MA32296B1 - Derives de piperidine 3,4-substitues comme inhibiteurs de la renine - Google Patents

Derives de piperidine 3,4-substitues comme inhibiteurs de la renine

Info

Publication number
MA32296B1
MA32296B1 MA33335A MA33335A MA32296B1 MA 32296 B1 MA32296 B1 MA 32296B1 MA 33335 A MA33335 A MA 33335A MA 33335 A MA33335 A MA 33335A MA 32296 B1 MA32296 B1 MA 32296B1
Authority
MA
Morocco
Prior art keywords
substituted piperidine
renin inhibitors
piperidine derivatives
renin
substituted
Prior art date
Application number
MA33335A
Other languages
Arabic (ar)
English (en)
Inventor
Austin Chih-Yu Chen
Daniel Dube
Pierre-Andre Fournier
Erich L Grimm
Patrick Lacombe
Sebastien Laliberte
Dwight Macdonald
D Bruce Mackay
Daniel James Mckay
Tom Yao-Hsiang Wu
Louis-Charles Campeau
Jeremy Peter Scott
Nadine Bremeyer
Original Assignee
Merck Frosst Canada Ltd
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Ltd, Merck Sharp & Dohme filed Critical Merck Frosst Canada Ltd
Publication of MA32296B1 publication Critical patent/MA32296B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention concerne des composés inhibiteurs de la rénine à base de pipéridinyle substitués en 3,4 portant en position 4 de l'oxopyridine et ayant la formule (i). L'invention concerne en outre des compositions pharmaceutiques contenant lesdits composés, ainsi que leur utilisation dans le traitement d'évènements cardiovasculaires et d'insuffisance rénale.
MA33335A 2008-05-05 2010-11-11 Derives de piperidine 3,4-substitues comme inhibiteurs de la renine MA32296B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12652908P 2008-05-05 2008-05-05
US18830308P 2008-08-07 2008-08-07
PCT/CA2009/000611 WO2009135299A1 (fr) 2008-05-05 2009-05-04 Dérivés de pipéridine substitués en 3,4 utilisés en tant qu'inhibiteurs de la rénine

Publications (1)

Publication Number Publication Date
MA32296B1 true MA32296B1 (fr) 2011-05-02

Family

ID=41264366

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33335A MA32296B1 (fr) 2008-05-05 2010-11-11 Derives de piperidine 3,4-substitues comme inhibiteurs de la renine

Country Status (23)

Country Link
US (1) US8889714B2 (fr)
EP (1) EP2274295B1 (fr)
JP (3) JP4790871B2 (fr)
KR (2) KR101403311B1 (fr)
CN (1) CN102015682B (fr)
AU (1) AU2009243875B2 (fr)
BR (1) BRPI0912388A2 (fr)
CA (1) CA2722734C (fr)
CO (1) CO6311081A2 (fr)
CR (1) CR11809A (fr)
DO (1) DOP2010000329A (fr)
EA (1) EA020853B1 (fr)
ES (1) ES2548134T3 (fr)
IL (1) IL208467A (fr)
MA (1) MA32296B1 (fr)
MX (1) MX2010012067A (fr)
MY (1) MY152042A (fr)
NI (1) NI201000188A (fr)
NZ (1) NZ589019A (fr)
PL (1) PL2274295T3 (fr)
SG (1) SG192543A1 (fr)
SV (1) SV2010003723A (fr)
WO (1) WO2009135299A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
US20110237622A1 (en) * 2008-12-10 2011-09-29 Merck Frosst Canada Ltd. Renin inhibitors
TWI562977B (en) * 2010-11-05 2016-12-21 Bayer Ip Gmbh Process for the preparation of substituted n-(benzyl)cyclopropanamines by imine hydrogenation
UA112897C2 (uk) * 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
CN107602381B (zh) * 2017-09-11 2021-03-16 陕西莱特光电材料股份有限公司 一种萘甲酸酯类衍生物及其制备方法
CN108033876A (zh) * 2017-12-20 2018-05-15 江汉大学 一种5-溴-2-氯苯甲醛的制备方法
EP3887357A1 (fr) 2018-11-28 2021-10-06 Basf Se Composés pesticides
EP4143167B1 (fr) 2020-04-28 2024-05-15 Basf Se Composés pesticides

