JP2011519871A5 - - Google Patents

Download PDF

Info

Publication number
JP2011519871A5
JP2011519871A5 JP2011507765A JP2011507765A JP2011519871A5 JP 2011519871 A5 JP2011519871 A5 JP 2011519871A5 JP 2011507765 A JP2011507765 A JP 2011507765A JP 2011507765 A JP2011507765 A JP 2011507765A JP 2011519871 A5 JP2011519871 A5 JP 2011519871A5
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
salt
pharmaceutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011507765A
Other languages
English (en)
Japanese (ja)
Other versions
JP4790871B2 (ja
JP2011519871A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CA2009/000611 external-priority patent/WO2009135299A1/en
Publication of JP2011519871A publication Critical patent/JP2011519871A/ja
Publication of JP2011519871A5 publication Critical patent/JP2011519871A5/ja
Application granted granted Critical
Publication of JP4790871B2 publication Critical patent/JP4790871B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011507765A 2008-05-05 2009-05-04 レニン阻害剤としての３，４−置換ピペリジン誘導体 Expired - Fee Related JP4790871B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12652908P 2008-05-05 2008-05-05
US61/126,529 2008-05-05
US18830308P 2008-08-07 2008-08-07
US61/188,303 2008-08-07
PCT/CA2009/000611 WO2009135299A1 (en) 2008-05-05 2009-05-04 3, 4 - substituted piperidine derivatives as renin inhibitors

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011123054A Division JP5587246B2 (ja) 2008-05-05 2011-06-01 レニン阻害剤としての３，４−置換ピペリジン誘導体
JP2011123057A Division JP5653842B2 (ja) 2008-05-05 2011-06-01 レニン阻害剤としての３，４−置換ピペリジン誘導体

Publications (3)

Publication Number Publication Date
JP2011519871A JP2011519871A (ja) 2011-07-14
JP2011519871A5 true JP2011519871A5 (enExample) 2011-08-25
JP4790871B2 JP4790871B2 (ja) 2011-10-12

Family

ID=41264366

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2011507765A Expired - Fee Related JP4790871B2 (ja) 2008-05-05 2009-05-04 レニン阻害剤としての３，４−置換ピペリジン誘導体
JP2011123057A Expired - Fee Related JP5653842B2 (ja) 2008-05-05 2011-06-01 レニン阻害剤としての３，４−置換ピペリジン誘導体
JP2011123054A Expired - Fee Related JP5587246B2 (ja) 2008-05-05 2011-06-01 レニン阻害剤としての３，４−置換ピペリジン誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011123057A Expired - Fee Related JP5653842B2 (ja) 2008-05-05 2011-06-01 レニン阻害剤としての３，４−置換ピペリジン誘導体
JP2011123054A Expired - Fee Related JP5587246B2 (ja) 2008-05-05 2011-06-01 レニン阻害剤としての３，４−置換ピペリジン誘導体

Country Status (23)

Country Link
US (1) US8889714B2 (enExample)
EP (1) EP2274295B1 (enExample)
JP (3) JP4790871B2 (enExample)
KR (2) KR101403311B1 (enExample)
CN (1) CN102015682B (enExample)
AU (1) AU2009243875B2 (enExample)
BR (1) BRPI0912388A2 (enExample)
CA (1) CA2722734C (enExample)
CO (1) CO6311081A2 (enExample)
CR (1) CR11809A (enExample)
DO (1) DOP2010000329A (enExample)
EA (1) EA020853B1 (enExample)
ES (1) ES2548134T3 (enExample)
IL (1) IL208467A (enExample)
MA (1) MA32296B1 (enExample)
MX (1) MX2010012067A (enExample)
MY (1) MY152042A (enExample)
NI (1) NI201000188A (enExample)
NZ (1) NZ589019A (enExample)
PL (1) PL2274295T3 (enExample)
SG (1) SG192543A1 (enExample)
SV (1) SV2010003723A (enExample)
WO (1) WO2009135299A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
AU2009326797B2 (en) * 2008-12-10 2012-12-13 Merck Canada Inc. 3,4 - substituted piperidine derivatives as renin inhibitors
TWI562977B (en) * 2010-11-05 2016-12-21 Bayer Ip Gmbh Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation
UA112897C2 (uk) * 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
CN107602381B (zh) * 2017-09-11 2021-03-16 陕西莱特光电材料股份有限公司 一种萘甲酸酯类衍生物及其制备方法
CN108033876A (zh) * 2017-12-20 2018-05-15 江汉大学 一种5-溴-2-氯苯甲醛的制备方法
WO2020109039A1 (en) 2018-11-28 2020-06-04 Basf Se Pesticidal compounds
CN115443267B (zh) 2020-04-28 2025-09-05 巴斯夫欧洲公司 杀害虫化合物

