JP2007269812A5 - - Google Patents

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Publication number
JP2007269812A5
JP2007269812A5 JP2007154127A JP2007154127A JP2007269812A5 JP 2007269812 A5 JP2007269812 A5 JP 2007269812A5 JP 2007154127 A JP2007154127 A JP 2007154127A JP 2007154127 A JP2007154127 A JP 2007154127A JP 2007269812 A5 JP2007269812 A5 JP 2007269812A5
Authority
JP
Japan
Prior art keywords
endotoxemia
inhibitor
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007154127A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007269812A (ja
JP4712001B2 (ja
Filing date
Publication date
Priority claimed from US08/461,675 external-priority patent/US5750664A/en
Application filed filed Critical
Publication of JP2007269812A publication Critical patent/JP2007269812A/ja
Publication of JP2007269812A5 publication Critical patent/JP2007269812A5/ja
Application granted granted Critical
Publication of JP4712001B2 publication Critical patent/JP4712001B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007154127A 1995-06-05 2007-06-11 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類 Expired - Lifetime JP4712001B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/461,675 US5750664A (en) 1995-06-05 1995-06-05 Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US08/461,675 1995-06-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP50186897A Division JP4009318B2 (ja) 1995-06-05 1996-06-05 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011018401A Division JP2011121970A (ja) 1995-06-05 2011-01-31 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類

Publications (3)

Publication Number Publication Date
JP2007269812A JP2007269812A (ja) 2007-10-18
JP2007269812A5 true JP2007269812A5 (enExample) 2008-01-24
JP4712001B2 JP4712001B2 (ja) 2011-06-29

Family

ID=23833509

Family Applications (3)

Application Number Title Priority Date Filing Date
JP50186897A Expired - Lifetime JP4009318B2 (ja) 1995-06-05 1996-06-05 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類
JP2007154127A Expired - Lifetime JP4712001B2 (ja) 1995-06-05 2007-06-11 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類
JP2011018401A Pending JP2011121970A (ja) 1995-06-05 2011-01-31 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP50186897A Expired - Lifetime JP4009318B2 (ja) 1995-06-05 1996-06-05 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011018401A Pending JP2011121970A (ja) 1995-06-05 2011-01-31 エンドトキセミアの治療及び防止に有用な置換されたリポ糖類

Country Status (21)

Country Link
US (8) US5681824A (enExample)
EP (1) EP0853627B1 (enExample)
JP (3) JP4009318B2 (enExample)
KR (1) KR100416335B1 (enExample)
CN (1) CN1067082C (enExample)
AT (1) ATE258185T1 (enExample)
AU (1) AU707779C (enExample)
CA (1) CA2223140C (enExample)
DE (1) DE69631376T2 (enExample)
DK (1) DK0853627T3 (enExample)
ES (1) ES2214543T3 (enExample)
HU (1) HU221342B1 (enExample)
IL (2) IL122251A0 (enExample)
MX (1) MX9709502A (enExample)
NO (1) NO310239B1 (enExample)
NZ (1) NZ312299A (enExample)
PT (1) PT853627E (enExample)
RU (1) RU2170738C2 (enExample)
TW (1) TW366345B (enExample)
WO (1) WO1996039411A1 (enExample)
ZA (1) ZA964666B (enExample)