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380758A (en) 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
TR199800409T1 (xx) 1995-09-07 1998-05-21 F.Hoffmann-La Roche Ag Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler
US5994294A (en) * 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
JP2001504457A (ja) 1996-11-01 2001-04-03 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ホスホジエステラーゼ阻害剤化合物、組成物及びその使用法
IT1295694B1 (it) * 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292426B1 (it) * 1997-06-27 1999-02-08 Nicox Sa Sali nitrati di ace-inibitori
ATE419239T1 (de) 2000-10-20 2009-01-15 Eisai R&D Man Co Ltd Verfahren zur herstellung von 4-phenoxy chinolin derivaten
WO2003093267A1 (fr) 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales
BR0312000A (pt) 2002-06-27 2005-03-22 Actelion Pharmaceuticals Ltd Compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, uso dos compostos
US20040204455A1 (en) 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
CN1780836A (zh) 2003-04-28 2006-05-31 埃科特莱茵药品有限公司 作为血管紧张肽原酶抑制剂的新型二氮杂双环壬烯和四氢吡啶衍生物
KR20060007041A (ko) 2003-04-29 2006-01-23 액테리온 파마슈티칼 리미티드 신규의 3,4-이치환된 1,2,3,6-테트라하이드로피리딘 유도체
CN1780833A (zh) 2003-04-30 2006-05-31 埃科特莱茵药品有限公司 托品烷衍生物及其作为血管紧张肽转化酶抑制剂的应用
CA2521938A1 (fr) 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives de 9-azabicyclo[3.3.1]non-6-ee a heteroatome en position 3 servant d'inhibiteurs de la renine
JP2006524654A (ja) 2003-04-30 2006-11-02 アクテリオン　ファマシューティカルズ　リミテッド 新規アザビシクロノネン誘導体
KR20060015573A (ko) 2003-05-02 2006-02-17 액테리온 파마슈티칼 리미티드 신규한 디아자비시클로노넨 유도체
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
CN1863773A (zh) 2003-10-09 2006-11-15 埃科特莱茵药品有限公司 四氢吡啶衍生物
JP2007508262A (ja) 2003-10-13 2007-04-05 アクテリオン　ファマシューティカルズ　リミテッド 新規ジアザビシクロノネン誘導体およびその使用
WO2005040173A1 (fr) 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
WO2005054243A1 (fr) 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine
AU2004295092A1 (en) 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd. Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
WO2006021401A2 (fr) 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Derives de bicyclononene
JP2008510755A (ja) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド ビシクロノネン誘導体
WO2006021403A1 (fr) 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Dérivés du bicyclononène
WO2006021399A2 (fr) 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Derives de bicyclononene
WO2006058546A1 (fr) 2004-12-01 2006-06-08 Actelion Pharmaceuticals Ltd Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine
TW200634014A (en) 2004-12-08 2006-10-01 Actelion Pharmaceuticals Ltd Novel diazabicyclononene derivative
WO2006063610A1 (fr) 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Dérivés de diazabicyclononène substitués par des groupements hétéroaryle
GB0428526D0 (en) * 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
RU2007132438A (ru) 2005-01-28 2009-03-10 Актелион Фармасьютикалз Лтд (Ch) Циклопропил-(2,3-диметилбензил)амид 7-{4-[2-(2,6-дихлор-4-метилфенокси)этокси]фенил}-3,9-диазабицикло[3.3.1]нон-6-ен-6-карбоновой кислоты в качестве ингибиторов ренина для лечения артериальной гипертензии
WO2006092268A1 (fr) 2005-03-02 2006-09-08 Actelion Pharmaceuticals Ltd Derives heteroaryle bicycliques a cinq chainons et leur utilisation en tant qu’inhibiteurs de la renine
GB0504850D0 (en) 2005-03-09 2005-04-13 Novartis Ag Organic compounds
AR055756A1 (es) 2005-03-31 2007-09-05 Speedel Experimenta Ag Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos
WO2006103275A1 (fr) 2005-03-31 2006-10-05 Speedel Experimenta Ag Piperidine a substitution 3,4,5 utiles en tant qu'inhibiteurs de la renine
GB0510810D0 (en) 2005-05-26 2005-06-29 Novartis Ag Organic compounds
JP4297972B2 (ja) 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
GB0511063D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
WO2006131884A2 (fr) 2005-06-07 2006-12-14 Actelion Pharmaceuticals Ltd Nouveaux derives de thiazole
WO2007009250A1 (fr) 2005-07-22 2007-01-25 Merck Frosst Canada Ltd. Inhibiteurs de la renine
WO2007034406A1 (fr) 2005-09-22 2007-03-29 Actelion Pharmaceuticals Ltd Derives amides d'acide pyrrolidine-3-carboxylique utilises comme inhibiteurs de la renine
WO2007034445A2 (fr) 2005-09-26 2007-03-29 Actelion Pharmaceuticals Ltd Nouveaux derives de la piperazine
WO2007049224A1 (fr) 2005-10-25 2007-05-03 Actelion Pharmaceuticals Ltd Nouveaux derives d'hexahydro- ou d'octahydro-cyclopenta[c]pyrrole
EP1968940B1 (fr) 2005-12-30 2014-04-02 Novartis AG Dérivés de pipéridine 3,5-substitués en tant qu'inhibiteurs de rénine
EP1816122A3 (fr) * 2006-01-19 2007-09-19 Speedel Experimenta AG Pipéridines substituées 3,4,5 en tant que composants thérapeutiques
AU2007210813A1 (en) * 2006-02-02 2007-08-09 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
EP2029542A2 (fr) 2006-03-03 2009-03-04 Actelion Pharmaceuticals Ltd. Amines primaires comme inhibiteurs de renine
AU2007224368A1 (en) 2006-03-08 2007-09-13 Actelion Pharmaceuticals Ltd New amines
ATE520690T1 (de) 2006-09-18 2011-09-15 Vitae Pharmaceuticals Inc Piperidinderivate als renin-inhibitoren
DE602007007664D1 (de) * 2006-11-17 2010-08-19 Merck Frosst Canada Inc Renininhibitoren
CA2688057A1 (fr) * 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Nouveaux inhibiteurs de rhenine
JP2010535716A (ja) 2007-08-07 2010-11-25 メルク フロスト カナダ リミテツド レニン阻害剤
US20100249163A1 (en) * 2007-12-04 2010-09-30 Daniel Dube Renin inhibitors
US20110152316A1 (en) 2008-05-22 2011-06-23 Austin Chih-Yu Chen 3,4-substituted piperidine derivatives as renin inhibitors
US20120190701A1 (en) 2009-08-18 2012-07-26 Merck Sharp & Dohme Corp. Renin inhibitors

