JP2006513261A5 - - Google Patents

Download PDF

Info

Publication number
JP2006513261A5
JP2006513261A5 JP2005506687A JP2005506687A JP2006513261A5 JP 2006513261 A5 JP2006513261 A5 JP 2006513261A5 JP 2005506687 A JP2005506687 A JP 2005506687A JP 2005506687 A JP2005506687 A JP 2005506687A JP 2006513261 A5 JP2006513261 A5 JP 2006513261A5
Authority
JP
Japan
Prior art keywords
methyl
phenyl
oxo
trifluoromethyl
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2005506687A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006513261A (ja
Filing date
Publication date
Priority claimed from SE0203348A external-priority patent/SE0203348D0/xx
Priority claimed from SE0300388A external-priority patent/SE0300388D0/xx
Priority claimed from SE0302120A external-priority patent/SE0302120D0/xx
Application filed filed Critical
Priority claimed from PCT/SE2003/001739 external-priority patent/WO2004043924A1/en
Publication of JP2006513261A publication Critical patent/JP2006513261A/ja
Publication of JP2006513261A5 publication Critical patent/JP2006513261A5/ja
Pending legal-status Critical Current

Links

JP2005506687A 2002-11-12 2003-11-11 好中球エラスターゼの阻害剤としての２−ピリドン誘導体 Pending JP2006513261A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0203348A SE0203348D0 (sv) 2002-11-12 2002-11-12 Novel compounds
SE0300388A SE0300388D0 (sv) 2003-02-12 2003-02-12 Novel compounds
SE0302120A SE0302120D0 (sv) 2003-07-22 2003-07-22 Novel compounds
PCT/SE2003/001739 WO2004043924A1 (en) 2002-11-12 2003-11-11 2-pyridone derivatives as inhibitors of neutrophile elastase

Publications (2)

Publication Number Publication Date
JP2006513261A JP2006513261A (ja) 2006-04-20
JP2006513261A5 true JP2006513261A5 (enExample) 2006-12-28

Family

ID=32314809

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005506687A Pending JP2006513261A (ja) 2002-11-12 2003-11-11 好中球エラスターゼの阻害剤としての２−ピリドン誘導体

Country Status (24)

