JP2010500345A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010500345A5 JP2010500345A5 JP2009523746A JP2009523746A JP2010500345A5 JP 2010500345 A5 JP2010500345 A5 JP 2010500345A5 JP 2009523746 A JP2009523746 A JP 2009523746A JP 2009523746 A JP2009523746 A JP 2009523746A JP 2010500345 A5 JP2010500345 A5 JP 2010500345A5
- Authority
- JP
- Japan
- Prior art keywords
- cyano
- acetamide
- ethyl
- benzimidazol
- methylethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 30
- -1 6-Chloro-7-fluoro-1H-benzimidazol-1-yl Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 17
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000001721 carbon Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 239000000460 chlorine Substances 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 3
- JSHORUKCXVFCSI-UHFFFAOYSA-N 2-(7-chloro-6-fluorobenzimidazol-1-yl)-n-[1-[4-(2-cyanopropan-2-yl)-3-methylphenyl]ethyl]acetamide Chemical compound C1=NC2=CC=C(F)C(Cl)=C2N1CC(=O)NC(C)C1=CC=C(C(C)(C)C#N)C(C)=C1 JSHORUKCXVFCSI-UHFFFAOYSA-N 0.000 claims 2
- UWSVWIRICXORPH-UHFFFAOYSA-N N-(6,7-difluorobenzimidazol-1-yl)acetamide Chemical compound C(C)(=O)NN1C=NC2=C1C(=C(C=C2)F)F UWSVWIRICXORPH-UHFFFAOYSA-N 0.000 claims 2
- 208000001294 Nociceptive Pain Diseases 0.000 claims 2
- 208000000491 Tendinopathy Diseases 0.000 claims 2
- 206010043255 Tendonitis Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 201000004415 tendinitis Diseases 0.000 claims 2
- FMNGJTZLSAZEMM-UHFFFAOYSA-N 2-(7-chloro-6-fluorobenzimidazol-1-yl)-n-[1-[4-(2-cyanopropan-2-yl)-3-fluorophenyl]ethyl]acetamide Chemical compound C1=NC2=CC=C(F)C(Cl)=C2N1CC(=O)NC(C)C1=CC=C(C(C)(C)C#N)C(F)=C1 FMNGJTZLSAZEMM-UHFFFAOYSA-N 0.000 claims 1
- JQEQXMUAJAWHFH-UHFFFAOYSA-N 2-(7-chlorobenzimidazol-1-yl)-n-[[4-(2-cyanopropan-2-yl)-3-fluorophenyl]methyl]acetamide Chemical compound C1=C(F)C(C(C)(C#N)C)=CC=C1CNC(=O)CN1C2=C(Cl)C=CC=C2N=C1 JQEQXMUAJAWHFH-UHFFFAOYSA-N 0.000 claims 1
- YAOGGQLFLBUIHI-HNNXBMFYSA-N 2-(7-cyanobenzimidazol-1-yl)-n-[(1s)-1-[4-(2-cyanopropan-2-yl)phenyl]ethyl]acetamide Chemical compound C1([C@@H](NC(=O)CN2C3=C(C#N)C=CC=C3N=C2)C)=CC=C(C(C)(C)C#N)C=C1 YAOGGQLFLBUIHI-HNNXBMFYSA-N 0.000 claims 1
- SKZQTBUGGJLXBA-UHFFFAOYSA-N 2-(7-cyanobenzimidazol-1-yl)-n-[1-[4-(2-cyanopropan-2-yl)-3-methylphenyl]ethyl]acetamide Chemical compound C1=NC2=CC=CC(C#N)=C2N1CC(=O)NC(C)C1=CC=C(C(C)(C)C#N)C(C)=C1 SKZQTBUGGJLXBA-UHFFFAOYSA-N 0.000 claims 1
- AQOZKGMSGBTFDO-UHFFFAOYSA-N 2-(7-cyanobenzimidazol-1-yl)-n-[[4-(2-cyanopropan-2-yl)-2-methylphenyl]methyl]acetamide Chemical compound CC1=CC(C(C)(C)C#N)=CC=C1CNC(=O)CN1C2=C(C#N)C=CC=C2N=C1 AQOZKGMSGBTFDO-UHFFFAOYSA-N 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- OOWYEILSUQLNPO-UHFFFAOYSA-N n-[1-[3-chloro-4-(2-cyanopropan-2-yl)phenyl]ethyl]-2-(6,7-difluorobenzimidazol-1-yl)acetamide Chemical compound C1=NC2=CC=C(F)C(F)=C2N1CC(=O)NC(C)C1=CC=C(C(C)(C)C#N)C(Cl)=C1 OOWYEILSUQLNPO-UHFFFAOYSA-N 0.000 claims 1
