JP2010529196A5 - - Google Patents
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- Publication number
- JP2010529196A5 JP2010529196A5 JP2010512186A JP2010512186A JP2010529196A5 JP 2010529196 A5 JP2010529196 A5 JP 2010529196A5 JP 2010512186 A JP2010512186 A JP 2010512186A JP 2010512186 A JP2010512186 A JP 2010512186A JP 2010529196 A5 JP2010529196 A5 JP 2010529196A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- deuterium
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 230000000155 isotopic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93420107P | 2007-06-12 | 2007-06-12 | |
| US6762708P | 2008-02-29 | 2008-02-29 | |
| PCT/US2008/007331 WO2008156632A1 (en) | 2007-06-12 | 2008-06-12 | Azapeptide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010529196A JP2010529196A (ja) | 2010-08-26 |
| JP2010529196A5 true JP2010529196A5 (enExample) | 2011-08-04 |
Family
ID=39730784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512186A Pending JP2010529196A (ja) | 2007-06-12 | 2008-06-12 | アザペプチド誘導体 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US20090036357A1 (enExample) |
| EP (3) | EP2322509B1 (enExample) |
| JP (1) | JP2010529196A (enExample) |
| KR (2) | KR20120029480A (enExample) |
| CN (2) | CN102424668A (enExample) |
| AR (1) | AR066972A1 (enExample) |
| AT (2) | ATE536343T1 (enExample) |
| AU (1) | AU2008267048C1 (enExample) |
| BR (2) | BRPI0823520A2 (enExample) |
| CA (1) | CA2692028C (enExample) |
| CO (1) | CO6241121A2 (enExample) |
| CY (1) | CY1109766T1 (enExample) |
| DE (1) | DE602008000255D1 (enExample) |
| DK (1) | DK2003120T3 (enExample) |
| ES (3) | ES2395137T3 (enExample) |
| HR (1) | HRP20100065T1 (enExample) |
| MX (1) | MX2009013565A (enExample) |
| PL (1) | PL2003120T3 (enExample) |
| PT (1) | PT2003120E (enExample) |
| RS (1) | RS51226B (enExample) |
| RU (2) | RU2448958C2 (enExample) |
| SI (1) | SI2003120T1 (enExample) |
| TW (1) | TW200908970A (enExample) |
| WO (1) | WO2008156632A1 (enExample) |
| ZA (1) | ZA200909079B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080241289A1 (en) * | 2007-02-23 | 2008-10-02 | Auspex Pharmaceuticals, Inc. | Preparation and utility of non-nucleoside reverse transcriptase inhibitors |
| WO2008156632A1 (en) | 2007-06-12 | 2008-12-24 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| EP2334318B1 (en) * | 2008-10-06 | 2016-02-10 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Hiv-1 integrase derived stimulatory peptides interfering with integrase - rev protein binding |
| WO2010132663A1 (en) * | 2009-05-13 | 2010-11-18 | Concert Pharmaceticals, Inc. | Pegylated azapeptide derivatives as hiv protease inhibitors |
| WO2010135424A1 (en) * | 2009-05-19 | 2010-11-25 | Glaxosmithkline Llc | Chemical compounds |
| RU2593790C2 (ru) * | 2009-12-21 | 2016-08-10 | Янссен Сайенсиз Айрлэнд Юси | Разлагаемый удаляемый имплантат для непрерывного высвобождения активного соединения |
| WO2011080562A1 (en) | 2009-12-29 | 2011-07-07 | Hetero Research Foundation | Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals |
| SI3135656T1 (sl) | 2011-06-20 | 2019-05-31 | H. Lundbeck A/S | Devterirani 1-piperazino-3-fenil indani za zdravljenje shizofrenije |
| CN106543073A (zh) * | 2015-09-17 | 2017-03-29 | 宁波杰尔盛化工有限公司 | 2-[4-（2-吡啶基）苄基]-肼羧酸叔丁酯的制备方法 |