Also Published As

Publication number Publication date
JP5653842B2 (ja) 2015-01-14
KR20100131007A (ko) 2010-12-14
SV2010003723A (es) 2011-01-24
JP2011225579A (ja) 2011-11-10
IL208467A0 (en) 2010-12-30
AU2009243875A1 (en) 2009-11-12
EP2274295A4 (fr) 2012-03-28
CN102015682A (zh) 2011-04-13
MX2010012067A (es) 2010-12-06
BRPI0912388A2 (pt) 2017-09-26
NZ589019A (en) 2012-10-26
US20110053940A1 (en) 2011-03-03
EP2274295A1 (fr) 2011-01-19
ES2548134T3 (es) 2015-10-14
CN102015682B (zh) 2014-07-16
CO6311081A2 (es) 2011-08-22
JP4790871B2 (ja) 2011-10-12
WO2009135299A1 (fr) 2009-11-12
IL208467A (en) 2014-07-31
MY152042A (en) 2014-08-15
SG192543A1 (en) 2013-08-30
EP2274295B1 (fr) 2015-08-05
DOP2010000329A (es) 2011-01-15
JP2011225580A (ja) 2011-11-10
PL2274295T3 (pl) 2016-01-29
KR101403311B1 (ko) 2014-06-05
EA201071269A1 (ru) 2011-06-30
EA020853B1 (ru) 2015-02-27
NI201000188A (es) 2012-02-02
JP5587246B2 (ja) 2014-09-10
CR11809A (es) 2011-01-10
US8889714B2 (en) 2014-11-18
CA2722734C (fr) 2013-11-05
CA2722734A1 (fr) 2009-11-12
JP2011519871A (ja) 2011-07-14
KR20130029116A (ko) 2013-03-21
AU2009243875B2 (en) 2011-12-01

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