JP2010521514A5 - - Google Patents
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- Publication number
- JP2010521514A5 JP2010521514A5 JP2009553997A JP2009553997A JP2010521514A5 JP 2010521514 A5 JP2010521514 A5 JP 2010521514A5 JP 2009553997 A JP2009553997 A JP 2009553997A JP 2009553997 A JP2009553997 A JP 2009553997A JP 2010521514 A5 JP2010521514 A5 JP 2010521514A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- cyclopentyl
- composition
- acceptable excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- DQJHTCZROXSXEZ-UHFFFAOYSA-N 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8h-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxybenzoic acid Chemical compound COC1=CC(C(O)=O)=CC=C1NC1=NC=C(N(C)C(=O)C(F)(F)CN2C3CCCC3)C2=N1 DQJHTCZROXSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- -1 cyclopentyl compound Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91935807P | 2007-03-22 | 2007-03-22 | |
| US60/919,358 | 2007-03-22 | ||
| PCT/EP2008/052847 WO2008113711A1 (en) | 2007-03-22 | 2008-03-11 | Substituted pyrimidodiazepines useful as plk1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521514A JP2010521514A (ja) | 2010-06-24 |
| JP2010521514A5 true JP2010521514A5 (enExample) | 2011-04-21 |
| JP5087640B2 JP5087640B2 (ja) | 2012-12-05 |
Family
ID=39415299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553997A Expired - Fee Related JP5087640B2 (ja) | 2007-03-22 | 2008-03-11 | Ｐｌｋ１阻害剤として有用な置換ピリミドジアゼピン |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7517873B2 (enExample) |
| EP (1) | EP2139892B1 (enExample) |
| JP (1) | JP5087640B2 (enExample) |
| KR (1) | KR101157848B1 (enExample) |
| CN (2) | CN102746175B (enExample) |
| AR (1) | AR065794A1 (enExample) |
| AT (1) | ATE524472T1 (enExample) |
| AU (1) | AU2008228303B2 (enExample) |
| BR (1) | BRPI0809088A2 (enExample) |
| CA (1) | CA2680757A1 (enExample) |
| CL (1) | CL2008000785A1 (enExample) |
| CY (1) | CY1112102T1 (enExample) |
| DK (1) | DK2139892T3 (enExample) |
| ES (1) | ES2371832T3 (enExample) |
| HR (1) | HRP20110807T1 (enExample) |
| IL (1) | IL200617A (enExample) |
| MX (1) | MX2009010034A (enExample) |
| PE (1) | PE20120495A1 (enExample) |
| PL (1) | PL2139892T3 (enExample) |
| PT (1) | PT2139892E (enExample) |
| SI (1) | SI2139892T1 (enExample) |
| TW (1) | TWI363629B (enExample) |
| WO (1) | WO2008113711A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ583061A (en) * | 2007-08-15 | 2012-06-29 | Vertex Pharma | 4-(9-(3,3-difluorocyclopentyl)-5,7,7-trimethyl-6-oxo-6,7,8,9-tetrahydro-5h-pyrimido[4,5-b[1,4]diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases |
| NZ584760A (en) * | 2007-09-25 | 2012-03-30 | Takeda Pharmaceutical | Polo-like kinase inhibitors |
| WO2009040556A1 (en) * | 2007-09-28 | 2009-04-02 | Cyclacel Limited | Pyrimidine derivatives as protein kinase inhibitors |
| WO2009067547A1 (en) * | 2007-11-19 | 2009-05-28 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| JP2011527667A (ja) | 2008-06-18 | 2011-11-04 | 武田薬品工業株式会社 | ハロ置換ピリミドジアゼピン |
| MX2011006152A (es) * | 2008-12-09 | 2011-07-28 | Gilead Sciences Inc | Moduladores de receptores tipo toll. |
| WO2010080712A2 (en) | 2009-01-06 | 2010-07-15 | Dana Farber Cancer Institute | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders |
| CN104151312B (zh) | 2009-06-17 | 2016-06-15 | 沃泰克斯药物股份有限公司 | 流感病毒复制抑制剂 |
| NZ598384A (en) | 2009-09-14 | 2014-04-30 | Gilead Sciences Inc | Modulators of toll-like receptors |
| MX2013006836A (es) | 2010-12-16 | 2013-09-26 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| EP2970317A4 (en) | 2013-03-15 | 2016-11-02 | Dana Farber Cancer Inst Inc | PYRIMIDODIAZEPINONE COMPOUNDS AND METHOD FOR THE TREATMENT OF DISEASES |
| KR20160034379A (ko) | 2013-07-25 | 2016-03-29 | 다나-파버 캔서 인스티튜트 인크. | 전사 인자의 억제제 및 그의 용도 |
| TWI652014B (zh) * | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