| RU2736941C2 (ru) * | 2015-12-02 | 2020-11-23 | Мерк Шарп энд Доум Корп. | Фармацевтические композиции, содержащие доравирин, тенофовира дизопроксила фумарат и ламивудин |
| AU2017241524B2 (en) | 2016-03-28 | 2021-07-08 | Incyte Corporation | Pyrrolotriazine compounds as TAM inhibitors |
| JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| TWI821200B (zh) | 2017-09-27 | 2023-11-11 | 美商英塞特公司 | Tam抑制劑之鹽 |
| US11241438B2 (en) | 2018-06-29 | 2022-02-08 | Incyte Corporation | Formulations of an AXL/MER inhibitor |
| TWI766172B (zh) | 2018-07-30 | 2022-06-01 | 美商基利科學股份有限公司 | 抗hiv化合物 |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| AU2021257341A1 (en) * | 2020-04-16 | 2022-11-17 | The Medical College Of Wisconsin, Inc. | Aerosolized formulations of HIV protease inhibitors for the treatment of airway reflux |
| CN114426568B (zh) * | 2022-01-11 | 2023-04-25 | 嘉兴安谛康生物科技有限公司 | 2-氧代-3-吡咯烷基丙腈类化合物及其药物组合物和用途 |
| AU2024283382A1 (en) | 2023-05-31 | 2025-11-13 | Gilead Sciences, Inc. | Anti-hiv compounds |
| CN116987024B (zh) * | 2023-08-01 | 2026-02-13 | 浙江荣耀生物科技股份有限公司 | 一种阿扎那韦中间体的制备方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ216172A (en) | 1985-05-15 | 1989-08-29 | Wellcome Found | Nucleosides and pharmaceutical compositions |
| GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| US5539122A (en) * | 1989-05-23 | 1996-07-23 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| KR100187990B1 (ko) | 1992-12-29 | 1999-06-01 | 스티븐 에프. 웨인스톡 | 레트로바이러스성 프로테아제 억제 화합물 제조용 합성 중간체 |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5849911A (en) | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| TW409125B (en) * | 1996-04-22 | 2000-10-21 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| WO1997046514A1 (en) | 1996-05-31 | 1997-12-11 | Novartis Ag | Process for the preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues |
| US6087383A (en) * | 1998-01-20 | 2000-07-11 | Bristol-Myers Squibb Company | Bisulfate salt of HIV protease inhibitor |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| GB9914821D0 (en) | 1999-06-24 | 1999-08-25 | Glaxo Group Ltd | Compounds |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| EP1104760B1 (en) * | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
| BR0209325A (pt) | 2001-05-03 | 2004-07-20 | Hoffmann La Roche | Forma de dosagem farmacêutica de mesilato de nelfinavir amorfo |
| CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Pharmaceuticals, Inc. | Delivery of drug esters through an inhalation route |
| EE200400065A (et) | 2001-08-31 | 2004-06-15 | Bristol-Myers Squibb Company | Atasanaviiri kasutamine HIV-i ravis |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| AU2004273773B2 (en) | 2003-02-21 | 2008-01-24 | Jarrow Formulas, Inc. | Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors |
| US20050131017A1 (en) | 2003-12-11 | 2005-06-16 | Degoey David A. | HIV protease inhibiting compounds |
| US20050148523A1 (en) | 2003-12-15 | 2005-07-07 | Colonno Richard J. | Method of treating HIV infection in atazanavir-resistant patients using a combination of atazanavir and another protease inhibitor |
| US7829720B2 (en) * | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| ES2402552T3 (es) * | 2004-07-06 | 2013-05-06 | Abbott Laboratories | Profármacos de inhibidores de proteasa de VIH |
| BRPI0516170A (pt) | 2004-09-29 | 2008-08-26 | Cordis Corp | formas de dosagens farmacêuticas estáveis e amorfas de compostos de rapamicina |
