WO2006059304A3 - Nouveaux derives bicycliques - Google Patents

Nouveaux derives bicycliques Download PDF

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Publication number
WO2006059304A3
WO2006059304A3 PCT/IB2005/054008 IB2005054008W WO2006059304A3 WO 2006059304 A3 WO2006059304 A3 WO 2006059304A3 IB 2005054008 W IB2005054008 W IB 2005054008W WO 2006059304 A3 WO2006059304 A3 WO 2006059304A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
renin inhibitors
derivatives
lactame
lactame derivatives
Prior art date
Application number
PCT/IB2005/054008
Other languages
English (en)
Other versions
WO2006059304A2 (fr
Inventor
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Walter Fischli
Corinna Grisostomi
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Thomas Weller
Dwight Macdonald
Daniel Mckay
David A Powell
Original Assignee
Actelion Pharmaceuticals Ltd
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Walter Fischli
Corinna Grisostomi
Lubos Remen
Sylvia Richard-Bildstein
Thierry Sifferlen
Thomas Weller
Dwight Macdonald
Daniel Mckay
David A Powell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Olivier Bezencon, Christoph Boss, Daniel Bur, Olivier Corminboeuf, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Thomas Weller, Dwight Macdonald, Daniel Mckay, David A Powell filed Critical Actelion Pharmaceuticals Ltd
Publication of WO2006059304A2 publication Critical patent/WO2006059304A2/fr
Publication of WO2006059304A3 publication Critical patent/WO2006059304A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention porte sur de nouveaux dérivés bicycliques et sur leur utilisation comme ingrédients actifs dans la préparation de compositions pharmaceutiques. Cette invention porte également sur des processus de préparation des composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés et, notamment, sur leur utilisation comme inhibiteurs de la rénine.
PCT/IB2005/054008 2004-12-01 2005-12-01 Nouveaux derives bicycliques WO2006059304A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2004/013610 WO2006058546A1 (fr) 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine
EPPCT/EP2004/013610 2004-12-01

Publications (2)

Publication Number Publication Date
WO2006059304A2 WO2006059304A2 (fr) 2006-06-08
WO2006059304A3 true WO2006059304A3 (fr) 2006-10-12

Family

ID=34959363

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2004/013610 WO2006058546A1 (fr) 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine
PCT/IB2005/054008 WO2006059304A2 (fr) 2004-12-01 2005-12-01 Nouveaux derives bicycliques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/013610 WO2006058546A1 (fr) 2004-12-01 2004-12-01 Nouveaux dérivés de lactame en tant qu’inhibiteurs de la rénine

Country Status (1)

Country Link
WO (2) WO2006058546A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129538B1 (en) 2007-03-28 2012-03-06 Takeda Pharmaceutical Company Limited Renin inhibitors
WO2008141462A1 (fr) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Nouveaux inhibiteurs de rhénine
AU2008288648A1 (en) 2007-08-20 2009-02-26 Merck Frosst Canada Ltd. Renin inhibitors
JP4790871B2 (ja) 2008-05-05 2011-10-12 メルク フロスト カナダ リミテツド レニン阻害剤としての３，４−置換ピペリジン誘導体

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096116A2 (fr) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene
WO2004096803A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives d'azabicyclononene
WO2004096366A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives de 9-azabicyclo'3.3.1!non-6-ee a heteroatome en position 3 servant d'inhibiteurs de la renine
WO2005040165A1 (fr) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine
WO2005040173A1 (fr) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
WO2005054244A2 (fr) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine comprenant une nouvelle chaine laterale

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096803A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives d'azabicyclononene
WO2004096366A1 (fr) * 2003-04-30 2004-11-11 Actelion Pharmaceuticals Ltd Derives de 9-azabicyclo'3.3.1!non-6-ee a heteroatome en position 3 servant d'inhibiteurs de la renine
WO2004096116A2 (fr) * 2003-05-02 2004-11-11 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene
WO2005040165A1 (fr) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et leur utilisation en tant qu'inhibiteurs de la renine
WO2005040173A1 (fr) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine utilises comme inhibiteurs de la renine
WO2005054244A2 (fr) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Derives de diazabicyclononene et de tetrahydropyridine comprenant une nouvelle chaine laterale

Also Published As

Publication number Publication date
WO2006059304A2 (fr) 2006-06-08
WO2006058546A1 (fr) 2006-06-08

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