JP2009506999A5 - - Google Patents

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Publication number
JP2009506999A5
JP2009506999A5 JP2008528474A JP2008528474A JP2009506999A5 JP 2009506999 A5 JP2009506999 A5 JP 2009506999A5 JP 2008528474 A JP2008528474 A JP 2008528474A JP 2008528474 A JP2008528474 A JP 2008528474A JP 2009506999 A5 JP2009506999 A5 JP 2009506999A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2008528474A
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English (en)
Japanese (ja)
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JP4850913B2 (ja
JP2009506999A (ja
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Priority claimed from PCT/EP2006/065526 external-priority patent/WO2007025901A1/en
Publication of JP2009506999A publication Critical patent/JP2009506999A/ja
Publication of JP2009506999A5 publication Critical patent/JP2009506999A5/ja
Application granted granted Critical
Publication of JP4850913B2 publication Critical patent/JP4850913B2/ja
Expired - Fee Related legal-status Critical Current
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JP2008528474A 2005-09-01 2006-08-21 P2x3及びp2x2/3調節因子としてのジアミノピリジン Expired - Fee Related JP4850913B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71339805P 2005-09-01 2005-09-01
US60/713,398 2005-09-01
PCT/EP2006/065526 WO2007025901A1 (en) 2005-09-01 2006-08-21 Diaminopyrimidines as p2x3 and p2x2/3 modulators

Publications (3)

Publication Number Publication Date
JP2009506999A JP2009506999A (ja) 2009-02-19
JP2009506999A5 true JP2009506999A5 (enExample) 2011-10-20
JP4850913B2 JP4850913B2 (ja) 2012-01-11

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ID=37116194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008528474A Expired - Fee Related JP4850913B2 (ja) 2005-09-01 2006-08-21 P2x3及びp2x2/3調節因子としてのジアミノピリジン

Country Status (9)

Country Link
US (1) US7799796B2 (enExample)
EP (1) EP1924566B1 (enExample)
JP (1) JP4850913B2 (enExample)
CN (1) CN101300235B (enExample)
AR (1) AR055619A1 (enExample)
CA (1) CA2620129C (enExample)
ES (1) ES2562056T3 (enExample)
TW (1) TW200745056A (enExample)
WO (1) WO2007025901A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1725540T5 (da) * 2004-03-05 2012-10-22 Hoffmann La Roche Diaminopyrimidiner som p2x3- og p2x2/3-antagonister
CA2619898C (en) * 2005-09-01 2014-03-18 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
CA2620034C (en) * 2005-09-01 2013-10-01 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
WO2008104474A1 (en) * 2007-02-28 2008-09-04 F. Hoffmann-La Roche Ag Diaminopyrimidines
WO2008104472A1 (en) * 2007-02-28 2008-09-04 F. Hoffmann-La Roche Ag 2, 4 -diaminopyrimidine derivatives and their use as p2x antagonists or as prodrugs thereof
TW200843739A (en) 2007-03-30 2008-11-16 Shionogi & Co Novel pyrrolinone derivative and composition containing the same
CN104058999A (zh) 2008-02-29 2014-09-24 伊沃泰克股份公司 酰胺化合物、组合物及其应用
EP2332923A4 (en) * 2008-09-12 2012-08-01 Kowa Co PROCESS FOR PREPARING 5- [2- (METHYLTHIO) ETHOXY] PYRIMIDIN-2-AMINE
WO2010035727A1 (ja) 2008-09-25 2010-04-01 塩野義製薬株式会社 新規ピロリノン誘導体およびそれを含有する医薬組成物
KR101422901B1 (ko) 2009-02-13 2014-07-23 시오노기 앤드 컴파니, 리미티드 신규 트라이아진 유도체 및 그것을 함유하는 의약 조성물
CA2771190C (en) 2009-08-17 2020-01-21 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
JP6075621B2 (ja) 2010-08-10 2017-02-08 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
EP2604595B1 (en) 2010-08-10 2016-03-16 Shionogi&Co., Ltd. Triazine derivative and pharmaceutical compound that contains same and exhibits analgesic activity
EP2736514B1 (en) * 2011-07-28 2017-10-18 Nerviano Medical Sciences S.r.l. Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
WO2013128927A1 (ja) * 2012-02-29 2013-09-06 国立大学法人東京医科歯科大学 新規アンドロゲン受容体アンタゴニスト
AU2013261267B2 (en) 2012-05-18 2017-06-29 Sumitomo Pharma Co., Ltd. Carboxylic acid compounds
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
JP6546592B2 (ja) 2013-08-23 2019-07-17 アファレント ファーマシューティカルズ インコーポレイテッド 急性、亜急性または慢性の咳を治療するためのジアミノピリミジンp2x3およびp2x2/3受容体モジュレーター
JP6616772B2 (ja) 2013-12-16 2019-12-04 アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー P2x3および/またはp2x2/3化合物ならびに方法
WO2015175707A1 (en) 2014-05-13 2015-11-19 Memorial Sloan Kettering Cancer Center Hsp70 modulators and methods for making and using the same
WO2016004358A1 (en) * 2014-07-03 2016-01-07 Afferent Pharmaceuticals, Inc. Methods and compositions for treating diseases and conditions
HUE061764T2 (hu) 2015-09-29 2023-08-28 Afferent Pharmaceuticals Inc Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében
JP6968810B2 (ja) * 2016-03-14 2021-11-17 アファレント ファーマシューティカルズ インコーポレイテッド ピリミジンおよびそのバリアント、ならびにそのための使用
US10662162B2 (en) 2016-03-25 2020-05-26 Afferent Pharmaceuticals, Inc. Pyrimidines and variants thereof, and uses therefor
US20230118751A1 (en) * 2019-12-30 2023-04-20 Wuhan Ll Science And Technology Development Co., Ltd. Fused ring compound and application thereof

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2953567A (en) 1956-11-23 1960-09-20 Burroughs Wellcome Co 5-phenylmercaptopyrimidines and method
US3582276A (en) * 1968-07-22 1971-06-01 Elcor Chem Corp Process for recovering a metal oxide and sulfur dioxide from metal sulfate
US3855265A (en) 1969-03-06 1974-12-17 Burroughs Wellcome Co 5-benzyl pyrimidines intermediates therefore, and method
US3991050A (en) 1969-03-06 1976-11-09 Burroughs Wellcome Co. Preparation of β-Amino-α-benzylacrylonitriles
US3852276A (en) 1969-03-06 1974-12-03 Burroughs Wellcome Co 5-benzyl pyrimidines intermediate therefore, and method
US3849470A (en) 1969-03-06 1974-11-19 Burroughs Wellcome Co 5-benzyl pyrimidines intermediates therefore,and method
US4052553A (en) 1969-03-06 1977-10-04 Burroughs Wellcome Co. 5-benzyl pyrimidines intermediates therefore, and method
US3850927A (en) 1969-03-06 1974-11-26 Burroughs Wellcome Co 5-benzyl pyrimidines intermediates therefore,and method
CH513181A (de) 1969-06-12 1971-09-30 Hoffmann La Roche Verfahren zur Herstellung von N-Oxyden von Benzylpyrimidinen
US4255574A (en) 1973-02-26 1981-03-10 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-pyrimidines
US4143227A (en) 1973-02-26 1979-03-06 Hoffmann-La Roche Inc. Process for substituted 5-benzyl-2,4-diamino-pyrimidines
US3931181A (en) 1973-07-27 1976-01-06 Hoffmann-La Roche Inc. 2,4-Diamino-5-benzylpyrimidines
US4515948A (en) 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
CH591457A5 (enExample) 1973-11-08 1977-09-15 Hoffmann La Roche
US3940393A (en) 1974-06-21 1976-02-24 American Home Products Corporation Synthesis of 2,6-diaminopyrimidines
US4039543A (en) 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
US4033962A (en) 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
GB1582245A (en) 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
US4115650A (en) 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
US4075209A (en) 1977-02-07 1978-02-21 Hoffmann-La Roche, Inc. Process for preparing substituted 2,4-diaminopyrimidines and isoxazole intermediate
DE2709634A1 (de) * 1977-03-05 1978-09-07 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
FR2397407A2 (fr) 1977-07-11 1979-02-09 Dick Pierre Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides
US4258045A (en) 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
DE3045720A1 (de) 1980-12-04 1982-07-08 Basf Ag, 6700 Ludwigshafen N-pyrimidinyl-carbaminsaeureester, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
FR2502152A1 (fr) 1981-03-20 1982-09-24 Panmedica Laboratoires Nouveaux derives solubles n2 substitues de la diamino-2,4-benzyl-5-pyrimidines, leur procede de preparation et medicaments les contenant
IT1138146B (it) 1981-08-11 1986-09-17 Proter Spa Processo per la produzione della 2,4-diammino-(3,5-dimetossi-4-metos sietossi-benzil)-pirimidina
