JP2010521514A5 - - Google Patents
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- Publication number
- JP2010521514A5 JP2010521514A5 JP2009553997A JP2009553997A JP2010521514A5 JP 2010521514 A5 JP2010521514 A5 JP 2010521514A5 JP 2009553997 A JP2009553997 A JP 2009553997A JP 2009553997 A JP2009553997 A JP 2009553997A JP 2010521514 A5 JP2010521514 A5 JP 2010521514A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- cyclopentyl
- composition
- acceptable excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Claims (7)
- R2がシクロペンチルである請求項1の化合物。
- 4−(9−シクロペンチル−7,7−ジフルオロ−5−メチル−6−オキソ−6,7,8,9−テトラヒドロ−5H−ピリミド[4,5−b][1,4]ジアゼピン−2−イルアミノ)−3−メトキシ安息香酸、及び医薬的に許容可能なその塩。
- 請求項1の化合物及び医薬的に許容可能な賦形剤を含んでなる組成物。
- 請求項2の化合物及び医薬的に許容可能な賦形剤を含んでなる組成物。
- 請求項3の化合物及び医薬的に許容可能な賦形剤を含んでなる組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91935807P | 2007-03-22 | 2007-03-22 | |
US60/919,358 | 2007-03-22 | ||
PCT/EP2008/052847 WO2008113711A1 (en) | 2007-03-22 | 2008-03-11 | Substituted pyrimidodiazepines useful as plk1 inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010521514A JP2010521514A (ja) | 2010-06-24 |
JP2010521514A5 true JP2010521514A5 (ja) | 2011-04-21 |
JP5087640B2 JP5087640B2 (ja) | 2012-12-05 |
Family
ID=39415299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009553997A Expired - Fee Related JP5087640B2 (ja) | 2007-03-22 | 2008-03-11 | Plk1阻害剤として有用な置換ピリミドジアゼピン |
Country Status (24)
Country | Link |
---|---|
US (1) | US7517873B2 (ja) |
EP (1) | EP2139892B1 (ja) |
JP (1) | JP5087640B2 (ja) |
KR (1) | KR101157848B1 (ja) |
CN (2) | CN102746175B (ja) |
AR (1) | AR065794A1 (ja) |
AT (1) | ATE524472T1 (ja) |
AU (1) | AU2008228303B2 (ja) |
BR (1) | BRPI0809088A2 (ja) |
CA (1) | CA2680757A1 (ja) |
CL (1) | CL2008000785A1 (ja) |
CY (1) | CY1112102T1 (ja) |
DK (1) | DK2139892T3 (ja) |
ES (1) | ES2371832T3 (ja) |
HK (1) | HK1139936A1 (ja) |
HR (1) | HRP20110807T1 (ja) |
IL (1) | IL200617A (ja) |
MX (1) | MX2009010034A (ja) |
PE (1) | PE20120495A1 (ja) |
PL (1) | PL2139892T3 (ja) |
PT (1) | PT2139892E (ja) |
SI (1) | SI2139892T1 (ja) |
TW (1) | TWI363629B (ja) |
WO (1) | WO2008113711A1 (ja) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5380447B2 (ja) * | 2007-08-15 | 2014-01-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患の処置のための、ヒトタンパク質キナーゼplk1ないしplk4の阻害剤としての4−(9−(3,3−ジフルオロシクロペンチル)−5,7,7−トリメチル−6−オキソ−6,7,8,9−テトラヒドロ−5h−ピリミド[4,5−b[1,4]ジアゼパン−2−イルアミノ]−3−メトキシベンザミド誘導体 |
WO2009042711A1 (en) * | 2007-09-25 | 2009-04-02 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
CA2700979C (en) | 2007-09-28 | 2017-06-20 | Cyclacel Limited | Pyrimidine derivatives as protein kinase inhibitors |
WO2009067547A1 (en) * | 2007-11-19 | 2009-05-28 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為vap-1抑制劑之用途 |
WO2009153197A1 (en) * | 2008-06-18 | 2009-12-23 | F. Hoffmann-La Roche Ag | Halo-substituted pyrimidodiazepines as plkl inhibitors |
EA021377B9 (ru) | 2008-12-09 | 2015-09-30 | Джилид Сайэнс, Инк. | Модуляторы толл-подобных рецепторов |
EP3255047B1 (en) * | 2009-01-06 | 2021-06-30 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and uses in treating disorders |
ES2604667T3 (es) | 2009-06-17 | 2017-03-08 | Vertex Pharmaceuticals Incorporated | Inhibidores de la replicación de virus de influenza |
ES2661850T3 (es) | 2009-09-14 | 2018-04-04 | Gilead Sciences, Inc. | Moduladores de receptores del tipo toll |
CA2822057A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
JP6553589B2 (ja) | 2013-03-15 | 2019-07-31 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | ピリミド−ジアゼピノン化合物および障害の治療方法 |
BR112016001457A2 (pt) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | Inibidores de fatores de transcrição e usos dos mesmos |
TWI652014B (zh) * | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
MX2016006200A (es) | 2013-11-13 | 2016-08-08 | Vertex Pharma | Metodos para preparar inhibidores de la replicacion de virus de influenza. |
EP3068776B1 (en) | 2013-11-13 | 2019-05-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
JP2017504651A (ja) * | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体の使用 |
