BRPI0508392A - materiais e métodos para tratar distúrbios de coagulação - Google Patents

materiais e métodos para tratar distúrbios de coagulação

Info

Publication number
BRPI0508392A
BRPI0508392A BRPI0508392-3A BRPI0508392A BRPI0508392A BR PI0508392 A BRPI0508392 A BR PI0508392A BR PI0508392 A BRPI0508392 A BR PI0508392A BR PI0508392 A BRPI0508392 A BR PI0508392A
Authority
BR
Brazil
Prior art keywords
sub
compounds
methods
materials
salts
Prior art date
Application number
BRPI0508392-3A
Other languages
English (en)
Inventor
Pascal Druzgala
Cyrus Becker
Original Assignee
Aryx Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/822,129 external-priority patent/US7145020B2/en
Application filed by Aryx Therapeutics filed Critical Aryx Therapeutics
Publication of BRPI0508392A publication Critical patent/BRPI0508392A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

MATERIAIS E MéTODOS PARA TRATAR DISTúRBIOS DE COAGULAçãO. A presente invenção refere-se a compostos anticoagulantes da fórmula (I): e sais farmaceuticamente aceitáveis do mesmo em que R~ 1~ R~ 3~ n e Ar são como definido aqui. Os compostos da presente invenção podem ser utilizados para tratar populações em risco desse modo dando alívio de sintomas, melhorando a qualidade de vida, evitando complicações agudas e de longa duração, reduzindo a mortalidade e tratando distúrbios associados. A invenção compreende ainda composições farmacêuticas que compreendem os compostos e sais da invenção, bem como método de utilizar os compostos sais e composições da invneção..
BRPI0508392-3A 2004-04-08 2005-04-08 materiais e métodos para tratar distúrbios de coagulação BRPI0508392A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56112104P 2004-04-08 2004-04-08
US10/822,129 US7145020B2 (en) 2001-04-24 2004-04-08 Materials and methods for treating coagulation disorders
PCT/US2005/012091 WO2005100336A1 (en) 2004-04-08 2005-04-08 Materials and methods for treating coagulation disorders

Publications (1)

Publication Number Publication Date
BRPI0508392A true BRPI0508392A (pt) 2007-08-07

Family

ID=34965219

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508392-3A BRPI0508392A (pt) 2004-04-08 2005-04-08 materiais e métodos para tratar distúrbios de coagulação

Country Status (18)

Country Link
US (1) US7285671B2 (pt)
EP (1) EP1735296B1 (pt)
JP (1) JP5036532B2 (pt)
KR (1) KR101203124B1 (pt)
AT (1) ATE451361T1 (pt)
AU (1) AU2005233614C1 (pt)
BR (1) BRPI0508392A (pt)
CA (1) CA2559568C (pt)
CY (1) CY1109763T1 (pt)
DE (1) DE602005018181D1 (pt)
DK (1) DK1735296T3 (pt)
ES (2) ES2436298T3 (pt)
HK (2) HK1105200A1 (pt)
IL (1) IL178122A (pt)
NO (1) NO338837B1 (pt)
PT (1) PT1735296E (pt)
RU (1) RU2495034C2 (pt)
WO (1) WO2005100336A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2445160A1 (en) * 2001-04-24 2002-10-31 Aryx Therapeutics Coumarin derivatives to be used as anticoagulants
DK2161261T3 (da) * 2004-04-08 2013-11-04 Armetheon Inc Materialer og fremgangsmåder til behandling af koagulationslidelser
NZ568720A (en) * 2005-12-01 2011-06-30 Auspex Pharmaceuticals Inc Substituted phenethylamines with serotoninergic and/or norepinephrinergic acitivity
CN101188435B (zh) * 2007-01-08 2011-03-16 中兴通讯股份有限公司 一种比特交织装置与方法
RU2010143600A (ru) 2008-03-26 2012-05-10 Дайити Санкио Компани, Лимитед (Jp) Производное гидроксихиноксалинкарбоксамида
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
WO2011072275A2 (en) 2009-12-11 2011-06-16 Nono, Inc. Agents and methods for treating ischemic and other diseases
CN102869255B (zh) 2010-02-12 2016-08-31 内瓦利斯治疗公司 S-亚硝基谷胱甘肽还原酶的新抑制剂
US8481590B2 (en) 2010-02-12 2013-07-09 N30 Pharmaceuticals, Inc. Chromone inhibitors of S-nitrosoglutathione reductase
US11013739B2 (en) 2014-01-15 2021-05-25 Southern Methodist University Inhibitors of multidrug resistance transporter p-glycoprotein
US9561227B2 (en) 2014-01-15 2017-02-07 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
US11234978B2 (en) 2014-01-15 2022-02-01 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
US10292982B2 (en) 2014-01-15 2019-05-21 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
CN114524791B (zh) * 2022-01-26 2024-01-26 江苏慧聚药业股份有限公司 替卡法林的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
GB9324517D0 (en) * 1993-11-30 1994-01-19 Octel Chem Ltd Process for the preparation of substituted 4-hydroxycoumarins
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
FR2807032B1 (fr) * 2000-03-29 2003-04-18 Warner Lambert Co Modification de la chimioselectivite lors de l'oxydation de composes organiques azotes
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
CA2445160A1 (en) * 2001-04-24 2002-10-31 Aryx Therapeutics Coumarin derivatives to be used as anticoagulants
JP2005508949A (ja) * 2001-10-10 2005-04-07 アリックス セラピューティクス 高血圧および狭心症の治療に有用なカルシウムチャネル遮断剤であるミベフラジルをベースとした化合物
US7179838B2 (en) * 2002-07-30 2007-02-20 New Century Pharmaceuticals, Inc. Coumarin analog compounds for safer anticoagulant treatment

Also Published As

Publication number Publication date
ES2340690T3 (es) 2010-06-08
KR20060133081A (ko) 2006-12-22
AU2005233614B2 (en) 2011-11-24
JP5036532B2 (ja) 2012-09-26
NO20065079L (no) 2006-11-03
ATE451361T1 (de) 2009-12-15
US20060287388A1 (en) 2006-12-21
DK1735296T3 (da) 2010-02-01
HK1105200A1 (en) 2008-02-06
RU2008120295A (ru) 2009-11-27
CA2559568A1 (en) 2005-10-27
DE602005018181D1 (de) 2010-01-21
PT1735296E (pt) 2010-02-09
EP1735296B1 (en) 2009-12-09
IL178122A0 (en) 2006-12-31
RU2495034C2 (ru) 2013-10-10
EP1735296A1 (en) 2006-12-27
NO338837B1 (no) 2016-10-24
KR101203124B1 (ko) 2012-11-20
WO2005100336A1 (en) 2005-10-27
JP2007532575A (ja) 2007-11-15
HK1138265A1 (en) 2010-08-20
US7285671B2 (en) 2007-10-23
CA2559568C (en) 2013-05-28
CY1109763T1 (el) 2014-09-10
AU2005233614A1 (en) 2005-10-27
IL178122A (en) 2013-01-31
AU2005233614C1 (en) 2012-07-19
ES2436298T3 (es) 2013-12-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ARMETHEON, INC (US)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]