JP2010077141A5 - - Google Patents

Download PDF

Info

Publication number
JP2010077141A5
JP2010077141A5 JP2009260665A JP2009260665A JP2010077141A5 JP 2010077141 A5 JP2010077141 A5 JP 2010077141A5 JP 2009260665 A JP2009260665 A JP 2009260665A JP 2009260665 A JP2009260665 A JP 2009260665A JP 2010077141 A5 JP2010077141 A5 JP 2010077141A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
patient
iii
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009260665A
Other languages
English (en)
Other versions
JP2010077141A (ja
JP5479857B2 (ja
Filing date
Publication date
Priority claimed from IL11997197A external-priority patent/IL119971A/xx
Application filed filed Critical
Publication of JP2010077141A publication Critical patent/JP2010077141A/ja
Publication of JP2010077141A5 publication Critical patent/JP2010077141A5/ja
Application granted granted Critical
Publication of JP5479857B2 publication Critical patent/JP5479857B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Claims (8)

  1. 式(III):

    (ここにおいてnは、12、13、15、及び16から選択される整数である)
    で表される化合物、又はその薬理学的に許容可能な塩、若しくは低級アルキルエステル。
  2. nが12である、請求項1に記載の化合物。
  3. 式(III):

    (ここにおいてnは、10ないし16から選択される整数である)
    で表される化合物、又はその薬理学的に許容可能な塩、若しくは低級アルキルエステルを有効成分として含む、成人期発病糖尿病、耐糖能障害(IGT)、又は非インスリン依存性の真性糖尿病(NIDDM)を治療するための薬剤組成物。
  4. nが12又は14である、請求項3に記載の薬剤組成物。
  5. 単位投与量の形態あたりの活性成分の量が50ないし500mgである、請求項3又は4に記載の薬剤組成物。
  6. 患者に経口投与される、請求項3〜5のいずれか1項に記載の薬剤組成物。
  7. 患者に非経口投与される、請求項3〜5のいずれか1項に記載の薬剤組成物。
  8. 患者に局所投与される、請求項3〜5のいずれか1項に記載の薬剤組成物。
JP2009260665A 1997-01-07 2009-11-16 カルボン酸及びその誘導体及びそれらを含む薬剤組成物 Expired - Fee Related JP5479857B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL119971 1997-01-07
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP53069798A Division JP2001507713A (ja) 1997-01-07 1997-12-25 カルボン酸及びその誘導体及びそれらを含む薬剤組成物

Publications (3)

Publication Number Publication Date
JP2010077141A JP2010077141A (ja) 2010-04-08
JP2010077141A5 true JP2010077141A5 (ja) 2012-07-26
JP5479857B2 JP5479857B2 (ja) 2014-04-23

Family

ID=11069666

Family Applications (2)

Application Number Title Priority Date Filing Date
JP53069798A Withdrawn JP2001507713A (ja) 1997-01-07 1997-12-25 カルボン酸及びその誘導体及びそれらを含む薬剤組成物
JP2009260665A Expired - Fee Related JP5479857B2 (ja) 1997-01-07 2009-11-16 カルボン酸及びその誘導体及びそれらを含む薬剤組成物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP53069798A Withdrawn JP2001507713A (ja) 1997-01-07 1997-12-25 カルボン酸及びその誘導体及びそれらを含む薬剤組成物

Country Status (10)