| HUE044667T2 (hu) | 2013-11-13 | 2019-11-28 | Vertex Pharma | Influenza vírus replikáció inhibitorok |
| RS57541B1 (sr) | 2013-11-13 | 2018-10-31 | Vertex Pharma | Postupci za pripremu inhibitora replikacije virusa gripa |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| RU2016134947A (ru) | 2014-01-31 | 2018-03-01 | Дана-Фарбер Кансер Институт, Инк. | Производные диаминопиримидин бензолсульфона и их применение |
| JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを治療するためのトール様受容体の調節因子 |
| EP3177626A4 (en) | 2014-08-08 | 2017-12-27 | Dana Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| EP3194401B1 (en) | 2014-09-16 | 2020-10-21 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
| CN107074860B (zh) | 2014-09-16 | 2022-07-15 | 吉利德科学公司 | 制备toll样受体调节剂的方法 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| CN108472300A (zh) | 2015-09-11 | 2018-08-31 | 达纳-法伯癌症研究所股份有限公司 | 氰基噻吩并三唑并二氮杂环庚三烯及其用途 |
| US10881668B2 (en) | 2015-09-11 | 2021-01-05 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
| MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| US11155556B2 (en) * | 2016-04-07 | 2021-10-26 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders |
| EP4034132A4 (en) * | 2019-09-27 | 2023-10-11 | Dana-Farber Cancer Institute, Inc. | Erk5 degraders as therapeutics in cancer and inflammatory diseases |
| US12403198B2 (en) * | 2020-03-27 | 2025-09-02 | Uppthera | Benzimidazole thiophene derivative compounds inducing selective degradation of PLK1 |
| WO2022145989A1 (ko) * | 2020-12-31 | 2022-07-07 | (주) 업테라 | 선택적 plk1 억제제로서의 피리미도디아제핀 유도체 |
| KR102604801B1 (ko) * | 2021-08-10 | 2023-11-22 | (주) 업테라 | 신규 plk1 분해 유도 화합물 |
| GB202313514D0 (en) | 2023-09-05 | 2023-10-18 | Cambridge Entpr Ltd | Treatment of inflammatory diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020063854A (ko) * | 1999-09-17 | 2002-08-05 | 애보트 게엠베하 운트 콤파니 카게 | 치료제로서의 키나제 억제제 |
| EA007062B1 (ru) * | 2001-09-04 | 2006-06-30 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств |
| CA2652648C (en) * | 2006-02-14 | 2016-10-25 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
-
2008
- 2008-03-11 WO PCT/EP2008/052847 patent/WO2008113711A1/en not_active Ceased
- 2008-03-11 KR KR1020097019761A patent/KR101157848B1/ko not_active Expired - Fee Related
- 2008-03-11 PT PT08717594T patent/PT2139892E/pt unknown
- 2008-03-11 CN CN201210030872.3A patent/CN102746175B/zh not_active Expired - Fee Related
- 2008-03-11 MX MX2009010034A patent/MX2009010034A/es active IP Right Grant
- 2008-03-11 DK DK08717594.9T patent/DK2139892T3/da active
- 2008-03-11 JP JP2009553997A patent/JP5087640B2/ja not_active Expired - Fee Related
- 2008-03-11 ES ES08717594T patent/ES2371832T3/es active Active
- 2008-03-11 AU AU2008228303A patent/AU2008228303B2/en not_active Ceased
- 2008-03-11 PL PL08717594T patent/PL2139892T3/pl unknown
- 2008-03-11 EP EP08717594A patent/EP2139892B1/en not_active Not-in-force
- 2008-03-11 CA CA002680757A patent/CA2680757A1/en not_active Abandoned
- 2008-03-11 HR HR20110807T patent/HRP20110807T1/hr unknown
- 2008-03-11 SI SI200830445T patent/SI2139892T1/sl unknown
- 2008-03-11 AT AT08717594T patent/ATE524472T1/de active
- 2008-03-11 BR BRPI0809088-2A patent/BRPI0809088A2/pt not_active IP Right Cessation
- 2008-03-11 CN CN2008800088890A patent/CN101636399B/zh not_active Expired - Fee Related
- 2008-03-18 CL CL2008000785A patent/CL2008000785A1/es unknown
- 2008-03-19 PE PE2011001933A patent/PE20120495A1/es not_active Application Discontinuation
- 2008-03-19 TW TW097109660A patent/TWI363629B/zh not_active IP Right Cessation
- 2008-03-19 AR ARP080101142A patent/AR065794A1/es unknown
- 2008-03-19 US US12/051,000 patent/US7517873B2/en not_active Expired - Fee Related
-
2009
- 2009-08-27 IL IL200617A patent/IL200617A/en not_active IP Right Cessation
-
2011
- 2011-11-30 CY CY20111101174T patent/CY1112102T1/el unknown