- ITQDJAWGKNGDPH-UHFFFAOYSA-N n-[1-[3-chloro-4-(2-cyanopropan-2-yl)phenyl]ethyl]-2-(7-cyanobenzimidazol-1-yl)acetamide Chemical compound C1=NC2=CC=CC(C#N)=C2N1CC(=O)NC(C)C1=CC=C(C(C)(C)C#N)C(Cl)=C1 ITQDJAWGKNGDPH-UHFFFAOYSA-N 0.000 claims 1
- AAHBXZFWPVEASC-UHFFFAOYSA-N n-[1-[4-(2-cyanopropan-2-yl)-2-methylphenyl]ethyl]-2-(7-fluorobenzimidazol-1-yl)acetamide Chemical compound C1=NC2=CC=CC(F)=C2N1CC(=O)NC(C)C1=CC=C(C(C)(C)C#N)C=C1C AAHBXZFWPVEASC-UHFFFAOYSA-N 0.000 claims 1
- WPCWWLZADISOFB-UHFFFAOYSA-N n-[1-[4-(3-cyanopentan-3-yl)phenyl]ethyl]-2-(6,7-difluorobenzimidazol-1-yl)acetamide Chemical compound C1=CC(C(CC)(C#N)CC)=CC=C1C(C)NC(=O)CN1C2=C(F)C(F)=CC=C2N=C1 WPCWWLZADISOFB-UHFFFAOYSA-N 0.000 claims 1
- GBACDVPSPPFDPL-UHFFFAOYSA-N n-[[4-(2-cyanopropan-2-yl)-2-methylphenyl]methyl]-2-(6,7-difluorobenzimidazol-1-yl)acetamide Chemical compound CC1=CC(C(C)(C)C#N)=CC=C1CNC(=O)CN1C2=C(F)C(F)=CC=C2N=C1 GBACDVPSPPFDPL-UHFFFAOYSA-N 0.000 claims 1
- FMKHQUDXZYJALB-UHFFFAOYSA-N n-[[4-(2-cyanopropan-2-yl)phenyl]methyl]-2-(6,7-difluorobenzimidazol-1-yl)acetamide Chemical compound C1=CC(C(C)(C#N)C)=CC=C1CNC(=O)CN1C2=C(F)C(F)=CC=C2N=C1 FMKHQUDXZYJALB-UHFFFAOYSA-N 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000020629 overactive bladder Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83724906P | 2006-08-11 | 2006-08-11 | |
| US60/837,249 | 2006-08-11 | ||
| PCT/SE2007/000720 WO2008018827A1 (en) | 2006-08-11 | 2007-08-10 | Benzimidazole derivatives useful in treatment of vallinoid receptor trpv1 related disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500345A JP2010500345A (ja) | 2010-01-07 |
| JP2010500345A5 true JP2010500345A5 (enExample) | 2010-09-24 |
| JP5140077B2 JP5140077B2 (ja) | 2013-02-06 |
Family
ID=39033277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523746A Expired - Fee Related JP5140077B2 (ja) | 2006-08-11 | 2007-08-10 | バニロイド受容体ＴＲＰＶｌ関連障害の処置において有用なベンゾイミダゾール誘導体 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7906654B2 (enExample) |
| EP (1) | EP2051967B1 (enExample) |
| JP (1) | JP5140077B2 (enExample) |
| KR (1) | KR101412881B1 (enExample) |
| CN (2) | CN101522637A (enExample) |
| AR (1) | AR062299A1 (enExample) |
| AU (1) | AU2007282186B2 (enExample) |
| BR (1) | BRPI0715746B8 (enExample) |
| CA (1) | CA2660529C (enExample) |
| CL (1) | CL2007002343A1 (enExample) |
| CO (1) | CO6150176A2 (enExample) |
| ES (1) | ES2533971T3 (enExample) |
| IL (1) | IL196672A0 (enExample) |
| MX (1) | MX2009001496A (enExample) |
| MY (1) | MY147649A (enExample) |
| NO (1) | NO20091054L (enExample) |
| NZ (1) | NZ575416A (enExample) |
| PE (1) | PE20081315A1 (enExample) |
