JP2010504343A5 - - Google Patents
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- Publication number
- JP2010504343A5 JP2010504343A5 JP2009529307A JP2009529307A JP2010504343A5 JP 2010504343 A5 JP2010504343 A5 JP 2010504343A5 JP 2009529307 A JP2009529307 A JP 2009529307A JP 2009529307 A JP2009529307 A JP 2009529307A JP 2010504343 A5 JP2010504343 A5 JP 2010504343A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- methoxymethyl
- dimethylamino
- der
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 nitro, methoxy, methoxymethyl Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 Cc1n[n]2c(C(*)*)cc(C)nc2c1* Chemical compound Cc1n[n]2c(C(*)*)cc(C)nc2c1* 0.000 description 8
- FRAKGJKEMLMXMD-UHFFFAOYSA-N Cc1ncn[n]1C Chemical compound Cc1ncn[n]1C FRAKGJKEMLMXMD-UHFFFAOYSA-N 0.000 description 2
- ROGDZYMBQCBLLX-UHFFFAOYSA-N CC(C)(C)c1cccc(C)n1 Chemical compound CC(C)(C)c1cccc(C)n1 ROGDZYMBQCBLLX-UHFFFAOYSA-N 0.000 description 1
Claims (4)
- 式Ｉ：
Ｒ１およびＲ２は独立に水素またはＣ１−Ｃ３アルキルであり、
Ｒ３は
Ｒ４はＣｌまたはメチルであり、
Ｒ５は水素、Ｂｒ、ニトロ、メトキシ、メトキシメチル、ジメチルアミノ、エトキシカルボニル、アセトアミド、アセトキシ、
の化合物またはその薬理学的に許容できる塩。 - Ｒ１およびＲ２が独立にエチルまたはｎ−プロピルであり、Ｒ ３ が
- Ｒ５がメトキシ、メトキシメチル、ジメチルアミノまたは
- 請求項１から３のいずれか１項に記載の化合物またはその薬理学的に許容できる塩と薬理学的に許容できる賦形剤とを含む、医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82627306P | 2006-09-20 | 2006-09-20 | |
| US60/826,273 | 2006-09-20 | ||
| PCT/US2007/078352 WO2008036541A1 (en) | 2006-09-20 | 2007-09-13 | Thiophene pyrazolopyrimidine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010504343A JP2010504343A (ja) | 2010-02-12 |
| JP2010504343A5 true JP2010504343A5 (ja) | 2010-11-04 |
| JP5184536B2 JP5184536B2 (ja) | 2013-04-17 |
Family
ID=38988344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529307A Expired - Fee Related JP5184536B2 (ja) | 2006-09-20 | 2007-09-13 | チオフェンピラゾロピリミジン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8110580B2 (ja) |
| EP (1) | EP2076515B1 (ja) |
| JP (1) | JP5184536B2 (ja) |
| KR (1) | KR101088196B1 (ja) |
| CN (1) | CN101516886B (ja) |
| AU (1) | AU2007297481B2 (ja) |
| BR (1) | BRPI0717070A2 (ja) |
| CA (1) | CA2662000C (ja) |
| EA (1) | EA016056B1 (ja) |
| ES (1) | ES2428543T3 (ja) |
| MX (1) | MX2009003098A (ja) |
| WO (1) | WO2008036541A1 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2250160B1 (en) | 2008-01-25 | 2015-11-11 | Millennium Pharmaceuticals, Inc. | Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| CA2750935A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| WO2012021615A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| PE20131304A1 (es) | 2010-08-11 | 2013-11-14 | Millennium Pharm Inc | Heteroarilos y sus usos |
| TW201307309A (zh) | 2010-10-13 | 2013-02-16 | Millennium Pharm Inc | 雜芳基化合物及其用途 |
| WO2013005153A1 (en) | 2011-07-05 | 2013-01-10 | Lupin Limited | Biaryl derivatives as nachr modulators |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP6585625B2 (ja) | 2014-01-21 | 2019-10-02 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 先天性副腎皮質過形成の処置のためのｃｒｆ１レセプターアンタゴニスト |
| JP6364967B2 (ja) * | 2014-05-30 | 2018-08-01 | 東ソー株式会社 | ジチエノベンゾジチオフェンの製造方法 |
| EP3238676B1 (en) | 2016-04-29 | 2019-01-02 | The Procter and Gamble Company | Absorbent core with profiled distribution of absorbent material |
| KR102644781B1 (ko) * | 2017-08-14 | 2024-03-06 | 스프루스 바이오사이언시스 인코포레이티드 | 코티코트로핀 방출 인자 수용체 길항제 |
| TW202134241A (zh) * | 2019-12-04 | 2021-09-16 | 美商紐羅克里生物科學有限公司 | Ｃｒｆ受體拮抗劑及使用方法 |
| EP4175572A4 (en) | 2020-08-12 | 2024-03-27 | Spruce Biosciences Inc | METHODS AND COMPOSITIONS FOR TREATING POLYCYSTIC OVARIAN SYNDROME |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ258690A (en) | 1992-12-17 | 1997-01-29 | Pfizer | Pyrrolopyrimidines and pharmaceutical compositions containing such compounds; intermediate pyrrole compounds |
| PL191271B1 (pl) | 1996-02-07 | 2006-04-28 | Neurocrine Biosciences Inc | Pochodna pirazolopirymidyny i jej zastosowanie oraz kompozycja farmaceutyczna |
| DE69738197T2 (de) | 1996-07-24 | 2008-07-17 | Bristol-Myers Squibb Pharma Co. | Azolotriazine und pyrimidine |
| DE69736711T2 (de) | 1996-08-28 | 2007-09-20 | Pfizer Inc. | Substituierte 6,5-heterobicyclische-derivate |
| AU7737900A (en) * | 1999-09-30 | 2001-04-30 | Neurogen Corporation | Amino substituted pyrazolo(1,5,-a)-1,5-pyrimidines and pyrazolo(1,5-a)-1,3,5-triazines |
| RU2394035C2 (ru) | 2003-12-22 | 2010-07-10 | Эс Би ФАРМКО ПУЭРТО РИКО ИНК. | Антагонисты crf-рецепторов и способы, относящиеся к ним |
| CN101142217B (zh) * | 2005-03-21 | 2010-12-08 | 伊莱利利公司 | 咪唑并哒嗪化合物 |
-
2007
- 2007-09-13 EP EP07814842.6A patent/EP2076515B1/en not_active Not-in-force
- 2007-09-13 MX MX2009003098A patent/MX2009003098A/es active IP Right Grant
- 2007-09-13 BR BRPI0717070-0A2A patent/BRPI0717070A2/pt not_active IP Right Cessation
- 2007-09-13 JP JP2009529307A patent/JP5184536B2/ja not_active Expired - Fee Related
- 2007-09-13 ES ES07814842T patent/ES2428543T3/es active Active
- 2007-09-13 US US12/438,953 patent/US8110580B2/en active Active
- 2007-09-13 KR KR1020097005694A patent/KR101088196B1/ko not_active IP Right Cessation
- 2007-09-13 CN CN2007800349472A patent/CN101516886B/zh not_active Expired - Fee Related
- 2007-09-13 EA EA200970302A patent/EA016056B1/ru not_active IP Right Cessation
- 2007-09-13 WO PCT/US2007/078352 patent/WO2008036541A1/en active Application Filing
- 2007-09-13 AU AU2007297481A patent/AU2007297481B2/en not_active Ceased
- 2007-09-13 CA CA2662000A patent/CA2662000C/en not_active Expired - Fee Related