JP2009525956A5 - - Google Patents
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- Publication number
- JP2009525956A5 JP2009525956A5 JP2008550608A JP2008550608A JP2009525956A5 JP 2009525956 A5 JP2009525956 A5 JP 2009525956A5 JP 2008550608 A JP2008550608 A JP 2008550608A JP 2008550608 A JP2008550608 A JP 2008550608A JP 2009525956 A5 JP2009525956 A5 JP 2009525956A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- chloro
- phenylamino
- quinazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610023526.7 | 2006-01-20 | ||
| CNA2006100235267A CN101003514A (zh) | 2006-01-20 | 2006-01-20 | 喹唑啉衍生物、其制备方法及用途 |
| PCT/CN2006/002786 WO2007082434A1 (en) | 2006-01-20 | 2006-10-20 | Quinazoline derivatives,preparation methods and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012173258A Division JP2012214502A (ja) | 2006-01-20 | 2012-08-03 | キナゾリン誘導体、その調製法および使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525956A JP2009525956A (ja) | 2009-07-16 |
| JP2009525956A5 true JP2009525956A5 (enExample) | 2012-02-23 |
| JP5478894B2 JP5478894B2 (ja) | 2014-04-23 |
Family
ID=38287245
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550608A Active JP5478894B2 (ja) | 2006-01-20 | 2006-10-20 | キナゾリン誘導体、その調製法および使用法 |
| JP2012173258A Withdrawn JP2012214502A (ja) | 2006-01-20 | 2012-08-03 | キナゾリン誘導体、その調製法および使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012173258A Withdrawn JP2012214502A (ja) | 2006-01-20 | 2012-08-03 | キナゾリン誘導体、その調製法および使用法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8044063B2 (enExample) |
| EP (2) | EP1990337B1 (enExample) |
| JP (2) | JP5478894B2 (enExample) |
| CN (2) | CN101003514A (enExample) |
| WO (1) | WO2007082434A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
| CN101245050A (zh) | 2007-02-14 | 2008-08-20 | 上海艾力斯医药科技有限公司 | 4-苯胺喹唑啉衍生物的盐 |
| UY31137A1 (es) * | 2007-06-14 | 2009-01-05 | Smithkline Beecham Corp | Derivados de quinazolina como inhibidores de la pi3 quinasa |
| CN101347433B (zh) * | 2007-07-20 | 2012-05-02 | 江苏艾力斯生物医药有限公司 | 4-苯胺喹唑啉衍生物的制药用途 |
| CN101357905B (zh) * | 2007-08-01 | 2012-06-20 | 江苏艾力斯生物医药有限公司 | 4-[3-氯-4-(3-氟-苄氧基)-苯胺基]-6-取代胺基-喹唑啉衍生物的制备方法 |
| AU2013231084B2 (en) * | 2008-03-25 | 2015-06-18 | Shanghai Allist Pharmaceuticals Co., Ltd. | The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof |
| CN101544609A (zh) * | 2008-03-25 | 2009-09-30 | 上海艾力斯医药科技有限公司 | 4-苯胺喹唑啉衍生物的结晶形式 |
| CN101584696A (zh) | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| AU2010221818A1 (en) | 2009-03-11 | 2011-10-06 | Auckland Uniservices Limited | Prodrug forms of kinase inhibitors and their use in therapy |
| CN101899011B (zh) * | 2009-05-26 | 2013-01-16 | 北京大学 | 氨基二硫代甲酸酯类化合物、其制备方法和应用 |
| RU2568639C2 (ru) * | 2009-09-02 | 2015-11-20 | Окленд Юнисервисиз Лимитед | Ингибиторы киназы, их пролекарственные формы и их применение в терапии |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| CN102153544B (zh) * | 2010-02-12 | 2015-04-29 | 上海阳帆医药科技有限公司 | 一类酪氨酸激酶抑制剂的制备及用途 |
| CN101857617A (zh) * | 2010-04-28 | 2010-10-13 | 中国海洋大学 | 喹唑啉类糖衍生物及其制备方法和应用 |
| CN101857618B (zh) * | 2010-06-13 | 2015-11-25 | 中国海洋大学 | 作为蛋白酪氨酸激酶抑制剂的一系列喹唑啉糖衍生物，其制备方法和应用 |
| JP6437820B2 (ja) | 2011-07-27 | 2018-12-12 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | キナゾリン誘導体、その製造方法、中間体、組成物及びその適用 |
| CN103304572A (zh) * | 2012-03-09 | 2013-09-18 | 上海医药集团股份有限公司 | 一类3-氰基喹啉类化合物及其药用组合物和应用 |