| US20070259894A1 (en) | 2004-12-03 | 2007-11-08 | Kelem Kassahun | Use of Atazanavir for Improving the Pharmacokinetics of Drugs Metabolized by Ugt1a1 |
| CA2624179A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| WO2008030382A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| WO2008156632A1 (en) * | 2007-06-12 | 2008-12-24 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| US20090076097A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched atazanavir |
| WO2010132663A1 (en) | 2009-05-13 | 2010-11-18 | Concert Pharmaceticals, Inc. | Pegylated azapeptide derivatives as hiv protease inhibitors |
-
2008
- 2008-06-12 WO PCT/US2008/007331 patent/WO2008156632A1/en not_active Ceased
- 2008-06-12 AR ARP080102501A patent/AR066972A1/es unknown
- 2008-06-12 US US12/157,712 patent/US20090036357A1/en not_active Abandoned
- 2008-06-12 DE DE602008000255T patent/DE602008000255D1/de active Active
- 2008-06-12 TW TW097122018A patent/TW200908970A/zh unknown
- 2008-06-12 AU AU2008267048A patent/AU2008267048C1/en not_active Ceased
- 2008-06-12 ES ES09075359T patent/ES2395137T3/es active Active
- 2008-06-12 SI SI200830012T patent/SI2003120T1/sl unknown
- 2008-06-12 ES ES08252023T patent/ES2356334T3/es active Active
- 2008-06-12 CN CN2011102869075A patent/CN102424668A/zh active Pending
- 2008-06-12 EP EP11155667A patent/EP2322509B1/en active Active
- 2008-06-12 CA CA2692028A patent/CA2692028C/en not_active Expired - Fee Related
- 2008-06-12 PT PT08252023T patent/PT2003120E/pt unknown
- 2008-06-12 MX MX2009013565A patent/MX2009013565A/es active IP Right Grant
- 2008-06-12 BR BRPI0823520-1A patent/BRPI0823520A2/pt not_active IP Right Cessation
- 2008-06-12 KR KR1020127003399A patent/KR20120029480A/ko not_active Withdrawn
- 2008-06-12 AT AT09075359T patent/ATE536343T1/de active
- 2008-06-12 BR BRPI0813911-3A patent/BRPI0813911A2/pt not_active IP Right Cessation
- 2008-06-12 CN CN2008800216013A patent/CN101711237B/zh not_active Expired - Fee Related
- 2008-06-12 DK DK08252023.0T patent/DK2003120T3/da active
- 2008-06-12 KR KR1020107000675A patent/KR101185899B1/ko not_active Expired - Fee Related
- 2008-06-12 PL PL08252023T patent/PL2003120T3/pl unknown
- 2008-06-12 AT AT08252023T patent/ATE447554T1/de active
- 2008-06-12 EP EP08252023A patent/EP2003120B9/en active Active
- 2008-06-12 ES ES11155667T patent/ES2394952T3/es active Active
- 2008-06-12 RS RSP-2010/0034A patent/RS51226B/sr unknown
- 2008-06-12 RU RU2010100821/04A patent/RU2448958C2/ru not_active IP Right Cessation
- 2008-06-12 JP JP2010512186A patent/JP2010529196A/ja active Pending
- 2008-06-12 EP EP09075359A patent/EP2116532B1/en active Active
-
2009
- 2009-12-11 CO CO09141805A patent/CO6241121A2/es not_active Application Discontinuation
- 2009-12-18 ZA ZA2009/09079A patent/ZA200909079B/en unknown
-
2010
- 2010-02-03 CY CY20101100099T patent/CY1109766T1/el unknown
- 2010-02-03 HR HR20100065T patent/HRP20100065T1/hr unknown
- 2010-04-06 US US12/755,184 patent/US8158805B2/en not_active Expired - Fee Related
-
2012
- 2012-01-19 RU RU2012101881/04A patent/RU2012101881A/ru not_active Application Discontinuation
- 2012-03-02 US US13/411,089 patent/US8258309B2/en not_active Expired - Fee Related
- 2012-08-27 US US13/595,511 patent/US20130041156A1/en not_active Abandoned