| RU (1) | RU2458055C2 (enExample) |
| SG (1) | SG173360A1 (enExample) |
| TW (1) | TWI433839B (enExample) |
| UA (1) | UA96764C2 (enExample) |
| UY (1) | UY30533A1 (enExample) |
| WO (1) | WO2008018827A1 (enExample) |
| ZA (1) | ZA200900961B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| UY30048A1 (es) | 2005-12-23 | 2007-07-31 | Astrazeneca Ab | Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
| TWI433839B (zh) * | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2264031B1 (en) | 2008-04-18 | 2015-04-15 | Daewoong Pharmaceutical Co., Ltd. | A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof |
| KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| CN104640857B (zh) | 2012-07-18 | 2017-07-04 | 圣路易斯大学 | 作为整合素拮抗剂的β氨基酸衍生物 |
| US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
| JO3719B1 (ar) | 2014-11-20 | 2021-01-31 | Takeda Pharmaceuticals Co | 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139 |
| KR102546020B1 (ko) | 2014-12-08 | 2023-06-20 | 롬 앤드 하아스 컴패니 | 폴리올레핀 첨가제, 처짐 저항성 폴리올레핀 및 이를 제조하는 방법 |
| JP2018052817A (ja) * | 2015-01-21 | 2018-04-05 | 大日本住友製薬株式会社 | 新規ベンズイミダゾール誘導体およびその医薬用途 |
| KR20180107121A (ko) | 2015-12-30 | 2018-10-01 | 세인트 루이스 유니버시티 | 팬 인테그린 길항제로서의 메타-아자사이클릭 아미노 벤조산 유도체 |
| EP3908574A4 (en) * | 2019-01-08 | 2022-10-26 | Neomed Institute | CRYSTALLINE FORMS OF (S)-2-(7-CYANO-1H-BENZIMIDAZOL-1YL)-N-{1-[4-(1-CYANO-1-METHYLETHYL)PHENYL]ETHYL}ACETAMIDE |
| US12370192B2 (en) | 2019-09-16 | 2025-07-29 | Takeda Pharmaceutical Company Limited | Azole-fused pyridazin-3(2H)-one derivatives |
| RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
| CN117623972A (zh) * | 2022-08-17 | 2024-03-01 | 上海慧聚药业有限公司 | 非离子型造影剂中间体的合成 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1186504A (en) | 1966-10-15 | 1970-04-02 | Fisons Pest Control Ltd | Substituted Heterocyclic Compounds |
| IT1036004B (it) * | 1968-05-21 | 1979-10-30 | Abc Ist Biolog Chem Spa | Acidt 3 indolil adetoidrossamici |
| BE793718A (fr) | 1972-01-07 | 1973-07-05 | Merck & Co Inc | Aminobenzimidazoles |
| DE3347290A1 (de) | 1983-12-28 | 1985-07-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| US4738981A (en) * | 1984-11-13 | 1988-04-19 | Warner-Lambert | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| JP2639000B2 (ja) | 1988-09-30 | 1997-08-06 | スズキ株式会社 | 酸素富化エンジンの酸素富化空気制御装置 |
| JPH0295767A (ja) | 1988-09-30 | 1990-04-06 | Showa Alum Corp | 吸気マニホルド |
| JPH06759B2 (ja) | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| DE4309969A1 (de) | 1993-03-26 | 1994-09-29 | Bayer Ag | Substituierte heteroanellierte Imidazole |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| IL124969A (en) | 1995-12-28 | 2002-09-12 | Fujisawa Pharmaceutical Co | History of benzimidazole, processes for their preparation and pharmaceutical preparations containing them |