RU2016134947A (ru) | 2014-01-31 | 2018-03-01 | Дана-Фарбер Кансер Институт, Инк. | Производные диаминопиримидин бензолсульфона и их применение |
TWI806081B (zh) | 2014-07-11 | 2023-06-21 | 美商基利科學股份有限公司 | 用於治療HIV之toll樣受體調節劑 |
JP2017526741A (ja) | 2014-08-08 | 2017-09-14 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体およびその使用 |
UY36298A (es) | 2014-09-16 | 2016-04-29 | Gilead Science Inc | Formas sólidas de un modulador del receptor tipo toll |
PT3194402T (pt) | 2014-09-16 | 2019-02-11 | Gilead Sciences Inc | Métodos de preparação de moduladores dos recetores tipo toll |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
RU2750164C2 (ru) | 2015-09-11 | 2021-06-22 | Дана-Фарбер Кэнсер Инститьют, Инк. | Цианотиенотриазолодиазепины и пути их применения |
BR112018004617A2 (pt) | 2015-09-11 | 2018-09-25 | Dana Farber Cancer Inst Inc | acetamida tienotriazoldiazepinas e usos das mesmas |
CR20180336A (es) | 2015-11-25 | 2018-08-06 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos |
WO2017177092A1 (en) * | 2016-04-07 | 2017-10-12 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders |
WO2021061894A1 (en) * | 2019-09-27 | 2021-04-01 | Dana-Farber Cancer Institute, Inc. | Erk5 degraders as therapeutics in cancer and inflammatory diseases |
KR20210122163A (ko) * | 2020-03-27 | 2021-10-08 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 피라졸로퀴나졸린 유도체 화합물 |
WO2022145989A1 (ko) * | 2020-12-31 | 2022-07-07 | (주) 업테라 | 선택적 plk1 억제제로서의 피리미도디아제핀 유도체 |
MX2024001774A (es) | 2021-08-10 | 2024-04-24 | Uppthera Inc | Compuesto inductor de la degradacion de plk1 novedoso. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ2002934A3 (cs) * | 1999-09-17 | 2002-07-17 | Abbott Gmbh & Co. Kg | Inhibitory kinázy jako terapeutická činidla |
CN1551881A (zh) * | 2001-09-04 | 2004-12-01 | ���ָ��Ӣ��ķ�������Ϲ�˾ | 新颖二氢喋啶酮,其制备方法及作为药物组合物的用途 |
DE602007008837D1 (de) * | 2006-02-14 | 2010-10-14 | Vertex Pharma | Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine |
TW200808325A (en) | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
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2008
- 2008-03-11 KR KR1020097019761A patent/KR101157848B1/ko not_active IP Right Cessation
- 2008-03-11 CN CN201210030872.3A patent/CN102746175B/zh not_active Expired - Fee Related
- 2008-03-11 WO PCT/EP2008/052847 patent/WO2008113711A1/en active Search and Examination
- 2008-03-11 AT AT08717594T patent/ATE524472T1/de active
- 2008-03-11 CN CN2008800088890A patent/CN101636399B/zh not_active Expired - Fee Related
- 2008-03-11 JP JP2009553997A patent/JP5087640B2/ja not_active Expired - Fee Related
- 2008-03-11 SI SI200830445T patent/SI2139892T1/sl unknown
- 2008-03-11 MX MX2009010034A patent/MX2009010034A/es active IP Right Grant
- 2008-03-11 AU AU2008228303A patent/AU2008228303B2/en not_active Ceased
- 2008-03-11 BR BRPI0809088-2A patent/BRPI0809088A2/pt not_active IP Right Cessation
- 2008-03-11 ES ES08717594T patent/ES2371832T3/es active Active
- 2008-03-11 PT PT08717594T patent/PT2139892E/pt unknown
- 2008-03-11 PL PL08717594T patent/PL2139892T3/pl unknown
- 2008-03-11 CA CA002680757A patent/CA2680757A1/en not_active Abandoned
- 2008-03-11 DK DK08717594.9T patent/DK2139892T3/da active
- 2008-03-11 EP EP08717594A patent/EP2139892B1/en not_active Not-in-force
- 2008-03-18 CL CL2008000785A patent/CL2008000785A1/es unknown
- 2008-03-19 TW TW097109660A patent/TWI363629B/zh not_active IP Right Cessation
- 2008-03-19 US US12/051,000 patent/US7517873B2/en not_active Expired - Fee Related
- 2008-03-19 AR ARP080101142A patent/AR065794A1/es unknown
- 2008-03-19 PE PE2011001933A patent/PE20120495A1/es not_active Application Discontinuation
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2009
- 2009-08-27 IL IL200617A patent/IL200617A/en not_active IP Right Cessation
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2010
- 2010-07-05 HK HK10106507.1A patent/HK1139936A1/xx not_active IP Right Cessation
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2011
- 2011-11-02 HR HR20110807T patent/HRP20110807T1/hr unknown
- 2011-11-30 CY CY20111101174T patent/CY1112102T1/el unknown