| CN102659764A (zh) * | 2012-04-16 | 2012-09-12 | 中国科学院广州生物医药与健康研究院 | 酪氨酸激酶不可逆抑制剂及其制备方法和用途 |
| CN102702116B (zh) * | 2012-06-13 | 2014-12-31 | 华南理工大学 | 4-(3-氯-4-甲氧基苯胺基)-6-(3-胺基苯基)喹唑啉类化合物或其药学上可接受的盐和制备方法与应用 |
| CN102924387B (zh) * | 2012-06-13 | 2015-07-01 | 黄唯燕 | 4-(3-氯-4-甲氧基苯胺基)-6-(3,4-取代苯基)喹唑啉及盐和制法与应用 |
| CN104119350B (zh) | 2013-04-28 | 2017-04-12 | 广东东阳光药业有限公司 | 氨基喹唑啉类衍生物及其盐和使用方法 |
| CN104513229A (zh) | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| WO2016100347A2 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of Michigan | Small molecule inhibitors of egfr and pi3k |
| RU2720810C2 (ru) | 2015-03-20 | 2020-05-13 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | Соли производного хиназолина и способ их получения |
| CN105384745A (zh) * | 2015-07-27 | 2016-03-09 | 北京师范大学 | 冠醚环状的喹唑啉类化合物及其制备方法和在制备肿瘤治疗与显像药物中的应用 |
| WO2018090973A1 (zh) * | 2016-11-17 | 2018-05-24 | 广东众生药业股份有限公司 | Fgfr4抑制剂及其制备方法和应用 |
| CA3188077A1 (en) * | 2020-08-10 | 2022-02-17 | Fei Yang | Egfr inhibitor, preparation method therefor and application thereof |
| IL303965A (en) | 2020-12-22 | 2023-08-01 | Mekanistic Therapeutics Llc | Transmuted heteroaryl aminobenzyl compounds as EGFR and/or PI3K inhibitors |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| TW321649B (enExample) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| DE69522717T2 (de) * | 1995-03-30 | 2002-02-14 | Pfizer Inc., New York | Chinazolinderivate |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| HU228446B1 (en) * | 1996-04-12 | 2013-03-28 | Warner Lambert Co | Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800575D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| ATE309225T1 (de) | 1998-07-30 | 2005-11-15 | Wyeth Corp | Substituierte chinazoline derivate |
| JP2003504363A (ja) * | 1999-07-09 | 2003-02-04 | グラクソ グループ リミテッド | プロテインチロシンキナーゼ阻害剤としてのアニリノキナゾリン類 |
| CZ20021010A3 (cs) * | 1999-09-21 | 2002-06-12 | Astrazeneca Ab | Nové sloučeniny chinazolinu a farmaceutické kompozice, které je obsahují |
| CN1391562A (zh) | 1999-09-21 | 2003-01-15 | 阿斯特拉曾尼卡有限公司 | 用作药物的喹唑啉衍生物 |
| GB9925958D0 (en) | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
| US20070123537A1 (en) * | 2003-10-06 | 2007-05-31 | Gpc Biotech Ag | Quinazoline derivatives for the treatment of herpesviral infections |
| EP1682123A1 (en) * | 2003-11-07 | 2006-07-26 | SmithKline Beecham (Cork) Limited | Cancer treatment method |
| WO2005097134A2 (en) * | 2004-03-31 | 2005-10-20 | The Scripps Research Institute | Quinazoline based protein kinase inhibitors |
| KR100735639B1 (ko) * | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| DK1854789T3 (da) * | 2005-02-23 | 2013-10-21 | Shionogi & Co | Quinazolinderivat med tyrosin-kinase inhibitorisk aktivitet |
| CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
-
2006
- 2006-01-20 CN CNA2006100235267A patent/CN101003514A/zh active Pending
- 2006-10-20 CN CN2006800012515A patent/CN101103005B/zh active Active
- 2006-10-20 EP EP06804996.4A patent/EP1990337B1/en active Active
- 2006-10-20 WO PCT/CN2006/002786 patent/WO2007082434A1/zh not_active Ceased
- 2006-10-20 US US12/096,508 patent/US8044063B2/en active Active
- 2006-10-20 EP EP10172688.3A patent/EP2248806B1/en active Active
- 2006-10-20 JP JP2008550608A patent/JP5478894B2/ja active Active
-
2011
- 2011-06-14 US US13/160,225 patent/US8309563B2/en active Active
-
2012
- 2012-08-03 JP JP2012173258A patent/JP2012214502A/ja not_active Withdrawn