JP2011121989A5 - - Google Patents
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- Publication number
- JP2011121989A5 JP2011121989A5 JP2011045147A JP2011045147A JP2011121989A5 JP 2011121989 A5 JP2011121989 A5 JP 2011121989A5 JP 2011045147 A JP2011045147 A JP 2011045147A JP 2011045147 A JP2011045147 A JP 2011045147A JP 2011121989 A5 JP2011121989 A5 JP 2011121989A5
- Authority
- JP
- Japan
- Prior art keywords
- ethylglycine
- boro
- proline
- boroproline
- boroalanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 0 C[C@@](B(*)OC)NC(C(*)C(C)(C)C)=O Chemical compound C[C@@](B(*)OC)NC(C(*)C(C)(C)C)=O 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
Images
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33351901P | 2001-11-26 | 2001-11-26 | |
| US60/333,519 | 2001-11-26 | ||
| US40553002P | 2002-08-23 | 2002-08-23 | |
| US60/405,530 | 2002-08-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547426A Division JP4771661B2 (ja) | 2001-11-26 | 2002-11-26 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014033295A Division JP2014139191A (ja) | 2001-11-26 | 2014-02-24 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011121989A JP2011121989A (ja) | 2011-06-23 |
| JP2011121989A5 true JP2011121989A5 (enExample) | 2011-08-04 |
Family
ID=26988769
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547426A Expired - Fee Related JP4771661B2 (ja) | 2001-11-26 | 2002-11-26 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
| JP2011045147A Pending JP2011121989A (ja) | 2001-11-26 | 2011-03-02 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
| JP2014033295A Abandoned JP2014139191A (ja) | 2001-11-26 | 2014-02-24 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547426A Expired - Fee Related JP4771661B2 (ja) | 2001-11-26 | 2002-11-26 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014033295A Abandoned JP2014139191A (ja) | 2001-11-26 | 2014-02-24 | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7727964B2 (enExample) |
| EP (2) | EP2316470A3 (enExample) |
| JP (3) | JP4771661B2 (enExample) |
| AU (1) | AU2002357767C1 (enExample) |
| CA (2) | CA2837936A1 (enExample) |
| WO (1) | WO2003045977A2 (enExample) |
Families Citing this family (88)
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| CN105601583A (zh) * | 2013-01-06 | 2016-05-25 | 天津市汉康医药生物技术有限公司 | 噻唑烷衍生物、其制备方法和用途 |
| CN111116622A (zh) * | 2014-02-03 | 2020-05-08 | 俄亥俄州创新基金会 | 硼酸酯和其药物制剂 |
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| WO2016144654A1 (en) | 2015-03-09 | 2016-09-15 | Washington University | Inhibitors of growth factor activation enzymes |
| EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
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| JP2020515639A (ja) | 2017-04-03 | 2020-05-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 進行性核上性麻痺の処置のためのPPARγアゴニスト |
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| WO2000010549A1 (en) | 1998-08-21 | 2000-03-02 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| DE60021254T2 (de) * | 1999-03-15 | 2006-04-20 | AXYS Pharmaceuticals, Inc., South San Francisco | N-cyanomethylamide als protease inhibitoren |
| CA2366671A1 (en) * | 1999-04-09 | 2000-10-19 | Trustees Of Tufts College | Methods and reagents for determining enzyme substrate specificity, and uses related thereto |
| AU781897B2 (en) | 1999-05-25 | 2005-06-23 | Point Therapeutics, Inc. | Anti-tumor comprising boroproline compounds |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| DE19940130A1 (de) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
| JP4748908B2 (ja) * | 1999-09-10 | 2011-08-17 | ザ・ユニバーシティ・オブ・シドニー | ジペプチジルペプチダーゼ |
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| JP2003535034A (ja) | 1999-11-12 | 2003-11-25 | ギルフォード ファーマシューティカルズ インコーポレイテッド | ジペプチジルペプチダーゼiv阻害剤並びにジペプチジルペプチダーゼiv阻害剤の製造及び使用法 |
| GB0010188D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
| DE10150203A1 (de) * | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| US6634939B2 (en) * | 2001-08-31 | 2003-10-21 | Thomas W. Johnson | Ventilation system and method |
| EP2316470A3 (en) | 2001-11-26 | 2011-08-24 | Trustees Of Tufts College | Peptidomimetic inhibitors of post-proline cleaving enzymes |
| WO2003045228A2 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Methods for treating autoimmune disorders, and reagents related thereto |
| US7691967B2 (en) | 2002-04-30 | 2010-04-06 | Trustees Of Tufts College | Smart pro-drugs of serine protease inhibitors |
| WO2004004661A2 (en) * | 2002-07-09 | 2004-01-15 | Point Therapeutics, Inc. | Boroproline compound combination therapy |
| ATE549028T1 (de) * | 2003-05-15 | 2012-03-15 | Tufts College | Stabile analoga von glp-1 |
| AU2005216970B2 (en) * | 2004-02-23 | 2011-07-07 | Trustees Of Tufts College | Inhibitors of dipeptidylpeptidase IV for regulating glucose metabolism |
| US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
-
2002
- 2002-11-26 EP EP10011373A patent/EP2316470A3/en not_active Withdrawn
- 2002-11-26 CA CA2837936A patent/CA2837936A1/en not_active Abandoned
- 2002-11-26 US US10/496,706 patent/US7727964B2/en not_active Expired - Lifetime
- 2002-11-26 JP JP2003547426A patent/JP4771661B2/ja not_active Expired - Fee Related
- 2002-11-26 CA CA002468192A patent/CA2468192A1/en not_active Abandoned
- 2002-11-26 WO PCT/US2002/038053 patent/WO2003045977A2/en not_active Ceased
- 2002-11-26 EP EP02792306A patent/EP1469873A4/en not_active Withdrawn
- 2002-11-26 AU AU2002357767A patent/AU2002357767C1/en not_active Ceased
-
2010
- 2010-06-01 US US12/791,517 patent/US20110082108A1/en not_active Abandoned
-
2011
- 2011-03-02 JP JP2011045147A patent/JP2011121989A/ja active Pending
-
2014
- 2014-02-24 JP JP2014033295A patent/JP2014139191A/ja not_active Abandoned
-
2016
- 2016-02-12 US US15/043,110 patent/US9757400B2/en not_active Expired - Fee Related
-
2017
- 2017-06-19 US US15/626,254 patent/US20170333461A1/en not_active Abandoned
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