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
PL193686B1 (pl) 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
US5994294A (en) * 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
WO1998019672A1 (en) 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292426B1 (it) * 1997-06-27 1999-02-08 Nicox Sa Sali nitrati di ace-inibitori
EP1415987B1 (en) 2000-10-20 2007-02-28 Eisai R&D Management Co., Ltd. Nitrogenous aromatic ring compounds as anti cancer agents
CA2483241C (en) 2002-04-29 2011-05-31 Actelion Pharmaceuticals Ltd Novel diazabicyclononene derivatives
US20060009497A1 (en) 2002-06-27 2006-01-12 Actelion Pharmaceuticals, Ltd. Novel tetrahydropyridine derivatives as renin inhibitors
US20040204455A1 (en) 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
US20060217371A1 (en) 2003-04-28 2006-09-28 Olivier Bezencon Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
CN1972912A (zh) 2003-04-29 2007-05-30 埃科特莱茵药品有限公司 新型3,4－二取代的1,2,3,6－四氢吡啶衍生物
BRPI0409818A (pt) 2003-04-30 2006-05-09 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos
US20060205768A1 (en) 2003-04-30 2006-09-14 Olivier Bezencon Tropane derivatives and their use as ace inhibitors
CN1780663A (zh) 2003-04-30 2006-05-31 埃科特莱茵药品有限公司 作为肾素抑制剂的新型3－位具有杂原子的9－氮杂双环壬烯衍生物
MXPA05011711A (es) 2003-05-02 2006-01-23 Actelion Pharmaceuticals Ltd Derivados de diazabiciclononeno.
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
CN1863773A (zh) 2003-10-09 2006-11-15 埃科特莱茵药品有限公司 四氢吡啶衍生物
WO2005040165A1 (en) 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
US20070135405A1 (en) 2003-10-23 2007-06-14 Olivier Bezencon Novel diazabicyclononene and tetrahydropyridine derivatives with a new polar side-chain
CA2547547A1 (en) 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
JP2007513107A (ja) 2003-12-05 2007-05-24 アクテリオン　ファマシューティカルズ　リミテッド ジアザビシクロノネンおよび新側鎖を有するテトラヒドロピリジン誘導体
AR053406A1 (es) 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
WO2006021401A2 (en) 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicylononene derivatives
AU2005276624B2 (en) 2004-08-25 2011-09-29 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives as renin inhibitors
WO2006021399A2 (en) 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Azabicyclononene derivatives as renin inhibitors
WO2006021403A1 (en) 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicyclononene derivatives
WO2006058546A1 (en) 2004-12-01 2006-06-08 Actelion Pharmaceuticals Ltd Novel lactame derivatives as renin inhibitors
AR052263A1 (es) 2004-12-08 2007-03-07 Actelion Pharmaceuticals Ltd Derivado de diazabiciclononeno
WO2006063610A1 (en) 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Heteroaryl substituted diazabicyclononene derivatives
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
CA2595986A1 (en) 2005-01-28 2006-08-03 Actelion Pharmaceuticals Ltd 7-{4-[2-(2,6-dichlor0-4-methylphenoxy)-ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amides as inhibitors of renin for the treatment of hypertension
WO2006092268A1 (en) 2005-03-02 2006-09-08 Actelion Pharmaceuticals Ltd Bicyclic five-membered heteroaryl derivatives and their use as renin inhibitors