| GB9713484D0 (en) | 1997-06-27 | 1997-09-03 | Smithkline Beecham Plc | Neuroprotective vanilloid compounds |
| JP2000095767A (ja) | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | 性腺刺激ホルモン放出ホルモン拮抗剤 |
| BR0013143A (pt) | 1999-08-12 | 2002-06-11 | Pharmacia Italia Spa | Derivados de 3 (5) amino pirazol, processo para sua preparação e uso dos mesmos como agentes antitumorais |
| US6534651B2 (en) * | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
| HK1050008A1 (zh) | 2000-05-05 | 2003-06-06 | Portola Pharmaceuticals, Inc. | 杂双环磺胺剂及以其作为血小板腺苷二磷酸(adp)受体抑制剂 |
| US6943174B2 (en) | 2000-06-14 | 2005-09-13 | Warner-Lambert Company | 6,5-Fused bicyclic heterocycles |
| US6448281B1 (en) * | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| CA2420042A1 (en) | 2000-08-22 | 2003-02-18 | Mikio Ogawa | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient |
| GB0031315D0 (en) * | 2000-12-21 | 2001-02-07 | Glaxo Group Ltd | Indole derivatives |
| ITTO20010110A1 (it) | 2001-02-08 | 2002-08-08 | Rotta Research Lab | Nuovi derivati benzamidinici dotati di attivita' anti-infiammatoria ed immunosoppressiva. |
| GB0105895D0 (en) | 2001-03-09 | 2001-04-25 | Smithkline Beecham Plc | Novel compounds |
| SE0101387D0 (sv) | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
| GB0110901D0 (en) | 2001-05-02 | 2001-06-27 | Smithkline Beecham Plc | Novel Compounds |
| US7144883B2 (en) | 2001-06-11 | 2006-12-05 | Biovitrum Ab | Bicyclic sulfonamide compounds |
| TWI239942B (en) | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
| WO2003014064A1 (en) | 2001-07-31 | 2003-02-20 | Bayer Healthcare Ag | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
| JP4059473B2 (ja) * | 2001-08-09 | 2008-03-12 | 株式会社ルネサステクノロジ | メモリカード及びメモリコントローラ |
| PE20030417A1 (es) | 2001-09-13 | 2003-08-06 | Smithkline Beecham Plc | Derivados de urea como antagonistas del receptor vainilloide |
| TWI231757B (en) | 2001-09-21 | 2005-05-01 | Solvay Pharm Bv | 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
| EP1463714A4 (en) | 2001-12-10 | 2005-10-19 | Amgen Inc | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS |
| GB0130550D0 (en) | 2001-12-20 | 2002-02-06 | Smithkline Beecham Plc | Novel compounds |
| JP2005526723A (ja) | 2002-02-15 | 2005-09-08 | グラクソ グループ リミテッド | バニロイド受容体モジュレーター |
| US20030158188A1 (en) * | 2002-02-20 | 2003-08-21 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| CN1662521A (zh) | 2002-06-20 | 2005-08-31 | 比奥维特罗姆股份公司 | 可用于治疗肥胖、ii型糖尿病和cns障碍的新化合物 |
| FR2842069B1 (fr) * | 2002-07-12 | 2004-09-10 | Pellenc Sa | Effeuilleuse, plus specialement destinee a l'effeuillage selectif de la vigne |
| GB0221157D0 (en) | 2002-09-12 | 2002-10-23 | Glaxo Group Ltd | Novel treatment |
