JP2007532575A5 - - Google Patents
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- Publication number
- JP2007532575A5 JP2007532575A5 JP2007507551A JP2007507551A JP2007532575A5 JP 2007532575 A5 JP2007532575 A5 JP 2007532575A5 JP 2007507551 A JP2007507551 A JP 2007507551A JP 2007507551 A JP2007507551 A JP 2007507551A JP 2007532575 A5 JP2007532575 A5 JP 2007532575A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- methyl
- substituted
- chromen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- QFLNTQDOVCLQKW-UHFFFAOYSA-N (1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yl) 4-[(4-hydroxy-2-oxochromen-3-yl)methyl]benzoate Chemical compound C1=CC(C(=O)OC(C)(C(F)(F)F)C(F)(F)F)=CC=C1CC1=C(O)C2=CC=CC=C2OC1=O QFLNTQDOVCLQKW-UHFFFAOYSA-N 0.000 claims 3
- -1 1, 1,1,3,3,3-hexachloro-2-methylpropan-2-yl Chemical group 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 150000002366 halogen compounds Chemical class 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- FQDXJYBXPOMIBX-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoro-2-methylpropan-2-ol Chemical compound FC(F)(F)C(O)(C)C(F)(F)F FQDXJYBXPOMIBX-UHFFFAOYSA-N 0.000 claims 1
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 claims 1
- CXRFNPZUQRGAKB-NSHDSACASA-N [(2s)-3,3,4,4,4-pentafluorobutan-2-yl] 4-[(4-hydroxy-2-oxochromen-3-yl)methyl]benzoate Chemical compound C1=CC(C(=O)O[C@@H](C)C(F)(F)C(F)(F)F)=CC=C1CC1=C(O)C2=CC=CC=C2OC1=O CXRFNPZUQRGAKB-NSHDSACASA-N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56112104P | 2004-04-08 | 2004-04-08 | |
| US10/822,129 US7145020B2 (en) | 2001-04-24 | 2004-04-08 | Materials and methods for treating coagulation disorders |
| US10/822,129 | 2004-04-08 | ||
| US60/561,121 | 2004-04-08 | ||
| PCT/US2005/012091 WO2005100336A1 (en) | 2004-04-08 | 2005-04-08 | Materials and methods for treating coagulation disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007532575A JP2007532575A (ja) | 2007-11-15 |
| JP2007532575A5 true JP2007532575A5 (enExample) | 2008-05-22 |
| JP5036532B2 JP5036532B2 (ja) | 2012-09-26 |
Family
ID=34965219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507551A Expired - Fee Related JP5036532B2 (ja) | 2004-04-08 | 2005-04-08 | 血液凝固疾患治療のための物質およびその方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7285671B2 (enExample) |
| EP (1) | EP1735296B1 (enExample) |
| JP (1) | JP5036532B2 (enExample) |
| KR (1) | KR101203124B1 (enExample) |
| AT (1) | ATE451361T1 (enExample) |
| AU (1) | AU2005233614C1 (enExample) |
| BR (1) | BRPI0508392A (enExample) |
| CA (1) | CA2559568C (enExample) |
| CY (1) | CY1109763T1 (enExample) |
| DE (1) | DE602005018181D1 (enExample) |
| DK (1) | DK1735296T3 (enExample) |
| ES (2) | ES2436298T3 (enExample) |
| IL (1) | IL178122A (enExample) |
| NO (1) | NO338837B1 (enExample) |
| PT (1) | PT1735296E (enExample) |
| RU (1) | RU2495034C2 (enExample) |
| WO (1) | WO2005100336A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6864279B2 (en) * | 2001-04-24 | 2005-03-08 | Aryx Therapeutics | Materials and methods for treating coagulation disorders |
| EP2161261B1 (en) * | 2004-04-08 | 2013-08-28 | Armetheon, Inc. | Materials and methods for treating coagulation disorders |
| DK1954669T3 (en) * | 2005-12-01 | 2015-10-12 | Auspex Pharmaceuticals Inc | SUBSTITUTED phenethylamines a serotonergic AND / OR NOREPINEPHRINERG ACTIVITY |
| CN101188435B (zh) * | 2007-01-08 | 2011-03-16 | 中兴通讯股份有限公司 | 一种比特交织装置与方法 |
| WO2009119537A1 (ja) | 2008-03-26 | 2009-10-01 | 第一三共株式会社 | ヒドロキシキノキサリンカルボキサミド誘導体 |
| US9549912B2 (en) | 2009-11-23 | 2017-01-24 | Armetheon, Inc. | Methods for treating atrial fibrillation |