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US6835721B2 (en) 1999-02-01 2004-12-28 Eisai Co., Ltd. Immunomodulatory compounds and methods of use thereof
IL144706A0 (en) 1999-02-10 2002-06-30 Sankyo Co Ether type lipid a-1 carboxylic acid analogue and pharmaceutical compositions containing the same
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JPWO2002088062A1 (ja) * 2001-04-23 2004-08-12 エーザイ株式会社 アルコール誘導体の製造方法
JPWO2002088072A1 (ja) * 2001-04-23 2004-08-12 エーザイ株式会社 アルキレン化合物の製造方法
WO2002085117A1 (en) * 2001-04-24 2002-10-31 Eisai Co., Ltd. Methods and compositions for preventing and treating septic shock and endotoxemia
JP4366081B2 (ja) * 2001-05-22 2009-11-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 高度に精製されたアンチエンドトキシン化合物
DE10125179A1 (de) * 2001-05-23 2002-12-05 Laves Ralph Georg Verwendung von LPS zur Behandlung intestinaler Entzündungsprozesse
US7727974B2 (en) * 2001-08-10 2010-06-01 Eisai R & D Management Co., Ltd. Methods of reducing the severity of mucositis
WO2003013440A2 (en) * 2001-08-10 2003-02-20 Eisai Co., Ltd. Treatment and prevention of heat shock protein-associated diseases and conditions
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WO2004058788A1 (ja) * 2002-12-24 2004-07-15 Sankyo Company, Limited 右糖グルコースリピドa類縁体
ES2556970T3 (es) * 2003-01-06 2016-01-21 Corixa Corporation Ciertos compuestos de fosfato de aminoalquil glucosaminida y sus usos
DE602004021901D1 (de) * 2003-01-28 2009-08-20 Academisch Ziekenhuis Leiden Aus ll-37 abgeleiteten peptidinhibitoren von toxinen
US7906633B2 (en) * 2003-02-20 2011-03-15 Eisai R&D Management Co., Ltd. Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof
US20080095786A9 (en) * 2003-03-05 2008-04-24 Mcshane James Compositions And Methods For Preventing And Treating Endotoxin-Related Diseases And Conditions
WO2005027826A2 (en) * 2003-07-14 2005-03-31 Eisai, Co, Ltd. Methods and treating severe acute respiratory syndrome
US20050208470A1 (en) 2003-12-16 2005-09-22 University Of Massachusetts Toll-like receptor assays
EP1702926A4 (en) * 2004-01-08 2010-03-17 Sankyo Co LEVULOSEGLUCOSELIPID-A-ANALOG
US20070292418A1 (en) * 2005-04-26 2007-12-20 Eisai Co., Ltd. Compositions and methods for immunotherapy
US7976852B2 (en) * 2005-04-26 2011-07-12 Eisai R&D Management Co., Ltd. Compositions and methods for cancer immunotherapy
EP1895842A4 (en) * 2005-06-17 2009-06-03 Univ Rochester METHOD AND COMPOSITIONS FOR EXPANDING THE IMMUNE MEMORY BY BLOCKING INTRA-HEPATIBLE ACTIVATED T-CELL ERASURE
JP5118968B2 (ja) * 2005-08-31 2013-01-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 リピッドａ類縁体の製造方法
CA2620027A1 (en) * 2005-08-31 2007-03-08 Eisai R & D Management Co., Ltd. Process for production of lipid a analogue
US7943588B2 (en) 2006-03-28 2011-05-17 Trustees Of Dartmouth College Method for preventing or treating neuropathic pain
WO2008059307A2 (en) * 2006-11-16 2008-05-22 Om Pharma Functionalized beta 1,6 glucosamine disaccharides and process for their preparation
JP5244608B2 (ja) * 2006-11-22 2013-07-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 二糖類化合物のナトリウム塩及びその製造方法並びにその使用
KR101541551B1 (ko) 2006-11-22 2015-08-03 에자이 알앤드디 매니지먼트 가부시키가이샤 이당류 화합물의 나트륨염 및 그의 제조 방법 및 그의 사용
EP2096914B1 (en) 2006-11-23 2011-09-21 Cadila Pharmaceuticals Limited Poly-tlr antagonist
US20110201569A1 (en) * 2009-09-16 2011-08-18 Heidi Ehrentraut Methods For Treating Myocardial Disorders
WO2011038537A1 (zh) * 2009-09-29 2011-04-07 上海南方基因科技有限公司 败血症以及败血症休克的预测、预防和治疗方法及试剂盒
GB201013785D0 (en) * 2010-08-17 2010-09-29 Ucl Business Plc Treatment
JP2012246470A (ja) 2011-05-31 2012-12-13 Sharp Corp 半導体ナノ粒子の製造方法、半導体ナノ粒子、ならびにこれを用いた蛍光体
WO2013093631A2 (en) * 2011-12-22 2013-06-27 Nanoco Technologies, Inc. Surface modified nanoparticles
JP6081574B2 (ja) 2012-03-28 2017-02-15 ユニヴァーシティー オブ メリーランド バルチモア オルトミクソウイルス感染を処置するためのエリトラン又は薬学的に許容されるその塩の投与
WO2014113048A1 (en) * 2013-01-18 2014-07-24 Loma Linda University Compositions and methods for diagnosing and treating sepsis
EP3019200B1 (en) 2013-07-11 2022-03-23 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
US9584991B1 (en) * 2014-06-19 2017-02-28 Isaac S. Daniel Method of communicating and accessing social networks using interactive coded messages
CA3015494C (en) * 2016-03-30 2021-10-26 Ayuvis Research, Inc. Novel compositions and therapeutic methods
KR102608769B1 (ko) 2016-09-14 2023-12-04 게노마티카 인코포레이티드 1,3-지방 디올 화합물 및 그 유도체
EP3512508B1 (en) * 2016-09-16 2022-03-16 Eisai R&D Management Co., Ltd. Method of use of eritoran as a tlr4 antagonist for treatment of ebola and marburg disease
CA3116146A1 (en) * 2018-12-17 2020-06-25 Eisai R&D Management Co., Ltd. Formulation comprising liposomes
WO2021207218A1 (en) 2020-04-06 2021-10-14 Eisai R&D Management Co., Ltd. Treatment of nidovirales infection with eritoran
CN113527396B (zh) * 2020-04-17 2024-02-02 上海医药工业研究院 一种疫苗佐剂mpla的中间体、合成及应用

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US6417172B1 (en) 1995-06-05 2002-07-09 Eisai Co., Ltd. Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs
US5681824A (en) 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
JP4235193B2 (ja) 2005-06-07 2009-03-11 日本電信電話株式会社 イベント履歴蓄積装置、イベント情報検証装置、イベント履歴蓄積方法、イベント情報検証方法およびイベント情報処理システム

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