MXPA05011497A - Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace). - Google Patents

Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace).

Info

Publication number
MXPA05011497A
MXPA05011497A MXPA05011497A MXPA05011497A MXPA05011497A MX PA05011497 A MXPA05011497 A MX PA05011497A MX PA05011497 A MXPA05011497 A MX PA05011497A MX PA05011497 A MXPA05011497 A MX PA05011497A MX PA05011497 A MXPA05011497 A MX PA05011497A
Authority
MX
Mexico
Prior art keywords
ace inhibitors
tropane derivatives
compounds
preparation
pharmaceutical compositions
Prior art date
Application number
MXPA05011497A
Other languages
English (en)
Inventor
Lubos Remen
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MXPA05011497A publication Critical patent/MXPA05011497A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La invencion se refiere a los nuevos derivados de tripano y a los compuestos relacionados y a su uso como ingredientes activos en la preparacion de composiciones farmaceuticas. La invencion tambien se refiere a los aspectos relacionados que incluyen los procesos para la preparacion de los compuestos, las composiciones farmaceuticas que contienen uno o mas de estos compuestos y especialmente su uso como inhibidores de la renina.
MXPA05011497A 2003-04-30 2004-04-26 Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace). MXPA05011497A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0304490 2003-04-30
PCT/EP2004/004375 WO2004096799A1 (en) 2003-04-30 2004-04-26 Tropane derivatives and their use as ace inhibitors

Publications (1)

Publication Number Publication Date
MXPA05011497A true MXPA05011497A (es) 2005-12-15

Family

ID=33395688

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011497A MXPA05011497A (es) 2003-04-30 2004-04-26 Derivados de tropano y su uso como inhibidores de la enzima de conversion de angiotensina (ace).

Country Status (13)

Country Link
US (1) US20060205768A1 (es)
EP (1) EP1622901A1 (es)
JP (1) JP2006524657A (es)
KR (1) KR20060015546A (es)
CN (1) CN1780833A (es)
AU (1) AU2004234042A1 (es)
BR (1) BRPI0409878A (es)
CA (1) CA2521957A1 (es)
MX (1) MXPA05011497A (es)
NO (1) NO20055624L (es)
RU (1) RU2005137184A (es)
WO (1) WO2004096799A1 (es)
ZA (1) ZA200509663B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005040173A1 (en) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors
WO2005054244A2 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
ATE462703T1 (de) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
WO2006092268A1 (en) * 2005-03-02 2006-09-08 Actelion Pharmaceuticals Ltd Bicyclic five-membered heteroaryl derivatives and their use as renin inhibitors
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
WO2007049224A1 (en) * 2005-10-25 2007-05-03 Actelion Pharmaceuticals Ltd Novel hexahydro- or octahydro-cyclopenta[c]pyrrole derivatives
EP2420491B1 (en) 2005-12-30 2013-07-03 Novartis AG 3 , 5-substitued piperidine compounds as renin inhibitors
KR20080091273A (ko) 2006-02-02 2008-10-09 액테리온 파마슈티칼 리미티드 레닌 저해제로서의 2차 아민
CA2646235A1 (en) * 2006-03-16 2007-09-20 Nicox S.A. Non-peptidic renin inhibitors nitroderivatives
WO2008141462A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Novel case of renin inhibitors
AU2008267287B2 (en) 2007-06-25 2012-02-16 Novartis Ag N5-(2-ethoxyethyl)-N3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors
AU2009243875B2 (en) 2008-05-05 2011-12-01 Idorsia Pharmaceuticals Ltd 3, 4 - substituted piperidine derivatives as renin inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US7011813B2 (en) * 1990-08-09 2006-03-14 Research Triangle Institute Cocaine receptor binding ligands
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
PL294866A1 (en) * 1991-06-21 1993-05-31 Hoechst Ag Method of obtaining novel rennin redtarding heterocyclic compounds
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
EP0863875B1 (de) * 1995-09-07 2003-06-04 F. Hoffmann-La Roche Ag Neue 4-(oxyalkoxyphenyl)-3-oxy-piperidine zur behandlung von herz- und niereninsuffizienz
US20030013883A1 (en) * 2000-06-16 2003-01-16 Tamagnan Gilles D. Tropane analogs binding to monoamine transporters
WO2002076440A2 (en) * 2001-03-23 2002-10-03 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease with piperidin derivates
AU2003233963B2 (en) * 2002-04-29 2008-09-11 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Also Published As

Publication number Publication date
EP1622901A1 (en) 2006-02-08
WO2004096799A1 (en) 2004-11-11
AU2004234042A1 (en) 2004-11-11
BRPI0409878A (pt) 2006-05-23
KR20060015546A (ko) 2006-02-17
RU2005137184A (ru) 2006-03-20
US20060205768A1 (en) 2006-09-14
ZA200509663B (en) 2006-09-27
NO20055624L (no) 2005-11-29
CA2521957A1 (en) 2004-11-11
JP2006524657A (ja) 2006-11-02
CN1780833A (zh) 2006-05-31

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Legal Events

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