ES2256340T3 - Activadores heteroaromaticos fusionados de la glucoquinasa. - Google Patents

Activadores heteroaromaticos fusionados de la glucoquinasa.

Info

Publication number
ES2256340T3
ES2256340T3 ES01999565T ES01999565T ES2256340T3 ES 2256340 T3 ES2256340 T3 ES 2256340T3 ES 01999565 T ES01999565 T ES 01999565T ES 01999565 T ES01999565 T ES 01999565T ES 2256340 T3 ES2256340 T3 ES 2256340T3
Authority
ES
Spain
Prior art keywords
cyclopentyl
phenyl
propionamide
methanesulfonyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01999565T
Other languages
English (en)
Spanish (es)
Inventor
Wendy Lea Corbett
Joseph Samuel Grimbsy
Nancy-Ellen Haynes
Robert Francis Kester
Paige Erin Mahaney
Ramakanth Sarabu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2256340T3 publication Critical patent/ES2256340T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ES01999565T 2000-12-06 2001-11-28 Activadores heteroaromaticos fusionados de la glucoquinasa. Expired - Lifetime ES2256340T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25163700P 2000-12-06 2000-12-06
US251637P 2000-12-06

Publications (1)

Publication Number Publication Date
ES2256340T3 true ES2256340T3 (es) 2006-07-16

Family

ID=22952803

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01999565T Expired - Lifetime ES2256340T3 (es) 2000-12-06 2001-11-28 Activadores heteroaromaticos fusionados de la glucoquinasa.

Country Status (21)

Country Link
US (3) US6441184B1 (enExample)
EP (1) EP1341774B1 (enExample)
JP (1) JP4109111B2 (enExample)
KR (1) KR100545431B1 (enExample)
CN (1) CN1226294C (enExample)
AR (1) AR031627A1 (enExample)
AT (1) ATE316965T1 (enExample)
AU (2) AU2002221902B2 (enExample)
BR (1) BR0115999A (enExample)
CA (1) CA2429642C (enExample)
DE (1) DE60117059T2 (enExample)
DK (1) DK1341774T3 (enExample)
ES (1) ES2256340T3 (enExample)
GT (1) GT200100243A (enExample)
MX (1) MXPA03005119A (enExample)
PA (1) PA8534301A1 (enExample)
PE (1) PE20020753A1 (enExample)
PT (1) PT1341774E (enExample)
UY (1) UY27055A1 (enExample)
WO (1) WO2002046173A1 (enExample)
ZA (1) ZA200303748B (enExample)

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ES2293005T3 (es) 2002-10-03 2008-03-16 F. Hoffmann-La Roche Ag Indol-3-carboxamidas como activadores de la glucocinasa.
GB0226931D0 (en) * 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
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BRPI0411699A (pt) * 2003-06-20 2006-08-29 Hoffmannn La Roche Ag F compostos para uso como substáncia terapeuticamente ativa; método para o tratamento e/ou profilaxia de doenças que estão associadas à modulação de receptores cb1 e uso destes compostos
BRPI0506662B8 (pt) 2004-01-06 2021-05-25 Novo Nordisk As compostos ativadores de glucoquinase
EP2048137A1 (en) * 2004-02-18 2009-04-15 AstraZeneca AB Benzamide derivatives and their use as glucokinase activating agents.
JP2007523905A (ja) * 2004-02-18 2007-08-23 アストラゼネカ アクチボラグ 化合物
PT1735322E (pt) * 2004-04-02 2012-01-12 Novartis Ag Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2
US7781451B2 (en) * 2004-04-02 2010-08-24 Novartis Ag Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
EA012204B1 (ru) * 2004-04-21 2009-08-28 Прозидион Лимитед Три(цикло)замещённые амидные соединения
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
MX2007001650A (es) 2004-08-12 2007-07-13 Prosidion Ltd Fenilacetamidas substituidas y su uso como activadores de glucocinasa.
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GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
GB0423044D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
BRPI0517232A (pt) 2004-11-02 2008-10-07 Banyu Pharma Co Ltd composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, ativador da glicocinase, e, agentes terapêuticos e/ou profiláticos para diabetes e para obesidade
DE102005012872A1 (de) * 2005-03-19 2006-09-28 Sanofi-Aventis Deutschland Gmbh Substituierte, bizyklische 8-Pyrrolidino-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP1891069A1 (en) * 2005-05-24 2008-02-27 AstraZeneca AB 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
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AT503354B1 (de) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen
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Also Published As

Publication number Publication date
US20020107396A1 (en) 2002-08-08
EP1341774A1 (en) 2003-09-10
CA2429642A1 (en) 2002-06-13
JP4109111B2 (ja) 2008-07-02
PE20020753A1 (es) 2002-08-27
ZA200303748B (en) 2004-08-16
KR20030068555A (ko) 2003-08-21
KR100545431B1 (ko) 2006-01-24
US6545155B2 (en) 2003-04-08
ATE316965T1 (de) 2006-02-15
DK1341774T3 (da) 2006-06-12
CN1476438A (zh) 2004-02-18
AR031627A1 (es) 2003-09-24
US20020103241A1 (en) 2002-08-01
PA8534301A1 (es) 2002-08-26
CA2429642C (en) 2007-11-20
DE60117059T2 (de) 2006-10-26
US6441184B1 (en) 2002-08-27
JP2004517087A (ja) 2004-06-10
CN1226294C (zh) 2005-11-09
BR0115999A (pt) 2003-09-30
DE60117059D1 (de) 2006-04-13
UY27055A1 (es) 2002-07-31
US20020103199A1 (en) 2002-08-01
EP1341774B1 (en) 2006-02-01
MXPA03005119A (es) 2004-10-15
AU2190202A (en) 2002-06-18
AU2002221902B2 (en) 2006-11-23
WO2002046173A1 (en) 2002-06-13
US6448399B1 (en) 2002-09-10
GT200100243A (es) 2002-06-04
PT1341774E (pt) 2006-05-31

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