| AU2003270199A1 (en) | 2002-09-13 | 2004-04-30 | Glaxo Group Limited | Urea compounds active as vanilloid receptor antagonists for the treatment of pain |
| US7582761B2 (en) * | 2002-10-17 | 2009-09-01 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| SE0301446D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| SE0301701D0 (sv) | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| OA13248A (en) | 2003-09-03 | 2007-01-31 | Pfizer | Benzimidazolone coumpounds having 5-HT4 receptor agonistic activity. |
| WO2005095327A1 (ja) | 2004-03-31 | 2005-10-13 | Ajinomoto Co., Inc. | アニリン誘導体 |
| SE0402284D0 (sv) * | 2004-09-21 | 2004-09-21 | Astrazeneca Ab | New heterocyclic amides |
| UY30048A1 (es) * | 2005-12-23 | 2007-07-31 | Astrazeneca Ab | Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
| TWI433839B (zh) * | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
-
2007
- 2007-08-07 TW TW096129068A patent/TWI433839B/zh not_active IP Right Cessation
- 2007-08-09 AR ARP070103520A patent/AR062299A1/es not_active Application Discontinuation
- 2007-08-09 US US11/836,221 patent/US7906654B2/en active Active
- 2007-08-10 PE PE2007001076A patent/PE20081315A1/es not_active Application Discontinuation
- 2007-08-10 KR KR1020097002681A patent/KR101412881B1/ko not_active Expired - Fee Related
- 2007-08-10 AU AU2007282186A patent/AU2007282186B2/en not_active Ceased
- 2007-08-10 RU RU2009103675/04A patent/RU2458055C2/ru active
- 2007-08-10 WO PCT/SE2007/000720 patent/WO2008018827A1/en not_active Ceased
- 2007-08-10 NZ NZ575416A patent/NZ575416A/en not_active IP Right Cessation
- 2007-08-10 CN CNA2007800380988A patent/CN101522637A/zh active Pending
- 2007-08-10 ES ES07794109.4T patent/ES2533971T3/es active Active
- 2007-08-10 CL CL200702343A patent/CL2007002343A1/es unknown
- 2007-08-10 CA CA2660529A patent/CA2660529C/en active Active
- 2007-08-10 CN CN201010003679A patent/CN101792436A/zh active Pending
- 2007-08-10 SG SG2011049962A patent/SG173360A1/en unknown
- 2007-08-10 JP JP2009523746A patent/JP5140077B2/ja not_active Expired - Fee Related
- 2007-08-10 BR BRPI0715746A patent/BRPI0715746B8/pt not_active IP Right Cessation
- 2007-08-10 UA UAA200900383A patent/UA96764C2/ru unknown
- 2007-08-10 MX MX2009001496A patent/MX2009001496A/es active IP Right Grant
- 2007-08-10 UY UY30533A patent/UY30533A1/es not_active Application Discontinuation
- 2007-08-10 MY MYPI20090512A patent/MY147649A/en unknown
- 2007-08-10 EP EP07794109.4A patent/EP2051967B1/en active Active
-
2009
- 2009-01-22 IL IL196672A patent/IL196672A0/en unknown
- 2009-01-29 CO CO09008297A patent/CO6150176A2/es unknown
- 2009-02-10 ZA ZA200900961A patent/ZA200900961B/xx unknown
- 2009-03-09 NO NO20091054A patent/NO20091054L/no not_active Application Discontinuation
-
2011
- 2011-02-08 US US13/023,112 patent/US8093402B2/en not_active Expired - Fee Related