Country Link
US (3) US6284903B1 (ja)
EP (2) EP2112134B1 (ja)
JP (2) JP2001507713A (ja)
KR (2) KR100806928B1 (ja)
AT (1) ATE431816T1 (ja)
AU (1) AU742945B2 (ja)
CA (1) CA2277075C (ja)
DE (1) DE69739415D1 (ja)
IL (1) IL119971A (ja)
WO (1) WO1998030530A1 (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6814962B1 (en) * 1994-06-02 2004-11-09 Aventis Pharma S.A. Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
BR0009520A (pt) 1999-04-01 2002-06-11 Esperion Therapeutics Inc Composto, método para sintetizar o mesmo, composição, metódos para o tratramento ou prevenção, em um paciente, de doença cardiovascular, dislipidemia, dislipoproteinemia, distúrbio de metabolismo de glucose, doença de alzheimer, sìndrome x ou sìndrome metabólica, septicemia, distúrbio trombótico, distúrbio associado com receptor ativado por proliferador de peroxissoma, obesidade, pancreatite, hipertensão, doença renal, câncer, inflamação, impotência, para reduzir o teor de gordura de carne de gado bovino, e, para reduzir o teor de colesterol de ovos de aves
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
CN1479721A (zh) 2000-10-11 2004-03-03 ͨ��ҽ�ƹ�˾ 用于胆固醇治疗和相关应用的亚砜和双亚砜化合物和组合物
MXPA03003020A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de cetona y composiciones para el control del colesterol y usos relacionados.
EP1363879A2 (en) 2000-10-11 2003-11-26 Esperion Therapeutics Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
BR0114617A (pt) 2000-10-11 2005-12-13 Esperion Therapeutics Inc Composto, composição farmacêutica, métodos para tratar ou previnir uma doença cardiovascular, uma dislipidemia, uma dislipoproteinemia, um distúrbio do metabolismo da glicose, trombótico e associado com o receptor ativado do proliferador de peroxissoma, a doença de alzheimer, a sìndrome x ou sìndrome metabólica, a septicemia, a obesidade, pancreatite, a hipertensão, doença renal, câncer, a inflamação e a impotência, em um paciente e para reduzir o teor de gordura da carne em animal de criação e de colesterol de ovos de aves domésticas
CA2513660C (en) 2003-01-23 2012-05-08 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
US7705177B2 (en) 2003-12-24 2010-04-27 Esperion Therapuetics, Inc. Ketone compounds and compositions for cholesterol management and related uses
KR20070015114A (ko) * 2003-12-30 2007-02-01 신드로멕스 리미티드 3,3,14,14 테트라메틸 헥사데칸 1,16 이산의 투여 방법
AU2006275514B2 (en) 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
CN101641339B (zh) 2007-02-01 2013-07-17 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
EP2167069B1 (en) 2007-05-23 2011-10-26 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
AU2010204106B2 (en) 2009-01-08 2014-05-08 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
MX2021012876A (es) 2009-03-18 2022-06-23 Resverlogix Corp Nuevos agentes anti-inflamatorios.
ES2821018T3 (es) 2009-04-22 2021-04-23 Resverlogix Corp Nuevos agentes antiinflamatorios
AU2010290931B2 (en) 2009-09-03 2014-02-06 Pfizer Vaccines Llc PCSK9 vaccine
CA2812109A1 (en) 2010-09-20 2012-03-29 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
US20140004142A1 (en) 2011-03-02 2014-01-02 Pfizer Inc. Pcsk9 vaccine
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
EP2787986B1 (en) 2011-12-08 2017-10-18 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
US10279019B2 (en) 2014-02-11 2019-05-07 Stc.Unm PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
US11207285B2 (en) 2016-06-02 2021-12-28 Syndromex Ltd. Diabetes treatment regimens using alpha, alpha-substituted long-chain amphipathic carboxylates
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
CA3144371A1 (en) 2019-06-21 2020-12-24 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268082A (en) 1969-08-08 1972-03-22 Orsymonde Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
US3773946A (en) * 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
BE755550A (fr) * 1969-09-02 1971-02-01 Parke Davis & Co Acides alcanedioiques, leurs sels et leurs esters abaissant la teneur en triglycerides du serum sanguin
FR2288516A2 (fr) 1974-10-21 1976-05-21 Orsymonde Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
DE3423166A1 (de) 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4634975A (en) * 1984-09-17 1987-01-06 Progressive Dynamics, Inc. Method and apparatus for producing electromagnetic surveillance fields
JPS61171417A (ja) * 1985-01-23 1986-08-02 Wakunaga Seiyaku Kk 抗糖尿病剤
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3634356A1 (de) * 1986-10-08 1988-04-21 Epis Sa Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren
DE4224670A1 (de) * 1992-07-25 1994-01-27 Boehringer Mannheim Gmbh Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
JP2003001549A (ja) * 2001-06-26 2003-01-08 Howa Mach Ltd 光電式刃具折れ検知装置

Similar Documents

Publication Publication Date Title
JP2010077141A5 (ja)
JP2021063088A5 (ja)
JP2013518107A5 (ja)
JP2014500861A5 (ja)
JP2013519632A5 (ja)
JP2009102342A5 (ja)
JP2013542247A5 (ja)
JP2007302689A5 (ja)
JP2012502037A5 (ja)
JP2013508279A5 (ja)
JP2012255026A5 (ja)
JP2009535352A5 (ja)
JP2009504763A5 (ja)
JP2006143751A5 (ja)
JP2016534063A5 (ja)
JP2010530376A5 (ja)
JP2010090149A5 (ja)
JP2020097577A5 (ja)
JP2009530398A5 (ja)
JP2011527299A5 (ja)
JP2009537554A5 (ja)
JP2011507896A5 (ja)
JP2015509075A5 (ja)
JP2014505017A5 (ja)
JP2008542386A5 (ja)