GB0504850D0 (en) * 2005-03-09 2005-04-13 Novartis Ag Organic compounds
AR055756A1 (es) 2005-03-31 2007-09-05 Speedel Experimenta Ag Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos
JP2008535825A (ja) 2005-03-31 2008-09-04 シュペーデル・エクスペリメンタ・アーゲー レニン阻害剤としての３，４，５−置換ピペリジン
GB0510810D0 (en) 2005-05-26 2005-06-29 Novartis Ag Organic compounds
US7799805B2 (en) 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
GB0511063D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
WO2006131884A2 (en) 2005-06-07 2006-12-14 Actelion Pharmaceuticals Ltd Thiazole substituted diazabicyclononane or-nonene derivatives as renin inhibitors
AU2006272348B2 (en) 2005-07-22 2011-06-16 Merck Frosst Canada Ltd Renin inhibitors
WO2007034406A1 (en) 2005-09-22 2007-03-29 Actelion Pharmaceuticals Ltd Pyrrolidine-3-carboxylic acid amide derivatives and their use as inhibitors of renin
WO2007034445A2 (en) 2005-09-26 2007-03-29 Actelion Pharmaceuticals Ltd Novel piperazine derivatives as renin inhibitors for cardiovascular events and renal insufficiency
WO2007049224A1 (en) 2005-10-25 2007-05-03 Actelion Pharmaceuticals Ltd Novel hexahydro- or octahydro-cyclopenta[c]pyrrole derivatives
NZ569135A (en) 2005-12-30 2011-08-26 Novartis Ag 3,5-Substituted piperidine compounds as renin inhibitors
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
KR20080091273A (ko) 2006-02-02 2008-10-09 액테리온 파마슈티칼 리미티드 레닌 저해제로서의 2차 아민
BRPI0708487A2 (pt) 2006-03-03 2011-05-31 Actelion Pharmaceuticals Ltd composto, composição farmacêutica que o compreende e seu uso
CL2007000595A1 (es) 2006-03-08 2008-01-04 Actelion Pharmaceuticals Ltd Compuestos derivados de piperidina; composicion farmaceutica y uso para el tratamiento y/o profilaxis de enfermedades seleccionadas entre hipertension, insuficiencia cardiaca congestiva e insuficiencia renal entre otras.
JP2010503682A (ja) 2006-09-18 2010-02-04 ビテ ファーマシューティカルズ， インコーポレイテッド レニン阻害剤としてのピペリジン誘導体
AU2007321671A1 (en) * 2006-11-17 2008-05-22 Merck Frosst Canada Ltd. Renin inhibitors
CA2688057A1 (en) * 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Novel case of renin inhibitors
JP2010535716A (ja) 2007-08-07 2010-11-25 メルク フロスト カナダ リミテツド レニン阻害剤
EP2229363A4 (en) * 2007-12-04 2010-12-15 Merck Frosst Canada Ltd Renin Inhibitors
AU2009250299A1 (en) 2008-05-22 2009-11-26 Merck Frosst Canada Ltd 3, 4 - substituted piperidine derivatives as renin inhibitors
US20120190701A1 (en) 2009-08-18 2012-07-26 Merck Sharp & Dohme Corp. Renin inhibitors

Similar Documents

Publication Publication Date Title
JP2012111758A5 (enExample)
JP2012107057A5 (enExample)
JP2007269812A5 (enExample)
JP2009149903A5 (enExample)
JP2009502793A5 (enExample)
JP2013532130A5 (enExample)
JP2010019854A5 (enExample)
JP2011105738A5 (enExample)
JP2009091351A5 (enExample)
JP2009091350A5 (enExample)
JP2012255926A5 (enExample)
JP2011510079A5 (enExample)
JP2013541578A5 (enExample)
JP2013532687A5 (enExample)
JP2011117499A5 (enExample)
JP2011518833A5 (enExample)
JP2009545527A5 (enExample)
JP2012031285A5 (enExample)
JP2010049241A5 (enExample)
JP2010070692A5 (enExample)
JP2012098270A5 (enExample)
JP2010233885A5 (enExample)
JP2010037339A5 (enExample)
NL300963I2 (nl) inotersen of een zout daarvan
JP2011037885A5 (enExample)