JP2006522813A5 - - Google Patents
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- Publication number
- JP2006522813A5 JP2006522813A5 JP2006509755A JP2006509755A JP2006522813A5 JP 2006522813 A5 JP2006522813 A5 JP 2006522813A5 JP 2006509755 A JP2006509755 A JP 2006509755A JP 2006509755 A JP2006509755 A JP 2006509755A JP 2006522813 A5 JP2006522813 A5 JP 2006522813A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- heterocyclyl
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1=N*C(IC)=N1 Chemical compound CC1=N*C(IC)=N1 0.000 description 2
- FLCDVLNNMVKCLZ-UHFFFAOYSA-N C[IH]c1c[nH]c(I)n1 Chemical compound C[IH]c1c[nH]c(I)n1 FLCDVLNNMVKCLZ-UHFFFAOYSA-N 0.000 description 1
- NFCNEDKYXMWATM-UHFFFAOYSA-N Ic1nc(I)n[nH]1 Chemical compound Ic1nc(I)n[nH]1 NFCNEDKYXMWATM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46147103P | 2003-04-09 | 2003-04-09 | |
| US60/461,471 | 2003-04-09 | ||
| PCT/US2004/010626 WO2004091480A2 (en) | 2003-04-09 | 2004-04-08 | Tie-2 modulators and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522813A JP2006522813A (ja) | 2006-10-05 |
| JP2006522813A5 true JP2006522813A5 (enExample) | 2007-06-14 |
| JP4881725B2 JP4881725B2 (ja) | 2012-02-22 |
Family
ID=33299820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509755A Expired - Fee Related JP4881725B2 (ja) | 2003-04-09 | 2004-04-08 | Ｔｉｅ−２モジュレータと使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8178570B2 (enExample) |
| EP (1) | EP1611123B8 (enExample) |
| JP (1) | JP4881725B2 (enExample) |
| AU (1) | AU2004229392A1 (enExample) |
| CA (1) | CA2520255C (enExample) |
| WO (1) | WO2004091480A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| EP1804786A4 (en) * | 2004-09-29 | 2008-01-02 | Cytovia Inc | SUBSTITUTED N-ARYL-9-OXO-9H-FLUORENE-1-CARBOXAMIDES AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS |
| KR101318012B1 (ko) | 2004-10-20 | 2013-10-14 | 메르크 세로노 에스.에이. | 3-아릴아미노 피리딘 유도체 |
| RU2404776C2 (ru) * | 2005-01-28 | 2010-11-27 | Новартис Аг | ПРИМЕНЕНИЕ ПИРИМИДИЛАМИНОБЕНЗАМИДОВ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, ЧУВСТВИТЕЛЬНЫХ К МОДУЛЯЦИИ АКТИВНОСТИ КИНАЗЫ Тie-2 |
| KR20090005195A (ko) * | 2006-04-19 | 2009-01-12 | 라보라뚜와르 세로노 에스. 에이. | Ｍｅｋ 저해제로서 신규한 헤테로아릴-치환된 아릴아미노피리딘 유도체 |
| ES2534573T3 (es) | 2007-04-06 | 2015-04-24 | Neurocrine Biosciences, Inc. | Antagonistas del receptor de la hormona liberadora de gonadotropina y métodos relacionados con los mismos |
| US8263588B2 (en) | 2007-04-06 | 2012-09-11 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| EP2671891A3 (en) | 2008-06-27 | 2014-03-05 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| JO3078B1 (ar) | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
| JP2013147428A (ja) * | 2010-04-27 | 2013-08-01 | Dainippon Sumitomo Pharma Co Ltd | 新規２−ヘテロアリール単環ピリミジン誘導体 |
| JPWO2012153729A1 (ja) * | 2011-05-10 | 2014-07-31 | 大正製薬株式会社 | ヘテロ芳香環誘導体 |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| HK1206558A1 (en) | 2013-03-15 | 2016-01-15 | Aerpio Therapeutics Inc | Compositions, formulations and methods for treating ocular diseases |
| JP2015131783A (ja) * | 2014-01-14 | 2015-07-23 | 株式会社日本ファインケム | アリール−１，２，４−トリアゾール誘導体の製造方法 |
| US9598381B2 (en) * | 2014-07-31 | 2017-03-21 | Abbvie Inc. | SMYD2 inhibitors |
| WO2018094005A1 (en) | 2016-11-16 | 2018-05-24 | The General Hospital Corporation | Myeloperoxidase imaging agents |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020214851A1 (en) * | 2019-04-18 | 2020-10-22 | Aerpio Pharmaceuticals, Inc. | Methods of treating hypertension with activators of tie-2 |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223558A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | Tricyclic amine compounds as cdk2 inhibitors |
| TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
| CN119930610A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC598A1 (fr) | 1966-02-16 | 1967-03-21 | Mauvernay Roland Yves | Nouveaux composés chimiques et procédé pour leur préparation |
| US3647809A (en) * | 1968-04-26 | 1972-03-07 | Chinoin Gyogyszer Es Vegyeszet | Certain pyridyl-1 2 4-oxadiazole derivatives |
| US3978054A (en) | 1974-11-29 | 1976-08-31 | Merck & Co., Inc. | 1,3,5-Trisubstituted-1,2,4-triazole compounds |
| AR230994A1 (es) * | 1981-08-31 | 1984-08-31 | Pfizer | Procedimiento para preparar compuesto de 3'-substituido-5'-(2-amino-4-piridil)-1',2',4'-triazol |
| GB8829296D0 (en) | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
| JPH0813446B2 (ja) * | 1990-05-30 | 1996-02-14 | 株式会社日立製作所 | スリツプキヤステイング法 |
| JP3217846B2 (ja) * | 1992-03-04 | 2001-10-15 | クミアイ化学工業株式会社 | トリアゾール誘導体及び殺虫剤 |
| AU2002210385A1 (en) * | 2000-10-16 | 2002-04-29 | Novo-Nordisk A/S | Furazanyl-triazole derivates for the treatment of diseases |
| CA2445568A1 (en) * | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Triazole-derived kinase inhibitors and uses thereof |
| AU2002313633B2 (en) | 2001-06-08 | 2007-03-01 | Cytovia, Inc. | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs |
| US20050004186A1 (en) * | 2002-12-20 | 2005-01-06 | Pfizer Inc | MEK inhibiting compounds |
| JP2007223901A (ja) | 2004-03-24 | 2007-09-06 | Takeda Chem Ind Ltd | 複素環化合物およびその用途 |
-
2004
- 2004-04-08 JP JP2006509755A patent/JP4881725B2/ja not_active Expired - Fee Related
- 2004-04-08 EP EP04759191.2A patent/EP1611123B8/en not_active Expired - Lifetime
- 2004-04-08 CA CA2520255A patent/CA2520255C/en not_active Expired - Fee Related
- 2004-04-08 AU AU2004229392A patent/AU2004229392A1/en not_active Abandoned
- 2004-04-08 WO PCT/US2004/010626 patent/WO2004091480A2/en not_active Ceased
- 2004-04-08 US US10/552,424 patent/US8178570B2/en not_active Expired - Fee Related
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