family

ID=26293154

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88311467T Expired - Lifetime ES2080726T3 (es) 1987-12-04 1988-12-02 Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer.

Country Status (10)

Country Link
US (1) US5098921A (es)
EP (1) EP0319329B1 (es)
JP (1) JPH01250360A (es)
AT (1) ATE129703T1 (es)
AU (1) AU625314B2 (es)
CA (1) CA1332738C (es)
DE (1) DE3854645T2 (es)
ES (1) ES2080726T3 (es)
GB (1) GB2213150B (es)
GR (1) GR3018343T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8728418D0 (en) * 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
US5073639A (en) * 1988-11-25 1991-12-17 Warner-Lambert Company Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents
GB9113487D0 (en) * 1991-06-21 1991-08-07 Amersham Int Plc Agents for hypoxic cells
DE4134224C2 (de) * 1991-10-16 2001-06-07 Apogepha Arzneimittel Gmbh Neue 1-Heterocyclylmethyl-3-nitro-1,2,4-triazole
MX9304399A (es) * 1992-07-31 1994-02-28 Warner Lambert Co Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
GB9404400D0 (en) * 1994-03-07 1994-04-20 Wood Pauline J Potentiation of bioreductive agents
JP2000247881A (ja) * 1999-02-26 2000-09-12 Tsutomu Kagitani 免疫増強剤
CN1270062A (zh) * 1999-04-08 2000-10-18 广州山河药业股份有限公司 一种放射、化学治疗增效剂—甘氨双唑金属盐及其制法和用途
US20060099712A1 (en) * 2004-11-08 2006-05-11 Eastman Kodak Company Correlation of anti-cancer activity of dyes with redox potentials
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1257238A (es) * 1968-10-31 1971-12-15
GB1425293A (en) * 1974-01-17 1976-02-18 Hoffmann La Roche Carbamate derivatives of 2-nitro-1-imidazol-alkanols-, emthods for their preparation and compositions containing them
IE47132B1 (en) * 1977-08-19 1983-12-28 Roche Products Ltd Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture
DE2948884A1 (de) * 1979-12-05 1981-06-11 Basf Ag, 6700 Ludwigshafen 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren
JPH0649697B2 (ja) * 1982-05-27 1994-06-29 ブリティッシュ・テクノロジー・グループ・リミテッド 放射線治療または化学療法に有用な化合物
CA1227211A (en) * 1982-05-27 1987-09-22 Israr Ahmed Nitro imidazolyl aziridino propanols
GB2131020B (en) * 1982-11-25 1986-10-01 Gerald Edward Adams Improvements relating to compounds useful in radiotherapy or chemotherapy

Also Published As

Publication number Publication date
JPH01250360A (ja) 1989-10-05
AU625314B2 (en) 1992-07-09
GB2213150A (en) 1989-08-09
AU2651088A (en) 1989-06-08
GR3018343T3 (en) 1996-03-31
DE3854645D1 (de) 1995-12-07
EP0319329A2 (en) 1989-06-07
ATE129703T1 (de) 1995-11-15
EP0319329A3 (en) 1990-03-07
GB2213150B (en) 1991-10-02
US5098921A (en) 1992-03-24
EP0319329B1 (en) 1995-11-02
GB8828196D0 (en) 1989-01-05
CA1332738C (en) 1994-10-25
DE3854645T2 (de) 1996-05-02

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