US4590271A (en) 1982-05-01 1986-05-20 Burroughs Wellcome Co. 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
US4587341A (en) 1982-05-07 1986-05-06 Burroughs Wellcome Co. 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
DE3603577A1 (de) 1986-02-06 1987-08-13 Joachim K Prof Dr Seydel Neue substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antibakterieller wirksamkeit
FR2595697B1 (fr) 1986-03-13 1988-07-08 Rousselot Cie Derives de benzyl-pyrimidine, leur procede de preparation ainsi que les compositions en contenant
HU199683B (en) 1987-07-22 1990-03-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical compositions analgesic, antiphlogistic, antipyretic, antianginic and/or antioxidative activity
US4996198A (en) 1988-07-11 1991-02-26 Hoffmann-La Roche Inc. Anticoccidial composition
US5240640A (en) 1990-06-04 1993-08-31 Coulter Corporation In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles
US5258373A (en) 1991-07-17 1993-11-02 Hoffmann-La Roche Inc. Anticoccidial compositions
TW394761B (en) 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
US5739333A (en) 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
US6136971A (en) 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
US6211185B1 (en) 1999-05-05 2001-04-03 Veterinary Pharmacy Corporation Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent
CA2361402C (en) 1999-09-03 2009-05-12 Actelion Pharmaceuticals Ltd Bis-sulfonamides
JP4919566B2 (ja) 1999-09-24 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗ウイルス組成物
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
AU2001263850A1 (en) 2000-04-20 2001-11-07 Actelion Pharmaceuticals Ltd Pyrimidine-sulfonamides having endothelin-antagonist activity
WO2001081338A1 (en) 2000-04-25 2001-11-01 Actelion Pharmaceuticals Ltd Substituted sulfonylaminopyrimidines
MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
JP2004509874A (ja) 2000-09-25 2004-04-02 アクテリオン ファマシューティカルズ リミテッド 新規なアリールアルカン−スルフォンアミド類
PT1345920E (pt) 2000-12-18 2006-08-31 Actelion Pharmaceuticals Ltd Novas sulfonamidas e sua utilizacao como antagonistas dos receptores de endotelina
US6423720B1 (en) 2001-02-01 2002-07-23 Duquesne University Of The Holy Ghost Pyrimidine compounds and methods for making and using the same
WO2002083650A1 (en) 2001-04-11 2002-10-24 Actelion Pharmaceuticals Ltd Novel sulfonylamino-pyrimidines
DE60206164T2 (de) * 2001-05-18 2006-06-22 Abbott Laboratories, Abbott Park Trisubstituierte-n-((1s)-1,2,3,4-tetrahydro-1-naphthalenyl) benzamide welche p2x3 und p2x2/3 enthaltende rezeptoren inhibieren
WO2003042190A1 (en) * 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
DK1725540T5 (da) * 2004-03-05 2012-10-22 Hoffmann La Roche Diaminopyrimidiner som p2x3- og p2x2/3-antagonister
CA2619898C (en) * 2005-09-01 2014-03-18 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators

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