PT2003120E - Derivados de azapéptido como inibidores de protease de hiv - Google Patents
Derivados de azapéptido como inibidores de protease de hivInfo
- Publication number
- PT2003120E PT2003120E PT08252023T PT08252023T PT2003120E PT 2003120 E PT2003120 E PT 2003120E PT 08252023 T PT08252023 T PT 08252023T PT 08252023 T PT08252023 T PT 08252023T PT 2003120 E PT2003120 E PT 2003120E
- Authority
- PT
- Portugal
- Prior art keywords
- protease inhibitors
- hiv protease
- azapeptide derivatives
- azapeptide
- derivatives
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93420107P | 2007-06-12 | 2007-06-12 | |
| US6762708P | 2008-02-29 | 2008-02-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2003120E true PT2003120E (pt) | 2010-02-11 |
Family
ID=39730784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT08252023T PT2003120E (pt) | 2007-06-12 | 2008-06-12 | Derivados de azapéptido como inibidores de protease de hiv |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20090036357A1 (pt) |
| EP (3) | EP2322509B1 (pt) |
| JP (1) | JP2010529196A (pt) |
| KR (2) | KR101185899B1 (pt) |
| CN (2) | CN101711237B (pt) |
| AR (1) | AR066972A1 (pt) |
| AT (2) | ATE447554T1 (pt) |
| AU (1) | AU2008267048C1 (pt) |
| BR (2) | BRPI0813911A2 (pt) |
| CA (1) | CA2692028C (pt) |
| CO (1) | CO6241121A2 (pt) |
| CY (1) | CY1109766T1 (pt) |
| DE (1) | DE602008000255D1 (pt) |
| DK (1) | DK2003120T3 (pt) |
| ES (3) | ES2394952T3 (pt) |
| HK (2) | HK1136576A1 (pt) |
| HR (1) | HRP20100065T1 (pt) |
| MX (1) | MX2009013565A (pt) |
| PL (1) | PL2003120T3 (pt) |
| PT (1) | PT2003120E (pt) |
| RS (1) | RS51226B (pt) |
| RU (2) | RU2448958C2 (pt) |
| SI (1) | SI2003120T1 (pt) |
| TW (1) | TW200908970A (pt) |
| WO (1) | WO2008156632A1 (pt) |
| ZA (1) | ZA200909079B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080241289A1 (en) * | 2007-02-23 | 2008-10-02 | Auspex Pharmaceuticals, Inc. | Preparation and utility of non-nucleoside reverse transcriptase inhibitors |
| WO2008156632A1 (en) | 2007-06-12 | 2008-12-24 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| WO2010041241A2 (en) * | 2008-10-06 | 2010-04-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Hiv-1 integrase derived peptides and compositions |
| WO2010132663A1 (en) * | 2009-05-13 | 2010-11-18 | Concert Pharmaceticals, Inc. | Pegylated azapeptide derivatives as hiv protease inhibitors |
| WO2010135424A1 (en) * | 2009-05-19 | 2010-11-25 | Glaxosmithkline Llc | Chemical compounds |
| EP2515877B1 (en) * | 2009-12-21 | 2016-08-10 | Janssen Sciences Ireland UC | Degradable removable implant for the sustained release of an active compound |
| WO2011080562A1 (en) | 2009-12-29 | 2011-07-07 | Hetero Research Foundation | Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals |
| SI2720989T1 (sl) | 2011-06-20 | 2016-11-30 | H. Lundbeck A/S | Devterirani 1-piperazino-3-fenil indani za zdravljenje shizofrenije |
| CN106543073A (zh) * | 2015-09-17 | 2017-03-29 | 宁波杰尔盛化工有限公司 | 2-[4-（2-吡啶基）苄基]-肼羧酸叔丁酯的制备方法 |
| WO2017095761A1 (en) * | 2015-12-02 | 2017-06-08 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine |
| JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| EP3813800A1 (en) * | 2018-06-29 | 2021-05-05 | Incyte Corporation | Formulations of an axl/mer inhibitor |
| TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
| CA3180487A1 (en) * | 2020-04-16 | 2021-10-21 | The Medical College Of Wisconsin, Inc. | Aerosolized formulations of hiv protease inhibitors for the treatment of airway reflux |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ216172A (en) | 1985-05-15 | 1989-08-29 | Wellcome Found | Nucleosides and pharmaceutical compositions |
| GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| US5696270A (en) | 1989-05-23 | 1997-12-09 | Abbott Laboratories | Intermediate for making retroviral protease inhibiting compounds |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| ATE230402T1 (de) | 1992-12-29 | 2003-01-15 | Abbott Lab | Hemmer der retroviralen protease |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5849911A (en) | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| TW409125B (en) * | 1996-04-22 | 2000-10-21 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| AU2959397A (en) | 1996-05-31 | 1998-01-05 | Novartis Ag | Process for the preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues |
| US6087383A (en) * | 1998-01-20 | 2000-07-11 | Bristol-Myers Squibb Company | Bisulfate salt of HIV protease inhibitor |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| GB9914821D0 (en) | 1999-06-24 | 1999-08-25 | Glaxo Group Ltd | Compounds |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| HU229938B1 (en) | 2001-05-03 | 2015-01-28 | Hoffmann La Roche | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
| CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| YU12204A (sh) * | 2001-08-31 | 2006-08-17 | Bristol Myers Squibb Company | Korišćenje atazanavira u terapiji hiv-a |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| CA2676567A1 (en) | 2003-02-21 | 2005-03-31 | Jarrow Formulas, Inc. | Methods for treatment of hiv or malaria using combinations of chloroquine and protease inhibitors |
| US20050131017A1 (en) | 2003-12-11 | 2005-06-16 | Degoey David A. | HIV protease inhibiting compounds |
| US20050148523A1 (en) | 2003-12-15 | 2005-07-07 | Colonno Richard J. | Method of treating HIV infection in atazanavir-resistant patients using a combination of atazanavir and another protease inhibitor |
| US7829720B2 (en) * | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| CN101023090B (zh) * | 2004-07-06 | 2013-03-27 | 雅培制药有限公司 | Hiv蛋白酶抑制剂的前药 |
| EP1809247A1 (en) | 2004-09-29 | 2007-07-25 | Cordis Corporation | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| MX2007006637A (es) | 2004-12-03 | 2007-06-19 | Merck & Co Inc | Uso de atazanavir para mejorar los parametros farmacocineticos de farmacos metabolizados por isoforma 1a1 de udp-glucuronosil- transferasa. |
| CA2624179A1 (en) | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| MX2009002398A (es) | 2006-09-05 | 2009-03-16 | Schering Corp | Combinaciones farmaceuticas para manejo de lipidos y en el tratamiento de aterosclerosis y estatosis hepatica. |
| WO2008156632A1 (en) | 2007-06-12 | 2008-12-24 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| US20090076097A1 (en) | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched atazanavir |
| WO2010132663A1 (en) | 2009-05-13 | 2010-11-18 | Concert Pharmaceticals, Inc. | Pegylated azapeptide derivatives as hiv protease inhibitors |
-
2008
- 2008-06-12 WO PCT/US2008/007331 patent/WO2008156632A1/en active Application Filing
- 2008-06-12 BR BRPI0813911-3A patent/BRPI0813911A2/pt not_active IP Right Cessation
- 2008-06-12 ES ES11155667T patent/ES2394952T3/es active Active
- 2008-06-12 EP EP11155667A patent/EP2322509B1/en active Active
- 2008-06-12 SI SI200830012T patent/SI2003120T1/sl unknown
- 2008-06-12 US US12/157,712 patent/US20090036357A1/en not_active Abandoned
- 2008-06-12 PT PT08252023T patent/PT2003120E/pt unknown
- 2008-06-12 RU RU2010100821/04A patent/RU2448958C2/ru not_active IP Right Cessation
- 2008-06-12 CN CN2008800216013A patent/CN101711237B/zh not_active Expired - Fee Related
- 2008-06-12 KR KR1020107000675A patent/KR101185899B1/ko not_active IP Right Cessation
