ATE129703T1 - Nitro substituierte aromatische und heteroaromatische verbindungen für krebsbehandlungen. - Google Patents
Nitro substituierte aromatische und heteroaromatische verbindungen für krebsbehandlungen.Info
- Publication number
- ATE129703T1 ATE129703T1 AT88311467T AT88311467T ATE129703T1 AT E129703 T1 ATE129703 T1 AT E129703T1 AT 88311467 T AT88311467 T AT 88311467T AT 88311467 T AT88311467 T AT 88311467T AT E129703 T1 ATE129703 T1 AT E129703T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted aromatic
- cancer treatments
- heteroaromatic compounds
- nitro substituted
- compound
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 title 1
- 150000001491 aromatic compounds Chemical class 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000002390 heteroarenes Chemical class 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000001146 hypoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878728418A GB8728418D0 (en) | 1987-12-04 | 1987-12-04 | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| GB888818348A GB8818348D0 (en) | 1987-12-04 | 1988-08-02 | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE129703T1 true ATE129703T1 (de) | 1995-11-15 |
Family
ID=26293154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88311467T ATE129703T1 (de) | 1987-12-04 | 1988-12-02 | Nitro substituierte aromatische und heteroaromatische verbindungen für krebsbehandlungen. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5098921A (de) |
| EP (1) | EP0319329B1 (de) |
| JP (1) | JPH01250360A (de) |
| AT (1) | ATE129703T1 (de) |
| AU (1) | AU625314B2 (de) |
| CA (1) | CA1332738C (de) |
| DE (1) | DE3854645T2 (de) |
| ES (1) | ES2080726T3 (de) |
| GB (1) | GB2213150B (de) |
| GR (1) | GR3018343T3 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
| US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
| US5073639A (en) * | 1988-11-25 | 1991-12-17 | Warner-Lambert Company | Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents |
| GB9113487D0 (en) * | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
| DE4134224C2 (de) * | 1991-10-16 | 2001-06-07 | Apogepha Arzneimittel Gmbh | Neue 1-Heterocyclylmethyl-3-nitro-1,2,4-triazole |
| MX9304399A (es) * | 1992-07-31 | 1994-02-28 | Warner Lambert Co | Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados. |
| GB9404400D0 (en) * | 1994-03-07 | 1994-04-20 | Wood Pauline J | Potentiation of bioreductive agents |
| JP2000247881A (ja) * | 1999-02-26 | 2000-09-12 | Tsutomu Kagitani | 免疫増強剤 |
| CN1270062A (zh) * | 1999-04-08 | 2000-10-18 | 广州山河药业股份有限公司 | 一种放射、化学治疗增效剂—甘氨双唑金属盐及其制法和用途 |
| US20060099712A1 (en) * | 2004-11-08 | 2006-05-11 | Eastman Kodak Company | Correlation of anti-cancer activity of dyes with redox potentials |
| US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
| WO2014062856A1 (en) | 2012-10-16 | 2014-04-24 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1257238A (de) * | 1968-10-31 | 1971-12-15 | ||
| GB1425293A (en) * | 1974-01-17 | 1976-02-18 | Hoffmann La Roche | Carbamate derivatives of 2-nitro-1-imidazol-alkanols-, emthods for their preparation and compositions containing them |
| IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
| DE2948884A1 (de) * | 1979-12-05 | 1981-06-11 | Basf Ag, 6700 Ludwigshafen | 2-hydroxypropylimidazole, verfahren zu ihrer herstellung und verwendung als oelloesliche korrosionsinhibitoren |
| US4581368A (en) * | 1982-05-27 | 1986-04-08 | National Research Development Corporation | Aziridino containing nitro imidazoles and pharmaceutical compositions |
| CA1227211A (en) * | 1982-05-27 | 1987-09-22 | Israr Ahmed | Nitro imidazolyl aziridino propanols |
| GB2131020B (en) * | 1982-11-25 | 1986-10-01 | Gerald Edward Adams | Improvements relating to compounds useful in radiotherapy or chemotherapy |
-
1988
- 1988-12-02 US US07/279,091 patent/US5098921A/en not_active Expired - Fee Related
- 1988-12-02 GB GB8828196A patent/GB2213150B/en not_active Expired - Fee Related
- 1988-12-02 CA CA000584851A patent/CA1332738C/en not_active Expired - Fee Related
- 1988-12-02 ES ES88311467T patent/ES2080726T3/es not_active Expired - Lifetime
- 1988-12-02 JP JP63305865A patent/JPH01250360A/ja active Pending
- 1988-12-02 DE DE3854645T patent/DE3854645T2/de not_active Expired - Fee Related
- 1988-12-02 AT AT88311467T patent/ATE129703T1/de not_active IP Right Cessation
- 1988-12-02 EP EP88311467A patent/EP0319329B1/de not_active Expired - Lifetime
- 1988-12-02 AU AU26510/88A patent/AU625314B2/en not_active Ceased
-
1995
- 1995-12-08 GR GR950403462T patent/GR3018343T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2651088A (en) | 1989-06-08 |
| GB8828196D0 (en) | 1989-01-05 |
| ES2080726T3 (es) | 1996-02-16 |
| GB2213150B (en) | 1991-10-02 |
| GB2213150A (en) | 1989-08-09 |
| EP0319329A2 (de) | 1989-06-07 |
| DE3854645D1 (de) | 1995-12-07 |
| JPH01250360A (ja) | 1989-10-05 |
| GR3018343T3 (en) | 1996-03-31 |
| US5098921A (en) | 1992-03-24 |
| DE3854645T2 (de) | 1996-05-02 |
| EP0319329B1 (de) | 1995-11-02 |
| CA1332738C (en) | 1994-10-25 |
| EP0319329A3 (en) | 1990-03-07 |
| AU625314B2 (en) | 1992-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |