DE69631376T2 - Substituierte liposaccaride, nützlich in der behandlung und vorbeugung von endotoxemie - Google Patents

Substituierte liposaccaride, nützlich in der behandlung und vorbeugung von endotoxemie Download PDF

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Publication number
DE69631376T2
DE69631376T2 DE69631376T DE69631376T DE69631376T2 DE 69631376 T2 DE69631376 T2 DE 69631376T2 DE 69631376 T DE69631376 T DE 69631376T DE 69631376 T DE69631376 T DE 69631376T DE 69631376 T2 DE69631376 T2 DE 69631376T2
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DE
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branched
straight
alkyl
compound
group
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Expired - Lifetime
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DE69631376T
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German (de)
English (en)
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DE69631376D1 (de
Inventor
J. William CHRIST
P. Daniel ROSSIGNOL
Seiichi Kobayashi
Tsutomu Kawata
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Eisai R&D Management Co Ltd
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Eisai Co Ltd
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Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
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Publication of DE69631376D1 publication Critical patent/DE69631376D1/de
Publication of DE69631376T2 publication Critical patent/DE69631376T2/de
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
DE69631376T 1995-06-05 1996-06-05 Substituierte liposaccaride, nützlich in der behandlung und vorbeugung von endotoxemie Expired - Lifetime DE69631376T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US461675 1983-01-27
US08/461,675 US5750664A (en) 1995-06-05 1995-06-05 Substituted liposaccharides useful in the treatment and prevention of endotoxemia
PCT/US1996/009578 WO1996039411A1 (en) 1995-06-05 1996-06-05 Substituted liposaccharides useful in the treatment and prevention of endotoxemia

Publications (2)

Publication Number Publication Date
DE69631376D1 DE69631376D1 (de) 2004-02-26
DE69631376T2 true DE69631376T2 (de) 2004-11-11

Family

ID=23833509

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631376T Expired - Lifetime DE69631376T2 (de) 1995-06-05 1996-06-05 Substituierte liposaccaride, nützlich in der behandlung und vorbeugung von endotoxemie

Country Status (21)

Country Link
US (8) US5750664A (enExample)
EP (1) EP0853627B1 (enExample)
JP (3) JP4009318B2 (enExample)
KR (1) KR100416335B1 (enExample)
CN (1) CN1067082C (enExample)
AT (1) ATE258185T1 (enExample)
AU (1) AU707779C (enExample)
CA (1) CA2223140C (enExample)
DE (1) DE69631376T2 (enExample)
DK (1) DK0853627T3 (enExample)
ES (1) ES2214543T3 (enExample)
HU (1) HU221342B1 (enExample)
IL (2) IL122251A0 (enExample)
MX (1) MX9709502A (enExample)
NO (1) NO310239B1 (enExample)
NZ (1) NZ312299A (enExample)
PT (1) PT853627E (enExample)
RU (1) RU2170738C2 (enExample)
TW (1) TW366345B (enExample)
WO (1) WO1996039411A1 (enExample)
ZA (1) ZA964666B (enExample)

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Also Published As

Publication number Publication date
CN1067082C (zh) 2001-06-13
US20030144503A1 (en) 2003-07-31
CN1192216A (zh) 1998-09-02
WO1996039411A1 (en) 1996-12-12
EP0853627A1 (en) 1998-07-22
ZA964666B (en) 1997-03-11
TW366345B (en) 1999-08-11
IL149971A (en) 2010-04-29
DE69631376D1 (de) 2004-02-26
DK0853627T3 (da) 2004-06-01
CA2223140A1 (en) 1996-12-12
KR100416335B1 (ko) 2004-07-27
JP2011121970A (ja) 2011-06-23
US20080214802A1 (en) 2008-09-04
JP4009318B2 (ja) 2007-11-14
HU221342B1 (en) 2002-09-28
CA2223140C (en) 2008-08-05
US6184366B1 (en) 2001-02-06
US5681824A (en) 1997-10-28
EP0853627A4 (en) 1998-10-07
HUP9802662A3 (en) 1999-06-28
JPH11506793A (ja) 1999-06-15
AU707779B2 (en) 1999-07-22
AU6380296A (en) 1996-12-24
AU707779C (en) 2001-12-06
US20020028927A1 (en) 2002-03-07
ATE258185T1 (de) 2004-02-15
US20100227835A1 (en) 2010-09-09
PT853627E (pt) 2004-05-31
KR19990022104A (ko) 1999-03-25
US5935938A (en) 1999-08-10
US7994154B2 (en) 2011-08-09
JP2007269812A (ja) 2007-10-18
MX9709502A (es) 1998-10-31
ES2214543T3 (es) 2004-09-16
EP0853627B1 (en) 2004-01-21
HUP9802662A2 (hu) 1999-05-28
NZ312299A (en) 1999-08-30
US5750664A (en) 1998-05-12
IL122251A0 (en) 1998-04-05
JP4712001B2 (ja) 2011-06-29
US7737129B2 (en) 2010-06-15
NO975644D0 (no) 1997-12-04
NO975644L (no) 1998-02-04
NO310239B1 (no) 2001-06-11
RU2170738C2 (ru) 2001-07-20

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