- 2008-06-12 EP EP09075359A patent/EP2116532B1/en active Active
- 2008-06-12 JP JP2010512186A patent/JP2010529196A/ja active Pending
- 2008-06-12 CA CA2692028A patent/CA2692028C/en not_active Expired - Fee Related
- 2008-06-12 EP EP08252023A patent/EP2003120B9/en active Active
- 2008-06-12 KR KR1020127003399A patent/KR20120029480A/ko not_active Application Discontinuation
- 2008-06-12 PL PL08252023T patent/PL2003120T3/pl unknown
- 2008-06-12 AR ARP080102501A patent/AR066972A1/es unknown
- 2008-06-12 CN CN2011102869075A patent/CN102424668A/zh active Pending
- 2008-06-12 ES ES08252023T patent/ES2356334T3/es active Active
- 2008-06-12 AT AT08252023T patent/ATE447554T1/de active
- 2008-06-12 RS RSP-2010/0034A patent/RS51226B/sr unknown
- 2008-06-12 DE DE602008000255T patent/DE602008000255D1/de active Active
- 2008-06-12 MX MX2009013565A patent/MX2009013565A/es active IP Right Grant
- 2008-06-12 AT AT09075359T patent/ATE536343T1/de active
- 2008-06-12 ES ES09075359T patent/ES2395137T3/es active Active
- 2008-06-12 DK DK08252023.0T patent/DK2003120T3/da active
- 2008-06-12 TW TW097122018A patent/TW200908970A/zh unknown
- 2008-06-12 BR BRPI0823520-1A patent/BRPI0823520A2/pt not_active IP Right Cessation
- 2008-06-12 AU AU2008267048A patent/AU2008267048C1/en not_active Ceased
-
2009
- 2009-06-17 HK HK10104316.7A patent/HK1136576A1/xx not_active IP Right Cessation
- 2009-06-17 HK HK09105433.5A patent/HK1127345A1/xx not_active IP Right Cessation
- 2009-12-11 CO CO09141805A patent/CO6241121A2/es not_active Application Discontinuation
- 2009-12-18 ZA ZA2009/09079A patent/ZA200909079B/en unknown
-
2010
- 2010-02-03 CY CY20101100099T patent/CY1109766T1/el unknown
- 2010-02-03 HR HR20100065T patent/HRP20100065T1/hr unknown
- 2010-04-06 US US12/755,184 patent/US8158805B2/en not_active Expired - Fee Related
-
2012
- 2012-01-19 RU RU2012101881/04A patent/RU2012101881A/ru not_active Application Discontinuation
- 2012-03-02 US US13/411,089 patent/US8258309B2/en not_active Expired - Fee Related
- 2012-08-27 US US13/595,511 patent/US20130041156A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1127345A1 (en) | Azapeptide derivatives as hiv protease inhibitors | |
| EP2139883A4 (en) | INHIBITORS OF HIV-1 PROTEASE | |
| IL197777A0 (en) | Enantiomerically pure phosphoindoles as hiv inhibitors | |
| SI2078001T1 (sl) | Derivati diazepan-acetamida kot selektivni zaviralci 11 -hsd1 | |
| HK1127351A1 (zh) | 抗病毒蛋白酶抑制劑 | |
| EP2632895A4 (en) | HIV PROTEASE INHIBITORS | |
| IL196000A0 (en) | 2-arylindole derivatives as npges-i inhibitors | |
| EP2304043A4 (en) | HIV PROTEASE INHIBITORS AND METHOD FOR THEIR USE | |
| IL183850A0 (en) | Hiv protease inhibitors | |
| EP2435037A4 (en) | HIV PROTEASE INHIBITORS | |
| AU2007337830A8 (en) | Benzenesulfonamide derivatives as HIV protease inhibitors | |
| EP1855672A4 (en) | HIV PROTEASE INHIBITORS | |
| EP2244571A4 (en) | SMALL INHIBITORY MOLECULES OF HIV PROTEASES | |
| ZA200804607B (en) | Substituted aminophenylsulfonamide compounds as HIV protease inhibitor | |
| EP2134336A4 (en) | HIV PROTEASE INHIBITORS DERIVED FROM BENZOFURAN | |
| EP2313426A4 (en) | NOVEL PROTEASE INHIBITORS | |
| ZA201102179B (en) | Protease inhibitors | |
| ZA200706305B (en) | HIV protease inhibitors | |
| ZA200902172B (en) | Enantiomerically pure phosphoindoles as HIV inhibitors | |
| GB0817425D0 (en) | Protease inhibitors | |
| ZA200804610B (en) | Aminophenylsulfonamide derivatives as HIV protease inhibitor | |
| GB0712176D0 (en) | Protease inhibitors | |
| GB0705213D0 (en) | Protease inhibitors | |
| GB0705212D0 (en) | Protease inhibitors | |
| GB0700369D0 (en) | Protease inhibitors |