Country Link
US (1) US20060035938A1 (enExample)
EP (1) EP1562902B1 (enExample)
JP (1) JP2006513261A (enExample)
KR (1) KR20050086516A (enExample)
AR (1) AR042024A1 (enExample)
AT (1) ATE325096T1 (enExample)
AU (1) AU2003276802B2 (enExample)
BR (1) BR0316081A (enExample)
CA (1) CA2504766A1 (enExample)
CY (1) CY1106130T1 (enExample)
DE (1) DE60305061T2 (enExample)
DK (1) DK1562902T3 (enExample)
ES (1) ES2262029T3 (enExample)
IS (1) IS2478B (enExample)
MX (1) MXPA05004818A (enExample)
MY (1) MY137133A (enExample)
NO (1) NO20052818L (enExample)
NZ (1) NZ539787A (enExample)
PL (1) PL376957A1 (enExample)
PT (1) PT1562902E (enExample)
RU (1) RU2328486C2 (enExample)
SI (1) SI1562902T1 (enExample)
TW (1) TW200500341A (enExample)
WO (1) WO2004043924A1 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
SE0302487D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
TW200640881A (en) * 2005-02-15 2006-12-01 Du Pont Fungicidal pyrazine derivatives
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
GB0605469D0 (en) * 2006-03-17 2006-04-26 Argenta Discovery Ltd Multimers of heterocyclic compounds and their use
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
CA2652417A1 (en) * 2006-05-19 2008-04-24 Bayer Healthcare Ag Pyridonecarboxamide derivatives useful in treating hyper-proliferative and angiogenesis disorders
CA2652859A1 (en) * 2006-06-21 2007-12-27 E.I. Du Pont De Nemours And Company Pyrazinones as cellular proliferation inhibitors
WO2008053199A1 (en) * 2006-10-30 2008-05-08 Astrazeneca Ab Combination therapy for the treatment of respiratory diseases
WO2008107398A2 (en) * 2007-03-02 2008-09-12 Basf Se Pyrazine compounds
AU2008325288B2 (en) * 2007-11-06 2011-12-22 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
US8008327B2 (en) 2008-04-29 2011-08-30 Boehringer Ingelheim International Gmbh Indazole compounds as CCR1 receptor antagonists
CA2722811C (en) 2008-05-06 2016-07-05 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
CA2737472A1 (en) 2008-09-26 2010-04-01 Boehringer Ingelheim International Gmbh Azaindazole compounds as ccr1 receptor antagonists
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
CA2773618A1 (en) * 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
WO2011049917A1 (en) 2009-10-21 2011-04-28 Boehringer Ingelheim International Gmbh Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
US9051296B2 (en) 2009-11-16 2015-06-09 Raqualia Pharma Inc. Aryl carboxamide derivatives as TTX-S blockers
AU2010328480A1 (en) * 2009-12-08 2012-05-17 Boehringer Ingelheim International Gmbh Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
TWI549943B (zh) * 2011-03-09 2016-09-21 杜邦股份有限公司 除草之含側氧與磺酸基(sulfono)雙氮雜環
AU2012291041A1 (en) 2011-08-01 2014-03-13 Sumitomo Dainippon Pharma Co., Ltd. Uracil derivative and use thereof for medical purposes
EP2562174A1 (de) * 2011-08-24 2013-02-27 Bayer Cropscience AG Herbizid wirksame 6-Oxo-1,6-dihydropyrimidin-5-carboxamide und 2-Oxo-1,2-dihydropyridin-3-carboxamide
US9206128B2 (en) 2011-11-18 2015-12-08 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
EP2780013A4 (en) 2011-11-18 2015-07-01 Constellation Pharmaceuticals Inc MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
EP2812001B1 (en) 2012-02-10 2017-06-14 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US20140057920A1 (en) * 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
JP5799117B2 (ja) * 2013-02-05 2015-10-21 大日本住友製薬株式会社 ウラシル誘導体からなる医薬
EP2970305B1 (en) 2013-03-15 2017-02-22 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
EP3033334A1 (en) 2013-08-15 2016-06-22 Constellation Pharmaceuticals, Inc. Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
US9221807B2 (en) * 2014-02-21 2015-12-29 Boehringer Ingelheim International Gmbh Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity
PT3174852T (pt) * 2014-07-30 2018-10-23 Abac Therapeutics S L Aril-hidrazidas contendo uma unidade 2-piridona como agentes antibacterianos seletivos
WO2017040190A1 (en) 2015-08-28 2017-03-09 Constellation Pharmaceuticals, Inc. Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide
EP3529242A1 (en) 2016-10-19 2019-08-28 Constellation Pharmaceuticals, Inc. Synthesis of inhibitors of ezh2
US11130740B2 (en) 2017-04-25 2021-09-28 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1H-indene analogs and methods using same
US11472774B2 (en) * 2018-02-01 2022-10-18 The University Of Sydney Anti-cancer compounds
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
US12083118B2 (en) 2018-03-29 2024-09-10 Arbutus Biopharma Corporation Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same
CA3154761A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
SI4106757T1 (sl) 2020-04-16 2023-11-30 Mereo Biopharma 4 Limited Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1
WO2023067103A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US541960A (en) * 1895-07-02 Nose-piece for eyeglasses
DE2706977A1 (de) * 1977-02-18 1978-08-24 Hoechst Ag Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung
US4816658A (en) * 1983-01-10 1989-03-28 Casi-Rusco, Inc. Card reader for security system
US5420297A (en) * 1990-10-24 1995-05-30 Fujisawa Pharmaceutical Co., Ltd. Peptides having substance P antagonistic activity
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
PT1142887E (pt) * 1993-11-19 2004-08-31 Parke Davis & Co Derivados de 5,6-di-hidropirona como inibidores de protease e agentes antivirais
CA2421499A1 (en) * 2000-09-08 2003-03-06 Ono Pharmaceutical Co., Ltd. Novel crystals of 1,3,4-oxadiazole derivative, process for producing the same and pharmaceutical agent containing the same as active ingredient
TWI287004B (en) * 2000-12-28 2007-09-21 Shionogi & Co A pyridone derivative having an affinity effect for cannabinoid 2 type receptor
GB0129260D0 (en) * 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
AU2002348856A1 (en) * 2001-12-21 2003-07-09 Milton Lawrence Weinbren Gas scrubber
SE0302324D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302323D0 (sv) * 2003-08-28 2003-08-28 Astrazeneca Ab Novel compounds
SE0302487D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds

Similar Documents

Publication Publication Date Title
JP2006513261A5 (enExample)
US6924302B2 (en) Substituted triazole diamine derivatives as kinase inhibitors
KR100659007B1 (ko) 아미드 화합물 및 그 의약으로서의 용도
RU2497822C2 (ru) Селективные к bcl-2 агенты, вызывающие апоптоз, для лечения рака и иммунных заболеваний
JP4693787B2 (ja) Ｃｂ１拮抗活性を有する１，３，５−三置換４，５−ジヒドロ−１ｈ−ピラゾール誘導体
TWI415845B (zh) 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
JP2014511869A5 (enExample)
JP2006514942A5 (enExample)
JP2005526723A5 (enExample)
JP2004504301A5 (enExample)
RU2009103313A (ru) Индолы в качестве модуляторов 5-нт6
JP2007519754A5 (enExample)
FI3743406T3 (fi) Tmem16a-modulaattoreita
JP2008517926A5 (enExample)
CA2476343A1 (en) 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
JP2011148803A (ja) 置換ピラゾール
JP2006513261A (ja) 好中球エラスターゼの阻害剤としての２−ピリドン誘導体
JP2005533803A5 (enExample)
RU2011127232A (ru) Апоптоз-индуцирующие средства для лечения рака и иммунных и аутоиммунных заболеваний
JP2005523901A (ja) Ｎｐｙアンタゴニストとしてのキノリン誘導体
JP2008500336A5 (enExample)
JP2011153144A (ja) 置換ピラゾール化合物
SK284675B6 (sk) Derivát acylpiperazinylpyrimidínu, spôsob jeho prípravy a farmaceutická kompozícia na jeho báze
KR100714585B1 (ko) 약학적인 활성 피롤리딘 유도체
JPH0662565B2 (ja) Ｎ―複素環―ｎ―（４―ピペリジル）アミド及び該化合物を含む薬剤組成物