WO2006058546A1 - Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine - Google Patents

Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine Download PDF

Info

Publication number
WO2006058546A1
WO2006058546A1 PCT/EP2004/013610 EP2004013610W WO2006058546A1 WO 2006058546 A1 WO2006058546 A1 WO 2006058546A1 EP 2004013610 W EP2004013610 W EP 2004013610W WO 2006058546 A1 WO2006058546 A1 WO 2006058546A1
Authority
WO
WIPO (PCT)
Prior art keywords
renal
cardiac
lower alkyl
phenyl
mmol
Prior art date
Application number
PCT/EP2004/013610
Other languages
English (en)
Inventor
Olivier Bezencon
Lubos Remen
Thierry Sifferlen
Corinna Grisostomi
Sylvia Richard-Bildstein
Daniel Bur
Christoph Boss
Olivier Corminboeuf
Walter Fischli
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Priority to PCT/EP2004/013610 priority Critical patent/WO2006058546A1/fr
Priority to PCT/IB2005/054008 priority patent/WO2006059304A2/fr
Publication of WO2006058546A1 publication Critical patent/WO2006058546A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Abstract

La présente invention décrit de nouveaux dérivés de lactame, des composés proches ainsi que l’emploi de ces substances en tant que principes actifs dans l’élaboration de préparations pharmaceutiques. La présente invention a également pour objet des aspects issus des précédents en ce qui concerne la synthèse des substances, les préparations pharmaceutiques contenant l'un au moins de ces composés, et plus particulièrement leur emploi en tant qu’inhibiteurs de la rénine.
PCT/EP2004/013610 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine WO2006058546A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/EP2004/013610 WO2006058546A1 (fr) 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine
PCT/IB2005/054008 WO2006059304A2 (fr) 2004-12-01 2005-12-01 Nouveaux derives bicycliques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2004/013610 WO2006058546A1 (fr) 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine

Publications (1)

Publication Number Publication Date
WO2006058546A1 true WO2006058546A1 (fr) 2006-06-08

Family

ID=34959363

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2004/013610 WO2006058546A1 (fr) 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine
PCT/IB2005/054008 WO2006059304A2 (fr) 2004-12-01 2005-12-01 Nouveaux derives bicycliques

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/054008 WO2006059304A2 (fr) 2004-12-01 2005-12-01 Nouveaux derives bicycliques

Country Status (1)

Country Link
WO (2) WO2006058546A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors
US8343968B2 (en) 2007-05-24 2013-01-01 Merck Canada Inc. Case of renin inhibitors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009135299A1 (fr) 2008-05-05 2009-11-12 Merck Frosst Canada Ltd. Dérivés de pipéridine substitués en 3,4 utilisés en tant qu'inhibiteurs de la rénine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096366A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives de 9-azabicyclo'3.3.1!non-6-ee a heteroatome en position 3 servant d'inhibiteurs de la renine
WO2004096803A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives d'azabicyclononene
WO2004096116A2 (fr) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene
WO2005040173A1 (fr) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
WO2005054244A2 (fr) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine comprenant une nouvelle chaine laterale

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004283821A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd. Diazabicyclononene derivatives and their use as renin inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096366A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives de 9-azabicyclo'3.3.1!non-6-ee a heteroatome en position 3 servant d'inhibiteurs de la renine
WO2004096803A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives d'azabicyclononene
WO2004096116A2 (fr) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene
WO2005040173A1 (fr) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
WO2005054244A2 (fr) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine comprenant une nouvelle chaine laterale

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
US8343968B2 (en) 2007-05-24 2013-01-01 Merck Canada Inc. Case of renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors

Also Published As

Publication number Publication date
WO2006059304A2 (fr) 2006-06-08
WO2006059304A3 (fr) 2006-10-12

Similar Documents

Publication Publication Date Title
ZA200509663B (en) Tropane derivatives and their use as ACE inhibitors
ZA200509667B (en) Azabicyclononene derivatives
US20060258648A1 (en) 9-Azabicyclo'3.3.1 inon-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors
US20060217371A1 (en) Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
WO2004096116A2 (fr) Derives de diazabicyclononene
US20070135406A1 (en) Diazabicyclononene and tetrahydropyridine derivatives with a new side-chain
US20070142363A1 (en) Novel diazabicyclonene derivatives and use thereof
US20070135405A1 (en) Novel diazabicyclononene and tetrahydropyridine derivatives with a new polar side-chain
US20070111989A1 (en) Novel diazabicyclononene derivatives and use
WO2006092268A1 (fr) Derives heteroaryle bicycliques a cinq chainons et leur utilisation en tant qu’inhibiteurs de la renine
WO2006063610A1 (fr) Dérivés de diazabicyclononène substitués par des groupements hétéroaryle
WO2006058546A1 (fr) Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine
US20060223795A1 (en) Novel diazabicyclononene derivatives
EP1622906A1 (fr) Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
EP1692132A2 (fr) Derives de diazabicyclononene et de tetrahydropyridine comprenant une nouvelle chaine laterale

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 04801184

Country of ref document: EP

Kind code of ref document: A1