DK2139892T3 - Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer - Google Patents

Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer

Info

Publication number
DK2139892T3
DK2139892T3 DK08717594.9T DK08717594T DK2139892T3 DK 2139892 T3 DK2139892 T3 DK 2139892T3 DK 08717594 T DK08717594 T DK 08717594T DK 2139892 T3 DK2139892 T3 DK 2139892T3
Authority
DK
Denmark
Prior art keywords
pyrimidodiazepines
substituted
useful
plk1 inhibitors
plk1
Prior art date
Application number
DK08717594.9T
Other languages
English (en)
Inventor
Jianping Cai
Shaoqing Chen
Xin-Jie Chu
Kang Le
Kin-Chun Thomas Luk
Peter Michael Wovkulich
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2139892(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of DK2139892T3 publication Critical patent/DK2139892T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
DK08717594.9T 2007-03-22 2008-03-11 Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer DK2139892T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91935807P 2007-03-22 2007-03-22
PCT/EP2008/052847 WO2008113711A1 (en) 2007-03-22 2008-03-11 Substituted pyrimidodiazepines useful as plk1 inhibitors

Publications (1)

Publication Number Publication Date
DK2139892T3 true DK2139892T3 (da) 2011-12-12

Family

ID=39415299

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08717594.9T DK2139892T3 (da) 2007-03-22 2008-03-11 Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer

Country Status (24)

Country Link
US (1) US7517873B2 (da)
EP (1) EP2139892B1 (da)
JP (1) JP5087640B2 (da)
KR (1) KR101157848B1 (da)
CN (2) CN102746175B (da)
AR (1) AR065794A1 (da)
AT (1) ATE524472T1 (da)
AU (1) AU2008228303B2 (da)
BR (1) BRPI0809088A2 (da)
CA (1) CA2680757A1 (da)
CL (1) CL2008000785A1 (da)
CY (1) CY1112102T1 (da)
DK (1) DK2139892T3 (da)
ES (1) ES2371832T3 (da)
HK (1) HK1139936A1 (da)
HR (1) HRP20110807T1 (da)
IL (1) IL200617A (da)
MX (1) MX2009010034A (da)
PE (1) PE20120495A1 (da)
PL (1) PL2139892T3 (da)
PT (1) PT2139892E (da)
SI (1) SI2139892T1 (da)
TW (1) TWI363629B (da)
WO (1) WO2008113711A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8461149B2 (en) 2007-08-15 2013-06-11 Vertex Pharmaceuticals Incorporated Compounds useful as protein kinase inhibitors
CA2699607A1 (en) * 2007-09-25 2009-04-02 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
CN101878216B (zh) 2007-09-28 2013-07-10 西克拉塞尔有限公司 作为蛋白激酶抑制剂的嘧啶衍生物
US20090291938A1 (en) * 2007-11-19 2009-11-26 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
EP2303889A1 (en) 2008-06-18 2011-04-06 F. Hoffmann-La Roche AG Halo-substituted pyrimidodiazepines as plkl inhibitors
PT2364314E (pt) 2008-12-09 2014-06-09 Gilead Sciences Inc Moduladores de recetores toll-like
JP5908728B2 (ja) 2009-01-06 2016-04-26 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ピリミド−ジアゼピノンキナーゼ骨格化合物及び疾患を治療する方法
NZ619259A (en) 2009-06-17 2015-07-31 Vertex Pharma Inhibitors of influenza viruses replication
ES2661850T3 (es) 2009-09-14 2018-04-04 Gilead Sciences, Inc. Moduladores de receptores del tipo toll
JP2013545816A (ja) 2010-12-16 2013-12-26 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルス複製阻害物質
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3670515B1 (en) * 2013-03-15 2024-03-06 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
AU2014292888B2 (en) 2013-07-25 2018-03-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
ME03460B (me) 2013-11-13 2020-01-20 Vertex Pharma Inhibitori replikacije virusa influence
BR112016010576B1 (pt) 2013-11-13 2022-05-24 Vertex Pharmaceuticals Incorporated Métodos de preparação de inibidores de replicação do vírus da gripe
RU2016134947A (ru) 2014-01-31 2018-03-01 Дана-Фарбер Кансер Институт, Инк. Производные диаминопиримидин бензолсульфона и их применение
JP2017504651A (ja) * 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
CN106714800B (zh) 2014-07-11 2021-09-03 吉利德科学公司 用于治疗hiv的toll样受体调节剂
EP3177626A4 (en) 2014-08-08 2017-12-27 Dana Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
BR102015023450A2 (pt) 2014-09-16 2016-04-12 Gilead Sciences Inc formas sólidas de um modulador do receptor semelhante a toll
MX2017003288A (es) 2014-09-16 2017-06-28 Gilead Sciences Inc Metodos para preparar modulares de receptor tipo toll.
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
WO2017044792A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazoldiazepines and uses thereof
WO2017044849A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
SG11201803210YA (en) 2015-11-25 2018-05-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
US11155556B2 (en) * 2016-04-07 2021-10-26 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
EP4034132A4 (en) * 2019-09-27 2023-10-11 Dana-Farber Cancer Institute, Inc. ERK5 DEGRADER AS THERAPEUTIC FOR CANCER AND INFLAMMATORY DISEASES
JP7440940B2 (ja) * 2020-03-27 2024-02-29 オップテラ インコーポレイテッド Ｐｌｋ１の選択的分解誘導化合物
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1390220A (zh) * 1999-09-17 2003-01-08 艾博特股份有限两合公司 作为治疗剂的激酶抑制剂
IL160440A0 (en) * 2001-09-04 2004-07-25 Boehringer Ingelheim Pharma Novel dihydropteridinones, method for producing the same and the use thereof as medicaments
RU2475488C2 (ru) * 2006-02-14 2013-02-20 Вертекс Фармасьютикалз Инкорпорейтед Дигидродиазепины, которые можно использовать в качестве ингибиторов протеинкиназ
TW200808325A (en) 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
US7517873B2 (en) 2009-04-14
TWI363629B (en) 2012-05-11
WO2008113711A1 (en) 2008-09-25
IL200617A (en) 2014-02-27
KR20090119913A (ko) 2009-11-20
SI2139892T1 (sl) 2011-12-30
AU2008228303B2 (en) 2012-04-19
IL200617A0 (en) 2010-05-17
CA2680757A1 (en) 2008-09-25
AR065794A1 (es) 2009-07-01
EP2139892A1 (en) 2010-01-06
CN101636399B (zh) 2012-04-18
AU2008228303A1 (en) 2008-09-25
BRPI0809088A2 (pt) 2014-09-09
CN102746175B (zh) 2014-01-15
PL2139892T3 (pl) 2012-03-30
CY1112102T1 (el) 2015-11-04
MX2009010034A (es) 2009-10-12
CN102746175A (zh) 2012-10-24
HK1139936A1 (en) 2010-09-30
CN101636399A (zh) 2010-01-27
JP5087640B2 (ja) 2012-12-05
PT2139892E (pt) 2011-11-21
ES2371832T3 (es) 2012-01-10
PE20120495A1 (es) 2012-05-12
ATE524472T1 (de) 2011-09-15
HRP20110807T1 (hr) 2011-12-31
KR101157848B1 (ko) 2012-07-11
JP2010521514A (ja) 2010-06-24
US20080234255A1 (en) 2008-09-25
CL2008000785A1 (es) 2009-03-27
TW200843781A (en) 2008-11-16
EP2139892B1 (en) 2011-09-14

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