| US20110136779A1 (en) * | 2009-11-23 | 2011-06-09 | Milner Peter G | Methods for stroke reduction in atrial fibrillation patients |
| AU2010327936B2 (en) * | 2009-12-11 | 2015-08-20 | Nono Inc. | Agents and methods for treating ischemic and other diseases |
| WO2011099978A1 (en) * | 2010-02-12 | 2011-08-18 | N30 Pharmaceuticals, Llc | Chromone inhibitors of s-nitrosoglutathione reductase |
| SI2533638T1 (sl) | 2010-02-12 | 2016-05-31 | Nivalis Therapeutics, Inc. | Novi inhibitorji S-nitrozoglutation reduktaze |
| US11234978B2 (en) | 2014-01-15 | 2022-02-01 | Southern Methodist University | Inhibitors of multidrug resistance transporter P-glycoprotein |
| US10292982B2 (en) | 2014-01-15 | 2019-05-21 | Southern Methodist University | Inhibitors of multidrug resistance transporter P-glycoprotein |
| US11013739B2 (en) | 2014-01-15 | 2021-05-25 | Southern Methodist University | Inhibitors of multidrug resistance transporter p-glycoprotein |
| US9561227B2 (en) | 2014-01-15 | 2017-02-07 | Southern Methodist University | Inhibitors of multidrug resistance transporter P-glycoprotein |
| CN114524791B (zh) * | 2022-01-26 | 2024-01-26 | 江苏慧聚药业股份有限公司 | 替卡法林的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL108459A0 (en) | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
| US5510375A (en) | 1993-11-19 | 1996-04-23 | Warner-Lambert Company | Coumarin derivatives as protease inhibitors and antiviral agents |
| GB9324517D0 (en) * | 1993-11-30 | 1994-01-19 | Octel Chem Ltd | Process for the preparation of substituted 4-hydroxycoumarins |
| FR2749585B1 (fr) * | 1996-06-11 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments |
| FR2807032B1 (fr) * | 2000-03-29 | 2003-04-18 | Warner Lambert Co | Modification de la chimioselectivite lors de l'oxydation de composes organiques azotes |
| US6864279B2 (en) * | 2001-04-24 | 2005-03-08 | Aryx Therapeutics | Materials and methods for treating coagulation disorders |
| US7145020B2 (en) | 2001-04-24 | 2006-12-05 | Aryx Therapeutics | Materials and methods for treating coagulation disorders |
| CA2462913A1 (en) * | 2001-10-10 | 2003-04-17 | Aryx Therapeutics | Mibefradil-based compounds as calcium channel blockers useful in the treatment of hypertension and angina |
| US7179838B2 (en) * | 2002-07-30 | 2007-02-20 | New Century Pharmaceuticals, Inc. | Coumarin analog compounds for safer anticoagulant treatment |
-
2005
- 2005-04-08 BR BRPI0508392-3A patent/BRPI0508392A/pt not_active Application Discontinuation
- 2005-04-08 ES ES09175606T patent/ES2436298T3/es not_active Expired - Lifetime
- 2005-04-08 EP EP05733799A patent/EP1735296B1/en not_active Expired - Lifetime
- 2005-04-08 DE DE602005018181T patent/DE602005018181D1/de not_active Expired - Lifetime
- 2005-04-08 JP JP2007507551A patent/JP5036532B2/ja not_active Expired - Fee Related
- 2005-04-08 KR KR1020067022954A patent/KR101203124B1/ko not_active Expired - Fee Related
- 2005-04-08 DK DK05733799.0T patent/DK1735296T3/da active
- 2005-04-08 CA CA2559568A patent/CA2559568C/en not_active Expired - Lifetime
- 2005-04-08 WO PCT/US2005/012091 patent/WO2005100336A1/en not_active Ceased
- 2005-04-08 ES ES05733799T patent/ES2340690T3/es not_active Expired - Lifetime
- 2005-04-08 PT PT05733799T patent/PT1735296E/pt unknown
- 2005-04-08 AU AU2005233614A patent/AU2005233614C1/en not_active Ceased
- 2005-04-08 AT AT05733799T patent/ATE451361T1/de active
-
2006
- 2006-08-28 US US11/467,813 patent/US7285671B2/en not_active Expired - Lifetime
- 2006-09-14 IL IL178122A patent/IL178122A/en active IP Right Grant
- 2006-11-03 NO NO20065079A patent/NO338837B1/no unknown
-
2008
- 2008-05-21 RU RU2008120295/04A patent/RU2495034C2/ru active
-
2010
- 2010-01-29 CY CY20101100096T patent/CY1109763T1/el unknown